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Search Results: 1 - 10 of 28559 matches for " Francis Lee; "
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Joe Moran: Interdisciplinarity
Francis Lee
Utbildning & Demokrati : Tidsskrift f?r Didaktik och Utbildningspolitik , 2006,
Abstract:
Análise dos impactos da competi??o pelo uso do solo no estado de Goiás durante o período 2000 a 2009 provenientes da expans?o do complexo sucroalcooleiro
Abdala, Klaus de Oliveira;Ribeiro, Francis Lee;
Revista Brasileira de Economia , 2011, DOI: 10.1590/S0034-71402011000400004
Abstract: this article aims to analyze the sugarcane specialization in goiás state, at the municipal level, as a result of competition for land use and the impacts of this process on: substitution of crops, in the use of forest remnants and in the consumptive use of water by sugarcane. the results suggest that the expansion of sugar cane promotes local specialization, where, preferentially, replaces temporary crops and induces the displacement ofthe other crops, endangering the forest fragments. in addition, part of the expansion is located in areas of moderate to high risk of drought for sugar cane cultivation.
Levantamento do perfil e avalia??o da frota de veiculos de passeio brasileira visando racionalizar as emiss?es de dióxido de carbono
Guimar?es, Leonardo Eustáquio;Lee, Francis;
Sociedade & Natureza , 2010, DOI: 10.1590/S1982-45132010000300013
Abstract: the objective of this study was to collect and evaluate the fleet of passenger cars in brazil, with twenty or more years of use, gasoline-powered, as well as quantifying their emissions of carbon dioxide. the intention was to evaluate the investment required to remove these vehicles from circulation, comparing it with the avoided emissions and the market value of these emissions.the results found the fossil co2 emissions avoided, with the removal of such vehicles are approximately seven million two hundred thousand carbon credits.
Levantamento do perfil e avalia o da frota de veículos de passeio brasileira visando racionalizar as emiss es de dióxido de carbono / Brazilian passenger vehicle fleet profile survey and evaluation to rationalize carbon dioxide emissions
Leonardo Eustáquio Guimar?es,Francis Lee
Revista Sociedade & Natureza , 2010,
Abstract: O objetivo deste trabalho foi levantar e avaliar a frota de veículos de passeio brasileira, com vinte anos ou mais de uso, movidos à gasolina, bem como quantificar suas emiss es de dióxido de carbono. A inten o foi avaliar o investimento necessário para retirar esses veículos de circula o, confrontando-o com as emiss es evitadas e com o valor de mercado dessas emiss es. Pelos resultados encontrados as emiss es fósseis de CO2 evitadas, com a retirada de circula o destes veículos s o de aproximadamente sete milh es e duzentos mil créditos de carbono.
Local structures on stratified spaces
David Ayala,John Francis,Hiro Lee Tanaka
Mathematics , 2014,
Abstract: We develop a theory of smoothly stratified spaces and their moduli, including a notion of maps classifying tangential structures. We characterize continuous, space-valued sheaves on these smoothly stratified spaces in terms of tangential data, and we similarly characterize 1-excisive invariants of stratified spaces. These results are based on the existence of open handlebody decompositions for stratified spaces, as well as functorial resolutions of singularities to smooth manifolds with corners.
Factorization homology of stratified spaces
David Ayala,John Francis,Hiro Lee Tanaka
Mathematics , 2014,
Abstract: This work forms a foundational study of factorization homology, or topological chiral homology, at the generality of stratified spaces with tangential structures. Examples of such factorization homology theories include intersection homology, compactly supported stratified mapping spaces, and Hochschild homology with coefficients. Our main theorem characterizes factorization homology theories by a generalization of the Eilenberg-Steenrod axioms; it can also be viewed as an perturbative analogue of the Baez-Dolan cobordism hypothesis formulated for the observables, rather than state spaces, of a topological quantum field theory. Using these axioms, we extend the nonabelian Poincar\'e duality of Salvatore and Lurie to the setting of stratified spaces - this is a nonabelian version of the Poincar\'e duality given by intersection homology. We pay special attention to the simple case of singular manifolds whose singularity datum is a properly embedded submanifold and give a further simplified algebraic characterization of these homology theories. In the case of 3-manifolds with 1-dimensional submanifolds, these structure gives rise to knot and link homology theories akin to Khovanov homology.
Structured singular manifolds and factorization homology
David Ayala,John Francis,Hiro Lee Tanaka
Mathematics , 2012,
Abstract: We provide a framework for the study of structured manifolds with singularities and their locally determined invariants. This generalizes factorization homology, or topological chiral homology, to the setting of singular manifolds equipped with various tangential structures. Examples of such factorization homology theories include intersection homology, compactly supported stratified mapping spaces, and Hochschild homology with coefficients. Factorization homology theories for singular manifolds are characterized by a generalization of the Eilenberg-Steenrod axioms. Using these axioms, we extend the nonabelian Poincar\'e duality of Salvatore and Lurie to the setting of singular manifolds -- this is a nonabelian version of the Poincar\'e duality given by intersection homology. We pay special attention to the simple case of singular manifolds whose singularity datum is a properly embedded submanifold and give a further simplified algebraic characterization of these homology theories. In the case of 3-manifolds with 1-dimensional submanifolds, this structure gives rise to knot and link homology theories akin to Khovanov homology.
Systemic Therapy in Patients with Resectable and Unresectable Cases of Giant Cell Tumor: A Systematic Review  [PDF]
Philip B. Kaiser, Jocelyn T. Compton, Jon-Michael E. Caldwell, Thomas R. Hickernell, Francis Y. Lee
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.54041
Abstract:

Background: Giant cell tumor (GCT) is a common benign tumor of the appendicular and axial skeleton that represents 5% of all primary bone tumors. In recent years, the combination of conventional aggressive curettage with targeted adjuvant anti-osteoclastic agents including bisphosphonates and denosumab have led to lower recurrence rates in patients with GCT in a small number of retrospective case series. Furthermore, efficacy of the same anti-osteoclastic agents has been shown in cases of unresectable GCT of bone, leading to decreased rates of tumor progression and stabilization of disease. This review assesses whether the current literature weakly, moderately, or strongly supports a targeted systemic treatment as the standard of care in patients with GCT. Methods: We conducted a current search of the MEDLINE database for literature pertaining to systemic GCT treatment. Our inclusion criteria were as follows: 1) studies that reported on a series of patients with resectable or unresectable cases of GCT; 2) a subset of patients must have been treated with systemic bisphosphonate or RANK-L inhibitor therapy; 3) each series had a minimum of 10 patients with histopathologically confirmed GCT; 4) each series stated their follow-up period. Results: Overall 6 studies, reporting on a total of 487 patients, were selected for inclusion in this review. For analysis, these 6 retrospective studies were subdivided into series where all GCT patients had resectable tumors (n = 4) and series where patients had a mix of resectable and unresectable tumors (n

Surmounting Chemotherapy and Radioresistance in Chondrosarcoma: Molecular Mechanisms and Therapeutic Targets
Anne C. Onishi,Alexander M. Hincker,Francis Y. Lee
Sarcoma , 2011, DOI: 10.1155/2011/381564
Abstract: Chondrosarcoma, a primary malignancy of bone, has eluded successful treatment with modern chemotherapeutic and radiation regimens. To date, surgical resection of these tumors remains the only curative treatment offered to patients with this diagnosis. Understanding and exploring the nature of chemotherapy and radiation resistance in chondrosarcoma could lead to new molecular targets and more directed therapy for these notoriously difficult-to-treat tumors. Here we review the most current hypotheses regarding the molecular mechanisms mediating chemotherapy and radiation resistance and the future direction of chondrosarcoma therapy research.
Erasing Sensorimotor Memories via PKMζ Inhibition
Lee Michael von Kraus,Todd Charlton Sacktor,Joseph Thachil Francis
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011125
Abstract: Sensorimotor cortex has a role in procedural learning. Previous studies suggested that this learning is subserved by long-term potentiation (LTP), which is in turn maintained by the persistently active kinase, protein kinase Mzeta (PKMζ). Whereas the role of PKMζ in animal models of declarative knowledge is established, its effect on procedural knowledge is not well understood. Here we show that PKMζ inhibition, via injection of zeta inhibitory peptide (ZIP) into the rat sensorimotor cortex, disrupts sensorimotor memories for a skilled reaching task even after several weeks of training. The rate of relearning the task after the memory disruption by ZIP was indistinguishable from the rate of initial learning, suggesting no significant savings after the memory loss. These results indicate a shared molecular mechanism of storage for declarative and procedural forms of memory.
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