oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Search Results: 1 - 10 of 2235 matches for " Gabriele Hakim "
All listed articles are free for downloading (OA Articles)
Page 1 /2235
Display every page Item
Effect of Plasma Membrane Cholesterol Depletion on Glucose Transport Regulation in Leukemia Cells
Cristiana Caliceti, Laura Zambonin, Cecilia Prata, Francesco Vieceli Dalla Sega, Gabriele Hakim, Silvana Hrelia, Diana Fiorentini
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041246
Abstract: GLUT1 is the predominant glucose transporter in leukemia cells, and the modulation of glucose transport activity by cytokines, oncogenes or metabolic stresses is essential for their survival and proliferation. However, the molecular mechanisms allowing to control GLUT1 trafficking and degradation are still under debate. In this study we investigated whether plasma membrane cholesterol depletion plays a role in glucose transport activity in M07e cells, a human megakaryocytic leukemia line. To this purpose, the effect of cholesterol depletion by methyl-β-cyclodextrin (MBCD) on both GLUT1 activity and trafficking was compared to that of the cytokine Stem Cell Factor (SCF). Results show that, like SCF, MBCD led to an increased glucose transport rate and caused a subcellular redistribution of GLUT1, recruiting intracellular transporter molecules to the plasma membrane. Due to the role of caveolae/lipid rafts in GLUT1 stimulation in response to many stimuli, we have also investigated the GLUT1 distribution along the fractions obtained after non ionic detergent treatment and density gradient centrifugation, which was only slightly changed upon MBCD treatment. The data suggest that MBCD exerts its action via a cholesterol-dependent mechanism that ultimately results in augmented GLUT1 translocation. Moreover, cholesterol depletion triggers GLUT1 translocation without the involvement of c-kit signalling pathway, in fact MBCD effect does not involve Akt and PLCγ phosphorylation. These data, together with the observation that the combined MBCD/SCF cell treatment caused an additive effect on glucose uptake, suggest that the action of SCF and MBCD may proceed through two distinct mechanisms, the former following a signalling pathway, and the latter possibly involving a novel cholesterol dependent mechanism.
Failure Analysis of an Aluminum Extension Portable Ladder  [PDF]
Abdel-Hakim Bouzid
Materials Sciences and Applications (MSA) , 2014, DOI: 10.4236/msa.2014.59069
Abstract:
The conditions of end supports of straight ladders are often the cause of major injuries. The firm and secure ladder ends against instability in general and sliding of the top and bottom ends in particular are among the check list of most ladder safety training books and manuals. However, the restraint to the free expansion of a ladder can cause a catastrophic failure due to buckling even at intermediate loads and should be presented in the latter as a serious potential hazard. This paper deals with an investigation of an extension. An analytical structural model that simulates the buckling behavior of an axially restrained ladder subjected to static and dynamic loading is developed. It compares two different ladder end conditions and shows that instability due to buckling can occur during ascension or descent in the case of an axially restrained ladder. The analytical results are supported and validated by a finite element model simulation conducted in parallel. This study may explain the root cause of similar incidents involving falls from portable ladders worldwide.
Structural Interpretation of Lineaments by Satellite Image Processing (Landsat TM) in the Region of Zahret Medien (Northern Tunisia)  [PDF]
Sonia Gannouni, Hakim Gabtni
Journal of Geographic Information System (JGIS) , 2015, DOI: 10.4236/jgis.2015.72011
Abstract: There are several techniques that were developed for determining the linear features. Lineament extractionfrom satellite data has been the most widely used applications in geology. In the present study, lineament hasbeen extracted from the digital satellite scene (Landsat 5, TM data), in the region of Zahret Median situated in the north west of Tunisia. The image was enhanced and used for automatic extraction. Several directions of features were mapped. The directions of major invoices are NE-SW and NW-SE oriented. The validation of the obtained results is carried out by comparison with the results geophysics as well as to the studies previous of mapping developed in the sector of study.
Modelling of the Usefulness of Carbon Nanotubes as Antiviral Compounds for Treating Alzheimer Disease  [PDF]
Hakim Al Garalleh
Advances in Alzheimer's Disease (AAD) , 2018, DOI: 10.4236/aad.2018.73006
Abstract: The new generations of nano-devices successfully apply with great promise as drug carriers in the treatment of different diseases. The proposed model aims to determine the pharmacological targets and evaluate the bio-safety of usefulness of carbon nanotube conjugated with two different antiviral compounds, Acetylcholine and Ravastigmine, for treating Alzheimer disease. We also obtain the medicinal model mathematically to evaluate the interaction energy arising from encapsulation of each antiviral compound inside the single-walled carbon nanotube. Acetylcholine is modelled as two-connected spheres, while Ravastigmine has two possible structures which are an ellipsoid and cylinder, all interacting with the interior wall of single-walled carbon nanotubes with variant radii rc . Our calculations show that the single-walled carbon nanotube of radius rc greater than 3.391 Å that will accept both drugs which are quite closer to the recent findings.
A Sieve for Prime Based on Extension Form of Not Prime  [PDF]
Gabriele Martino
American Journal of Computational Mathematics (AJCM) , 2013, DOI: 10.4236/ajcm.2013.31014
Abstract:

This paper will illustrate two versions of an algorithm for finding prime number up to N, which give the first version complexity

\"\" (1)

where c1, c2 are constants, and N is the input dimension, and gives a better result for the second version. The method is based on an equation that expresses the behavior of not prime numbers. With this equation it is possible to construct a fast iteration to verify if the not prime number is generated by a prime and with which parameters. The second method differs because it does not pass other times over a number that has been previously evaluated as not prime. This is possible for a recurrence of not prime number that is (mod 3) = 0. The complexity in this case is better than the first. The comparison is made most with Mathematics than by computer calculation as the number N should be very big to appreciate the difference between the two versions. Anyway the second version results better. The algorithms have been

Primality Test  [PDF]
Gabriele Martino
American Journal of Computational Mathematics (AJCM) , 2013, DOI: 10.4236/ajcm.2013.31009
Abstract:

In this paper we will give an algorithm that in the worst case solve the question about the primality of a number in \"\" but that gives better result if the number is not prime (constant operation). Firstly, we will introduce an equation on which are based not prime numbers. With this equation it is possible to deduce the prime number that generates a not prime number and to establish an equation in which if exists a certain integer the number is not prime and therefore vice versa to deduce if it is prime.

Solving a Traveling Salesman Problem with a Flower Structure  [PDF]
Gabriele Martino
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.27079
Abstract:

This works aims to give an answer to the problem P = NP? The result is positive with the criteria that solve the Traveling Salesman Problem in polynomial cost of the input size and a proof is given. This problem gets a solution because a polyhedron, with a cut flower looking, is introduced instead of graph (e.g. tree).

Perception of risk and benefit in patient-centered communication and care
Hakim A
Patient Intelligence , 2011, DOI: http://dx.doi.org/10.2147/PI.S9482
Abstract: ception of risk and benefit in patient-centered communication and care Review (3184) Total Article Views Authors: Hakim A Published Date May 2011 Volume 2011:3 Pages 39 - 48 DOI: http://dx.doi.org/10.2147/PI.S9482 Amin Hakim Healthcare Consulting, Staten Island, NY, USA Abstract: There has been an increase in the adoption of patient-centered communication and accountable care that has generated greater interest in understanding patient perception of risk and benefit (PPRB). Patients find complex medical information hard to understand, resulting in inaccurate conclusions. Health behavior models describe the processes that individuals use to arrive at decisions concerning their own care. Studies have shown that their perception and decision making are associated with many factors such as age, gender, race, past experience, cost, and familiarity. Communication plays an important role in health literacy, and many adults are not proficient in the latter, regardless of their education. Clinicians have long provided educational materials but as our understanding of practitioner–patient communication and PPRB increased, so has the need for better ways to present medical advice and potential outcomes to the patient. Educational materials should be accessible, understandable, and actionable. They should have a reading level of grade 5 or 6, and where possible include graphical representations. New print and multimedia tools incorporate easier to understand summaries of risks and benefits, but they often need additional improvements. Patients frequently have a great desire to share in decision making regarding their health, and may prefer to do so in a collaborative fashion with their health care providers. A shared decision will have the patient’s input and promises better clinical outcomes as suggested by the literature; however, evidence from randomized controlled trials is scant. Additional studies should examine these and other types of outcomes. Patients tend to delegate decision making to clinicians in emergent or serious conditions. Practitioners need to have a positive communication style that engages patients in a shared decision making process and elicits the latter’s preferences. Clinicians and patients often have divergent views on desired interventions and outcomes, and providers should be aware of their personal biases.
Perception of risk and benefit in patient-centered communication and care
Hakim A
Patient Intelligence , 2011,
Abstract: Amin HakimHealthcare Consulting, Staten Island, NY, USAAbstract: There has been an increase in the adoption of patient-centered communication and accountable care that has generated greater interest in understanding patient perception of risk and benefit (PPRB). Patients find complex medical information hard to understand, resulting in inaccurate conclusions. Health behavior models describe the processes that individuals use to arrive at decisions concerning their own care. Studies have shown that their perception and decision making are associated with many factors such as age, gender, race, past experience, cost, and familiarity. Communication plays an important role in health literacy, and many adults are not proficient in the latter, regardless of their education. Clinicians have long provided educational materials but as our understanding of practitioner–patient communication and PPRB increased, so has the need for better ways to present medical advice and potential outcomes to the patient. Educational materials should be accessible, understandable, and actionable. They should have a reading level of grade 5 or 6, and where possible include graphical representations. New print and multimedia tools incorporate easier to understand summaries of risks and benefits, but they often need additional improvements. Patients frequently have a great desire to share in decision making regarding their health, and may prefer to do so in a collaborative fashion with their health care providers. A shared decision will have the patient’s input and promises better clinical outcomes as suggested by the literature; however, evidence from randomized controlled trials is scant. Additional studies should examine these and other types of outcomes. Patients tend to delegate decision making to clinicians in emergent or serious conditions. Practitioners need to have a positive communication style that engages patients in a shared decision making process and elicits the latter’s preferences. Clinicians and patients often have divergent views on desired interventions and outcomes, and providers should be aware of their personal biases.Keywords: perception, risk, benefit, preference, patient-centered, communication
SISTEM INFORMASI LINGKUNGAN SEBAGAI PENGEMBANGAN SISTEM KEWASPADAAN DINI MALARIA (Kajian di Kabupaten Ciamis Provinsi Jawa Barat)
Lukman Hakim
Media of Health Research and Development , 2012,
Abstract: Nowadays, the detection system of outbreak uses Early Warning System (EWS), whereas the base of EWS is the malaria case founded If the outbreak information is late accepted by malaria program organizer in district/municipality level, it could cause the unoptimal malaria outbreak control. An Environmental Information System (EIS) would be developed to prevent it. In order to develop EIS, it need to be determined the research location to get EIS parameter. The research objective is, to research the relation between environmental factor (the tide of sea water, rainfall, salinity, and algae) with An. sundaicus larva density. An. sundaicus mosquito density, and malaria case to be utilized as parameter in compilation of EIS. The design of the research is analytic epidemiology study to evaluate the hypothesis of the possibility of causal relations's between risk factor and the disease. Format of the study is observational study by using a retrospective and prospective research plans. The analysis unit is the individual group that is bordered by geographically, between High Case Incidence village with Anopheles sundaicus vector. By using the SPSS version 10.0 software, data is processed to answer the hypothesis of the research and by using the programming language of Borland Delphi 7, the model of EIS can be compiled; and also Matlab software version 7.1 is used to analyze the approximation, to formulate, that will become a parameter in EIS and for the Data Base Management System, SQL Server 2000 software is used that has been conducted in Informatics Laboratory of the S2/S3 Study Program of Electrical Engineering, Faculty of Engineering, Gadjah Mada University. The tide of sea water factor, rainfall, salinity, algae, density of An. sundaicus larva, density of An. sundaicus mosquito, and malaria case, could be used as EIS parameter. A competent model of EIS in technical programming has been developed, that could be used easily, beneficially and optimally in the effort ofprevention of malaria outbreak. To conclude, environment factor, has a relation with An. sundaicus larva density, and An. sundaicus mosquito density. Environment factor such as rainfall, salinity, and algae, also An. sundaicus larva density, and An. sundaicus mosquito density gives the multiple regression impact to 51,9% of malaria case factor. That could be used as EIS parameter are rainfall, salinity, and algae, also An. sundaicus larva density, and An.sundaicus mosquito density, and malaria case. The utilization of environmental information system, is coordinated by health centre. Keyword: en
Page 1 /2235
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.