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Search Results: 1 - 10 of 1796 matches for " Gabriele Beinoraité "
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Concerted Action of the Ubiquitin-Fusion Degradation Protein 1 (Ufd1) and Sumo-Targeted Ubiquitin Ligases (STUbLs) in the DNA-Damage Response
Julie Bonne K?hler, Maria Louise M?nster J?rgensen, Gabriele Beinoraité, Michael Thorsen, Geneviève Thon
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080442
Abstract: In eukaryotes many players in the DNA-damage response (DDR) catalyze protein sumoylation or ubiquitylation. Emphasis has been placed on how these modifications orchestrate the sequential recruitment of repair factors to sites of DNA damage or stalled replication forks. Here, we shed light on a pathway in which sumoylated factors are eliminated through the coupled action of Sumo-targeted ubiquitin ligases (STUbLs) and the ubiquitin-fusion degradation protein 1 (Ufd1). Ufd1 is a subunit of the Cdc48-Ufd1-Npl4 complex implicated in the sorting of ubiquitylated substrates for degradation by the proteasome. We find that in fission yeast, Ufd1 interacts physically and functionally with the Sumo-targeted ubiquitin ligase (STUbL) Rfp1, homologous to human RNF4, and with the Sumo E3 ligase Pli1, homologous to human PIAS1. Deleting a C-terminal domain of Ufd1 that mediates the interaction of Ufd1 with Rfp1, Pli1, and Sumo (ufd1ΔCt213-342) lead to an accumulation of high-molecular-weight Sumo conjugates and caused severe genomic instabilities. The spectrum of sensitivity of ufd1ΔCt213-342 cells to genotoxins, the epistatic relationships of ufd1ΔCt213-342 with mutations in DNA repair factors, and the localization of the repair factor Rad22 in ufd1ΔCt213-342 cells point to ufd1ΔCt213-342 cells accumulating aberrant structures during replication that require homologous recombination (HR) for their repair. We present evidence that HR is however often not successful in ufd1ΔCt213-342 cells and we identify Rad22 as one of the high-molecular-weight conjugates accumulating in the ufd1ΔCt213-342 mutant consistent with Rad22 being a STUbL/Ufd1 substrate. Suggesting a direct role of Ufd1 in the processing of Sumo-conjugates, Ufd1 formed nuclear foci colocalizing with Sumo during the DDR, and Sumo-conjugates accumulated in foci in the ufd1ΔCt213-342 mutant. Broader functional relationships between Ufd1 and STUbLs conceivably affect numerous cellular processes beyond the DDR.
A Sieve for Prime Based on Extension Form of Not Prime  [PDF]
Gabriele Martino
American Journal of Computational Mathematics (AJCM) , 2013, DOI: 10.4236/ajcm.2013.31014

This paper will illustrate two versions of an algorithm for finding prime number up to N, which give the first version complexity

\"\" (1)

where c1, c2 are constants, and N is the input dimension, and gives a better result for the second version. The method is based on an equation that expresses the behavior of not prime numbers. With this equation it is possible to construct a fast iteration to verify if the not prime number is generated by a prime and with which parameters. The second method differs because it does not pass other times over a number that has been previously evaluated as not prime. This is possible for a recurrence of not prime number that is (mod 3) = 0. The complexity in this case is better than the first. The comparison is made most with Mathematics than by computer calculation as the number N should be very big to appreciate the difference between the two versions. Anyway the second version results better. The algorithms have been

Primality Test  [PDF]
Gabriele Martino
American Journal of Computational Mathematics (AJCM) , 2013, DOI: 10.4236/ajcm.2013.31009

In this paper we will give an algorithm that in the worst case solve the question about the primality of a number in \"\" but that gives better result if the number is not prime (constant operation). Firstly, we will introduce an equation on which are based not prime numbers. With this equation it is possible to deduce the prime number that generates a not prime number and to establish an equation in which if exists a certain integer the number is not prime and therefore vice versa to deduce if it is prime.

Solving a Traveling Salesman Problem with a Flower Structure  [PDF]
Gabriele Martino
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.27079

This works aims to give an answer to the problem P = NP? The result is positive with the criteria that solve the Traveling Salesman Problem in polynomial cost of the input size and a proof is given. This problem gets a solution because a polyhedron, with a cut flower looking, is introduced instead of graph (e.g. tree).

On the Fractal Design in Human Brain and Nervous Tissue  [PDF]
Gabriele A. Losa
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.512165

Digital imaging techniques have enabled to gain insight into complex structure-functional processes involved in the neo-cortex maturation and in brain development, already recognized in anatomical and histological preparations. Despite such a refined technical progress most diagnostic records sound still elusive and unreliable because of use of conventional morphometric approaches based on a unique scale of measure, inadequate for investigating irregular cellular components and structures which shape nervous and brain tissues. Instead, these could be efficiently analyzed by adopting principles and methodologies derived from the Fractal Geometry. Through his masterpiece, The Fractal Geometry of Nature [1], Benoît Mandelbrot has provided a novel epistemological framework for interpreting the real life and the natural world as they are, preventing whatever approximation or subjective sight. Founded upon a body of well-defined laws and coherent principles, the Fractal Geometry is a powerful tool for recognizing and quantitatively describing a good many kinds of complex shapes, living forms, organized patterns, and morphologic features long range correlated with a broad network of functional interactions and metabolic processes that contribute to building up adaptive responses making life sustainable. Scale free dynamics characterized biological systems which develop through the iteration of single generators on different scales thus preserving proper self-similar traits. In the last decades several studies have contributed to showing how relevant may be the recognition of fractal properties for a better understanding of brain and nervous tissues either in healthy conditions or in altered and pathological states.

Immune evasion by Plasmodium falciparum parasites: converting a host protection mechanism for the parasite′s benefit  [PDF]
Bismarck Dinko, Gabriele Pradel
Advances in Infectious Diseases (AID) , 2016, DOI: 10.4236/aid.2016.62011
Abstract: Immune evasion is a strategy used by pathogenic microbes to evade the host immune system in order to ensure successful propagation. Immune evasion is particularly important for the blood stages of Plasmodium falciparum, the causative agent of the deadly disease malaria tropica. Because Plasmodium blood stage parasites require human erythrocytes for replication, their ability to evade attack by the human immune system is essential for parasite survival. In order to escape immunity-induced killing, the intraerythrocytic parasites have evolved a variety of evasion mechanisms, including expansion of plasmodial surface proteins, organ-specific sequestration of the infected red blood cells and acquisition of immune-regulatory proteins by the parasite. This review aims to highlight recent advances in the molecular understanding of the immune evasion strategies by P. falciparum, including antigenic variation, surface protein polymorphisms and invasion ligand diversification. The review will further discuss new findings on the regulatory mechanisms applied by P. falciparum to avoid lysis by the human complement as well as killing by immune factors of the mosquito vector.
Applications of Fractional Calculus to Newtonian Mechanics  [PDF]
Gabriele U. Varieschi
Journal of Applied Mathematics and Physics (JAMP) , 2018, DOI: 10.4236/jamp.2018.66105
Abstract: We investigate some basic applications of Fractional Calculus (FC) to Newtonian mechanics. After a brief review of FC, we consider a possible generalization of Newton’s second law of motion and apply it to the case of a body subject to a constant force. In our second application of FC to Newtonian gravity, we consider a generalized fractional gravitational potential and derive the related circular orbital velocities. This analysis might be used as a tool to model galactic rotation curves, in view of the dark matter problem. Both applications have a pedagogical value in connecting fractional calculus to standard mechanics and can be used as a starting point for a more advanced treatment of fractional mechanics.
Supercritical Water Technology Applied to the Purification of Waters Contaminated by Toxic Micro-Polluting Organic Compounds  [PDF]
Gabriele Di Giacomo, Luca Taglieri
Journal of Water Resource and Protection (JWARP) , 2012, DOI: 10.4236/jwarp.2012.47053
Abstract: Purification of water contaminated by toxic organic compounds at low and very low concentration is a quite interesting challenge from both the technical and the economical point of view. In fact, the direct destruction of organic compounds dissolved in very diluted aqueous solution is very costly and hardly achievable. To overcome this problems it was studied and developed a new water purification process which is made of three steps: a) removal of the diluted and toxic polluting compounds by adsorption on activated carbon beds operating at ambient P ant T; b) regeneration of the exhausted carbon bed with supercritical water in order to obtain a mixture of water and polluting compounds signifi-cantly more concentrated than the contaminated liquid water; c) destruction of the toxic compounds in a continuous Supercritical Water Oxidation Reactor. Step a) was studied at laboratory scale in order to obtain all the required information for modeling the adsorption operation; step b) was modeled by using literature experimental data and, step c) was validated at pilot plant scale. In all the above mentioned steps, phenol was used as representative of polluting compounds.
On Extremal Self-Dual Ternary Codes of Length 48
Gabriele Nebe
International Journal of Combinatorics , 2012, DOI: 10.1155/2012/154281
Abstract: All extremal ternary self-dual codes of length 48 that have some automorphism of prime order ≥5 are equivalent to one of the two known codes, the Pless code or the extended quadratic residue code.
"Etica ed Estetica sono tutt?uno" Riflessioni su TLP 6.421
Tomasi, Gabriele;
Trans/Form/A??o , 2011, DOI: 10.1590/S0101-31732011000400008
Abstract: the early wittgenstein conceived of ethics and aesthetics as one and the same. this essay aims to provide an interpretation of this idea. it examines the way it is put forward in the tractatus and in some remarks from the tagebücher 1914-1916, and argues that the unity of ethics and aesthetics is for wittgenstein a way of looking at the world in such a way that the world does not appear to set limits for human life. ethics extends the ability to confer meaning that men and women use in the realm of art-making, dealing with particular objects, to the realm of life and of the world taken as a whole. claiming that ethics and aesthetics are one wittgenstein points out that at the roots of ethics there is a certain way of looking at the world, a certain disposition towards life. this point of view on the world does not attribute value to the world because of the way it is. the world is seen, instead, as a source of wonder, and it is this fact that makes it valuable.
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