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Search Results: 1 - 10 of 58744 matches for " GUO Ya-jing "
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Effect of Bizhongxiao decoction and its dismantled formulae on IL-1 and TNF levels in collagen-induced arthritis in rat synovial joints
Guo Ya-jing,Chen Jiang,Xiong Xin-gui,Wu Dan
Theoretical Biology and Medical Modelling , 2012, DOI: 10.1186/1742-4682-9-47
Abstract: Background Rheumatoid arthritis (RA), a chronic autoimmune disease, affects sufferers in many different ways. Treatment of this chronic condition is particularly challenging. Traditional Chinese Medicine (TCM) provides alternatives. Bizhongxiao decoction (BZX) is a TCM complex, which has been used clinically for many years to treat RA. The purpose of this study is to compare the effects of BZX decoction and its dismantled formulae on IL-1 and TNF-1 levels in rats with RA, and to elucidate its mechanism of action. Methods Ninety healthy normal female SD rats were randomly divided into six groups: normal (control), model, BZX decoction, and the three dismantled formulae (I: heat-clearing and detoxication, II: dissipating dampness, and III: blood circulation promotion). Apart from the normal (control) group, the rats in each group were injected subcutaneously with bovine type II collagen and complete Freund adjuvant to establish a collagen-induced arthritis model, so that inhibition of foot swelling in the rats by BZX decoction and its dismantled formulae could be observed. Immunohistochemistry was used to assess the levels of the inflammatory cytokines IL-1 and TNF in synovial joints at various time points. Results Twenty-one days after the model was established, the levels of TNF and IL-1 were significantly higher in the model group, BZX decoction group and dismantled formula groups I, II and III than in the normal controls (P < 0.05). The levels of these cytokines were significantly higher in the model group than the BZX decoction or the three dismantled formula groups (P <0.01). At longer times, the TNF and IL-1 levels in model group rose gradually; those in the BZX decoction and dismantled formula groups were gradually reduced. The cytokine levels in the BZX decoction group were lower than in the three dismantled formula groups and continued to decline. Conclusions BZX decoction and the three dismantled formulae examined down-regulated the inflammatory factors IL-1 and TNF in collagen-induced arthritis rat models, but BZX exerted the strongest effect.
Effects of Cyclic Intermittent Hypoxia on ET-1 Responsiveness and Endothelial Dysfunction of Pulmonary Arteries in Rats
Zhuo Wang, Ai-Ying Li, Qiu-Hong Guo, Jian-Ping Zhang, Qi An, Ya-jing Guo, Li Chu, J. Woodrow Weiss, En-Sheng Ji
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058078
Abstract: Obstructive sleep apnoea (OSA) is a risk factor for cardiovascular disorders and in some cases is complication of pulmonary hypertension. We simulated OSA by exposing rats to cyclic intermittent hypoxia (CIH) to investigate its effect on pulmonary vascular endothelial dysfunction. Sprague-Dawley Rats were exposed to CIH (FiO2 9% for 1 min, repeated every 2 min for 8 h/day, 7 days/wk for 3 wk), and the pulmonary arteries of normoxia and CIH treated rats were analyzed for expression of endothelin-1 (ET-1) and ET receptors by histological, immunohistochemical, RT-PCR and Western Blot analyses, as well as for contractility in response to ET-1. In the pulmonary arteries, ET-1 expression was increased, and ET-1 more potently elicited constriction of the pulmonary artery in CIH rats than in normoxic rats. Exposure to CIH induced marked endothelial cell damage associated with a functional decrease of endothelium-dependent vasodilatation in the pulmonary artery. Compared with normoxic rats, ETA receptor expression was increased in smooth muscle cells of the CIH rats, while the expression of ETB receptors was decreased in endothelial cells. These results demonstrated endothelium-dependent vasodilation was impaired and the vasoconstrictor responsiveness increased by CIH. The increased responsiveness to ET-1 induced by intermittent hypoxia in pulmonary arteries of rats was due to increased expression of ETA receptors predominantly, meanwhile, decreased expression of ETB receptors in the endothelium may also participate in it.
Prevalence of canine leishmaniasis in Beichuan County, Sichuan, China and phylogenetic evidence for an undescribed Leishmania sp. in China based on 7SL RNA
Ke Sun, Wang Guan, Jian-Guo Zhang, Ya-Jing Wang, Yu Tian, Lin Liao, Bin-Bin Yang, Da-Li Chen, Jian-Ping Chen
Parasites & Vectors , 2012, DOI: 10.1186/1756-3305-5-75
Abstract: In this study, rK39 dip-stick, ELISA and PCR methods were used to investigate the prevalence of canine leishmaniasis (CanL) in Beichuan County, Sichuan Province, China.Among the 86 dogs which were included in the study, 13 dogs were positive using the dip-stick test (15.12%), while 8 dogs were positive using ELISA (9.30%) and 19 dogs were positive for PCR (22.03%). In total, 32 dogs were positive for one or more tests (37.21%). Interestingly, phylogenetic analysis based on the partial 7SL RNA fragment provided evidence that an undescribed Leishmania species, which is clearly a causative agent of CanL and human visceral leishmaniasis, does exist in China. This result is consistent with our previous study.Our work confirmed that canine leishmaniasis is still prevalent in Beichuan County. Further control is urgently needed, as canine leishmaniasis is of great public health importance. The phylogenetic analysis based on 7SL RNA segment provides evidence for the existence of an undescribed Leishmania sp. in China.Leishmaniasis is a vector-borne disease caused by different species of the genus Leishmania, including subgenera Viannia and Leishmania. The diseases are characterized by a spectrum of clinical manifestations: cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL) and visceral leishmaniasis (VL) [1]. Globally, leishmaniasis affects 88 countries, which is an estimated 500,000 cases of VL and 1–1.5 million cases of CL each year [2]. Epidemiologically, canines are the major reservoirs of Leishmania, the etiological agent of human visceral leishmaniasis [3-7]. Following the accelerating urbanization and population mobility, canine leishmaniasis is epidemic in America, Asia and Europe [8-14].Leishmaniasis is still endemic in China, especially in the west and northwest regions. The prevalence of human leishmaniasis in west China was alarming according to the reports of Wang et al. [15] and Qu et al. [16]. Moreover, as our previous study [17,18] indicated, Lei
Research progresses of exosomes for diagnosis and treatment of central nervous system diseases

CHEN Ya-jing
, LIU Jian-rong, YANG Guo-yuan

- , 2015, DOI: 10.3969/j.issn.1674-8115.2015.11.026
Abstract: 外泌体是细胞内的多囊泡体与细胞质膜融合后主动分泌到细胞外的一种大小在30~100 nm的小囊泡。外泌体内含有脂质、蛋白质、miRNA等活性物质,可通过与靶细胞受体结合或水平转移内含物发挥生物学功能。外泌体作为一种新型的细胞间交流方式,在中枢神经系统参与形成神经元—胶质信号网络。脑细胞及干细胞分泌的外泌体在中枢神经系统疾病的发病及损伤修复机制中起着重要的调控作用。大量研究显示外泌体不仅可作为生物学标志物,同时具有良好的治疗潜能。本文着重阐述外泌体的一般特性、功能及其在中枢神经系统疾病诊治中的研究进展。
: Exosomes are 30-100nm vesicles secreted automatically from multivesicular bodies into extracellular environment after multivesicular bodies fusing with plasma membrane. Enriched of bioactive substances such as lipid, protein and miRNA, exosomes exert various biological functions by binding to the receptor of target cells or through horizontal transfer of contents. As a novel way of cell-cell communication, exosomes may mediate inter-neuronal signaling through the neuro-glia interaction in central nervous system (CNS). Exosomes secreted by brain cells and stem cells play an important regulatory role in pathogenesis and damage repair mechanism of CNS diseases. Abundant researches have proven that exosomes can be regarded as biomarkers and have good potential for treatment. This paper reviews general characteristics and functions of exosomes, as well as research progresses of exosomes for diagnosis and treatment of CNS diseases
Dynamic discovery of authors research interest based on the combined topic evolutional model

YU Chuan-ming
, ZUO Yu-heng, GUO Ya-jing, AN Lu

- , 2018, DOI: 10.6040/j.issn.1671-9352.1.2017.044
Abstract: 摘要: 以金融领域的科技文献作为实验数据,提出了一种新的用于动态挖掘领域相关的作者研究兴趣的复合主题演化模型。该模型能够获取作者在不同时间片下的主题概率分布以及主题下词汇概率分布,并充分考虑作者在合作作者文献中的排名对于其研究主题和主题变化的影响。通过金融领域的实证研究表明,该复合主题演化模型能够有效地揭示金融领域作者研究兴趣的动态变化。
Abstract: We propose a new combined topic model, i.e. author topic time-latent dirichlet allocation(ATT-LDA)with author ranking(AR), for the of dynamic discovery of researchers' interest, which is based on the academic literature in the financial field. Through the proposed model, we can easily acquire the probability distribution of the authors' interest, as well as the probability distribution of topics on deferent words. The influence of the ranking in the co-author list are fully taken into consideration. The empirical study shows that the proposed method can effectively reveal the dynamic change of interest of the authors in the financial field
Phase Behavior of Sphere-Forming Triblock Copolymers in Films  [PDF]
Hong-Ge Tan, Qing-Gong Song, Xin-Huan Yang, Ya-Jing Deng
Open Journal of Applied Sciences (OJAppS) , 2012, DOI: 10.4236/ojapps.2012.23023
Abstract: The self-assembly of sphere-forming triblock copolymers confined between two thin homogeneous surfaces is investigated based on mean-field dynamic density functional theory. The morphologies deviating from the bulk sphere-forming phase are revealed, including cylinders oriented perpendicular to the surface, cylinders oriented parallel to the surface, perforated lamellae and lamellae by varying film thickness and surface field strength. The phase diagram of surface reconstruction is also constructed. By comparing the present phase diagram with the other relevant phase diagram for the cylinder-forming triblock copolymer film, the difference between the sphere-forming and the cylinder-forming triblock copolymer thin film is discussed.
Partial equilibrium approximations in Apoptosis
Ya-Jing Huang,Wen-An Yong
Quantitative Biology , 2012,
Abstract: Apoptosis is one of the most basic biological processes. In apoptosis, tens of species are involved in many biochemical reactions with times scales of widely differing orders of magnitude. By the law of mass action, the process is mathematically described with a large and stiff system of ODEs (ordinary differential equations). The goal of this work is to simplify such systems of ODEs with the PEA (partial equilibrium approximation) method. In doing so, we propose a general framework of the PEA method together with some conditions, under which the PEA method can be justified rigorously. The main condition is the principle of detailed balance for fast reactions as a whole. With the justified method as a tool, we made many attempts via numerical tests to simplify the Fas-signaling pathway model due to Hua et al. (2005) and found that nine of reactions therein can be well regarded as relatively fast. This paper reports our simplification of Hua at el.'s model with the PEA method based on the fastness of the nine reactions, together with numerical results which confirm the reliability of our simplified model.
The caloric content of plant species and its role in a Leymus chinensis steppe community of Inner Mongolia, China

BAO Ya-Jing,LI Zheng-Hai,HAN Xing-Guo,HAN Guo-Dong,ZHONG Yan-Kai,

生态学报 , 2007,
Abstract: 根据11a的野外实验对内蒙古羊草草原群落42种植物的能量含量(含灰分)及其在群落中的相对生物量进行了研究。不同植物种地上部分的能量含量在(13156±1141)J/g和(18141±527)J/g之间变动,所有物种的平均能量含量为(16899±840)J/g,种间变异系数4.9%。小叶锦鸡儿具有最高的能量含量。禾草的平均能量含量高于杂草。根据生活型和生长型,草本物种被进一步分组,能量含量从高到低的排列顺序为:高禾草(17717±92)J/g〉豆科植物(17228±433)J/g〉矮禾草(17250±218)J/g〉其余杂草(16784±529)J/g〉半灌木(16719±69)J/g〉1、2年生植物(15911±1759)J/g。42种植物的能量含量和它们在群落中的相对生物量存在显著正相关关系。根据它们在群落中的构成比例进行分组,以物种在群落中的相对生物量为权重,各组能量含量依次为:优势种(17740J/g)〉伴生种(17244J/g。)〉偶见种(16653J/g)。高能量含量的植物更具竞争力,在群落中通常占据优势地位,而低能量含量的植物竞争力通常较弱,构成草原群落的伴生种或偶见种。
Myosin Light-Chain Kinase Is Necessary for Membrane Homeostasis in Cochlear Inner Hair Cells
Guang-Jie Zhu, Fang Wang, Chen Chen, Lin Xu, Wen-Cheng Zhang, Chi Fan, Ya-Jing Peng, Jie Chen, Wei-Qi He, Shi-Ying Guo, Jian Zuo, Xia Gao, Min-Sheng Zhu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034894
Abstract: The structural homeostasis of the cochlear hair cell membrane is critical for all aspects of sensory transduction, but the regulation of its maintenance is not well understood. In this report, we analyzed the cochlear hair cells of mice with specific deletion of myosin light chain kinase (MLCK) in inner hair cells. MLCK-deficient mice showed impaired hearing, with a 5- to 14-dB rise in the auditory brainstem response (ABR) thresholds to clicks and tones of different frequencies and a significant decrease in the amplitude of the ABR waves. The mutant inner hair cells produced several ball-like structures around the hair bundles in vivo, indicating impaired membrane stability. Inner hair cells isolated from the knockout mice consistently displayed less resistance to hypoosmotic solution and less membrane F-actin. Myosin light-chain phosphorylation was also reduced in the mutated inner hair cells. Our results suggest that MLCK is necessary for maintaining the membrane stability of inner hair cells.
Assessment of the overall arrangement of urban modern agriculture industry in Beijing using location quotient technique

GUO Ya-Jing,GAO Shang-Bin,FANG Fang,WU Wen-Liang,ZHANG Jun-Lian,

中国生态农业学报 , 2008,
Abstract: Based on location quotient technique, we analyzed the comparative advantages of agricultural sub-sectors of Beijing municipality over surrounding provinces, and those among 18 districts and counties of Beijing. The appropriate industrial composition of urban modern agriculture for Beijing municipality was advanced. The research results indicate no significant comparative advantage of agriculture industry of Beijing over other surrounding provinces; no advantage for crop and fish culture; but there is a significant advantage for forestry and animal husbandry. Among the districts and counties of Beijing, agriculture still has a higher proportion in local industrial economics of Yanqing, Miyun, Pinggu, Daxing, Tongzhou, Shunyi and Fangshan. For the inner structure of agriculture, crop production is higher in Fengtai, Daxing, Pinggu, Changping and Tongzhou. Comparative advantage of forestry is remarkable for Mentougou, Chaoyang, Fengtai, Changping, Huairou and Haidian. Animal production is comparatively advantageous for Huairou, Miyun, Fangshan, Shunyi, Mentougou and Yanqing. Agricultural service is outstanding (from the perspective of comparative advantage) in Haidian and Chaoyang. Consequently, in combination with natural resources and position situation, the overall arrangement of industrial development in urban agriculture in Beijing can be categorized into four different cycles: suburban agricultural cycle, exurb-plain agricultural cycle, mountain-ecology agricultural cycle, and cooperative agricultural cycle.
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