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Search Results: 1 - 10 of 102281 matches for " Fu-Chao Liu "
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Red wine extract, resveratrol, on maintenance of organ function following trauma-hemorrhage
Fu-Chao Liu,Huang-Ping Yu
Functional Foods in Health and Disease , 2012,
Abstract: ABSTRACT:Resveratrol, is a polyphenol that can be extracted from grapes and red wine, possess potential anti-inflammatory effects, which would result in the reduction of cytokine production, the alteration of the expression of adhesion molecule molecules, and the inhibition of neutrophil function. Resveratrol might also act as an antioxidant, anti-aging, and control of cell cycle and apoptosis. Resveratrol has been shown to have protective effects for patients inshock-like states. Such protective phenomenon is reported to be implicated in a variety of intracellular signaling pathways including the regulation of the mitogen-activated protein kinases (MAPK)/ hemeoxygenase-1 (HO-1) pathway, activates estrogen receptor (ER), and the mediation of pro-inflammatory cytokines, reactive oxygen species (ROS) formation and reactive. Moreover, through anti-inflammatory effects and antioxidant properties, the resveratrol is believed to maintain organ function following trauma-hemorrhage.
Mechanism of Salutary Effects of Astringinin on Rodent Hepatic Injury following Trauma-Hemorrhage: Akt-Dependent Hemeoxygenase-1 Signaling Pathways
Fu-Chao Liu, Tsong-Long Hwang, Ying-Tung Lau, Huang-Ping Yu
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025907
Abstract: Astringinin can attenuate organ injury following trauma-hemorrhage, the mechanism remains unknown. Protein kinase B/hemeoxygenase-1 (Akt/HO-1) pathway exerts potent anti-inflammatory effects in various tissues. The aim of this study is to elucidate whether Akt/HO-1 plays any role in astringinin-mediated attenuation of hepatic injury following trauma-hemorrhage. For study this, male Sprague-Dawley rats underwent trauma-hemorrhage (mean blood pressure 35–40 mmHg for 90 min) followed by fluid resuscitation. A single dose of astringinin (0.3 mg/kg body weight) with or without a PI3K inhibitor (wortmannin) or a HO antagonist (chromium-mesoporphyrin) was administered during resuscitation. Various parameters were measured at 24 h post-resuscitation. Results showed that trauma-hemorrhage increased plasma aspartate and alanine aminotransferases (AST and ALT) concentrations and hepatic myeloperoxidase activity, cytokine induced neutrophil chemoattractant (CINC)-1, CINC-3, intercellular adhesion molecule-1, and interleukin-6 levels. These parameters were significantly improved in the astringinin-treated rats subjected to trauma-hemorrhage. Astringinin treatment also increased hepatic Akt activation and HO-1 expression as compared with vehicle-treated trauma-hemorrhaged rats. Co-administration of wortmannin or chromium-mesoporphyrin abolished the astringinin-induced beneficial effects on post-resuscitation pro-inflammatory responses and hepatic injury. These findings collectively suggest that the salutary effects of astringinin administration on attenuation of hepatic injury after trauma-hemorrhage are likely mediated via Akt dependent HO-1 up-regulation.
Effect of Warm Lidocaine on the Sensory Onset of Epidural Anesthesia: A Randomized Trial
Fu-Chao Liu,Jiin-Tarng Liou,Yuan-Ji Day,Allen H. Li
Chang Gung Medical Journal , 2009,
Abstract: Background: Administration of local anesthetics at body temperature has been reported toshorten the onset time of regional block; however, studies examining theeffects of warmed lidocaine on the onset of epidural anesthesia are limited.Here, we ascertain whether warming lidocaine solution to body temperatureshortens the time to onset of epidural anesthesia.Methods: Eighty patients were randomly allocated into two groups of equal size. Bothreceived 16 ml of lidocaine solution injected via the epidural route at the L4-5 interspace, with one group receiving the solution at room temperature (RT,18°C) and the other receiving the solution warmed to body temperature (BT,36°C). Sensory blocks at the T10, T12, and L3 dermatomes, perianal region,and upper level dermatomes were assessed by pinprick and their onset timesrecorded. Patients with incomplete anal sensory block were excluded.Results: Seventy-seven patients were included for analysis. The pH value of the localanesthetic solution was significantly increased at BT compared to RT (6.570.11 vs. 6.47 0.11, p < 0.05). Significantly shorter onset times of sensoryblock were observed at the T12 (10.03 3.55 vs. 11.71 3.76 min) andL3 (7.49 3.19 vs. 9.92 3.46 min) dermatomes for the BT compared tothe RT group (p < 0.005). The onset time of sensory block at the anal regionwas also shorter in the BT than the RT group (11.54 4.35 vs. 12.50 4.06min, p < 0.05). No differences between groups with respect to gender, age,height, weight, visual analogue pain score, upper sensory level, or adverseevents were observed.Conclusions: Administration of lidocaine at BT compared to RT shortens the onset time ofsensory block in epidural anesthesia with no associated adverse effects.
Ultrasound-Guided Axillary Brachial Plexus Block in Patients with Chronic Renal Failure: Report of Sixteen Cases
Fu-Chao Liu,Lung-I Lee,Jiin-Tarng Liou,Yu-Ling Hui
Chang Gung Medical Journal , 2005,
Abstract: In this report, 16 patients with end-stage renal disease undergoing forearm arteriovenousshunt surgery were subjected to an ultrasound-guided axillary approach for brachialplexus nerve block. Two doses of 15 ml lidocaine 1.5% were injected using a double-shottechnique The spread of the solution within the plexus sheath could be visualized using ahigh-resolution 12-MHz imaging probe. Most patients (94%) experienced an excellent analgesiain the regions innervated by median, ulnar and radial nerves with a lower percentageof complete analgesia (63%) in the areas innervated by musculocutaneous nerve. Threepatients, who complained of pain during the surgery required further supplements of narcotics.There were no complications such as, nerve injury, puncture of the axillary vessels orother systemic reactions. This technique provides adequate analgesia - without complicationsand without difficulty - for extremity surgery in patients with end-stage renal diseases.
Acute Unilateral Parotid Glands Enlargement Following Endotracheal General Anesthesia: Report of Two Cases
Fu-Chao Liu,Jiin-Tarng Liou,Allen H. Li,Hung-Jr Chiou
Chang Gung Medical Journal , 2007,
Abstract: Acute parotid gland enlargement in association with general anesthesia is rare and hasalso been called anesthesia mumps. We present two patients who were scheduled for lumbarspine surgery under general anesthesia. Each developed acute unilateral parotid glandenlargement over one side of the face proven by sonography. Case 1: A 52-year-old manwas scheduled for his third lumbar spine to first sacral spine surgery for scoliosis andspondylolisthesis. The patient was provided general anesthesia with oral endotracheal intubationand placed in the prone position with the neck flexed at approximately 10 degrees.The head was turned to the left side and the right side of the face was placed on a soft gelrolling pad. After 6 hours of surgery, swelling of the right parotid gland was noted uponendotracheal extubation. Twenty four hours later, the patient received sonographic examinationof the salivary gland which showed dilatation of the right parotid duct with obstructiveinflammation. After receiving non-steroidal anti-inflammatory drug (NSAID) treatment, hissymptoms and signs subsided 2 weeks after the surgery. Case 2: A 53-year-old woman wasscheduled for her third lumbar spine to fifth lumbar spine instrumentation and internal fixationsfor spondylolisthesis. A similar anesthetic regimen and surgical position was providedas with Case 1. The duration of the surgery was about 5 hours and swelling of the rightparotid gland was also noted postoperatively. Sonographic examination of the salivary glandshowed only an inflammatory process without dilatation of the parotid duct. She had completerecovery of the condition 10 days after surgery. There were no complications nor residualenlargement of the parotid gland in either of our two patients after conservative treatment.
Efficacy of Ultrasound-Guided Axillary Brachial Plexus Block: A Comparative Study with Nerve Stimulator-Guided Method
Fu-Chao Liu,Jiin-Tarng Liou,Yung-Fong Tsai,Allen H. Li
Chang Gung Medical Journal , 2005,
Abstract: Background: The aim of this study was to compare the efficacy of axillary brachial plexusblock using an ultrasound-guided method with the nerve stimulator-guidedmethod. We also compared the efficacy of ultrasound-guided single-injectionwith those of double-injection for the quality of the block.Methods: Ninety patients scheduled for surgery of the forearm or hand were randomlyallocated into three groups (n = 30 per group), i.e., nerve stimulator-guidedand double-injection (ND) group, ultrasound-guided and double-injection(UD) group, and ultrasound-guided and single-injection (US) group. Eachpatient received 0.5 ml kg-1 of 1.5% lidocaine with 5 μg kg-1 epinephrine.Patients in the ND group received half the volume of lidocaine injected nearthe median and radial nerves after identification using a nerve stimulator.Patients in the UD group received half the volume of lidocaine injectedaround the lateral and medial aspects of the axillary artery, while those in theUS group were given the entire volume near the lateral aspect of the axillaryartery. The extent of the sensory blockade of the seven nerves and motorblockades of the four nerves were assessed 40 min after the performance ofaxillary brachial plexus block.Results: Seventy percent of the patients in the ND and US groups as well as 73% ofthe patients in the UD group obtained satisfactory sensory and motor blockades.The success rate of performing the block was 90% in patients in theND and UD groups and 70% in the US group. The incidence of adverseevents was significantly higher in the ND group (20%) compared with that inthe US group and the UD group (0%; p = 0.03).Conclusions: Ultrasound-guided axillary brachial plexus block, using either single- or double-injection technique, provided excellent sensory and motor blockadeswith fewer adverse events.
Maraviroc Attenuates Trauma-Hemorrhage-Induced Hepatic Injury through PPAR Gamma-Dependent Pathway in Rats
Fu-Chao Liu, Yung-Fong Tsai, Huang-Ping Yu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0078861
Abstract: Maraviroc is a CC-chemokine receptor 5 (CCR5) antagonist with potent antiviral and cancer preventive effects. Recent evidence suggests that the co-existence of CCR5 in various cell types is involved in inflammation. However, the effects that CCR5 antagonists produce in trauma-hemorrhage remain unknown. The peroxisome proliferator-activated receptor gamma (PPARγ) pathway exerts anti-inflammatory effects in injury. In this study, we hypothesized that maraviroc administration in male rats, after trauma-hemorrhage, decreases cytokine production and protects against hepatic injury through a PPARγ-dependent pathway. Male Sprague-Dawley rats underwent trauma-hemorrhage (mean blood pressure maintained at approximately 35-40 mmHg for 90 minutes), followed by fluid resuscitation. During resuscitation, a single dose of maraviroc (3 mg/kg, intravenously) with and without a PPARγ antagonist GW9662 (1 mg/kg, intravenously), GW9662 or vehicle was administered. Plasma alanine aminotransferase (ALT) with aspartate aminotransferase (AST) concentrations and various hepatic parameters were measured (n=8 rats/group) at 24 hours after resuscitation. The results showed that trauma-hemorrhage increased hepatic myeloperoxidase activity, intercellular adhesion molecule-1 and interleukin-6 levels, and plasma ALT and AST concentrations. These parameters were significantly improved in the maraviroc-treated rats subjected to trauma-hemorrhage. Maraviroc treatment also increased hepatic PPARγ expression compared with vehicle-treated trauma-hemorrhaged rats. Co-administration of GW9662 with maraviroc abolished the maraviroc-induced beneficial effects on the above parameters and hepatic injury. These results suggest that the protective effect of maraviroc administration on alleviation of hepatic injury after trauma-hemorrhage, which is, at least in part, through PPARγ-dependent pathway.
Osthole Attenuates Hepatic Injury in a Rodent Model of Trauma-Hemorrhage
Huang-Ping Yu, Fu-Chao Liu, Yung-Fong Tsai, Tsong-Long Hwang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065916
Abstract: Recent evidences show that osthole possesses anti-inflammatory properties and protective effects following shock-like states, but the mechanism of these effects remains unknown. The p38 mitogen-activated protein kinase (p38 MAPK) pathway exerts anti-inflammatory effects in injury. The aim of this study was to investigate whether p38 MAPK plays any role in the osthole-mediated attenuation of hepatic injury after trauma-hemorrhage. Male Sprague-Dawley rats underwent trauma-hemorrhage (mean blood pressure maintained at approximately 35–40 mmHg for 90 minutes), followed by fluid resuscitation. During resuscitation, a single dose of osthole (3 mg/kg, intravenously) with and without a p38 MAPK inhibitor SB-203580 (2 mg/kg, intravenously), SB-203580 or vehicle was administered. Plasma alanine aminotransferase (ALT) with aspartate aminotransferase (AST) concentrations and various hepatic parameters were measured (n = 8 rats/group) at 24 hours after resuscitation. The results showed that trauma-hemorrhage increased hepatic myeloperoxidase activity, intercellular adhesion molecule-1 and interleukin-6 levels, and plasma ALT and AST concentrations. These parameters were significantly improved in the osthole-treated rats subjected to trauma-hemorrhage. Osthole treatment also increased hepatic phospho-p38 MAPK expression compared with vehicle-treated trauma-hemorrhaged rats. Co-administration of SB-203580 with osthole abolished the osthole-induced beneficial effects on the above parameters and hepatic injury. These results suggest that the protective effect of osthole administration on alleviation of hepatic injury after trauma-hemorrhage, which is, at least in part, through p38 MAPK-dependent pathway.
Protective Effect of Tropisetron on Rodent Hepatic Injury after Trauma-Hemorrhagic Shock through P38 MAPK-Dependent Hemeoxygenase-1 Expression
Fu-Chao Liu, Huang-Ping Yu, Tsong-Long Hwang, Yung-Fong Tsai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0053203
Abstract: Tropisetron can decrease inflammatory cell responses and alleviate organ damage caused by trauma-hemorrhage, but the mechanism of these effects remains unknown. The p38 mitogen-activated protein kinase/hemeoxygenase-1 (p38 MAPK/HO-1) pathway exerts anti-inflammatory effects on different tissues. The aim of this study was to investigate whether p38 MAPK/HO-1 plays any role in the tropisetron-mediated attenuation of hepatic injury after trauma-hemorrhage. Male Sprague-Dawley rats underwent trauma-hemorrhage (mean blood pressure maintained at approximately 35–40 mmHg for 90 min), followed by fluid resuscitation. During resuscitation, several treatment regimens were administered: four doses of tropisetron alone (0.1, 0.3, 1, 3 mg/kg body weight), or a single dose of tropisetron (1 mg/kg body weight) with and without a p38 MAPK inhibitor (SB-203580, 2 mg/kg body weight) or HO antagonist (chromium-mesoporphyrin, 2.5 mg/kg body weight). Various parameters were measured, and the animals were sacrificed at 24 h post-resuscitation. The results showed that trauma-hemorrhage increased the following parameters: plasma concentrations of aspartate (AST) and alanine aminotransferases (ALT), hepatic myeloperoxidase (MPO) activity, and levels of cytokine-induced neutrophil chemoattractant-1 and -3 (CINC-1 and CINC-3), intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and macrophage inflammatory protein-1α (MIP-1α). These parameters were significantly improved in the tropisetron-treated rats subjected to trauma-hemorrhage. Tropisetron treatment also increased hepatic p38 MAPK and HO-1 expression compared with vehicle-treated trauma-hemorrhaged rats. Co-administration of SB-203580 or chromium-mesoporphyrin with tropisetron abolished the tropisetron-induced beneficial effects on the above parameters and hepatic injury. These results suggest that the protective effect of tropisetron administration on alleviation of hepatic injury after trauma-hemorrhage is likely mediated through p38 MAPK-dependent HO-1 expression.
Mean Shift Based Adaptive Filtering and Its Applications to Spectra Signal Processing
基于均值漂移的自适应滤波及其在光谱信号处理中的应用

Liu Rong,Duan Fu-qing,Liu San-yang,Wu Fu-chao,
刘 蓉
,段福庆,刘三阳,吴福朝

电子与信息学报 , 2006,
Abstract: An adaptive bilateral filtering method based on mean shift algorithm is presented. The filter is governed by the kernel width in spatial domain, which controls the spatial extent of nearby data for filtering. Its kernel width in range domain is chosen adaptively by the local characteristic of the signal. It can remove impulsive noise and improve smoothing of non-impulsive noise with edges preserved. Comparisons with Gaussian filter and median filter were made. Applications to spectra signal processing show this method can suppress noises in spectra effectively and reduce the amount of smoothing near spectral lines.
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