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Search Results: 1 - 10 of 190275 matches for " G. Lis "
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Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature
Digant Gupta, Christopher G Lis
Nutrition Journal , 2010, DOI: 10.1186/1475-2891-9-69
Abstract: A systematic search of the literature using the MEDLINE database (January 1995 through June 2010) to identify epidemiologic studies on the relationship between serum albumin and cancer survival. To be included in the review, a study must have: been published in English, reported on data collected in humans with any type of cancer, had serum albumin as one of the or only predicting factor, had survival as one of the outcome measures (primary or secondary) and had any of the following study designs (case-control, cohort, cross-sectional, case-series prospective, retrospective, nested case-control, ecologic, clinical trial, meta-analysis).Of the 29 studies reviewed on cancers of the gastrointestinal tract, all except three found higher serum albumin levels to be associated with better survival in multivariate analysis. Of the 10 studies reviewed on lung cancer, all excepting one found higher serum albumin levels to be associated with better survival. In 6 studies reviewed on female cancers and multiple cancers each, lower levels of serum albumin were associated with poor survival. Finally, in all 8 studies reviewed on patients with other cancer sites, lower levels of serum albumin were associated with poor survival.Pretreatment serum albumin levels provide useful prognostic significance in cancer. Accordingly, serum albumin level could be used in clinical trials to better define the baseline risk in cancer patients. A critical gap for demonstrating causality, however, is the absence of clinical trials demonstrating that raising albumin levels by means of intravenous infusion or by hyperalimentation decreases the excess risk of mortality in cancer.Cancer is a major public health problem in the United States (US) and many other parts of the world. The World Health Organization (WHO) estimates that by 2020, globally, more than 15 million people will experience cancer and 10 million will die from it each year [1]. With the changing trends and advances in diagnostic aids, c
Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature
Digant Gupta, Christopher G Lis
Journal of Ovarian Research , 2009, DOI: 10.1186/1757-2215-2-13
Abstract: Ovarian cancer is the leading cause of mortality from gynecologic cancers in the United States (US), resulting in approximately 14,500 deaths annually [1]. The overall lifetime risk of developing ovarian cancer for women in the US is 1.4% to 1.8%. This risk varies from 0.6% for women with no family history, at least three term pregnancies, and four or more years of oral contraceptive use, to 3.4% for nulliparous women with no oral contraceptive use. For women with a family history, the lifetime risk for ovarian cancer is estimated at 9.4% [2]. The overall age-adjusted incidence rate for all ovarian cancer cases as reported by the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute is 16.23 cases per 100,000 women standardized to the 2000 US standard population [3]. There is marked geographical variation in age standardized incidence and mortality rates of ovarian cancer, with the highest rates observed in Northern and Western Europe, notably Scandinavia, and in North America [4].Ovarian cancer is often asymptomatic in its early stages and thus most patients have widespread disease at the time of diagnosis [5]. Unfortunately, the majority of epithelial ovarian cancers remain clinically undetected until patients have developed late stage disease and only a mere 25% of cancers are detected as stage I disease [6]. When diagnosed in Stage I, however, the cure rate can approach 90% with currently available cytoreductive surgery and combination chemotherapy [7]. Ovarian cancer remains a disease that proves fatal to the majority of patients, but where chemotherapy has been established as a treatment that improves survival. A minority of patients attain long survival after such treatment [8]. Despite the achievements of high response rates with surgery followed by chemotherapy [9-11], 75% of women ultimately die of complications associated with disease progression. Once stage III and IV ovarian cancer, which is defined by peritoneal an
The relationship between perceived service quality and patient willingness to recommend at a national oncology hospital network
Christopher G Lis, Mark Rodeghier, Digant Gupta
BMC Health Services Research , 2011, DOI: 10.1186/1472-6963-11-46
Abstract: A total of 2018 returning cancer patients treated at Cancer Treatment Centers of America? (CTCA) responded to an internally developed service quality questionnaire, which covered the following dimensions: operations and services, treatment and care with a multidisciplinary team and patient endorsements. Items were measured on a 7-point Likert-type scale ranging from "completely dissatisfied" to "completely satisfied." Patient willingness to, "recommend this facility to friends and associates" was measured on an 11-point scale ranging from "not at all likely" to "extremely likely", which was subsequently dichotomized into two categories: top box response (10) versus all others (0-9). The relationship between perceived service quality and "willingness to recommend" was assessed via Kendall's tau b correlation and univariate and multivariate logistic regression.Of the 2018 patients, 959 were newly diagnosed while 1059 were previously treated. 902 were males and 1116 females. The mean age was 54.2 years and the most frequent diagnoses were breast (412), lung (294), prostate (260), colorectal (179) and pancreas (169). 1553 patients said they were "extremely likely" to recommend CTCA to friends and associates, resulting in 77% "top box" responses while 465 (23%) responded in all other categories. The key service quality drivers that were statistically significant in the final logistic model were "team helping you understand your medical condition", "staff genuinely caring for you as an individual", "whole person approach to patient care" and "CTCA medical oncologist."In this multi-center study, we demonstrate the predictive significance of perceived service quality as it relates to patient willingness to recommend an oncology service provider. This study is unique in reporting on the role of perceived service quality as a predictor of patient willingness to recommend in a large sample of cancer patients.As consumerism continues to increase in healthcare, there has been a
Distribution and determinants of patient satisfaction in oncology: A review of the literature
Christopher G Lis, Mark Rodeghier, Digant Gupta
Patient Preference and Adherence , 2009, DOI: http://dx.doi.org/10.2147/PPA.S6351
Abstract: tribution and determinants of patient satisfaction in oncology: A review of the literature Review (7231) Total Article Views Authors: Christopher G Lis, Mark Rodeghier, Digant Gupta Published Date August 2009 Volume 2009:3 Pages 287 - 304 DOI: http://dx.doi.org/10.2147/PPA.S6351 Christopher G Lis, Mark Rodeghier, Digant Gupta Cancer Treatment Centers of America at Midwestern Regional Medical Center, 2610 Sheridan Road, Zion, IL, 60099, USA Abstract: Cancer is one of the leading causes of morbidity and mortality in the United States. It places considerable mental, physical, and emotional stress on patients and requires them to make major adjustments in many key areas of their lives. As a consequence, the demands on health care providers to satisfy the complex care needs of cancer patients increase manifold. Of late, patient satisfaction has been recognized as one of the key indicators of health care quality and is now being used by health care institutions for monitoring health care improvement programs, gaining accreditation, and marketing strategies. The patient satisfaction information is also being used to compare and benchmark hospitals, identify best-performance institutions, and discover areas in need of improvement. However, the existing literature on patient satisfaction with the quality of cancer care they receive is inconsistent and heterogeneous because of differences in study designs, questionnaires, study populations, and sample sizes. The aim of this review was therefore to systematically evaluate the available information on the distribution and determinants of patient satisfaction in oncology.
Distribution and determinants of patient satisfaction in oncology: A review of the literature
Christopher G Lis,Mark Rodeghier,Digant Gupta
Patient Preference and Adherence , 2009,
Abstract: Christopher G Lis, Mark Rodeghier, Digant GuptaCancer Treatment Centers of America at Midwestern Regional Medical Center, 2610 Sheridan Road, Zion, IL, 60099, USAAbstract: Cancer is one of the leading causes of morbidity and mortality in the United States. It places considerable mental, physical, and emotional stress on patients and requires them to make major adjustments in many key areas of their lives. As a consequence, the demands on health care providers to satisfy the complex care needs of cancer patients increase manifold. Of late, patient satisfaction has been recognized as one of the key indicators of health care quality and is now being used by health care institutions for monitoring health care improvement programs, gaining accreditation, and marketing strategies. The patient satisfaction information is also being used to compare and benchmark hospitals, identify best-performance institutions, and discover areas in need of improvement. However, the existing literature on patient satisfaction with the quality of cancer care they receive is inconsistent and heterogeneous because of differences in study designs, questionnaires, study populations, and sample sizes. The aim of this review was therefore to systematically evaluate the available information on the distribution and determinants of patient satisfaction in oncology.Keywords: patient satisfaction, determinants, oncology
Distribution and determinants of patient satisfaction in oncology with a focus on health related quality of life
Christopher G Lis, Mark Rodeghier, James F Grutsch, Digant Gupta
BMC Health Services Research , 2009, DOI: 10.1186/1472-6963-9-190
Abstract: A cohort of 538 cancer patients treated at Cancer Treatment Centers of America? (CTCA) was assessed. A patient satisfaction questionnaire developed in-house by CTCA was used. It covered the following dimensions of patient satisfaction: hospital operations and services, physicians and staff, and patient endorsements for themselves and others. QoL was assessed using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (QLQ-C30). The clinical, demographic and QoL factors were evaluated for predictive significance using univariate and multivariate logistic regression.The mean age of our patient population was 54.1 years (SD = 10.5, range 17-86), with a slight preponderance of females (57.2%). Breast cancer (n = 124) and lung cancer (n = 101) were the most frequent cancer types. 481 (89.4%) patients were "very satisfied" with their overall experience. Age and several QoL function and symptom scales were predictive of overall patient satisfaction upon univariate analysis. In the multivariate modeling, only those with a score above the median on the fatigue measure (i.e. worse fatigue) had reduced odds of 0.28 of being very satisfied (p = 0.03).Patient fatigue, as reported by the QoL fatigue scale, was an independent significant predictor of overall patient satisfaction. This finding argues for special attention and programs for cancer patients who report higher levels of fatigue given that fatigue is the most frequently reported symptom in cancer patients.In recent years, awareness has risen of how patients perceive the quality of their care [1,2]. In an extremely competitive environment, patient satisfaction has become a tool to gain attention and value amongst the patients as well as providers. Hospitals and other health care centers are increasingly using this information while making important decisions regarding the operational and treatment plans [3]. The patient satisfaction data is the key indicator of the quality of car
2-(Furan-2-yl)-3-hydroxy-4H-chromen-4-one
Michał Wera,Vasyl G. Pivovarenko,Artur Sikorski,Tadeusz Lis
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536810053596
Abstract: In the crystal structure of the title compound, C13H8O4, the inversely oriented molecules form inversion dimers through pairs of O—H...O hydrogen-bonding interactions. An intramolecular O—H...O hydrogen bond occurs. In the packing of the molecules, the nearly planar 2-(furan-2-yl)-4H-chromene units [dihedral angle between the chromene and furan rings = 3.8 (1)°] are either parallel or inclined at an angle of 80.7 (1)°.
Interacting partially directed self avoiding walk. From phase transition to the geometry of the collapsed phase
P. Carmona,G. B. Nguyen,N. Pétrélis
Mathematics , 2013,
Abstract: In this paper, we investigate a model for a $1+1$ dimensional self-interacting and partially directed self-avoiding walk, usually referred to by the acronym IPDSAW. The interaction intensity and the free energy of the system are denoted by $\beta$ and $f$, respectively. The IPDSAW is known to undergo a collapse transition at $\beta_c$. We provide the precise asymptotic of the free energy close to criticality, that is we show that $f(\beta_c-\epsilon)\sim \gamma \epsilon^{3/2}$ where $\gamma$ is computed explicitly and interpreted in terms of an associated continuous model. We also establish some path properties of the random walk inside the collapsed phase $(\beta>\beta_c)$. We prove that the geometric conformation adopted by the polymer is made of a succession of long vertical stretches that attract each other to form a unique macroscopic bead, we identify the horizontal extension of the random walk inside the collapsed phase and we establish the convergence of the rescaled envelope of the macroscopic bead towards a deterministic Wulff shape.
Phase transformations in low-carbon manganese steel 6Mn16
J. Lis,A. Lis
Metalurgija , 2009,
Abstract: The kinetics of phase transformations of the austenite of 6Mn16 steel during continuous cooling are presented in a CCT diagram. Manganese partitioning between ferrite and austenite during intercritical annealing is enhanced by prior soft annealing. Due to the increased Mn concentration in austenite, the temperatures BS and MS have decreased, as compared to those achieved during cooling from the complete austenite region.
Austenite formation during intercritical annealing
J. Lis,A. Lis
Journal of Achievements in Materials and Manufacturing Engineering , 2008,
Abstract: Purpose: of this paper is the effect of the soft annealing of initial microstructure of the 6Mn16 steel on the kinetics of the austenite formation during next intercritical annealing.Design/methodology/approach: Analytical TEM point analysis with EDAX system attached to Philips CM20 was used to evaluate the concentration of Mn, Ni and Cr in the microstructure constituents of the multiphase steel and mainly Bainite- Martensite islands.Findings: The increase in soft annealing time from 1-60 hours at 625°C increases Mn partitioning between ferrite and cementite and new formed austenite and decreases the rate of the austenite formation during next intercritical annealing in the (α+γ) temperature range at 700 and 750°C. The general equations for carbide dissolution and austenite formation in intercritical temperature range were established.Research limitations/implications: The final multiphase microstructure can be optimised by changing the time / temperature parameters of the intercritical heating in the (α+γ) temperature range.Originality/value: The knowledge of partitioning of alloying elements mainly Mn during soft annealing and intercritical heating is very important to optimise the processing technology of intercritical annealing for a given amount of the austenite.
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