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Search Results: 1 - 10 of 5081 matches for " Gabriela Mustata "
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Aromatase inhibitors and antiepileptic drugs: a computational systems biology analysis
Yagmur Muftuoglu, Gabriela Mustata
Reproductive Biology and Endocrinology , 2011, DOI: 10.1186/1477-7827-9-92
Abstract: Through a pharmacophore search, this study shows that a model previously designed to search for new classes of aromatase inhibitors is able to identify antiepileptic drugs from the set of drugs approved by the Food and Drug Administration. Chemical and structural similarity analyses were performed using five potent AIs, and these studies returned a set of AEDs that the model identifies as hits.The pharmacophore model returned 73% (19 out of 26) of the drugs used specifically to treat epilepsy and approximately 82% (51 out of 62) of the compounds with anticonvulsant properties. Therefore, this study supports the possibility of identifying AEDs with a pharmacophore model that had originally been designed to identify new classes of aromatase inhibitors. Potential candidates for anticonvulsant therapy identified in this manner are also reported. Additionally, the chemical and structural similarity between antiepileptic compounds and aromatase inhibitors is proved using similarity analyses.This study demonstrates that a pharmacophore search using a model based on aromatase inhibition and the enzyme's structural features can be used to screen for new candidates for antiepileptic therapy. In fact, potent aromatase inhibitors and current antiepileptic compounds display significant - over 70% - chemical and structural similarity, and the similarity analyses performed propose a number of antiepileptic compounds with high potential for aromatase inhibition.The need to discover and develop new antiepileptic drugs (AEDs) is clear. The adverse side effects of the existent therapies - from cognitive impairment [1] to depression, anorexia, somnolence [2], and even birth defects [3] - have long been reported. Even the newer anticonvulsant medications have offered little relief [1,2]. In fact, harmful side effects seem to be the most significant factor in the approximately 35% long-term or 3-year retention rate for all new AEDs [1]. As a result, less toxic and more tolerable AEDs are
Functional Dynamics of Proteins
Lee-Wei Yang,Silvina Matysiak,Shang-Te Danny Hsu,Gabriela Mustata Wilson,Yasumasa Joti
Computational and Mathematical Methods in Medicine , 2012, DOI: 10.1155/2012/242903
A universal étale lift of a proper local embedding
Anca Mustata,Andrei Mustata
Mathematics , 2010,
Abstract: To any finite local embedding of Deligne--Mumford stacks $g: Y\to X$ we associate an \'etale, universally closed morphism $F_{Y/X}\to X$ such that for the complement $Y^2_X$ of the image of the diagonal $Y \to Y\times_XY$, the stack $F_{Y^2_X/Y}$ admits a canonical closed embedding in $F_{Y/X}$, and $F_{Y/X}\times_XY$ is a disjoint union of copies of $F_{Y^2_X/Y}$. The stack $F_{Y/X}$ has a natural functorial presentation, and the morphism $F_{Y/X}\to X$ commutes with base-change. The image of $Y^2_X$ in $Y$ is the locus of points where the morphism $Y \to g(Y)$ is not smooth. Thus for many practical purposes, the morphism $g$ can be replaced in a canonical way by copies of the closed embedding $F_{Y^2_X/Y}\to F_{Y/X}$.
The Chow ring of Mbar_{0,m}(n, d)
Anca Mustata,Andrei Mustata
Mathematics , 2005,
Abstract: We describe the Chow ring with rational coefficients of the moduli space of stable maps with marked points Mbar_{0,m}(n,d) as the subring of invariants of a ring B, relative to the action of the group of symmetries of d elements. B is computed by following a sequence of intermediate spaces for Mbar_{0,m}(n,d) and relating them to substrata of Mbar_{0,1}(n,d+m-1). An additive basis for the Chow ring is presented.
Gromov-Witten invariants for varieties with C* action
Anca Mustata,Andrei Mustata
Mathematics , 2015,
Abstract: For any smooth projective variety with a C* action, we reduce the problem of computing its Gromov-Witten invariants to the similar problem for its fixed locus. Starting from the stacky version of variation of GIT for our variety, we construct the building blocks for the fixed loci of the moduli space of stable maps. We use this construction to compute their contribution to the virtual fundamental class.
Dana Mustata
View : Journal of European Television History and Culture , 2012,
Abstract: Doing European television history is as much a theoretical and methodological challenge as it is a practical one. This novice field of study requires first and foremost answers to a few fundamental questions: How do we define European television? What tools do we employ to engage in television research that goes beyond or against national borders of television in Europe? How do we integrate Europe in a field of research that has been predominantly Western?
History In The Backstage Of Romanian Television Archives
Dana Mustata
View : Journal of European Television History and Culture , 2012,
Abstract: The historical value of audiovisual archives lies as much in the documented collection they have to offer as in the losses that history has imprinted on them. Controversial material that has been confiscated by the secret police in communist Romania or records of programmes that have been destroyed due to economizing practices of ‘taking the silver out of the pellicle’ are important facts in the history of Romanian television. Equally important for history is the ‘leftover’ material filmed during the Romanian revolution, which now lives in the shadow of the screened footage. Pursuing the life story of an archival institution and understanding its relations with history forms an important preliminary step for the historian in assessing the documented history within the archive.
Degree 1 Curves in the Dwork Pencil and the Mirror Quintic
Anca Mustata
Mathematics , 2003,
Abstract: We give a description of the relative Hilbert scheme of lines in the Dwork pencil of quintic threefolds. We describe the corresponding relative Hilbert scheme associated to the mirror family of quintic threefolds.
Multiplier ideals of hyperplane arrangements
Mircea Mustata
Mathematics , 2004,
Abstract: We compute the multiplier ideals of hyperplane arrangements via the interpretation of these ideals in terms of spaces of arcs, due to Ein, Lazarsfeld and the author.
Bernstein-Sato polynomials in positive characteristic
Mircea Mustata
Mathematics , 2007,
Abstract: In characteristic zero, the Bernstein-Sato polynomial of a hypersurface can be described as the minimal polynomial of the action of an Euler operator on a suitable D-module. We consider the analogous D-module in positive characteristic, and use it to define a sequence of Bernstein-Sato polynomials (corresponding to the fact that we need to consider also divided powers Euler operators). We show that the information contained in these polynomials is equivalent to that given by the F-jumping exponents of the hypersurface, in the sense of Hara and Yoshida.
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