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Search Results: 1 - 10 of 29129 matches for " Francisco Edilson Leite;Brandt "
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Bacterial translocation in rats nonfunctioning diverted distal colon
Pinto Júnior, Francisco Edilson Leite;Brandt, Carlos Teixeira;Medeiros, Aldo da Cunha;Oliveira, Ariano José Freitas de;Jer?nimo, Selma Maria;Brito, Helena Marques Fonseca de;
Acta Cirurgica Brasileira , 2007, DOI: 10.1590/S0102-86502007000300007
Abstract: purpose: to investigate whether the alterations of the diverted colon segment mucosa, evidenced in fecal colitis, would be able to alter bacterial translocation (bt). methods: sixty-two wistar male rats ranging from 220 to 320 grams of weight, were divided in two groups: a (colostomy) and b (control), with 31 animals each one. in group a, all animals underwent end colostomy, one stoma, in ascending colon; and in the 70th pod was injected in five rats, by rectal route diverted segment - 2ml of a 0.9% saline solution in animals (a1 subgroup); in eight it was inoculated, by rectal route, 2ml of a solution containing escherichia coli atcc 25922 (american type culture collection), in a concentration of 108 colony forming unit for milliliters (cfu/ml) - a2 subgroup; in ten animals the same solution of e. coli was inoculated, in a concentration of 1011 cfu/ml (a3 subgroup); and in eight it was collected part of the mucus found in the diverted distal colonic segment for neutral sugars and total proteins dosage (a4 subgroup). the animals from the group b underwent the same procedures of group a, but with differences in the colostomy confection. in rats from subgroups a1, a2, a3, b1, b2, and b3 2ml of blood were aspirated from the heart, and fragments from mesenteric lymphatic nodule, liver, spleen, lung and kidney taken for microbiological analysis, after their death. this analysis consisted of evidencing the presence of e. coli atcc 25922 cfu. mann-whitney and anova tests were applied as analytic techniques for association of variables. results: the occurrence of bt was evidenced only in those animals in which inoculated concentration of e. coli atcc 25922, reached levels of 1011cfu/ml, i.e. in subgroups a3 and b3, although, being significantly greater (80%) in those animals without colostomy (subgroup b3) when compared to the ones with colostomy (20%) from the subgroup a3 (p <0.05). lung, liver and mesenteric lymphatic nodules were the tissues with larger percentile of bac
Perfura??o espontanea de colédoco em adolescente
Pinto Júnior, Francisco Edilson Leite;Oliveira, Ariano José Freitas de;Oliveira, Andrea Fernandes de;
Revista do Colégio Brasileiro de Cirurgi?es , 2000, DOI: 10.1590/S0100-69912000000200013
Abstract: spontaneous perforation of the common bile duct is rare. it happens predominantly in children and it is related to obstructive disease of the biliary tract. we present a case of an 18 year-old male patient, with ulcerative rectocolitis associated with malignant tumor of the head of pancreas. the patient developed an acute abdomen syndrome and laparotomy, a spontaneous perforation of common bile duct was evidenced. the authors make a revision of the clinical aspects of that pathology.
Síndrome de chilaiditi associada a megaduodeno e megacólon transverso
Pinto Júnior, Francisco Edilson Leite;Fernandes, Andrea;Jo?o, Samir Assi;
Revista do Colégio Brasileiro de Cirurgi?es , 2000, DOI: 10.1590/S0100-69912000000100013
Abstract: chilaiditi syndrome is a rare abnormality, uncommon in children, whith an incidence increasing with the age, ranging from 0.025% to 0.28% in the general population usually affecting males. the patients are usually asymptomatics and the syndrome is incidently discover through radiologic exams. however, abdominal pain and distention, nauseas, vomits and changes in intestinal habits, and even intestinal obstruction can occur. the authors report a case of a patient with chilaiditi's syndrome associated to megastomach, megaduodenum and megacolon.
Neoplasia papilar cística do pancreas
Pinto Junior, Francisco Edilson Leite;Moraes, Marcus Vinícius de;Oliveira, álisson Giovani Freitas de;
Revista do Colégio Brasileiro de Cirurgi?es , 2001, DOI: 10.1590/S0100-69912001000400015
Abstract: papyllary cystic tumor of the pancreas, so-called frantz's tumor, is rare. clinical presentation of this disease is usually a slowly growing abdominal mass with or without abdominal pain, affecting predominantly young females. its pathogenesis is still unknown . surgical resection is usually curative, and prognosis is excellent. the authors report two pancreatic tumor cases(frantz's tumor) in women aged 26 and 31 years old. pre operative assessment showed a solid-cystic tumor of the tail and body of the pancreas. an extended distal pancreatectomy was performed without splenic preservation.
Abscesso esplênico
Pinto Júnior, Francisco Edilson Leite;Oliveira, Ariano José Freitas de;Medeiros, Aldo da Cunha;
Revista do Colégio Brasileiro de Cirurgi?es , 2000, DOI: 10.1590/S0100-69912000000300012
Abstract: splenic abscess is a rare disease usually associated with immunosuppressed states. its diagnosis may be difficult due to non-specific symptoms . the authors report a case of a healthy woman, 42 years old, bearer of splenic and renal abscesses , treated with antibiotics and splenectomy. a review of the literature is presented with emphasis on the diagnosis and treatment.
Infec o hospitalar em pacientes cirúrgicos de Hospital Universitário
Medeiros Aldo da Cunha,Aires Neto Tertuliano,Dantas Filho Ant?nio Medeiros,Pinto Jr Francisco Edilson Leite
Acta Cirurgica Brasileira , 2003,
Abstract: OBJETIVO: Analisar fatores intercorrentes e a incidência da infec o em pacientes operados no Hospital Universitário da UFRN. MéTODOS: Foram estudados, através de protocolo previamente estabelecido, 3.120 pacientes internados que se submeteram a procedimentos cirúrgicos no período de janeiro de 1999 a outubro de 2002. RESULTADOS: O índice de infec o hospitalar foi de 5,9%, e a topografia de maior incidência foi a ferida operatória (3,7%). Infec o respiratória ocorreu em 1,2%, urinária em 0,6% e bacteremia em 0,1%. O índice de infec o comunitária foi de 9,2%, predominando infec o urinária (5%) e respiratória (2,1%). Quanto ao grau de contamina o das feridas operatórias, as feridas limpas (1479) apresentaram infec o em 2,9%, as feridas limpas-contaminadas (1277) em 6,0% dos casos, as feridas contaminadas (270) em 15,1%, e as ferida infectadas (94) resultaram em infec o em 30,75% dos casos. CONCLUS O: Concluiu-se que a incidência de infec o cirúrgica foi compatível com os índices na literatura mundial. A partir desses dados, ratifica-se a importancia de medidas de controle de infec o hospitalar de forma sistemática, como vem sendo realizado no hospital onde o estudo foi realizado.
Nitric oxide monocyte production levels in patients with the hepatosplenic form of Scistosoma mansoni infection who underwent splenectomy, ligature of the left gastric vein and auto implantation of spleen tissue in the major omentum
Brandt Carlos Teixeira,Leite Carlos Roberto Carvalho,Manhaes-de-Castro Francisco Machado,Macedo érika Michelle Correia de
Acta Cirurgica Brasileira , 2006,
Abstract: PURPOSE: To measure the levels of NO production by monocytes in patients with the hepatosplenic form of schistosomiasis mansoni who underwent splenectomy, ligature of the left gastric vein and auto implantation of spleen tissue in the major omentum. METHODS: Four groups of volunteers were enrolled in the investigation: G1 - 12 patients with S. mansoni infection in its hepatosplenic form without any kind of treatment (SMH); G2 - 13 SMH patients who underwent medical treatment and portal hypertension decompression splenectomy and ligature of the left gastric vein (SMH/SLGV); G3 - 19 patients similar to the later group, but additionally received auto implantation of spleen morsels in the major omentum (SMH/SLGV/AI); and G4 - 15 individuals with no S. mansoni infection coming from the same geographical area and presenting similar socio economical status (CG). Nitrite production by monocytes was determined by a standard Griess reaction adapted to microplates. The results were presented by mean ? SD for each group. Significant differences in NO production by monocytes were determined by Tukey-Kramer multicomparisons test. Probability values of 0.05 were considered significant. RESULTS: Patients from G1 (SMH) showed lower level of NO production by monocytes (5.28 ? 1.28mmol/ml). Patients from G2 (SMH/SLGV) showed similar results (6.67 ? 0.44mmol/ml - q = 2.681 p > 0.05). Individuals of G4 (CG) showed higher level of NO production by monocytes (8.19 ? 2.74mmol/ml). Patients from G3 (SMH/SGLV/AI) showed similar NO production by PBMC as compared to individuals of G4 (CG) - (7.41 ? 1.65mmol/ml - q = 1.615 p > 0.05). The volunteers from G4 (CG) and G3 (SMH/SLGV/AI) showed significantly greater levels of NO production by monocytes as compared to those from G1 (SMH) - (q = 5.837 p < 0.01, and q = 4.285 p < 0.05). CONCLUSION: Collectively, the results point to a restoration of NO normal production by monocytes in SHM patients who underwent medical and surgical treatments, especially in those who had received auto implantation of spleen tissue in the major omentum after splenectomy and ligature of the left gastric vein. The data gives further support to the hypothesis that this additional procedure is important in the restoration of the immune response of these patients, since NO synthesis by the monocytes correlates with protective immunity against infection; thus, protecting them against overwhelming post splenectomy infection.
Infec??o hospitalar em pacientes cirúrgicos de Hospital Universitário
Medeiros, Aldo da Cunha;Aires Neto, Tertuliano;Dantas Filho, Ant?nio Medeiros;Pinto Jr, Francisco Edilson Leite;Uch?a, Raquel Araújo Costa;Carvalho, Mariana Rêgo de;
Acta Cirurgica Brasileira , 2003, DOI: 10.1590/S0102-86502003000700003
Abstract: objective: a study was accomplished in order to observe the infection incidence in patients operated in the hospital universitário-ufrn. methods: a prospective study was performed involving 3120 patients submitted to surgical procedures from january 1999 to october 2000. results: the nosocomial surgical infection ratio was 5,99%. surgical wound infection was the most common (3,7%), followed by respiratory infection (1,2%), urinary (0,6%), intraabdominal (0,3%) and bacteremia (0,1%). the communitary infection ratio was 9,2%. from these, the urynary infection was the most common (5%), followed by respiratory (2,1%). infection occured in 2,9% of 1479 clean wounds, 6% of 1277 clean-contaminated, 15,1% of contaminated and 30,7% of infected wounds. conclusion: these data permit to conclude that the incidence of surgical infection is compatible with that observed in the world literature. so, it confirms the importance of the nosocomial infection control in a systematic way, as it has been accomplished in the studied hospital.
Repercuss?es do tempo operatório em pulm?es de ratos idosos
Medeiros, Aldo da Cunha;Rocha, Keyla Borges Ferreira;Dantas Filho, Ant?nio Medeiros;Aires Neto, Tertuliano;Pinto Jr, Francisco Edilson Leite;Medeiros, Bruno Cunha;
Acta Cirurgica Brasileira , 2003, DOI: 10.1590/S0102-86502003000700008
Abstract: the duration of the operations can represent an important factor for a series of postoperative complications, especially in the aged. objective: study the repercussion in the lungs, of operations of different duration. methods: twenty aged rats (18 months old) and 20 young (3 months old) were randomly separated in groups a and b respectively. the groups were divided in a1, a2, a3, a4, b1, b2, b3 and b4, with five rats each. the animals were anesthetized with pentobarbital (20mg/kg) intraperitoneal. in the group a1 and b1 a 30 minutes operation was done, in the groups a2 and b2 60 minutes, in the a3 and b3 the operation was done in 120 minutes and in the a4 and b4 control groups the animals were not operated. the procedure consisted of laparotomy that was opened and closed so many times as necessary to reach the operative times. after the 5th postoperative day the animals were killed with anesthetic's overdosis and biopsies of both lungs were performed. the biopsies were processed and colored by he. the histologic findings were transformed in scores for each group. results: the following results were seen: the groups of the young rats had the scores: a1= score 6, a2=11; a3=28; a4=5. old rats had the following scores: b1=12; b2=34; b3=51 e b4=6. the statistical analysis revealed significant difference among the scores of the groups a and b. conclusion: the prolonged time of surgery in rats contributes to significant histopatologic alterations in the lungs. as larger the operative time, larger and more frequent the pulmonary complications.
Transloca??o bacteriana para o pulm?o na icterícia obstrutiva experimental em ratos
Medeiros, Aldo da Cunha;Carvalho, Maria Goretti Freire de;Dantas Filho, Ant?nio Medeiros;Pinto Jr, Francisco Edilson Leite;Macedo Filho, Robson;Uch?a, Raquel Araújo Costa;
Revista do Colégio Brasileiro de Cirurgi?es , 2001, DOI: 10.1590/S0100-69912001000200002
Abstract: background: it has been demonstrated that obstructive jaundice provokes depression of the immunologic system, changes the pattern of intestinal bacterial colonization and possibly permits bacterial translocation lumen to the portal and systemic circulations. an experimental study performed done in rats to assess the incidence of enteric bacteria translocation to the lungs after choledocus closure. method: twenty wistar male rats weighing 178 to 215g were randomly assigned to 2 groups. in group i, (n=10) it the choledocus was tied with 0000 silk suture and in group ii the choledocus was manipulated with atraumatic instrument (sham operation). in the 7th day the animals were killed with anesthetic overdose, blood sample was colected for bilirrubin dosage and the lungs were ressected under aseptic conditions. half of each lung was homogenized and cultured in agar mcconkey and agar blood. the other half was processed by conventional histologic methods. the sections were cut and stained by gram, haematoxilin and eosin and examined with light microscopy. data were analyzed by t test (p <0,05). results: mean total bilirrubin was 18,7±3,6 and 0,7±0,2 in groups i and ii, respectively (p<0,05). colonies of klebsiela sp were isolated in the lungs of 30% and e. coli in 20% of group i, and histopathological scores presented an average of 6.2±2.08. no bacteria was detected in the lungs of group ii and the scores histopathological reached 1,8±1,16 (p <0,05). conclusions: obstructive resulting jaundice in rats promotes translocation of gram negative bacteria to the lungs, resulting in significant histopatologic alterations.
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