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Search Results: 1 - 10 of 73620 matches for " Francesca Maria Giugliano "
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Prevention and Treatment of Radiation Induced Skin Damage in Breast Cancer  [PDF]
Rossella Di Franco, Vincenzo Ravo, Sara Falivene, Angela Argenone, Valentina Borzillo, Francesca Maria Giugliano, Elena Sammarco, Matteo Muto, Salvatore Cappabianca, Paolo Muto
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2014, DOI: 10.4236/jcdsa.2014.41003

Introduction: Skin toxicity is a frequent side effect of radio and chemo-treatments in patients treated for breast cancer after conservative surgery. The aim of this paper is to report our experience in the management of skin toxicity evaluating radiotherapy planning and using preventive local aids. Materials and Methods: We have observed 300 patients undergoing radiotherapy. All received the prescription of a prophylactic moisturizing cream. Skin toxicity was valuated according to Acute Radiation Morbidity Scoring Criteria of the RTOG. Moreover, in a subgroup of 100 patients, we correlated the study of breast volume and features of treatment plans, with the addition of topic prophylactic treatment, using an oral therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor?). In another subgroup, 100 patients were subjected to corneometry assessing numerically skin hydration before, during and after radiotherapy. Results: In all patients, we related skin toxicity and the type of cream used. All patients completed the radiotherapy treatment, and G4 cutaneous toxicity was not observed in any of them. In patients treated with topic treatment and therapy based on Resveratrol, Lycopene, Vitamin C and Anthocyanins (Ixor?), the protective effect of (Ixor?) is more detected in patients with PTV (Planning Target Volume) <500 ml, when Dmax reaches values lower or equal to 107%, but not exceeding 110% of the prescribed dose, and in patients undergoing adjuvant chemotherapy with anthracyclines and taxanes. The values of corneometry allow us to evaluate the moisturizing

Helical Tomotherapy in Children and Adolescents: Dosimetric Comparisons, Opportunities and Issues
Maurizio Mascarin,Francesca Maria Giugliano,Elisa Coassin,Annalisa Drigo,Paola Chiovati,Andrea Dassie,Giovanni Franchin,Emilio Minatel,Mauro Gaetano Trovò
Cancers , 2011, DOI: 10.3390/cancers3043972
Abstract: Helical Tomotherapy (HT) is a highly conformal image-guided radiation technique, introduced into clinical routine in 2006 at the Centro di Riferimento Oncologico Aviano (Italy). With this new technology, intensity-modulated radiotherapy (IMRT) is delivered using a helicoidal method. Here we present our dosimetric experiences using HT in 100 children, adolescents and young adults treated from May 2006 to February 2011. The median age of the patients was 13 years (range 1–24). The most common treated site was the central nervous system (50; of these, 24 were craniospinal irradiations), followed by thorax (22), head and neck (10), abdomen and pelvis (11), and limbs (7). The use of HT was calculated in accordance to the target dose conformation, the target size and shape, the dose to critical organs adjacent to the target, simultaneous treatment of multiple targets, and re-irradiation. HT has demonstrated to improve target volume dose homogeneity and the sparing of critical structures, when compared to 3D Linac-based radiotherapy (RT). In standard cases this technique represented a comparable alternative to IMRT delivered with conventional linear accelerator. In certain cases (e.g., craniospinal and pleural treatments) only HT generated adequate treatment plans with good target volume coverage. However, the gain in target conformality should be balanced with the spread of low-doses to distant areas. This remains an open issue for the potential risk of secondary malignancies (SMNs) and longer follow-up is mandatory.
Placental Vascularization and Apoptosis in Rats Orally Exposed to Low Doses of Bisphenol A  [PDF]
Jacopo Troisi, Luigi Giugliano, Antonio D’Antonio, Andrea Viggiano, Rosaria Meccariello, Marika Scafuro, Marcellino Monda, Angelo Colucci, Giovanni Scala, Maria Cofano, Maurizio Guida
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.811097
Abstract: Aim: Exposure to the ubiquitous endocrine disrupter Bisphenol A (BPA) has been associated, in pregnancy, with low birth weight. The aim of our study is the identification of the damage caused by Bisphenol A on placental tissue through the evaluation of its effects on micro-vessel density and apoptosis. Methods: After fertilization, we exposed 3 female rats to oral BPA, by means of a free access to a beverage solution containing 100 μg/L of BPA. Three female rats were used as controls. Placentas underwent histological examination and immunohistochemistry for von Willebr and factor (F-VIII) and caspase-9. Results: Sixty-seven fetuses have been produced, 30 from control rats and 37 from exposed rats. Exposed fetuses showed a lower longitudinal/transverse diameter ratio than controls (2.57 ± 0.29 vs. 2.78 ± 0.38, p < 0.05). Also, exposed fetuses showed a significant reduction in the number of placental vessels per field (124.86 ± 19.15 vs. 143.54 ± 22.09, p < 0.05). On the other hand, apoptosis is not increased by exposure, as shown by caspase-9 levels. Conclusion: Exposure to BPA during pregnancy may affect placental vascularization, and this phenomenon may explain the lower birth weight reported. However, our results do not show the increase in apoptosis observed in vitro.
Pour une histoire de la terminologie fran aise de l’énergie électrique
Maria Francesca Bonadonna
Synergies Espagne , 2012,
Abstract: L’histoire du lexique fran ais de l’énergie électrique commence dans la première moitié du XVIIIe siècle, quand les recherches autour de l’électricité se multiplient en Europe et aux Etats-Unis. Au fil des décennies, les transformations de l’électricité ont contribué au développement des sciences et des techniques, de la physique à la médecine, aussi bien qu’au bouleversement de l’industrie, du monde des transports et de la vie domestique. C’est en examinant les étapes principales de cette terminologie, en observant les termes les plus significatifs ainsi que les différentes typologies textuelles qui en ont marqué l’évolution, que l’on parvient à une meilleure compréhension d’un secteur si remarquable aux niveaux économique, institutionnel et social.
L’influence du fran ais sur la terminologie italienne de l’énergie électrique au XVIIIe siècle. Les traductions de l’abbé Nollet
Bonadonna Maria Francesca
SHS Web of Conferences , 2012, DOI: 10.1051/shsconf/20120100089
Abstract: Nous nous proposons d’explorer l’influence que la langue fran aise a exercée sur le lexique italien de l’électricité au XVIIIe siècle, à travers l’approfondissement des éditions italiennes des uvres de Jean Antoine Nollet, dit l’abbé Nollet. Auteur de découvertes fondamentales (entre autres, l'électroscope à boules de sureau et l’électroscope à feuilles d’or) qui ouvrent la voie à une véritable science autour de l’électricité, ce physicien fran ais a créé des unités lexicales nouvelles pour désigner les notions et les machines inédites liées à ce domaine. Notre objectif est d’analyser dans quelle mesure ses néologismes sont pénétrés dans la terminologie de la communauté scientifique italienne dès les années 40 du XVIIIe siècle, à travers la diffusion des textes originaux et des traductions vers l’italien. Après la présentation du corpus qui fait l’objet de cette analyse, nous observerons les phénomènes lexicaux qui se posent dans le passage d’une langue à l’autre, notamment par rapport aux sous-domaines des machines, des phénomènes et des professions. Des cas significatifs seront ainsi examinés: entre autres, la traduction corrente elettrica du fran ais courant électrique, elettroscopio de électroscope. Nous sommes convaincue qu’un approfondissement historique peut restituer l’organisation conceptuelle de la terminologie de l’énergie électrique, ainsi que permettre l’étude de la communication spécialisée d’un domaine si complexe et si important aujourd’hui.
Disulfide Bonding in Neurodegenerative Misfolding Diseases
Maria Francesca Mossuto
International Journal of Cell Biology , 2013, DOI: 10.1155/2013/318319
Abstract: In recent years an increasing number of neurodegenerative diseases has been linked to the misfolding of a specific protein and its subsequent accumulation into aggregated species, often toxic to the cell. Of all the factors that affect the behavior of these proteins, disulfide bonds are likely to be important, being very conserved in protein sequences and being the enzymes devoted to their formation among the most conserved machineries in mammals. Their crucial role in the folding and in the function of a big fraction of the human proteome is well established. The role of disulfide bonding in preventing and managing protein misfolding and aggregation is currently under investigation. New insights into their involvement in neurodegenerative diseases, their effect on the process of protein misfolding and aggregation, and into the role of the cellular machineries devoted to disulfide bond formation in neurodegenerative diseases are emerging. These studies mark a step forward in the comprehension of the biological base of neurodegenerative disorders and highlight the numerous questions that still remain open. 1. Introduction Neurodegenerative misfolding diseases (NMD) are a group of diseases involving the misfolding of one or two proteins and their accumulation into aggregated species toxic to neurons, leading to a wide range of neurological symptoms (Table 1). Among these are Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), prion-related disorders (PrDs), and amyotrophic lateral sclerosis (ALS). In each case a specific protein loses its functional structure to populate partially unfolded species that reorganize themselves into polymeric structures with different degrees of ordered structure, from oligomers to amyloid fibrils [1]. Table 1: Presence of disulfide bonds in proteins involved in neurodegenerative misfolding diseases. The fate of a protein depends on two major factors, its sequence and its cellular environment. From the sequence perspective, many studies have identified several features of the amino acid sequence of a protein that help predict its aggregation behavior, such as charge, hydrophobicity, patterns of polar and nonpolar residues, and tendency to form secondary structures [2, 3]. After peptide bond, the disulfide bond is the most common covalent link between amino acids in proteins. Disulfide bonds are known to stabilize proteins thermodynamically by decreasing the entropy of the unfolded state, to increase mechanical stability and to confine conformational changes [4]. From the cellular environment point
Long-Term Effect of Mediterranean-Style Diet and Calorie Restriction on Biomarkers of Longevity and Oxidative Stress in Overweight Men
Katherine Esposito,Carmen Di Palo,Maria Ida Maiorino,Michela Petrizzo,Giuseppe Bellastella,Isabella Siniscalchi,Dario Giugliano
Cardiology Research and Practice , 2011, DOI: 10.4061/2011/293916
Abstract: We report the effects of a Mediterranean-style diet, with or without calorie restriction, on biomarkers of aging and oxidative stress in overweight men. 192 men were randomly assigned to either a Mediterranean-style diet or a conventional diet. The intervention program was based on implementation of a Mediterranean dietary pattern in the overweight group (MED diet group), associated with calorie restriction and increased physical activity in the obese group (lifestyle group). Both groups were compared with participants in two matched control groups (advice groups). After 2 years, there was a significant difference in weight loss between groups, which was −14 kg (95% CI −20 to −8) in lifestyle groups and −2.0 kg (−4.4 to 0) in the advice groups, with a difference of −11.9 kg (CI −19 to −4.7 kg, <.001); moreover, there was a significant difference between groups at 2 years for insulin (=.04), 8-iso-PGF2α (=.037), glucose (=.04), and adiponectin (=.01). Prolonged adherence to a Mediterranean-style diet, with or without caloric restriction, in overweight or obese men is associated with significant amelioration of multiple risk factors, including a better cardiovascular risk profile, reduced oxidative stress, and improved insulin sensitivity.
Cocoa Powder as Delivery Medium for Probiotic Lactobacillus Strains  [PDF]
Giovanni Ricci, Francesca Borgo, Chiara Ferrario, Maria Grazia Fortina
Advances in Microbiology (AiM) , 2011, DOI: 10.4236/aim.2011.11001
Abstract: Three Lactobacillus strains previously isolated from artisanal Italian cheeses and identified by species-specific PCR as L. helveticus, L. paracasei and L. rhamnosus, were evaluated for the presence of functional traits, such as acidifying activity, cell surface hydrophobicity, antibiotic resistance, survival in low pH and in presence of bile salts, in comparison with two commercially available probiotic strains (Lactobacillus acidophilus La-5 and L. rhamnosus GG). Subsequently, with the aim to develop a new non-dairy functional product, cocoa powder was used as a medium for incorporating freeze-dried cultures of each tested strain and survival at different time/temperature conditions was investigated. The results obtained demonstrated that artisanal dairy products are interesting sources of new probiotic strains; in particular, the dairy origin strain L. rhamnosus showed a good probiotic performance and the highest level of survival during storage. Finally, we showed that cocoa powder represents a good delivery medium for lactobacilli: it could be considered a novel functional food exhibiting high antioxidant power and presenting probiotic potential.
The Analysis of Real Data Using a Stochastic Dynamical System Able to Model Spiky Prices  [PDF]
Lorella Fatone, Francesca Mariani, Maria Cristina Recchioni, Francesco Zirilli
Journal of Mathematical Finance (JMF) , 2012, DOI: 10.4236/jmf.2012.21001
Abstract: In this paper we use filtering and maximum likelihood methods to solve a calibration problem for a stochastic dynamical system used to model spiky asset prices. The data used in the calibration problem are the observations at discrete times of the asset price. The model considered has been introduced by V.A. Kholodnyi in [1,2] and describes spiky as-set prices as the product of two independent stochastic processes: the spike process and the process that represents the asset prices in absence of spikes. A Markov chain is used to regulate the transitions between presence and absence of spikes. As suggested in [3] in a different context the calibration problem for this model is translated in a maximum likelihood problem with the likelihood function defined through the solution of a filtering problem. The estimated values of the model parameters are the coordinates of a constrained maximizer of the likelihood function. Furthermore, given the calibrated model, we develop a sort of tracking procedure able to forecast forward asset prices. Numerical examples using synthetic and real data of the solution of the calibration problem and of the performance of the tracking procedure are presented. The real data studied are electric power price data taken from the UK electricity market in the years 2004-2009. After calibrating the model using the spot prices, the forward prices forecasted with the tracking procedure and the observed forward prices are compared. This comparison can be seen as a way to validate the model, the formulation and the solution of the calibration problem and the forecasting procedure. The result of the comparison is satisfactory. In the website: http://www.econ.univpm.it/recchioni/finance/w10 some auxiliary material including animations that helps the understanding of this paper is shown. A more general reference to the work of the authors and of their coauthors in mathematical finance is the website: http://www.econ.univpm.it/ recchioni/finance.
Some Explicitly Solvable SABR and Multiscale SABR Models: Option Pricing and Calibration  [PDF]
Lorella Fatone, Francesca Mariani, Maria Cristina Recchioni, Francesco Zirilli
Journal of Mathematical Finance (JMF) , 2013, DOI: 10.4236/jmf.2013.31002

A multiscale SABR model that describes the dynamics of forward prices/rates is presented. New closed form formulae for the transition probability density functions of the normal and lognormal SABR and multiscale SABR models and for the prices of the corresponding European call and put options are deduced. The technique used to obtain these formulae is rather general and can be used to study other stochastic volatility models. A calibration problem for these models is formulated and solved. Numerical experiments with real data are presented.

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