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Search Results: 1 - 10 of 7310 matches for " Francesco Girolamo "
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Left atrial voltage remodeling after pulmonary venous isolation with multipolar radiofrequency ablation  [PDF]
Francesco Laurenzi, Piergiuseppe De Girolamo, Augusto Pappalardo, Andrea Avella
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.38078
Abstract: Purpose: Pulmonary vein isolation (PVI) is the accepted primary endpoint for catheter ablation of atrial fibrillation (AF). The aim of this study was to evaluate the level of PVI by PVAC, a multipolar circular catheter utilizing bipolar/unipolar radiofrequency (RF) energy. Methods: Twenty patients with paroxysmal AF underwent PVAC ablation. PVI was validated by voltage reduction and pacing tests. Before and after RF ablation, left atrium (LA) and PV electroanatomic mapping (EAM) were performed by EnSite NavX system. Voltage abatement was considered for potentials < 0.5 mV. RF lesion setting was compared to the PVs anatomy previously acquired by a cardiac CT scan. Results: Seventeen patients had four veins and three had a left common PV. All 77 PVs were isolated by PVAC. After RF, EAM showed low voltages areas at the proximal PV ostium and LA. Segmental voltage abatement slightly distal to the anatomic PV ostia was achieved in 20/77 (26%) PVs, more frequently in veins > 24mm: 9/20 (45%) vs 11/57 (19%), p < 0.05. Antral lesions were evident in 38/77 PVs (49%), limited to a part of the antrum in 29/38 (76%) veins, with larger occurrence in round than in oval PVs ostia: 25/36 (69%) vs 13/41 (32%), p < 0.001. Conclusions: Electrophysiological PVI with PVAC is achieved in all the veins with low voltages areas at the proximal PV ostium. A low voltage circumferential lesion at the anatomic PV ostia is more challenging in larger veins. Antral lesions, frequently affecting part of the antra, were more frequent in round PV ostia.
Successful radiofrequency ablation of long-standing persistent atrial fibrillation in a patient with esophageal achalasia  [PDF]
Andrea Avella, Piergiuseppe De Girolamo, Francesco Laurenzi, Augusto Pappalardo, Vitaliano Buffa
World Journal of Cardiovascular Diseases (WJCD) , 2012, DOI: 10.4236/wjcd.2012.24047
Abstract: A 54-year-old man was referred for ablation of symptomatic drug-refractory long-lasting persistent atrial fibrillation. His past medical history was negative for cardiac disease but included a diagnosis of esophageal achalasia. The patient underwent an ablation procedure, guided by barium esophagram, including isolation of the pulmonary veins, ablation of complex fractionated left atrial electrograms recorded on the sep-tal wall and, finally, linear ablation of the cavo-tricuspid isthmus. The ablation procedure was performed with multielectrode ablation catheters using duty-cycled bipolar/unipolar radiofrequency energy. During 6 months of follow-up no recurrences of atrial fibrillation were documented. The reported case demonstrates how an ablation procedure for long-standing persistent AF may be safely performed even in a patient presenting with a achalasia, outlining the mega-esophagus position with a simple barium paste.
Forest soil conditions in the CONECOFOR Permanent Monitoring Plots and in the Level I Network in Italy
Francesco ALIANIELLO,Francesco A. BIONDI,Cinzia FERRARI,Girolamo MECELLA
Journal of Limnology , 2002, DOI: 10.4081/jlimnol.2002.s1.25
Abstract: The study of forest health is not complete without an assessment of soil condition. Forest soils were monitored in 20 Italian sites in the CONECOFOR programme with different pedological and climatic conditions, the Permanent Monitoring Plots (PMPs). The main objective was the evaluation of the effect of acid depositions on soils and nutrient availability. The FAO classification was applied to all the CONECOFOR soils. Other analyses were carried out on the organic layer and on four mineral layers. Although the number of sites is too small for this monitoring to be considered wholly representative of the state of Italian forest soils, the analyses yield some general information. In addition, a smaller number of determinations were carried out on a higher number of soils (70 soils in the first level monitoring programme (FLP), including the twenty PMPs). Results show that no soils have pH <3 and few soils have pH between 3.0-3.5 (measured in CaCl2 solution). Furthermore, the soils with low pH values are naturally acid, due to the parent material. The parameters that provide information on the sensitivity of soil to acidification, such as base saturation and the sum of exchangeable base cations in the mineral layers, as well as the amount of total K, Ca and Mg in the organic layer, show that there are hardly any soils in poor health. A high proportion of Italian soils have a lower content of organic matter than other European soils, due to Mediterranean climatic conditions; these are very different from those in central and northern Europe, which represent the majority of the European soils monitored. The availability of nutrients (particularly nitrogen and phosphorus) is on the whole sufficient. The results of the determinations of the FLP programme confirm the evaluations expressed for the PMPs, but provide more information, for example regarding the C/N ratio in the different soil layers: several anomalous sites, where the C/N ratio is higher in the surface mineral layer than in the organic layer, were found in this programme, but not in CONECOFOR.
Neoadjuvant Treatment in Rectal Cancer: Actual Status
Ingrid Garajová,Stefania Di Girolamo,Francesco de Rosa,Jody Corbelli,Valentina Agostini,Guido Biasco,Giovanni Brandi
Chemotherapy Research and Practice , 2011, DOI: 10.1155/2011/839742
Abstract: Neoadjuvant (preoperative) concomitant chemoradiotherapy (CRT) has become a standard treatment of locally advanced rectal adenocarcinomas. The clinical stages II (cT3-4, N0, M0) and III (cT1-4, N
Efficient siRNA Delivery by the Cationic Liposome DOTAP in Human Hematopoietic Stem Cells Differentiating into Dendritic Cells
Sabata Martino,Ilaria di Girolamo,Roberto Tiribuzi,Francesco D'Angelo,Alessandro Datti,Aldo Orlacchio
Journal of Biomedicine and Biotechnology , 2009, DOI: 10.1155/2009/410260
Abstract: RNA interference technology is an ideal strategy to elucidate the mechanisms associated with human CD34
Primitive Neuroectodermal Tumor (PNET) of the kidney: a case report
Giorgio Pomara, Francesco Cappello, Maria G Cuttano, Francesca Rappa, Girolamo Morelli, Pierantonio Mancini, Cesare Selli
BMC Cancer , 2004, DOI: 10.1186/1471-2407-4-3
Abstract: The surgical specimens were formalin-fixed and paraffin embedded. The sections were stained with routinary H&E. Immunohistochemistry was performed.The immunohistochemical evaluation revealed a diffuse CD99 positivity in the cytoplasm of the neoplastic cells. Pankeratin, cytokeratin AE1/AE3, vimentin, desmin, S100, cromogranin were negative. The clinical presentation and the macroscopic aspect, together with the histological pattern, the cytological characteristic and the cellular immunophenotype addressed the diagnosis towards primary PNET of kidney.Since sometimes it is difficult to discriminate between PNET and Ewing's tumour, we reviewed the difficulties in differential diagnosis. These tumors have a common precursor but the stage of differentiation in which it is blocked is probably different. This could also explain their different biological behaviour and prognosis.The peripheral Primitive Neuroectodermal Tumor (PNET), firstly recognized by Arthur Purdy Stout in 1918, is a member of the family of "small round-cell tumors". Primitive renal localization is very rare. There are almost 50 cases reported in the literature, although it is difficult to estimate the exact number since often it has not been differentiated from Ewing's Sarcoma [1-13]. Renal PNET is more aggressive than in the other sites. It frequently arises during childhood or adolescence, having an aggressive clinical course towards metastatic disease and death. It often recurs locally and metastasises early to regional lymph nodes, lungs, liver, bone and bone marrow, resulting in a poor prognosis. The 5-year disease-free survival rate, for patients presenting well confined extra-skeletal PNET, is around 45–55% and cases with advanced disease at presentation have a median relapse-free survival of only 2 years [1].A 27-year-old woman was referred because of a mild left flank pain and haematuria. Ultrasonography identified a left renal mass homogeneously hyperechogenic in comparison with renal parenchy
Secondary aortoduodenal fistula
Girolamo Geraci, Franco Pisello, Francesco Li Volsi, Tiziana Facella, Lina Platia, Giuseppe Modica, Carmelo Sciumè
World Journal of Gastroenterology , 2008,
Abstract: Aorto-duodenal fistulae (ADF) are the most frequent aorto-enteric fistulae (80%), presenting with upper gastrointestinal bleeding. We report the first case of a man with a secondary aorto-duodenal fistula presenting with a history of persistent occlusive syndrome. A 59-year old man who underwent an aortic-bi-femoral bypass 5 years ago, presented with dyspepsia and biliary vomiting. Computed tomography scan showed in the third duodenal segment the presence of inflammatory tissue with air bubbles between the duodenum and prosthesis, adherent to the duodenum. The patient was submitted to surgery, during which the prosthesis was detached from the duodenum, the intestine failed to close and a gastrojejunal anastomosis was performed. The post-operative course was simple, secondary ADF was a complication (0.3%-2%) of aortic surgery. Mechanical erosion of the prosthetic material into the bowel was due to the lack of interposed retroperitoneal tissue or the excessive pulsation of redundantly placed grafts or septic procedures. The third or fourth duodenal segment was most frequently involved. Diagnosis of ADF was difficult. Surgical treatment is always recommended by explorative laparotomy. ADF must be suspected whenever a patient with aortic prosthesis has digestive bleeding or unexplained obstructive syndrome. Rarely the clinical picture of ADF is subtle presenting as an obstructive syndrome and in these cases the principal goal is to effectively relieve the mechanical bowel obstruction.
Neoadjuvant Treatment in Rectal Cancer: Actual Status
Ingrid Garajová,Stefania Di Girolamo,Francesco de Rosa,Jody Corbelli,Valentina Agostini,Guido Biasco,Giovanni Brandi
Chemotherapy Research and Practice , 2011, DOI: 10.1155/2011/839742
Abstract: Neoadjuvant (preoperative) concomitant chemoradiotherapy (CRT) has become a standard treatment of locally advanced rectal adenocarcinomas. The clinical stages II (cT3-4, N0, M0) and III (cT1-4, N+, M0) according to International Union Against Cancer (IUCC) are concerned. It can reduce tumor volume and subsequently lead to an increase in complete resections (R0 resections), shows less toxicity, and improves local control rate. The aim of this review is to summarize actual approaches, main problems, and discrepancies in the treatment of locally advanced rectal adenocarcinomas. 1. Indication and Benefit of Neoadjuvant Treatment Rectal cancer is one of the most common cancers and accounts for approximately 1/3 of the deaths due to colorectal cancer in 2009 [1]. In well-selected patients (i.e., those with well-differentiated T1 cancers involving <40% of the circumference, without lymphovascular invasion), particularly when the only other option is abdominoperineal resection (APR), local excision seems to be a viable option [2]. Locally advanced rectal cancer is comprised of tumors with extension beyond the muscularis propria (≥T3) and/or those with clinical or pathologic evidence for lymph node metastasis (N+); in these cases multimodality approaches are recommended [1]. Such multimodality approaches are applicable to patients with rectal cancers at or below the peritoneal reflection. This designation generally represents cancers below 12?cm from the anal verge. Generally, the treatment of tumors localized more than 12?cm from anal verge is based on the colon cancer paradigm. The determination of “node positivity” in patients with locally advanced rectal cancer can be difficult. Most lymph nodes involved by rectal cancer are less than 1?cm, but not all lymph nodes detected by MRI or TRUS represent metastatic disease; therefore, some patients can be understaged. Neoadjuvant CRT may also be considered if the preoperative staging evaluation suggests the presence of mesorectal invasion [3]. This finding is highly predictive of residual tumor at the circumferential margin [4]. Neoadjuvant CRT is more effective than adjuvant therapy in reducing local recurrence and in minimizing toxicity [5]. It is associated with tumor downstaging, significantly higher rate of pathologic complete response (pCR), significantly less advanced pT and pN stage, and fewer cases with venous, perineural, or lymphatic invasion, increased tumor resectability [6]. Multivariate analyses confirmed that the response to neoadjuvant CRT was predictive of improved OS among the patients with
Prospects for Gamma-Ray Bursts detection by the Cherenkov Telescope Array
Elisabetta Bissaldi,Tristano Di Girolamo,Francesco Longo,Piero Vallania,Carlo Vigorito
Physics , 2015,
Abstract: The first Gamma-Ray Burst (GRB) catalog presented by the Fermi-Large Area Telescope (LAT) collaboration includes 28 GRBs, detected above 100 MeV over the first three years since the launch of the Fermi mission. However, more than 100 GRBs are expected to be found over a period of six years of data collection thanks to a new detection algorithm and to the development of a new LAT event reconstruction, the so-called "Pass 8." Our aim is to provide revised prospects for GRB alerts in the CTA era in light of these new LAT discoveries. We focus initially on the possibility of GRB detection with the Large Size Telescopes (LSTs). Moreover, we investigate the contribution of the Middle Size Telescopes (MSTs), which are crucial for the search of larger areas on short post trigger timescales. The study of different spectral components in the prompt and afterglow phase, and the limits on the Extragalactic background light are highlighted. Different strategies to repoint part of - or the entire array - are studied in detail.
Tomo I - Prima sessione - La base giuridica dell'espropriazioni: il vincolo preordinato all'sproprio, la dichiarazione di pubblica utilità e l'occupazione acquisitiva
Girolamo Sciullo
Aestimum , 2003,
Abstract:
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