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Search Results: 1 - 10 of 470303 matches for " Frank A. Pigula "
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Arch Reconstruction in Hypoplastic Left Heart Syndrome: Handling the Diminutive Aorta  [PDF]
Francisco J. Boye, Frank A. Pigula
World Journal of Cardiovascular Surgery (WJCS) , 2013, DOI: 10.4236/wjcs.2013.36039
Abstract: The diminutive aorta presents technical challenges in the palliation of hypoplastic left heart syndrome. Furthermore, aortic arch caliber changes and variable great vessel relationships can add complexity to an already difficult arch repair. We describe a technical approach that simplifies the aortic reconstruction and makes the procedure more generalizable and reproducible.
Inhaled Carbon Monoxide Provides Cerebral Cytoprotection in Pigs
Vicki L. Mahan, David Zurakowski, Leo E. Otterbein, Frank A. Pigula
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041982
Abstract: Carbon monoxide (CO) at low concentrations imparts protective effects in numerous preclinical small animal models of brain injury. Evidence of protection in large animal models of cerebral injury, however, has not been tested. Neurologic deficits following open heart surgery are likely related in part to ischemia reperfusion injury that occurs during cardiopulmonary bypass surgery. Using a model of deep hypothermic circulatory arrest (DHCA) in piglets, we evaluated the effects of CO to reduce cerebral injury. DHCA and cardiopulmonary bypass (CPB) induced significant alterations in metabolic demands, including a decrease in the oxygen/glucose index (OGI), an increase in lactate/glucose index (LGI) and a rise in cerebral blood pressure that ultimately resulted in increased cell death in the neocortex and hippocampus that was completely abrogated in piglets preconditioned with a low, safe dose of CO. Moreover CO-treated animals maintained normal, pre-CPB OGI and LGI and corresponding cerebral sinus pressures with no change in systemic hemodynamics or metabolic intermediates. Collectively, our data demonstrate that inhaled CO may be beneficial in preventing cerebral injury resulting from DHCA and offer important therapeutic options in newborns undergoing DHCA for open heart surgery.
What an Optimist Looks Like: Separating Optimistic Bias from Social Reality  [PDF]
Amber A. Fultz, Frank J. Bernieri
Psychology (PSYCH) , 2018, DOI: 10.4236/psych.2018.93026
Abstract: Optimists hold positive expectancies for their future, which some have suggested leads to advantages in the social realm (Carver, Scheier, & Segerstrom, 2010). Unfortunately, the research supporting this notion is scant and suffers from the confound that self-reports from optimists reflect their optimistic perspective. To address this issue, the present study examined the impact of optimism on interpersonal outcomes assessed from the perspective of those in relationships with each target. We recruited 182 participants to complete a series of psychological measures and interpersonal activities over the course of ten weeks. Participants rated themselves and each other on the five-factor traits at three stages in the developing relationship: zero-acquaintance, after their first conversation with each other, and after nine weeks of acquaintance. Two additional informants nominated by each target as those who knew them well (i.e. friends or family members) provided more extensive personality descriptions using a California Q-Set. Optimists consistently rated themselves as more agreeable and less neurotic than those low in optimism, but only the difference in neuroticism was detectable by perceivers. Furthermore, this difference was discernable only after nine-weeks of acquaintanceship had been established. Target optimism had no impact on first impressions. Although there may exist an optimistic personality profile across the five major traits, we found little evidence to suggest that anything other than lower neuroticism contributes to the impact that optimism might have on one’s social life and relationships.
Distribution of Lutra maculicollis in Rwanda : ecological constraints
Lejeune A.,Frank A.
IUCN Otter Specialist Group Bulletin , 1990,
Abstract: The study of 10 rwandese lakes, where there are still quite important populations of Lutra maculicollis, has pointed out a few characteristics of the habitat favorable to the survival of these populations. The ecological constraints for the survival of these populations are: the abundance of small fishes, the continuity of the lake side vegetation, the absence of crocodiles and pollution by pesticides, and the low level of predation by man.
Introducing Weighted Nodes to Evaluate the Cloud Computing Topology  [PDF]
Gbolasere A. A. Akanmu, Frank Z. Wang, Huankai Chen
Journal of Software Engineering and Applications (JSEA) , 2012, DOI: 10.4236/jsea.2012.531111
Abstract: Typical data centers house several powerful ICT (Information and Communication Technology) equipment such as servers, storage devices and network equipment that are high-energy consuming. The nature of these high-energy consuming equipment is mostly accountable for the very large quantities of emissions which are harmful and unfriendly to the environment. The costs associated with energy consumption in data centers increases as the need for more computational resources increases, so also the appalling effect of CO2 (Carbon IV Oxide) emissions on the environment from the constituent ICT facilities-Servers, Cooling systems, Telecommunication systems, Printers, Local Area Network etc. Energy related costs would traditionally account for about 42% (forty-two per cent) of the total costs of running a typical data center. There is a need to have a good balance between optimization of energy budgets in any data center and fulfillment of the Service Level Agreements (SLAs), as this ensures continuity/profitability of business and customer’s satisfaction. A greener computing from what used to be would not only save/sustain the environment but would also optimize energy and by implication saves costs. This paper addresses the challenges of sustainable (or green computing) in the cloud and proffer appropriate, plausible and possible solutions. The idle and uptime of a node and the traffic on its links (edges) has been a concern for the cloud operators because as the strength and weights of the links to the nodes (data centres) increases more energy are also being consumed by and large. It is hereby proposed that the knowledge of centrality can achieve the aim of energy sustainability and efficiency therefore enabling efficient allocation of energy resources to the right path. Mixed-Mean centrality as a new measure of the importance of a node in a graph is introduced, based on the generalized degree centrality. The mixed-mean centrality reflects not only the strengths (weights) and numbers of edges for degree centrality but it combines these features by also applying the closeness centrality measures while it goes further to include the weights of the nodes in the consideration for centrality measures. We illustrate the benefits of this new measure by applying it to cloud computing, which is typically a complex system. Network structure analysis is important in characterizing such complex systems.
Cancer: The Whole Story
Steven A. Frank
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1001044
Abstract:
Maladaptation and the Paradox of Robustness in Evolution
Steven A. Frank
PLOS ONE , 2007, DOI: 10.1371/journal.pone.0001021
Abstract: Background Organisms use a variety of mechanisms to protect themselves against perturbations. For example, repair mechanisms fix damage, feedback loops keep homeostatic systems at their setpoints, and biochemical filters distinguish signal from noise. Such buffering mechanisms are often discussed in terms of robustness, which may be measured by reduced sensitivity of performance to perturbations. Methodology/Principal Findings I use a mathematical model to analyze the evolutionary dynamics of robustness in order to understand aspects of organismal design by natural selection. I focus on two characters: one character performs an adaptive task; the other character buffers the performance of the first character against perturbations. Increased perturbations favor enhanced buffering and robustness, which in turn decreases sensitivity and reduces the intensity of natural selection on the adaptive character. Reduced selective pressure on the adaptive character often leads to a less costly, lower performance trait. Conclusions/Significance The paradox of robustness arises from evolutionary dynamics: enhanced robustness causes an evolutionary reduction in the adaptive performance of the target character, leading to a degree of maladaptation compared to what could be achieved by natural selection in the absence of robustness mechanisms. Over evolutionary time, buffering traits may become layered on top of each other, while the underlying adaptive traits become replaced by cheaper, lower performance components. The paradox of robustness has widespread implications for understanding organismal design.
Ca2+-Regulated Photoproteins: Effective Immunoassay Reporters
Ludmila A. Frank
Sensors , 2010, DOI: 10.3390/s101211287
Abstract: Ca2+-regulated photoproteins of luminous marine coelenterates are of interest and a challenge for researchers as a unique bioluminescent system and as a promising analytical instrument for both in vivo and in vitro applications. The proteins are comprehensively studied as to biochemical properties, tertiary structures, bioluminescence mechanism, etc. This knowledge, along with available recombinant proteins serves the basis for development of unique bioluminescent detection systems that are “self-contained”, triggerable, fast, highly sensitive, and non-hazardous. In the paper, we focus on the use of photoproteins as reporters in binding assays based on immunological recognition element—bioluminescent immunoassay and hybridization immunoassay, their advantages and prospects.
The 5th annual European League Against Rheumatism congress in Berlin: a personal perspective
Frank A Wollheim
Arthritis Research & Therapy , 2004, DOI: 10.1186/ar1474
Abstract: This European League Against Rheumatism (EULAR) congress started like its forerunners with an opening ceremony at the end of the first day of the congress. It had been preceded by 12 parallel scientific and educational sessions followed by several drug industry satellite symposia. Hall 1 of the conference center boasts that it is Europe's largest venue of its kind, seating 5008. It was well filled but there was plenty of space for the latecomers. The ceremony started 15 minutes late; the reason given was that the musicians were out smoking (!). But then all went to schedule, and the Dvo?ák melodies were pleasant and not too long interludes between talks. The president talked in a relaxed and statesmanlike way about the burden of disease and the Alliance Against Arthritis, which was launched by him with active support of the Bone and Joint Decade in Brussels in March of this year. One aim is to convince the European Union that research money should be earmarked for rheumatic diseases in analogy to what is done with cancer and diabetes. The German minister of education and research responded favorably to this and said her government did realize the importance of this initiative. The awards were duly presented, and it was gratifying to see Kimmo Aho from Finland receive the Meritorious Rheumatologist award for his lifetime achievements in research (Fig. 1). The recipient was particularly pleased that his wife finally could appreciate why he had always been late home during the past 50 years. The ceremony ended with a surprise. The stage wall disappeared and behind it a mini Brandenburger Tor opened the way to the buffet reception in the adjacent hall. The president and the minister were the first to walk through the Tor. There were unlimited supplies of food and drink, and mingling conditions could not have been better.The cost for the venue in Berlin is substantial. Hall 1, where the opening took place, can be rented for the handsome sum of €17,880 per 12 hours. Fortu
Morgenr?the or business as usual: a personal account of the 2nd Annual EULAR Congress, Prague
Frank A Wollheim
Arthritis Research & Therapy , 2001, DOI: 10.1186/ar333
Abstract: This is not a meeting report. Any attempt to summarize a 4-day meeting with a multitude of parallel sessions, posters and other activities is doomed to be either biased or superficial, or both. Rather, the aim is to give a personal account of some reflections in the mind of an old European after attending what turned out to be the largest congress in the history of our specialty. It should be known that I made no secret of my disappointment with some arrangements in last year's 1st Annual EULAR Congress in Nice. The editors' invitation to write about Prague gives me the opportunity to air some views and hopes.The 8300 registered delegates made this the largest EULAR, and probably rheumatology, congress ever. The turnout does not become less impressive considering that registration was not cheap: 800 Euro on site. The income for the EULAR should make the outgoing treasurer, Josef Smolen (Vienna), and the incoming Ferdinand Breedveld (Leiden) happy. Even the 10% of the surplus that goes to the hosting Czech society will be good news to Karel Pavelka, the president of the meeting, and his countrymen. In addition to all the money from registration fees, the organization received revenue from no less than 17 satellite industrial symposia, industrial exhibitors, and so on. This commercial success makes the EULAR economically sound, which is certainly not a negative thing. The concern is, however, related to the fact that at least 80% of the delegates were sponsored by industry. Some companies were flying in over 1000 delegates from all continents. The individual who pays his own way is an endangered species at the EULAR congresses. Availability of grant money to attend congresses is limited, and in some countries is extremely limited. The generous travel sponsorship of industry eliminates motivation for the organizers to reduce registration fees. It should be added, however, that the fee includes an annual subscription to Annals of the Rheumatic Diseases, the EULAR journa
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