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Search Results: 1 - 10 of 56238 matches for " Francisco;Salazar-Martínez "
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Sesgos en estudios epidemiológicos Biases in epidemiological studies
Mauricio Hernández-ávila,Francisco Garrigo MC,Eduardo Salazar-Martínez
Revista Cubana de Higiene y Epidemiología , 2008,
Abstract:
Sesgos en estudios epidemiológicos
Hernández-Avila Mauricio,Garrido Francisco,Salazar-Martínez Eduardo
Salud Pública de México , 2000,
Abstract:
Panorama epidemiológico de la mortalidad por cáncer en el Instituto Mexicano del Seguro Social: 1991-1995
SALMERóN-CASTRO,JORGE; FRANCO-MARINA,FRANCISCO; SALAZAR-MARTíNEZ,EDUARDO; LAZCANO-PONCE,EDUARDO CéSAR;
Salud Pública de México , 1997, DOI: 10.1590/S0036-36341997000400004
Abstract: objective. this paper describes the global cancer mortality and the specific mortality patterns for the main neoplasms among adult members of the mexican institute of social security (imss). material and methods. using official death certificates and information about the population of the imss members during 1991-1995, national and regional annual global cancer mortality as well as specific mortality rates for the 10 most important malignant neoplasms by sex were estimated among people older than 20 years of age. the trends for these neoplasms during the study period were estimated by means of poisson regression. the rate differences in specific cancer mortality by region and sex, for the two major neoplasms, were calculated subtracting specific regional rates from the respective national rate in 1995. results. the global mortality rate for cancer among men increased from 76.2 in 1991 to 94.8 x 100 000 imss′members in 1995; and among women from 85.6 to 105.8 x 100 000 imss′members, representing an increment of 24.4 and 24% men and women, respectively, during the study period. among men, neoplasm of kidney, leukemia, pancreas, prostate and lung showed the major increment; among women, neoplasm of colon, breast, pancreas, leukemia and liver showed the most significant increment. conclusions. in the imss it is necessary the integration of a population based cancer registry. the registry will play a main role in disease surveillance and control; will give basic information over incidence and temporal variation, and could be the main source of information for epidemiologic research, as well as planning and evaluation of the quality of medical attention services such as prevention and early diagnosis and treatment.
Panorama epidemiológico de la mortalidad por cáncer en el Instituto Mexicano del Seguro Social: 1991-1995
SALMERóN-CASTRO JORGE,FRANCO-MARINA FRANCISCO,SALAZAR-MARTíNEZ EDUARDO,LAZCANO-PONCE EDUARDO CéSAR
Salud Pública de México , 1997,
Abstract: Objetivo. Describir el comportamiento de la mortalidad global por cáncer, así como la mortalidad específica para las principales neoplasias malignas en población adulta derechohabiente (DH) del Instituto Mexicano del Seguro Social (IMSS). Material y métodos. A partir de los registros oficiales de defunción y de la información sobre la población para los a os 1991-1995, se estimaron las tasas anuales de mortalidad global y específica para las 10 principales neoplasias malignas por sexo, en mayores de 20 a os. Asimismo, se estimaron las tendencias nacionales y estatales para las principales neoplasias malignas para cada sexo por medio de regresión de Poisson. Se calcularon las diferencias de tasas de mortalidad específica para las dos principales neoplasias por sexo restando las tasas estatales a su respectiva tasa nacional en 1995. Resultados. La mortalidad global por cáncer en los hombres se incrementó de 76.2 en 1991, a 94.8 por 100 000 DH en 1995; entre las mujeres, ésta se incrementó de 85.6 a 105.8 por 100 000 DH, representando un incremento de 24.4 y de 24% en hombres y mujeres, respectivamente, durante el periodo de estudio. Entre los hombres las neoplasias de ri ón, leucemia, páncreas, próstata y pulmón; y entre mujeres las de colon, mama, páncreas, leucemias e hígado, mostraron los incrementos más significativos. Conclusiones. En el IMSS es impostergable la conformación de un registro poblacional de cáncer que permita una mejor vigilancia epidemiológica de las neoplasias y una evaluación permanente del impacto de programas específicos para la prevención y control de este padecimiento en las instituciones.
Valor pronóstico del inmunofenotipo en la respuesta temprana de la leucemia aguda linfoblástica pre-B en ni?os
Correa-González, Lourdes Cecilia;Mandeville, Peter B;Manrique-Due?as, Javier;Alejo-González, Francisco;Salazar-Martínez, Abel;Pérez-Ramírez, Oscar de Jesús;Hernández-Sierra, Juan Francisco;
Gaceta médica de México , 2005,
Abstract: objective: to determine the prognostic value of pre b immunophenotype and its variants on early treatment response among of acute pediatric lymphoblast leukemia. patients and methods: a case control study nested in a cohort was carried out with male and female patients 15 years and younger with recently diagnosed pre b lymphoblast leukemia. a panel of b, t, monoclonal antibodies of the myelo monocytic and megakaryocytic cell type was used. response was assessed by bone marrow aspiration 14 days post treatment. results: 54 patients were included. the median age was 7 years (2 months - 14 years) median leukocyte count was 13,450/mm3 (1200-986,000/mm3). we identified 29 cases with late pre b immune phenotype, 19 cases with common pre b and 6 cases with early pre b immunophenotype. eleven patients also displayed myeloid antigens. a significant association (p=0.034) was found between early treatment response and the presence of myeloid antigens. no association was found between the pre b immunophenotype, age and leukocyte count with early treatment response (p=0.264). conclusions: we need to pay special emphasis on early treatment response in children with lymphoblast leukemia as our study did not corroborate the common finding that clinical factors and immune phenotype can be predictive factors.
Haplotypes in the CRP Gene Associated with Increased BMI and Levels of CRP in Subjects with Type 2 Diabetes or Obesity from Southwestern Mexico
América Martínez-Calleja,Irma Quiróz-Vargas,Isela Parra-Rojas,José Francisco Mu oz-Valle,Marco A. Leyva-Vázquez,Gloria Fernández-Tilapa,Amalia Vences-Velázquez,Miguel Cruz,Eduardo Salazar-Martínez,Eugenia Flores-Alfaro
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/982683
Abstract: Objective. We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease. Methods. We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology. Results. The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP (; 95%CI: 0.1, 0.5; ) and haplotype 7 (TGGG) with higher body mass index (BMI) (; 95%CI: 0.1, 0.3; ). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype. Conclusions. The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico.
Haplotypes in the CRP Gene Associated with Increased BMI and Levels of CRP in Subjects with Type 2 Diabetes or Obesity from Southwestern Mexico
América Martínez-Calleja,Irma Quiróz-Vargas,Isela Parra-Rojas,José Francisco Mu?oz-Valle,Marco A. Leyva-Vázquez,Gloria Fernández-Tilapa,Amalia Vences-Velázquez,Miguel Cruz,Eduardo Salazar-Martínez,Eugenia Flores-Alfaro
Journal of Diabetes Research , 2012, DOI: 10.1155/2012/982683
Abstract: Objective. We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease. Methods. We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Genotyping was performed by PCR/RFLP, and the risk score for coronary heart disease was determined by the Framingham's methodology. Results. The TT genotype of SNP rs1130864 was associated with increased body mass index and T2D patients with obesity. We found that the haplotype 2 (TGAG) was associated with increased levels of CRP ( ; 95%CI: 0.1, 0.5; ) and haplotype 7 (TGGG) with higher body mass index (BMI) ( ; 95%CI: 0.1, 0.3; ). The risk score for coronary heart disease was associated with increased levels of CRP, but not with any polymorphism or haplotype. Conclusions. The association between the TT genotype of SNP rs1130864 with obesity and the haplotype 7 with BMI may explain how obesity and genetic predisposition increase the risk of diseases such as T2D in the population of Southwestern Mexico. 1. Introduction It has been proposed that the C-reactive protein (CRP) has clinical utility as a biomarker in predicting risk of cardiovascular events [1] and a predictive value in the progression of type 2 diabetes (T2D) [2]. In obesity, there is an increase in the risk of coronary heart disease (CHD) by constant and progressive vascular damage, generated by a chronic low-grade inflammatory state [3]. It has been determined that adipocytes produce one-third of interleukin-6 (IL-6), the main stimulus for hepatic CRP production. Overweight or obese subjects have higher levels of this protein [4], which promotes the atherosclerotic process by increasing the expression of adhesion molecules (ICAM-1, VCAM-1), E-selectin, and the monocyte chemotactic protein-1 (MCP-1) in the endothelium [5]. CRP is also involved in decreased expression and mRNA half-life of endothelial nitric oxide synthase and activation of nuclear factor kappa B (NFκB) that is involved in the transcription of numerous genes related with the inflammatory process [5]. It has also been involved in the modulation of angiogenesis and atherosclerotic, plaque instability by activating the signaling pathway of phosphatidylinositol-3 kinase (PI3?K) and extracellular signal-regulated kinases 1 and 2 (ERK 1/2) [6]. Obesity, age, gender, and diabetes
Dise?os de investigación en epidemiología genética
Flores-Alfaro,Eugenia; Burguete-García,Ana I.; Salazar-Martínez,Eduardo;
Revista Panamericana de Salud Pública , 2012, DOI: 10.1590/S1020-49892012000100013
Abstract: this article describes the features of the epidemiologic research designs most commonly used in genetic association studies. case-control studies are efficient in evaluating associations between candidate genes and disease. cohort studies, in contrast, yield a greater degree of causality but are not efficient for the initial exploration to identify gene-disease associations. cross-sectional studies are less expensive, require less time, and are useful for estimating the prevalence of diseases, risk factors, and genetic variants. family-based studies have been successful in finding alleles that confer greater risk for developing mendelian inheritance disorders.
Estudios de cohorte: Metodología, sesgos y aplicación Cohort study: Methodology, biases and application
Eduardo Lazcano-Ponce,Esteve Fernández,Eduardo Salazar-Martínez,Mauricio Hernández-ávila
Revista Cubana de Higiene y Epidemiología , 2007,
Abstract:
Estudios epidemiológicos de casos y controles: Fundamento teórico, variantes y aplicaciones Case-control epidemiological studies: Theoretical foundation, variants and applications
Eduardo Lazcano-Ponce,Eduardo Salazar-Martínez,Mauricio Hernández-ávila
Revista Cubana de Higiene y Epidemiología , 2007,
Abstract:
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