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Search Results: 1 - 10 of 3070 matches for " Francesca Bersani "
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Met Receptor Acts Uniquely for Survival and Morphogenesis of EGFR-Dependent Normal Mammary Epithelial and Cancer Cells
Paolo Accornero, Silvia Miretti, Francesca Bersani, Elena Quaglino, Eugenio Martignani, Mario Baratta
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044982
Abstract: Mammary gland development and breast cancer growth require multiple factors both of endocrine and paracrine origin. We analyzed the roles of Epidermal Growth Factor Receptor (EGFR) and Hepatocyte Growth Factor Receptor (Met) in mammary epithelial cells and mammary tumor cells derived from a mutated-ErbB2 transgenic mice. By using highly specific tyrosine kinase inhibitors we found that MCF-10A and NMuMG mammary epithelial cell lines are totally dependent on EGFR activation for their growth and survival. Proliferation and 3D-morphogenesis assays showed that HGF had no role in maintaining mammary cell viability, but was the only cytokine able to rescue EGFR-inhibited mammary cells. Insulin-Like Growth Factor-I (IGF-I), basic-Fibroblast Growth Factor (b-FGF) and Neuregulin, which are well known mammary morphogenic factors, did not rescue proliferation or morphogenesis in these cell lines, following EGFR inhibition. Similarly, ErbB2-driven tumor cells are EGFR-dependent and also display HGF-mediated rescue. Western-blot analysis of the signaling pathways involved in rescue after EGFR inhibition indicated that concomitant ERK1/2 and AKT activation was exclusively driven by Met, but not by IGF-I or b-FGF. These results describe a unique role for EGFR and Met in mammary epithelial cells by showing that similar pathways can be used by tumorigenic cells to sustain growth and resist to EGFR-directed anti-tumorigenic drugs.
Stevens-Johnson Syndrome Associated with Drugs and Vaccines in Children: A Case-Control Study
Umberto Raucci, Rossella Rossi, Roberto Da Cas, Concita Rafaniello, Nadia Mores, Giulia Bersani, Antonino Reale, Nicola Pirozzi, Francesca Menniti-Ippolito, Giuseppe Traversa, Italian Multicenter Study Group for Vaccine Safety in Drug and Children
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068231
Abstract: Objective Stevens-Johnson Syndrome (SJS) is one of the most severe muco-cutaneous diseases and its occurrence is often attributed to drug use. The aim of the present study is to quantify the risk of SJS in association with drug and vaccine use in children. Methods A multicenter surveillance of children hospitalized through the emergency departments for acute conditions of interest is currently ongoing in Italy. Cases with a diagnosis of SJS were retrieved from all admissions. Parents were interviewed on child’s use of drugs and vaccines preceding the onset of symptoms that led to the hospitalization. We compared the use of drugs and vaccines in cases with the corresponding use in a control group of children hospitalized for acute neurological conditions. Results Twenty-nine children with a diagnosis of SJS and 1,362 with neurological disorders were hospitalized between 1st November 1999 and 31st October 2012. Cases were more frequently exposed to drugs (79% vs 58% in the control group; adjusted OR 2.4; 95% CI 1.0–6.1). Anticonvulsants presented the highest adjusted OR: 26.8 (95% CI 8.4–86.0). Significantly elevated risks were also estimated for antibiotics use (adjusted OR 3.3; 95% CI 1.5–7.2), corticosteroids (adjusted OR 4.2; 95% CI 1.8–9.9) and paracetamol (adjusted OR 3.2; 95% CI 1.5–6.9). No increased risk was estimated for vaccines (adjusted OR: 0.9; 95% CI 0.3–2.8). Discussion Our study provides additional evidence on the etiologic role of drugs and vaccines in the occurrence of SJS in children.
Comparison of facial expression in patients with obsessive-compulsive disorder and schizophrenia using the Facial Action Coding System: a preliminary study
Bersani G,Bersani FS,Valeriani G,Robiony M
Neuropsychiatric Disease and Treatment , 2012,
Abstract: Giuseppe Bersani,1 Francesco Saverio Bersani,1,2 Giuseppe Valeriani,1 Maddalena Robiony,1 Annalisa Anastasia,1 Chiara Colletti,1,3 Damien Liberati,1 Enrico Capra,2 Adele Quartini,1 Elisa Polli11Department of Medical-Surgical Sciences and Biotechnologies, 2Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, 3Department of Neuroscience and Behaviour, Section of Psychiatry, Federico II University of Naples, Naples, ItalyBackground: Research shows that impairment in the expression and recognition of emotion exists in multiple psychiatric disorders. The objective of the current study was to evaluate the way that patients with schizophrenia and those with obsessive-compulsive disorder experience and display emotions in relation to specific emotional stimuli using the Facial Action Coding System (FACS).Methods: Thirty individuals participated in the study, comprising 10 patients with schizophrenia, 10 with obsessive-compulsive disorder, and 10 healthy controls. All participants underwent clinical sessions to evaluate their symptoms and watched emotion-eliciting video clips while facial activity was videotaped. Congruent/incongruent feeling of emotions and facial expression in reaction to emotions were evaluated.Results: Patients with schizophrenia and obsessive-compulsive disorder presented similarly incongruent emotive feelings and facial expressions (significantly worse than healthy participants). Correlations between the severity of psychopathological condition (in particular the severity of affective flattening) and impairment in recognition and expression of emotions were found.Discussion: Patients with obsessive-compulsive disorder and schizophrenia seem to present a similarly relevant impairment in both experiencing and displaying of emotions; this impairment may be seen as a chronic consequence of the same neurodevelopmental origin of the two diseases. Mimic expression could be seen as a behavioral indicator of affective flattening. The FACS could be used as an objective way to evaluate clinical evolution in patients.Keywords: schizophrenia, obsessive-compulsive disorder, facial expression, Facial Action Coding System
The Use of Materials from Biomass as Construction Materials  [PDF]
Francesca Giglio
Open Journal of Civil Engineering (OJCE) , 2013, DOI: 10.4236/ojce.2013.32A009

The paper describes some studies conducted by the author, about low impact materials and, particularly, on alternative uses of biomass materials for building materials. Italy needs to develop renewable energy sources and agriculture offers many opportunities: biomass, vegetable residues for livestock breeding, food industry waste, organic waste, solid biofuels, biogas, and biofuels, will be the new renewable energy sources. Researches for promoting sustainable development, including chemistry field are increasing interest in the exploitation of vegetal biomass, in particular waste as a raw material for production of bio-products and biofuels. Not always, however, the use of waste materials such as biomass is the most appropriate, or in any case, the one with less energy expenditure. As ever more evident, in fact, the construction sector is approaching the possibility of using these materials for other purposes, combining the demands of saving natural resources, the need for energy efficiency in buildings and production processes.

Public Private Partnerships for Transportation Infrastructure Delivery  [PDF]
Francesca Leccis
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.35004

The term Public Private Partnerships includes different forms of collaboration between the public and the private sector. These formulas are adopted in a constantly increasing number of countries all over the world in order to overcome the chronic lack of funding and ensure the delivery of infrastructure projects. The paper illustrates the vital role of cooperation between public bodies and private entities in the delivery of public transportation infrastructure. In particular, it focuses on toll roads and highways. Key factors of success and risk are identified and illustrated through five case studies from Chile, Hungary, South Africa-Mozambique, United Kingdom and California.

S. Pirani,C. Bersani,C. Cantoni
Italian Journal of Food Safety , 2013, DOI: 10.4081/ijfs.2009.6.83
Abstract: This study is aimed at the development of a method for integrated mite control in the industrial production of speck. The investigation were carried out on the premises of five factories in the north-east of Italy. Tyrophagus putrescentiae and T. longior were predominant. The gaseous ozone treatment at low level (0.4 ppm) was able to kill mites in a period within 15 days and 1 month. The characteristic layer of mould on the product surface reappears within 1 month from the end of treatment with ozone.
Participatory Design of Websites with Web Design Workshops
Nancy Fried Foster,Nora Dimmock,Alison Bersani
Code4Lib Journal , 2008,
Abstract: At the University of Rochester's River Campus Libraries we have included users in technology development with great success. "Participatory design" entails collaboration among designers, developers, and users from the earliest stages of conception through to implementation of websites and other technology. Using participatory methods, a project to redesign the library website began with workshops to identify user needs and preferences. The results of these workshops led to the identification of key tasks for the main page. They also generated a hierarchy of tasks for sub-pages and rich information about how students and faculty members use current websites in their work. In our article, we explain our reasons for running participatory design workshops, describe our methods, review participants and recruitment, and summarize key findings. We also include information about our local implementation and general conclusions about the value of design workshops for website design and development.
An LTL Semantics of Business Workflows with Recovery
Luca Ferrucci,Marcello M. Bersani,Manuel Mazzara
Computer Science , 2014,
Abstract: We describe a business workflow case study with abnormal behavior management (i.e. recovery) and demonstrate how temporal logics and model checking can provide a methodology to iteratively revise the design and obtain a correct-by construction system. To do so we define a formal semantics by giving a compilation of generic workflow patterns into LTL and we use the bound model checker Zot to prove specific properties and requirements validity. The working assumption is that such a lightweight approach would easily fit into processes that are already in place without the need for a radical change of procedures, tools and people's attitudes. The complexity of formalisms and invasiveness of methods have been demonstrated to be one of the major drawback and obstacle for deployment of formal engineering techniques into mundane projects.
Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant
Giuseppe Bersani,Pietropaolo Marino,Giuseppe Valeriani,Valentina Cuoco,Claudia Zitelli,Claudia Melcore,Francesco Saverio Bersani
Case Reports in Psychiatry , 2013, DOI: 10.1155/2013/926395
Abstract: Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended. 1. Introduction Calcineurin-inhibitor Tacrolimus (FK506; Fujisawa, Deerfield, IL, USA) is considered one of the mainstays of posttransplant immunosuppression [1]. Discovered in 1984, it is a macrolide lactone extracted from Streptomyces tsukubaensis as an alternative to cyclosporine [2]. Tacrolimus mechanism of action is fulfilled through the binding with the cytoplasmic protein macrophilin 12 and the consequent inhibition of calcium-dependent phosphatase calcineurin, which is followed by the blockade of the transcription factor NF-AT [3]. Tacrolimus has a narrow therapeutic window with wide interindividual variability in pharmacokinetics and clearance [4, 5]. Its availability mostly depends on the activity of hepatic and intestinal CYP3A4, and its active transport is mediated by intestinal P-glycoprotein [6]. Less than 1% of the drug is excreted unchanged in the urine [7]. Based on FK506 consensus reports by Jusko et al. [8] and Wong [9], its therapeutic ranges in kidney transplanted patients should be 10–15?μg/L in the first 6 months of treatment; 8–12?μg/L in the following semester; and 5–10?μg/L as maintenance therapy after 1 year. Even if this highly beneficial drug is critical for post-transplant survival, a significant number of transplant recipients experience neurological side effects, with potential severe impact on mental status and cognition. Numerous cases of mild neurological side effects including tremors, paresthesias, and headache [10] have been described, while more severe neurological and psychiatric side effects seem to occur more rarely (Table 1). Table 1: Neurologic complications of tacrolimus therapy in transplants patients (1, 2, 3). Later, we describe the case of a 46-year-old man who developed a manic-like psychosis as a consequence of high blood concentrations of tacrolimus. 2. Case Report Mr. MP was a 46-year-old man who underwent left kidney transplant in 1996; therefore, he was treated with the following
Identity in Sport Teams  [PDF]
Cristina Zucchermaglio, Francesca Alby
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.23031
Abstract: In this paper we analyze identity in a soccer team using a discursive perspective, in which individual psycho-logical functioning is considered to be built in and through social interactions within groups. Analysis is based on naturally-occurring interactions that were audio recorded during technical meetings before and after the match. The data were collected within an ethnographic investigation of an Italian soccer tam carried out over a two-month period. The results show that the team’s members made rhetorical use of a complex repertoire of their own and others’ social identities, and that two main variables influenced the use of social identity markers: a) the role of the speakers (in particular the “power” role of the coach); b) the result of the match around which the interactive discourse revolved. Against this background, we discuss how narratives and identity positionings were used to achieve specific goals and to perform specific actions, such as the planning of future matches and the interpretation of victories and defeats.
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