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Search Results: 1 - 10 of 106 matches for " Fotini Baziaka "
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The Importance of Fever as a Predictive Symptom for the Potency of Host's Monocytes to Release Pro- and Anti-Inflammatory Mediators
Magdalini Kyriakopoulou,Anastasia Antonopoulou,Maria Raftogiannis,Fotini Baziaka,Thomas Tsaganos,Kyriaki Kanellakopoulou,Evangelos J. Giamarellos-Bourboulis
Mediators of Inflammation , 2008, DOI: 10.1155/2008/450196
Abstract: Objective. To clarify whether time lapsing from advent of fever as a first sign of sepsis may be indicative of the potency of monocytes for the release of pro- and anti-inflammatory mediators. Methods. Monocytes were isolated from blood of 51 septic patients and 9 healthy donors. Monocytes were incubated in the absence and presence of patients' serum and concentrations of tumour necrosis factor-alpha (TNF), interleukin (IL)-6, IL-10, and malondialdehyde (MDA) were estimated in supernatants. Patients were divided into three groups: group A: <12 hours; group B: 12–24 hours, and group C: >24 hours between initiation of fever and blood sampling. Results. TNF of supernatants of groups B and C was higher than controls, as also were IL-6 of A and C, IL-10 of A and B, and MDA of A. IL-6 of group A was increased after addition of patients serum. A negative correlation was found between time from initiation of symptoms and IL-6 of monocyte supernatants incubated in the presence of patients serum. Median IL-6 of survivors was higher than nonsurvivors. Conclusion. Monocytes are potent for the release of pro- and anti-inflammatory mediators within the first 24 hours upon advent of fever related to sepsis; serum stimulates further release of IL-6 within the first 12 hours.
Compartmentalization of lipid peroxidation in sepsis by multidrug-resistant gram-negative bacteria: experimental and clinical evidence
Chryssoula Toufekoula, Vassileios Papadakis, Thomas Tsaganos, Christina Routsi, Stylianos E Orfanos, Anastasia Kotanidou, Dionyssia-Pinelopi Carrer, Maria Raftogiannis, Fotini Baziaka, Evangelos J Giamarellos-Bourboulis
Critical Care , 2013, DOI: 10.1186/cc11930
Abstract: Lethal sepsis was induced in rats by the intraperitoneal injection of one MDR isolate of Pseudomonas aeruginosa. Produced malondialdehyde (MDA) was measured in tissues 5 hours after bacterial challenge with the thiobarbiturate assay followed by high-performance liquid chromatography (HPLC) analysis. Results were compared with those from a cohort of patients with ventilator-associated pneumonia (VAP) and sepsis by MDR Gram-negative bacteria. More precisely, serum MDA was measured on 7 consecutive days, and it was correlated with clinical characteristics.MDA of septic rats was greater in the liver, spleen, and aortic wall, and it was lower in the right kidney compared with sham operated-on animals. Findings were confirmed by the studied cohort. Circulating MDA was greater in patients with hepatic dysfunction and acute respiratory distress syndrome (ARDS) compared with patients without any organ failures. The opposite was found for patients with acute renal dysfunction. No differences were found between patients with ARDS without or with cardiovascular (CV) failure and patients without any organ failure. Serial measurements of MDA in serum of patients indicated that levels of MDA were greater in survivors of hepatic dysfunction and ARDS and lower in survivors of acute renal dysfunction.Animal findings and results of human sepsis are complementary, and they suggest a compartmentalization of lipid peroxidation in systemic infections by MDR gram-negative bacteria.Oxidative stress results from an imbalance between production of reactive oxygen and nitrogen species (ROS and RNS) and endogenous antioxidant defense mechanisms [1]. A growing body of evidence suggests that many of the effects of cellular dysfunction under oxidative stress are mediated by products of nonenzymatic reactions, such as the peroxidative degradation of polyunsaturated fatty acids. Aldehyde molecules generated during lipid peroxidation are considered ultimate mediators of toxic effects elicited by oxid
Children’s Judgments and Feelings about Their Own Drawings  [PDF]
Fotini Bonoti, Panayiota Metallidou
Psychology (PSYCH) , 2010, DOI: 10.4236/psych.2010.15042
Abstract: The aim of the present study was to investigate possible age differences in drawing performance of preschool and primary school children, as well as in metacognitive experiences that are activated before and after the drawing process. The study is comprised of 222 children of both genders, aged from 4 to 12. They were tested individually in their schools. They were asked to produce four drawings, which vary on their level of complexity, and to rate before each drawing on a four-point scale the frequency of drawing similar themes and their feeling of difficulty. After the drawing they were asked to estimate again the difficulty they felt as well as the feeling of liking the drawing they produced and the correctness of the drawing. The results of a series of analyses of variance confirmed the expected improvement of drawing performance with age. There wasn’t found, however, the same developmental course in the case of metacognitive experiences. On the contrary, there was found a significant decrease in the feeling of liking and the estimation of correctness of the drawings, especially after the second grade.
Noise Reduction in Pavement Made of Rubberized Bituminous Top Layer  [PDF]
Fotini Kehagia, Sofia Mavridou
Open Journal of Civil Engineering (OJCE) , 2014, DOI: 10.4236/ojce.2014.43017

In Greece more than 60,000 tn End of Life Tires are stockpiled every year often uncontrollable, causing severe environmental and other socio-economic negative impacts. Studies up to date are focused mainly on mechanical and physical characteristics of rubberized mixtures (based on cement, asphalt or soil) in which tire rubber is used either as alternative to natural aggregates or as additive. However, effect of tire rubber on noise reduction in rubberized bituminous layers, which is the main topic of present paper, has not been widely studied. In particular, this research paper is dealing with a sustainable use of tire rubber in asphalt pavement, leading to its generated noise reduction. An experimental pilot application has been conducted in the frame of a European Research Project, which has been implemented in a heavy traffic road section, cited outside Lamia city of Greece, (Vasilikon Street). The upper surface layer of the pavement has been made of rubberized bituminous mixture, produced by the wet process. Rheological characteristics of rubberized bitumen as well as basic properties of the implemented, rubberized bituminous mixture are presented. Moreover, measurements of noise level, deriving from vehicles’ motion, under operational conditions took place at the road section right after its implementation as well as after 8 months of its operation, while all data are presented in details. Results of the measurements on conventional and modified pavement sections are compared, certifying that rubberized asphalt layers can be not only environmentally friendly—since a category of solid wastes (worn automobile tires) is utilized—but also, addition of tire rubber particles in bituminous binder provides up to 3dB noise reducing bituminous mixtures and pavements, noise reduction that remains even after 8 months of road section’s operation.

Effect of the Novel Influenza A (H1N1) Virus in the Human Immune System
Evangelos J. Giamarellos-Bourboulis,Maria Raftogiannis,Anastasia Antonopoulou,Fotini Baziaka,Pantelis Koutoukas,Athina Savva,Theodora Kanni,Marianna Georgitsi,Aikaterini Pistiki,Thomas Tsaganos,Nikolaos Pelekanos,Sofia Athanassia,Labrini Galani,Efthymia Giannitsioti,Dimitra Kavatha,Flora Kontopidou,Maria Mouktaroudi,Garyfallia Poulakou,Vissaria Sakka,Periklis Panagopoulos,Antonios Papadopoulos,Kyriaki Kanellakopoulou,Helen Giamarellou
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008393
Abstract: The pandemic by the novel H1N1 virus has created the need to study any probable effects of that infection in the immune system of the host.
Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection
Charalambos Gogos, Antigone Kotsaki, Aimilia Pelekanou, George Giannikopoulos, Ilia Vaki, Panagiota Maravitsa, Stephanos Adamis, Zoi Alexiou, George Andrianopoulos, Anastasia Antonopoulou, Sofia Athanassia, Fotini Baziaka, Aikaterini Charalambous, Sofia Christodoulou, Ioanna Dimopoulou, Ioannis Floros, Efthymia Giannitsioti, Panagiotis Gkanas, Aikaterini Ioakeimidou, Kyriaki Kanellakopoulou, Niki Karabela, Vassiliki Karagianni, Ioannis Katsarolis, Georgia Kontopithari, Petros Kopterides, Ioannis Koutelidakis, Pantelis Koutoukas, Hariklia Kranidioti, Michalis Lignos, Konstantinos Louis
Critical Care , 2010, DOI: 10.1186/cc9031
Abstract: The statuses of the innate and adaptive immune systems were prospectively compared in 505 patients. Whole blood was sampled within less than 24 hours of advent of sepsis; white blood cells were stained with monoclonal antibodies and analyzed though a flow cytometer.Expression of HLA-DR was significantly decreased among patients with severe sepsis/shock due to acute pyelonephritis and intraabdominal infections compared with sepsis. The rate of apoptosis of natural killer (NK) cells differed significantly among patients with severe sepsis/shock due to ventilator-associated pneumonia (VAP) and hospital-acquired pneumonia (HAP) compared with sepsis. The rate of apoptosis of NKT cells differed significantly among patients with severe sepsis/shock due to acute pyelonephritis, primary bacteremia and VAP/HAP compared with sepsis. Regarding adaptive immunity, absolute counts of CD4-lymphocytes were significantly decreased among patients with severe sepsis/shock due to community-acquired pneumonia (CAP) and intraabdominal infections compared with sepsis. Absolute counts of B-lymphocytes were significantly decreased among patients with severe sepsis/shock due to CAP compared with sepsis.Major differences of the early statuses of the innate and adaptive immune systems exist between sepsis and severe sepsis/shock in relation to the underlying type of infection. These results may have a major impact on therapeutics.The incidence of sepsis has dramatically increased over the past decade. It is estimated that 1.5 million people in the USA and another 1.5 million people in Europe present annually with severe sepsis and/or septic shock: 35 to 50% of them die. The enormous case-fatality had led to an intense research effort to understand the complex pathogenesis of sepsis and to apply the acquired knowledge in therapeutic interventions of immunomodulation [1]. The majority of trials of application of immunomodulatory therapies have failed to disclose clinical benefit probably as a res
Interview with Prof. Katherine Vig
Fotini Mouameletzi
Hellenic Orthodontic Review , 2007,
Amarynthian Artemis
Fotini Koutsafti
Intellectum , 2008,
Abstract: Fotini Koutsafti studied, inter alia, History and Archaeology in the Aristotle University of Thesaloniki, Philosophy in the Wurzburg University in Germany and later involved in literature, writing poems, prose and essays. She composed the poetry collection "Amarynthian Artemis" in 2007, a little before she passed away. Despite the fact that Intellectum Journal does not publish poetry, it was decided to make an exception in order to honour her memory and thus include the particular poem in the current issue
Quantum causal histories
Fotini Markopoulou
Physics , 1999, DOI: 10.1088/0264-9381/17/10/302
Abstract: Quantum causal histories are defined to be causal sets with Hilbert spaces attached to each event and local unitary evolution operators. The reflexivity, antisymmetry, and transitivity properties of a causal set are preserved in the quantum history as conditions on the evolution operators. A quantum causal history in which transitivity holds can be treated as ``directed'' topological quantum field theory. Two examples of such histories are described.
An algebraic approach to coarse graining
Fotini Markopoulou
Physics , 2000,
Abstract: We propose that Kreimer's method of Feynman diagram renormalization via a Hopf algebra of rooted trees can be fruitfully employed in the analysis of block spin renormalization or coarse graining of inhomogeneous statistical systems. Examples of such systems include spin foam formulations of non-perturbative quantum gravity as well as lattice gauge and spin systems on irregular lattices and/or with spatially varying couplings. We study three examples which are Z_2 lattice gauge theory on irregular 2-dimensional lattices, Ising/Potts models with varying bond strengths and (1+1)-dimensional spin foam models.
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