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Search Results: 1 - 10 of 22289 matches for " Francisco Ridocci "
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Induction of PGC-1α Expression Can Be Detected in Blood Samples of Patients with ST-Segment Elevation Acute Myocardial Infarction
óscar Fabregat-Andrés, Alberto Tierrez, Manuel Mata, Jordi Estornell-Erill, Francisco Ridocci-Soriano, María Monsalve
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026913
Abstract: Following acute myocardial infarction (MI), cardiomyocyte survival depends on its mitochondrial oxidative capacity. Cell death is normally followed by activation of the immune system. Peroxisome proliferator activated receptor γ-coactivator 1α (PGC-1α) is a transcriptional coactivator and a master regulator of cardiac oxidative metabolism. PGC-1α is induced by hypoxia and facilitates the recovery of the contractile capacity of the cardiac muscle following an artery ligation procedure. We hypothesized that PGC-1α activity could serve as a good molecular marker of cardiac recovery after a coronary event. The objective of the present study was to monitor the levels of PGC-1α following an ST-segment elevation acute myocardial infarction (STEMI) episode in blood samples of the affected patients. Analysis of blood mononuclear cells from human patients following an STEMI showed that PGC-1α expression was increased and the level of induction correlated with the infarct size. Infarct size was determined by LGE-CMR (late gadolinium enhancement on cardiac magnetic resonance), used to estimate the percentage of necrotic area. Cardiac markers, maximum creatine kinase (CK-MB) and Troponin I (TnI) levels, left ventricular ejection function (LVEF) and regional wall motion abnormalities (RWMA) as determined by echocardiography were also used to monitor cardiac injury. We also found that PGC-1α is present and active in mouse lymphocytes where its expression is induced upon activation and can be detected in the nuclear fraction of blood samples. These results support the notion that induction of PGC-1α expression can be part of the recovery response to an STEMI and could serve as a prognosis factor of cardiac recovery.
Septal rupture with right ventricular wall dissection after myocardial infarction
Carlos J Soriano, José L Pérez-Boscá, Sergio Canovas, Francisco Ridocci, Pau Federico, Ildefonso Echanove, Rafael Paya
Cardiovascular Ultrasound , 2005, DOI: 10.1186/1476-7120-3-33
Abstract: We present a case of a 59-year-old man who had a septal rupture with right ventricular wall dissection after inferior and right ventricular myocardial infarction. Transthoracic echocardiography, as first line examination, established the diagnosis, and prompt surgical repair allowed long-term survival in our patient.Outcomes after right ventricular intramyocardial dissection following septal rupture related to myocardial infarction has been reported to be dismal. Early recognition of this complication using transthoracic echocardiography at patient bedside, and prompt surgical repair are the main factors to achieve long-term survival in these patients.The occurrence of ventricular septal rupture after acute myocardial infarction is an uncommon complication in the reperfusion era [1], however, this condition implies a high mortality rate, even after surgical repair [2]. In patients with inferior myocardial infarction, septal rupture generally involves basal inferoposterior septum, and the communicating tract between left and right ventricle is often serpiginous with a variable degree of right ventricular wall extension [3]. Right ventricular wall dissection following septal rupture related to previous myocardial infarction has been reported in a very few cases [4-6], in many of them this condition has been diagnosed in post-mortem studies [4]. In a recent report long-term survival has been achieved after promptly echocardiographic diagnosis and surgical repair [6].A 59-year-old man was admitted to Coronary Care Unit because of suspected ST-segment-elevation myocardial infarction. The patient was complaining of typical coronary chest pain during the last twelve hours. He had a history of dyslipidemia, type 2 diabetes mellitus, smoking habit and a transient ischemic attack without any sensitive or motor squele one year ago. On admission, his blood pressure was 100/60 and heart rate was 110 beats per minute. Cardiac examination revealed jugular vein distension, and no s
PGC-1α Induction in Pulmonary Arterial Hypertension
Manuel Mata,Irene Sarrion,Lara Milian,Gustavo Juan,Mercedes Ramon,Dolores Naufal,Juan Gil,F. Ridocci,O. Fabregat-Andrés,Julio Cortijo
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/236572
Abstract: Idiopathic Pulmonary arterial hypertension (IPAH) is characterized by the obstructive remodelling of pulmonary arteries, and a progressive elevation in pulmonary arterial pressure (PAP) with subsequent right-sided heart failure and dead. Hypoxia induces the expression of peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α) which regulates oxidative metabolism and mitochondrial biogenesis. We have analysed the expression of PGC-1α, cytochrome C (CYTC), superoxide dismutase (SOD), the total antioxidant status (TAS) and the activity of glutathione peroxidase (GPX) in blood samples of IPAH patients. Expression of PGC-1α was detected in IPAH patients but not in healthy volunteers. The mRNA levels of SOD were lower in IPAH patients compared to controls (3.93 ± 0.89 fold change). TAS and GPX activity were lower too in patients compared to healthy donors, (0.13 ± 0.027 versus 0.484 ± 0.048 mM and 56.034 ± 10.37 versus 165.46 ± 11.38 nmol/min/mL, resp.). We found a negative correlation between expression levels of PGC-1α and age, PAP and PVR, as well as a positive correlation with CI, PaO2, mRNA levels of CYTC and SOD, TAS and GPX activity. These results taken together are indicative of the possible role of PGC-1α as a potential biomarker of the progression of IPAH.
PGC-1α Induction in Pulmonary Arterial Hypertension
Manuel Mata,Irene Sarrion,Lara Milian,Gustavo Juan,Mercedes Ramon,Dolores Naufal,Juan Gil,F. Ridocci,O. Fabregat-Andrés,Julio Cortijo
Oxidative Medicine and Cellular Longevity , 2012, DOI: 10.1155/2012/236572
Abstract: Idiopathic Pulmonary arterial hypertension (IPAH) is characterized by the obstructive remodelling of pulmonary arteries, and a progressive elevation in pulmonary arterial pressure (PAP) with subsequent right-sided heart failure and dead. Hypoxia induces the expression of peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α) which regulates oxidative metabolism and mitochondrial biogenesis. We have analysed the expression of PGC-1α, cytochrome C (CYTC), superoxide dismutase (SOD), the total antioxidant status (TAS) and the activity of glutathione peroxidase (GPX) in blood samples of IPAH patients. Expression of PGC-1α was detected in IPAH patients but not in healthy volunteers. The mRNA levels of SOD were lower in IPAH patients compared to controls (3.93 ± 0.89 fold change). TAS and GPX activity were lower too in patients compared to healthy donors, (0.13 ± 0.027 versus 0.484 ± 0.048?mM and 56.034 ± 10.37 versus 165.46 ± 11.38?nmol/min/mL, resp.). We found a negative correlation between expression levels of PGC-1α and age, PAP and PVR, as well as a positive correlation with CI, PaO2, mRNA levels of CYTC and SOD, TAS and GPX activity. These results taken together are indicative of the possible role of PGC-1α as a potential biomarker of the progression of IPAH. 1. Introduction Pulmonary arterial hypertension (PAH) is a complex disorder characterized by the obstructive remodelling of pulmonary arteries, leading to a progressive elevation of pulmonary arterial pressure (PAP) and subsequent right-sided heart failure and death [1]. There are five categories in which pulmonary hypertension (PH) diseases can be grouped according to specific therapeutic interventions directed at dealing with the cause of (1) PAH, (2) pulmonary hypertension with left heart disease, (3) PH associated with disorders of the respiratory system or hypoxemia, (4) PH caused by thrombotic or embolic diseases, and (5) PH caused by multifactorial mechanisms [2]. Idiopathic PAH (IPAH) is included in group 1 and within patients with a mean pulmonary artery pressure (PAPm) ≥25?mmHg, and a pulmonary capillary wedge pressure (PCWP), left atrial pressure, or left ventricular end-diastolic pressure ≤15?mmHg, and a pulmonary vascular resistance greater than three Wood units [3]. Remodelling of pulmonary arteries leads to an increase of pulmonary vascular resistance (PVR) which produces right ventricular (RV) overload, hypertrophy and dilatation, and eventually RV failure and death [4]. These changes are due to an inadequate adaptation of myocardial contractility [5]. Although
Electromagnetic Gauges and Maxwell Lagrangians Applied to the Determination of Curvature in the Space-Time and their Applications  [PDF]
Francisco Bulnes
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2012, DOI: 10.4236/jemaa.2012.46035
Abstract: If we consider the finite actions of electromagnetic fields in Hamiltonian regime and use vector bundles of geodesic in movement of the charges with a shape operator (connection) that measures the curvature of a geometrical space on these geodesic (using the light caused from these points (charges) acting with the infinite null of gravitational field (background)) we can establish a model of the curvature through gauges inside the electromagnetic context. In partular this point of view is useful when it is about to go on in a quantized version from the curvature where the space is distorted by the interactions between particles. This demonstrates that curvature and torsion effect in the space-time are caused in the quantum dimension as back-reaction effects in photon propagation. Also this permits the observational verification and encodes of the gravity through of light fields deformations. The much theoretical information obtained using the observable effects like distortions is used to establish inside this Lagrangian context a classification of useful spaces of electro-dynamic configuration for the description of different interactions of field in the Universe related with gravity. We propose and design one detector of curvature using a cosmic censor of the space-time developed through distortional 3-dimensional sphere. Some technological applications of the used methods are exhibited.
Penrose Transform on D-Modules, Moduli Spaces and Field Theory  [PDF]
Francisco Bulnes
Advances in Pure Mathematics (APM) , 2012, DOI: 10.4236/apm.2012.26057
Abstract: We consider a generalization of the Radon-Schmid transform on coherent D-modules of sheaves of holomorphic complex bundles inside a moduli space, with the purpose of establishing the equivalences among geometric objects (vector bundles) and algebraic objects as they are the coherent D-modules, these last with the goal of obtaining conformal classes of connections of the holomorphic complex bundles. The class of these equivalences conforms a moduli space on coherent sheaves that define solutions in field theory. Also by this way, and using one generalization of the Penrose transform in the context of coherent D-modules we find conformal classes of the space-time that include the heterotic strings and branes geometry.
Penrose Transform on Induced DG/H-Modules and Their Moduli Stacks in the Field Theory  [PDF]
Francisco Bulnes
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.32035
Abstract:

We consider generalizations of the Radon-Schmid transform on coherent DG/H-Modules, with the intention of obtaining the equivalence between geometric objects (vector bundles) and algebraic objects (D-Modules) characterizing conformal classes in the space-time that determine a space moduli [1] on coherent sheaves for the securing solutions in field theory [2]. In a major context, elements of derived categories like D-branes and heterotic strings are considered, and using the geometric Langlands program, a moduli space is obtained of equivalence between certain geometrical pictures (non-conformal world sheets [3]) and physical stacks (derived sheaves), that establishes equivalence between certain theories of super symmetries of field of a Penrose transform that generalizes the implications given by the Langlands program. With it we obtain extensions of a cohomology of integrals for a major class of field equations to corresponding Hecke category.

Mathematical Nanotechnology: Quantum Field Intentionality  [PDF]
Francisco Bulnes
Journal of Applied Mathematics and Physics (JAMP) , 2013, DOI: 10.4236/jamp.2013.15005
Abstract:

Considering the finite actions of a field on the matter and the space which used to infiltrate their quantum reality at level particle, methods are developed to serve to base the concept of intentional action of a field and their ordered and supported effects (synergy) that must be realized for the organized transformation of the space and matter. Using path integrals, these transformations are decoded and their quantum principles are shown.

Derived Categories in Langlands Geometrical Ramifications: Approaching by Penrose Transforms  [PDF]
Francisco Bulnes
Advances in Pure Mathematics (APM) , 2014, DOI: 10.4236/apm.2014.46034
Abstract:

Some derived categories and their deformed versions are used to develop a theory of the ramifications of field studied in the geometrical Langlands program to obtain the correspondences between moduli stacks and solution classes represented cohomologically under the study of the kernels of the differential operators studied in their classification of the corresponding field equations. The corresponding D-modules in this case may be viewed as sheaves of conformal blocks (or co-invariants) (images under a version of the Penrose transform) naturally arising in the framework of conformal field theory. Inside the geometrical Langlands correspondence and in their cohomological context of strings can be established a framework of the space-time through the different versions of the Penrose transforms and their relation between them by intertwining operators (integral transforms that are isomorphisms between cohomological spaces of orbital spaces of the space-time), obtaining the functors that give equivalences of their corresponding categories.(For more information,please refer to the PDF version.)

Overview of the Australian Commonwealth Administrative Law System: Preliminary Issues for Consideration  [PDF]
Francisco Esparraga
Beijing Law Review (BLR) , 2014, DOI: 10.4236/blr.2014.51006
Abstract:

Administrative law is the body of law which provides the mechanisms for challenging and regulating government decision making. There are two fundamental elements in Australian administrative law—judicial review and merits review. Judicial review is concerned with the legality of administrative decisions, and is the sole province of the courts. Merits review is concerned with the substance of a decision and is carried out by various review bodies. Reasons for decisions lie at the heart of administrative decision-making. A statement of reasons should provide fairness by enabling decisions to be properly explained and defended and will assist the person affected by a decision to decide whether to exercise rights of review or appeal. Australian law does not yet recognize a general duty to give reasons for administrative decisions. However, there are legislative provisions which encapsulate an obligation to provide reasons. It is all part and parcel of procedural fairness—Findings on Material Questions of Fact; Reference to Evidence on which Findings of Fact are Based; Dealing with Inadequate Statements of Reasons; Requests for Further and Better Particulars.

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