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Search Results: 1 - 10 of 8311 matches for " Fran?oise Rimareix "
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3D-conformal Accelerated Partial Breast Irradiation treatment planning: the value of surgical clips in the delineation of the lumpectomy cavity
Maia Dzhugashvili, Elodie Tournay, Charlotte Pichenot, Ariane Dunant, Eduardo Pessoa, Adel Khallel, Sébastien Gouy, Catherine Uzan, Jean-Rémy Garbay, Franoise Rimareix, Marc Spielmann, Philippe Vielh, Hugo Marsiglia, Céline Bourgier
Radiation Oncology , 2009, DOI: 10.1186/1748-717x-4-70
Abstract: Forty CT-based 3D-APBI plans were retrieved on which a total of 4 radiation oncologists, two trainee and two experienced physicians, outlined the lumpectomy cavity. The inter-observer variability of LC contouring was assessed when the CTV was defined as the delineation that encompassed both surgical clips and remodelled breast tissue.The conformity index of tumour bed delineation was significantly improved by the placement of surgical clips within the LC (median at 0.65). Furthermore, a better conformity index of LC was observed according to the experience of the physicians (median CI = 0.55 for trainee physicians vs 0.65 for experienced physicians).The placement of surgical clips improved the accuracy of lumpectomy cavity delineation in 3D-APBI. However, a learning curve is needed to improve the conformity index of the lumpectomy cavity.Accelerated Partial Breast Irradiation (APBI) is still under investigation to demonstrate equivalence to whole breast irradiation in terms of local control. Among the different APBI techniques (invasive or non-invasive), 3D-conformal APBI is widely used given its accessibility in radiotherapy centres [1]. However, several issues related to this technique still warrant investigation: e.g. the identification and contouring of the lumpectomy cavity (LC), the patient's set-up and optimal dose determination. The definition of the lumpectomy cavity is an essential part of 3D-conformal APBI treatment planning as the irradiation is confined to a limited volume of breast tissue adjacent to the lumpectomy cavity. Unlike intra-operative partial breast irradiation, LC determination is critical as treatment delivery is delayed after breast surgery. In 3D-APBI, the GTV (Gross Tumour Volume) and CTV (Clinical Target Volume) are generally defined as the contouring of a seroma within the lumpectomy cavity, expanded by a 1 cm margin [2,3]. However, the delineation of the seroma could vary among different observers and even among experienced ones[4].I
Interaction between peroxisomes and mitochondria in fatty acid metabolism  [PDF]
Franoise Le Borgne, Jean Demarquoy
Open Journal of Molecular and Integrative Physiology (OJMIP) , 2012, DOI: 10.4236/ojmip.2012.21005
Abstract: Peroxisomes and mitochondria are ubiquitously found organelles. They both are dynamic structures able to divide, to fuse and to undergo autophagic processes. Their activities are dependent on proteins that are, for most (mitochondria) or all (peroxisome) of them, synthesized in the cytosol from the nuclear genome. Nevertheless, the membrane structures and the DNA content differ between these two organelles. Mitochondria possess a small circular genome while peroxisomes don’t. The control of their dynamic is dependent on specific factors even if some of those are able to affect both. These two organelles are metabolically connected: they are both involved in lipid metabolism. They are both able to beta oxidize fatty acids and are implicated in ROS production. However, their precise function in these metabolic pathways and their physiological functions are different. While mitochondrial metabolism is closely related to energy production, peroxisome does not seem to be associated with energy production but with the production of bioactive molecules and in detoxification processes.
Your Synapse or Mine? Promiscuous Protein Exchanges between Neighboring Synapses
Franoise Chanut
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0040297
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Chance Fluctuations in mRNA Output in Mammalian Cells
Franoise Chanut
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0040319
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The Sound of Dinner
Franoise Chanut
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0040107
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A New Tile in the Biochemical Puzzle of Insulin Biology
Franoise Chanut
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0040059
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The Sirt1 Gene Promotes Insulin Secretion in Accord with Diet
Franoise Chanut
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0040044
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X Chromosomes' Shape-Shifting Foreshadows Random Inactivation
Franoise Chanut
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0040195
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Correction: Interphase Chromosomes Mingle with Their Peers
Franoise Chanut
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0040217
Abstract:
Interphase Chromosomes Mingle with Their Peers
Franoise Chanut
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0040174
Abstract:
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