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Search Results: 1 - 10 of 7231 matches for " Francesco Cellini "
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Quadruple therapy with moxifloxacin and bismuth for first-line treatment of Helicobacter pylori
Antonio Francesco Ciccaglione,Luigina Cellini,Laurino Grossi,Leonardo Marzio
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i32.4386
Abstract: AIM: To compare triple therapy vs quadruple therapy for 10 d as first-line treatment of Helicobacter pylori (H. pylori) infection. METHODS: Consecutive H. pylori positive patients never treated in the past for this infection were randomly treated with triple therapy of pantoprazole (PAN) 20 mg bid, amoxicillin (AMO) 1 g bid and moxifloxacin (MOX) 400 mg bid for 10 d (PAM) or with quadruple therapy of PAN 20 mg bid, AMO 1 g bid, MOX 400 mg bid and bismuth subcitrate 240 mg bid for 10 d (PAMB). All patients were found positive at 13 C-Urea breath test (UBT) performed within ten days prior to the start of the study. A successful outcome was confirmed with an UBT performed 8 wk after the end of treatment. χ2 analysis was used for statistical comparison. Per protocol (PP) and intention-to-treat (ITT) values were also calculated. RESULTS: Fifty-seven patients were enrolled in the PAM group and 50 in the PAMB group. One patient in each group did not return for further assessment. Eradication was higher in the PAMB group (negative: 46 and positive: 3) vs the PAM group (negative: 44 and positive: 12). The H. pylori eradication rate was statistically significantly higher in the PAMB group vs the PAM group, both with the PP and ITT analyses (PP: PAMB 93.8%, PAM 78.5%, P < 0.02; ITT: PAMB 92%, PAM 77.1 %, P <0.03). CONCLUSION: The addition of bismuth subcitrate can be considered a valuable adjuvant to triple therapy in those areas where H. pylori shows a high resistance to fluoroquinolones.
Effect of air heat treatment time on physical, chemical and DNA quality properties of strawberries fruit (cv. candonga)
Mauro Musto,Raffaele Lopardo,Francesco Cellini,Pasquale Domenico Grieco
Italian Journal of Agronomy , 2011, DOI: 10.4081/ija.2011.e11
Abstract: Changes in quality properties of air heat-treated (45°C for 0, 2 and 4 h) strawberries were investigated. As treatment time increased, most of physical, chemical and DNA quality properties decreased significantly. After 4 h, however, fruits showed the highest L* value, Hue angle, pH, SSC and total phenolic accumulation. The results of multiplex PCR assays showed two amplified fragments for all samples extracted from achenes. In thalamus, conversely, the number of amplified fragments decreased with time, indicating great degradation of DNA in this tissue.
Su che cos’è l’economia politica
Roberto Cellini
Moneta e Credito , 2012,
Abstract: The article discusses the contribution by Aldo Montesano in this number, with a special focus on the definitions of economics and of political economy. In trying to answer if economics is a moral discipline and if it is a science, the article highlights that different schools of economists have interpreted and defined differently what economics is concerned with. It is pointed out that none of these approaches was born and is now dead, but rather different perspectives still coexist. For this reason, it is important on the one hand to allow for pluralism and on the other not to endorse caricatured representations of the discipline.
Identification by Virtual Screening and In Vitro Testing of Human DOPA Decarboxylase Inhibitors
Frederick Daidone, Riccardo Montioli, Alessandro Paiardini, Barbara Cellini, Antonio Macchiarulo, Giorgio Giardina, Francesco Bossa, Carla Borri Voltattorni
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031610
Abstract: Dopa decarboxylase (DDC), a pyridoxal 5′-phosphate (PLP) enzyme responsible for the biosynthesis of dopamine and serotonin, is involved in Parkinson's disease (PD). PD is a neurodegenerative disease mainly due to a progressive loss of dopamine-producing cells in the midbrain. Co-administration of L-Dopa with peripheral DDC inhibitors (carbidopa or benserazide) is the most effective symptomatic treatment for PD. Although carbidopa and trihydroxybenzylhydrazine (the in vivo hydrolysis product of benserazide) are both powerful irreversible DDC inhibitors, they are not selective because they irreversibly bind to free PLP and PLP-enzymes, thus inducing diverse side effects. Therefore, the main goals of this study were (a) to use virtual screening to identify potential human DDC inhibitors and (b) to evaluate the reliability of our virtual-screening (VS) protocol by experimentally testing the “in vitro” activity of selected molecules. Starting from the crystal structure of the DDC-carbidopa complex, a new VS protocol, integrating pharmacophore searches and molecular docking, was developed. Analysis of 15 selected compounds, obtained by filtering the public ZINC database, yielded two molecules that bind to the active site of human DDC and behave as competitive inhibitors with Ki values ≥10 μM. By performing in silico similarity search on the latter compounds followed by a substructure search using the core of the most active compound we identified several competitive inhibitors of human DDC with Ki values in the low micromolar range, unable to bind free PLP, and predicted to not cross the blood-brain barrier. The most potent inhibitor with a Ki value of 500 nM represents a new lead compound, targeting human DDC, that may be the basis for lead optimization in the development of new DDC inhibitors. To our knowledge, a similar approach has not been reported yet in the field of DDC inhibitors discovery.
A new mutant genetic resource for tomato crop improvement by TILLING technology
Silvia Minoia, Angelo Petrozza, Olimpia D'Onofrio, Florence Piron, Giuseppina Mosca, Giovanni Sozio, Francesco Cellini, Abdelhafid Bendahmane, Filomena Carriero
BMC Research Notes , 2010, DOI: 10.1186/1756-0500-3-69
Abstract: To apply TILLING to tomato, a new mutant collection was generated in the genetic background of the processing tomato cultivar Red Setter by treating seeds with two different ethylemethane sulfonate doses (0.7% and 1%). An associated phenotype database, LycoTILL, was developed and a TILLING platform was also established. The interactive and evolving database is available online to the community for phenotypic alteration inquiries. To validate the Red Setter TILLING platform, induced point mutations were searched in 7 tomato genes with the mismatch-specific ENDO1 nuclease. In total 9.5 kb of tomato genome were screened and 66 nucleotide substitutions were identified. The overall mutation density was estimated and it resulted to be 1/322 kb and 1/574 kb for the 1% EMS and 0.7% EMS treatment respectively.The mutation density estimated in our collection and its comparison with other TILLING populations demonstrate that the Red Setter genetic resource is suitable for use in high-throughput mutation discovery. The Red Setter TILLING platform is open to the research community and is publicly available via web for requesting mutation screening services.Tomato (Solanum lycopersicum) is one of the most important vegetable plants in the world. Its fruits are end products both for the fresh market and food processing industry. Tomato presents a relatively small genome highly syntenic to others economically important Solanaceae species and was selected as a reference species for sequencing a Solanaceae genome. In addition to the availability of a number of genomic resources, including transcriptome [1-3] and metabolome [4], large collections of genetic resources are available to dissect the biochemical and the metabolic pathways in tomato [5]. Large EMS and fast neutron mutant collections, in the background of M82 tomato cultivar, have been generated and more then 3,000 phenotype alterations catalogued [6]. An EMS-induced mutation library of the miniature dwarf tomato cultivar Mi
Clinical target volume delineation including elective nodal irradiation in preoperative and definitive radiotherapy of pancreatic cancer
Luciana Caravatta, Giuseppina Sallustio, Fabio Pacelli, Gilbert DA Padula, Francesco Deodato, Gabriella Macchia, Mariangela Massaccesi, Vincenzo Picardi, Savino Cilla, Alfonso Marinelli, Numa Cellini, Vincenzo Valentini, Alessio G Morganti
Radiation Oncology , 2012, DOI: 10.1186/1748-717x-7-86
Abstract: The anatomical structures of interest, as well as the abdominal vasculature were identified on intravenous contrast-enhanced CT scans of two different patients with pancreatic cancer of the head and the body. To delineate the lymph node area, a margin of 10?mm was added to the arteries.We proposed a set of guidelines for elective treatment of high-risk nodal areas and CTV delineation. Reference CT images were provided.The proposed guidelines could be used for preoperative or definitive RT for carcinoma of the head and body of the pancreas. Further clinical investigations are needed to validate the defined CTVs.
Root polytopes and abelian ideals
Paola Cellini,Mario Marietti
Mathematics , 2012, DOI: 10.1007/s10801-013-0458-5
Abstract: We study the root polytope $\mathcal P_\Phi$ of a finite irreducible crystallographic root system $\Phi$ using its relation with the abelian ideals of a Borel subalgebra of a simple Lie algebra with root system $\Phi$. We determine the hyperplane arrangement corresponding to the faces of codimension 2 of $\mathcal P_\Phi$ and analyze its relation with the facets of $\mathcal P_\Phi$. For $\Phi$ of type $A_n$ or $C_n$, we show that the orbits of some special subsets of abelian ideals under the action of the Weyl group parametrize a triangulation of $\mathcal P_\Phi$. We show that this triangulation restricts to a triangulation of the positive root polytope $\mathcal P_\Phi^+$.
ad-Nilpotent ideals of a Borel subalgebra II
Paola Cellini,Paolo Papi
Mathematics , 2001,
Abstract: We provide an explicit bijection between the ad-nilpotent ideals of a Borel subalgebra of a simple Lie algebra g and the orbits of \check{Q}/(h+1)\check{Q} under the Weyl group (\check{Q} being the coroot lattice and h the Coxeter number of g). From this result we deduce in a uniform way a counting formula for the ad-nilpotent ideals.
ad-nilpotent ideals of a Borel subalgebra III
P. Cellini,P. Papi
Mathematics , 2003,
Abstract: This paper is devoted to a detailed study of certain remarkable posets which form a natural partition of all abelian ideals of a Borel subalgebra. Our main result is a nice uniform formula for the dimension of maximal ideals in these posets. We also obtain results on ad-nilpotent ideals which complete the analysis started in \cite{CP2}, \cite{CP3}.
Polar Root Polytopes that are Zonotopes
Paola Cellini,Mario Marietti
Mathematics , 2015,
Abstract: Let $\mathcal P_{\Phi}$ be the root polytope of a finite irreducible crystallographic root system $\Phi$, i.e., the convex hull of all roots in $\Phi$. The polar of $\mathcal P_{\Phi}$, denoted $\mathcal P_{\Phi}^*$, coincides with the union of the orbit of the fundamental alcove under the action of the Weyl group. In this paper, we establishes which polytopes $\mathcal P_{\Phi}^*$ are zonotopes and which are not. The proof is constructive.
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