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Search Results: 1 - 10 of 3054 matches for " Francesca Tarantini "
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Bilateral Simultaneous Nonarteritic Anterior Ischemic Optic Neuropathy after Ingestion of Sildenafil for Erectile Dysfunction
Anna Tarantini,Alessandra Faraoni,Francesca Menchini,Paolo Lanzetta
Case Reports in Medicine , 2012, DOI: 10.1155/2012/747658
Abstract: Purpose. To describe a patient who developed bilateral, simultaneous nonarteritic anterior ischemic optic neuropathy (NAION) after ingestion of Sildenafil citrate (Viagra) for erectile dysfunction. Methods. Observational case report. Results. A 60-year-old diabetic man noted sudden decrease of vision in both eyes 16 hours after his third consecutive 50 mg daily Sildenafil ingestion. A diagnosis of bilateral NAION was made and he was treated for three days with methylprednisolone 1 g/d intravenously, followed by oral prednisone 75 mg/d. Final visual acuity was 20/50 right eye (OD) and 20/20 left eye (OS). He had preexisting diabetes. Conclusion. This is the first reported case of simultaneous bilateral NAION occurred in a diabetic patient early after Sildenafil intake. Patients with predisposing conditions such as diabetes have to be warned against the use of PDE inhibitors.
Biomarkers of Alzheimer's Disease: From Central Nervous System to Periphery?
Enrico Mossello,Elena Ballini,Anna Maria Mello,Francesca Tarantini,David Simoni,Samuele Baldasseroni,Niccolò Marchionni
International Journal of Alzheimer's Disease , 2011, DOI: 10.4061/2011/342980
Abstract: Alzheimer's Disease (AD) is the most frequent form of dementia and represents one of the main causes of disability among older subjects. Up to now, the diagnosis of AD has been made according to clinical criteria. However, the use of such criteria does not allow an early diagnosis, as pathological alterations may be apparent many years before the clear-cut clinical picture. An early diagnosis is even more valuable to develop new treatments, potentially interfering with the pathogenetic process. During the last decade, several neuroimaging and cerebrospinal fluid (CSF) parameters have been introduced to allow an early and accurate detection of AD patients, and, recently, they have been included among research criteria for AD diagnosis. However, their use in clinical practice suffers from limitations both in accuracy and availability. The increasing amount of knowledge about peripheral biomarkers will possibly allow the future identification of reliable and easily available diagnostic tests.
Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities
Enrico Mossello,Elena Ballini,Marta Boncinelli,Matteo Monami,Giuseppe Lonetto,Anna Maria Mello,Francesca Tarantini,Samuele Baldasseroni,Edoardo Mannucci,Niccolò Marchionni
Experimental Diabetes Research , 2011, DOI: 10.1155/2011/281674
Abstract: Metabolic and neurodegenerative disorders have a growing prevalence in Western countries. Available epidemiologic and neurobiological evidences support the existence of a pathophysiological link between these conditions. Glucagon-like peptide 1 (GLP-1), whose activity is reduced in insulin resistance, has been implicated in central nervous system function, including cognition, synaptic plasticity, and neurogenesis. We review the experimental researches suggesting that GLP-1 dysfunction might be a mediating factor between Type 2 diabetes mellitus (T2DM) and neurodegeneration. Drug treatments enhancing GLP-1 activity hold out hope for treatment and prevention of Alzheimer's disease (AD) and cognitive decline.
Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities
Enrico Mossello,Elena Ballini,Marta Boncinelli,Matteo Monami,Giuseppe Lonetto,Anna Maria Mello,Francesca Tarantini,Samuele Baldasseroni,Edoardo Mannucci,Niccolò Marchionni
Journal of Diabetes Research , 2011, DOI: 10.1155/2011/281674
Abstract: Metabolic and neurodegenerative disorders have a growing prevalence in Western countries. Available epidemiologic and neurobiological evidences support the existence of a pathophysiological link between these conditions. Glucagon-like peptide 1 (GLP-1), whose activity is reduced in insulin resistance, has been implicated in central nervous system function, including cognition, synaptic plasticity, and neurogenesis. We review the experimental researches suggesting that GLP-1 dysfunction might be a mediating factor between Type 2 diabetes mellitus (T2DM) and neurodegeneration. Drug treatments enhancing GLP-1 activity hold out hope for treatment and prevention of Alzheimer's disease (AD) and cognitive decline. 1. Insulin Resistance and Cognitive Decline During the last years, Alzheimer’s disease (AD) and clinical syndromes associated to insulin resistance have shown an ever-increasing prevalence in Western countries. These conditions pose a great threat to present and future population’s health and represent two of the main causes of disability and health expenditures. Several research lines during the last decade have suggested an association among Type 2 diabetes mellitus (T2DM), insulin resistance, and cognitive decline, both in cross-sectional and in longitudinal studies. Cross-sectional studies have found that older subjects with T2DM on average show a poorer cognitive performance than age-matched controls [1]. This association seems independent of other vascular risk factors and is attributable not only to a greater extent of white matter lesions but also to a more severe cortical atrophy [2], especially in temporo-mesial areas (hippocampus, amygdala) [3]. Moreover insulin resistance is associated to a worse cognitive performance in nondiabetic subjects too [4]. On the other hand cross-sectional studies have observed a significant association of dementia, AD in particular, with T2DM [5] and insulin resistance [6]. Also several longitudinal studies have observed an association of T2DM with dementia risk over years [7]. Moreover it has been observed that older nondiabetic subjects with metabolic syndrome and increased level of inflammatory markers have an increased risk of subsequent cognitive decline [8]. Recently published data have shown that, among nondiabetic nondemented older subjects, insulin resistance is associated with AD incidence after a few years [9]. In keeping with this observation, insulin resistance has been associated recently with a greater extent of AD-like neuropathology at autopsy [10]. Therefore it is plausible that, among older
Adiponectin, diabetes and ischemic heart failure: a challenging relationship
Samuele Baldasseroni, Alessandro Antenore, Claudia Di Serio, Francesco Orso, Giuseppe Lonetto, Nadia Bartoli, Alice Foschini, Andrea Marella, Alessandra Pratesi, Salvatore Scarantino, Stefano Fumagalli, Matteo Monami, Edoardo Mannucci, Niccolò Marchionni, Francesca Tarantini
Cardiovascular Diabetology , 2012, DOI: 10.1186/1475-2840-11-151
Abstract: We evaluated the level of adiponectin in patients with ischemic HF, with and without type 2 diabetes, to elucidate whether the metabolic syndrome was able to influence the relationship between AD and HF.We demonstrated that AD rises in patients with advanced HF, but to a lesser extent in diabetics than in non-diabetics. Diabetic patients with reduced systolic performance orchestrated a slower rise of AD which began only in face of overt HF. The different behavior of AD in the presence of diabetes was not entirely explained by differences in body mass index. In addition, NT-proBNP, the second strongest predictor of AD, did not differ significantly between diabetic and non-diabetic patients. These data indicate that some other mechanisms are involved in the regulation of AD in patients with type 2 diabetes and coronary artery disease.AD rises across chronic heart failure stages but this phenomenon is less evident in type 2 diabetic patients. In the presence of diabetes, the progressive increase of AD in relation to the severity of LV dysfunction is hampered and becomes evident only in overt HF.The adipose tissue should not be regarded as a simple site of lipid storage [1]; indeed it is able to secrete several peptides with hormonal properties that are involved in energy homeostasis as well as modulation of inflammation and regulation of many immunological mechanisms [2]. This heterogeneous group of hormones is named adipokines. Among these, adiponectin (AD) is by far the most abundant protein secreted by the adipose tissue [3]. Although it is produced almost exclusively by adipocytes, plasma levels of AD are found to be inversely correlated to visceral adiposity and body mass index (BMI) [3]. AD promotes peripheral insulin sensitivity [4] and inhibition of liver gluconeogenesis [5]. As a matter of fact, hypoadiponectinemia is known to be the molecular link between obesity and insulin-resistance, at the base of metabolic syndrome [2]. AD is able to predict diabetes ons
The Use of Materials from Biomass as Construction Materials  [PDF]
Francesca Giglio
Open Journal of Civil Engineering (OJCE) , 2013, DOI: 10.4236/ojce.2013.32A009
Abstract:

The paper describes some studies conducted by the author, about low impact materials and, particularly, on alternative uses of biomass materials for building materials. Italy needs to develop renewable energy sources and agriculture offers many opportunities: biomass, vegetable residues for livestock breeding, food industry waste, organic waste, solid biofuels, biogas, and biofuels, will be the new renewable energy sources. Researches for promoting sustainable development, including chemistry field are increasing interest in the exploitation of vegetal biomass, in particular waste as a raw material for production of bio-products and biofuels. Not always, however, the use of waste materials such as biomass is the most appropriate, or in any case, the one with less energy expenditure. As ever more evident, in fact, the construction sector is approaching the possibility of using these materials for other purposes, combining the demands of saving natural resources, the need for energy efficiency in buildings and production processes.

Public Private Partnerships for Transportation Infrastructure Delivery  [PDF]
Francesca Leccis
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.35004
Abstract:

The term Public Private Partnerships includes different forms of collaboration between the public and the private sector. These formulas are adopted in a constantly increasing number of countries all over the world in order to overcome the chronic lack of funding and ensure the delivery of infrastructure projects. The paper illustrates the vital role of cooperation between public bodies and private entities in the delivery of public transportation infrastructure. In particular, it focuses on toll roads and highways. Key factors of success and risk are identified and illustrated through five case studies from Chile, Hungary, South Africa-Mozambique, United Kingdom and California.

Estimación de la masa corporal de las especies de osos fósiles y actuales (Ursidae, Tremarctinae) de América del Sur
Soibelzon,Leopoldo Héctor; Tarantini,Viviana Beatriz;
Revista del Museo Argentino de Ciencias Naturales , 2009,
Abstract: precise estimates of body mass in fossil taxa are elementary to paleobiological reconstruction. using demonstrated relationships between body mass and anatomical measurements in modern mammals, several authors proposed prediction equations to estimate the body mass of fossil taxa. we calculate the body mass of extant and fossil south american bears (tremarctos ornatus and arctotherium respectively) applying 61 selected allometric equations to 19 cranial, dental and postcranial measurements. we also estimate the body mass ranges of the five arctotherium species by simple size comparison to size and weight of extant bears. extrapolating on the basis of geometric similitude with t. ornatus we further estimated the body mass of arctotherium in order to know if our estimations, bias published equations, were feasible. also we test the prediction equations results with a specimen of tremarctos ornatus of known body mass. we found that the best prediction equations for all arctotherium species are based on femoral (8 equations) and cranial (one equation) measurements. in turn the best prediction equations for t. ornatus are based on cranial (one equation), first lower molar (one equation), femoral (two equations) and humeral measurements (three equations).
Estimación de la masa corporal de las especies de osos fósiles y actuales (Ursidae, Tremarctinae) de América del Sur Body mass estimation of extinct and extant South American bears (Ursidae, Tremarctinae)
Leopoldo Héctor Soibelzon,Viviana Beatriz Tarantini
Revista del Museo Argentino de Ciencias Naturales , 2009,
Abstract: Contar con estimaciones precisas de la masa corporal de los taxones fósiles es esencial para realizar reconstrucciones paleobiológicas. Empleando relaciones demostradas entre la masa corporal y medidas anatómicas en mamíferos modernos algunos autores han propuesto ecuaciones predictivas a fin de estimar la masa de los taxones fósiles. En este trabajo calculamos la masa corporal de los osos vivientes y fósiles de América del Sur (Tremarctos ornatus y Arctotherium respectivamente) aplicando 61 ecuaciones alométricas seleccionadas a 19 medidas craneanas, dentarias y postcranenas. Adicionalmente estimamos el rango de masa de las cinco especies de Arctotherium por simple comparación de tama o con el tama o y peso de los osos actuales. Luego, por extrapolación a base de similitud morfológica con T. ornatus estimamos la masa de Arctotherium a fin de saber si nuestras estimaciones obtenidas con las ecuaciones alométricas eran posibles. También pusimos a prueba las ecuaciones empleadas utilizando un espécimen de T. ornatus de masa conocida. Nuestros resultados indican que las mejores ecuaciones para predecir la masa de Arctotherium son las basadas en medidas del fémur (8 ecuaciones) y craneanas (una ecuación). Por otra parte, las mejores ecuaciones para predecir la masa de T. ornatus son aquellas basadas en medidas del cráneo (una ecuación), fémur (dos ecuaciones) y húmero (tres ecuaciones). Precise estimates of body mass in fossil taxa are elementary to paleobiological reconstruction. Using demonstrated relationships between body mass and anatomical measurements in modern mammals, several authors proposed prediction equations to estimate the body mass of fossil taxa. We calculate the body mass of extant and fossil South American bears (Tremarctos ornatus and Arctotherium respectively) applying 61 selected allometric equations to 19 cranial, dental and postcranial measurements. We also estimate the body mass ranges of the five Arctotherium species by simple size comparison to size and weight of extant bears. Extrapolating on the basis of geometric similitude with T. ornatus we further estimated the body mass of Arctotherium in order to know if our estimations, bias published equations, were feasible. Also we test the prediction equations results with a specimen of Tremarctos ornatus of known body mass. We found that the best prediction equations for all Arctotherium species are based on femoral (8 equations) and cranial (one equation) measurements. In turn the best prediction equations for T. ornatus are based on cranial (one equation), first lower molar (one eq
Identity in Sport Teams  [PDF]
Cristina Zucchermaglio, Francesca Alby
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.23031
Abstract: In this paper we analyze identity in a soccer team using a discursive perspective, in which individual psycho-logical functioning is considered to be built in and through social interactions within groups. Analysis is based on naturally-occurring interactions that were audio recorded during technical meetings before and after the match. The data were collected within an ethnographic investigation of an Italian soccer tam carried out over a two-month period. The results show that the team’s members made rhetorical use of a complex repertoire of their own and others’ social identities, and that two main variables influenced the use of social identity markers: a) the role of the speakers (in particular the “power” role of the coach); b) the result of the match around which the interactive discourse revolved. Against this background, we discuss how narratives and identity positionings were used to achieve specific goals and to perform specific actions, such as the planning of future matches and the interpretation of victories and defeats.
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