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Search Results: 1 - 10 of 184802 matches for " Flávia Aparecida de;Reis "
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Acidente humano por picadas de abelhas africanizadas
Oliveira, Flávia Aparecida de;Guimar?es, Janaína Valadares;Reis, Marlene Ant?nia dos;Teixeira, Vicente de Paula Antunes;
Revista da Sociedade Brasileira de Medicina Tropical , 2000, DOI: 10.1590/S0037-86822000000400012
Abstract: it is report five cases of stings of africanized bees (ab). four of them were vitims of multiple stings, varying from 25 to 60, that presented severe headache, nauseas and vomits, related to the clinic effect of the toxicity of the venom, with good evolution. the other case was victim of a single sting of ab and died after probable anaphylaxis.
Acidente humano por picadas de abelhas africanizadas
Oliveira Flávia Aparecida de,Guimar?es Janaína Valadares,Reis Marlene Ant?nia dos,Teixeira Vicente de Paula Antunes
Revista da Sociedade Brasileira de Medicina Tropical , 2000,
Abstract: S o relatados cinco casos de pessoas picadas por abelhas africanizadas (AA). Quatro foram vítimas de múltiplas picadas variando de 25 a 60, que apresentaram cefaléia intensa, náuseas e v mitos, relacionados aos efeitos tóxicos do veneno, mas evoluíram bem. O outro caso foi vítima de uma única picada de AA e evoluiu para o óbito, por provável anafilaxia.
Analysis of a single-centrifugation protocol to prepare platelet-rich plasma (PRP) — a study in rabbits
Michel Reis MESSORA,Maria José Hitomi NAGATA,Luiz Gustavo Nascimento de MELO,Flávia Aparecida Chaves FURLANETO
RSBO , 2009,
Abstract: Introduction and objective:The purpose of this study was to evaluate a single-centrifugation protocol to prepare platelet-rich plasma (PRP). Material and methods:Ten white adult male (New Zealand)rabbits weighing 2.8 to 4 kg were used. After general anesthesia, 10 ml of blood were drawn from each animal via cardiac puncture. Each blood sample was centrifuged according to a single-centrifugation protocol to prepare PRP . The platelets in the whole blood and PRP samples from each animal were counted manually. Data were submitted to statistical analysis. Results: The normality of the data was confirmed and the Student’s t test was applied (p < 0.05). PRP samples presented an average platelet count significantly higher than that of whole blood (781.875 ± 217.693 and 446.389 ± 181.538, respectively). The average percentage increase in PRP platelet count in relation to the whole blood was 180.73% ± 31.01. Conclusion: Within the limits of this study, it can be concluded that the single-centrifugation protocol achieved lower platelet concentrations than the double amount of platelets presented in the whole blood. Further studies are required to evaluatate the biological effects of PRP samples prepared according to this protocol.
Aspectos macroscópicos da cardiopatia chagásica cr?nica no envelhecimento
Oliveira, Flávia Aparecida de;Teixeira, Vicente de Paula Antunes;Lino Junior, Ruy de Souza;Vinaud, Marina Clare;Reis, Marlene Ant?nia dos;
Arquivos Brasileiros de Cardiologia , 2007, DOI: 10.1590/S0066-782X2007000400020
Abstract: objective: to describe the macroscopic characteristics of chronic chagas heart disease in autopsied elderly. methods: the elderly studied were 60 or older. twenty of them had chronic chagas heart disease (chd) and positive serology for the disease, and 14 had no heart disease (whd) nor morphological changes suggestive of it and were serologically negative for chagas disease. results: the chd elderly had cardiac weight greater than the whd (385 ± 141.1 vs 306.8 ± 62.1g, respectively; p > 0.05), in addition to significantly higher heart weight-to-body weight ratio (0.71% [0.5-1.42%] vs 0.59% [0.47-0.91%] p < 0.05). when compared, the chd elderly presented lower fibrous thickening and/or atherosclerosis in the ascending aorta, mitral and tricuspid valves, and left and right coronaries than the whd elderly. in the aortic and mitral valves, the lesions were significantly less severe (p < 0.05). left ventricular apical lesion was observed in 45% of the chd elderly, and intracardiac thrombosis in the left ventricle was found in 10% of them. conclusion: fibrous thickening and/or atherosclerosis were found to be less severe in the valves and arteries of the chd elderly. moreover, heart weight and intracardiac thrombosis frequency were lower than those detailed in the literature for non-elderly individuals.
Cerebral and cardiac amyloidosis in autopsied elderly individuals
Nunes, Lucas Martins de Exel;Salge, Ana Karina Marques;Oliveira, Flávia Aparecida de;Teixeira, Vicente de Paula A.;Reis, Marlene Ant?nia dos;
Clinics , 2006, DOI: 10.1590/S1807-59322006000200005
Abstract: introduction: amyloidosis in elderly individuals can be an independent alteration and a characteristic of aging. however, the clinical, pathophysiologic, and biochemical characteristics of amyloidosis related to age remain uncertain. objective: the purpose of this study was to determine the extent to which the heart and/or the brain of individuals aged 60 years or over exhibits amyloid deposits. materials and methods: the autopsy findings of individuals who were at least 60 years old were studied. the autopsies took place between the years of 1976 and 2000. a total of 10 cases were selected that had hearts without cardiopathies, had negative serology for chagas' disease, and had brains without morphological changes related to encephalopathies. slides with fragments of heart and brain were processed and analyzed using polarized and common light microscopy. results: of the 10 cases, 4 were positive for amyloidosis. all had positive findings in the brain, and 1 case also had positive findings in the heart. among the positive cases, 50% were of people aged 60 to 69 years. there appeared to be a relationship between the presence of amyloid deposits and the ratio of brain and body weight, with the ratio in the positive cases being smaller than in the negative cases. conclusions: the analysis of amyloid deposits in the brains and hearts of elderly individuals shows that such deposits may lead to a systemic attack of senility, common to natural aging. it is not certain that beta-amyloid deposits would alone bring such drastic repercussions to the individual. some additional disorders of the organism could cause the breakdown of the natural balance related to the accumulation of these proteins, leading the way to the pathological contexts of amyloidosis.
Doen?as infecciosas como causas de morte em idosos autopsiados
Oliveira, Flávia Aparecida de;Reis, Marlene Ant?nia dos;Castro, Eumênia Costa da Cunha;Cunha, Selma Freire de Carvalho da;Teixeira, Vicente de Paula Antunes;
Revista da Sociedade Brasileira de Medicina Tropical , 2004, DOI: 10.1590/S0037-86822004000100009
Abstract: the population aging in brazil was associated with the alterations in the morbimortality of the population. the aim of this study was to verify the causes of death and other pathological processes in autopsied elderly. the elderly with 60 years or more in the period from 1976 to 1998 represented 394 cases (24.4%). the age median was 69 years ranged from 60 to 120 years, being higher in the women (70.5 versus 68yrs;p<0.05). the male gender (67.5%), white color (69.8%), and the cardiovascular (43.7%) and infectious (31%) causes of death were dominate. in the malnourished (76.2%) it had association of pneumonia and cystitis, (p<0.05). arteriosclerosis (61.9%), and the chagasic (42.1%) and hypertensive cardiopathies (39.1%) were the most frequent processes. therefore, it was observed an overlapping of chronic-degenerative and infectious causes of death. this study shows the necessity to value of follow up of body mass index and of risk factors for the development of illness in aging patients like pneumonia.
Doen as infecciosas como causas de morte em idosos autopsiados
Oliveira Flávia Aparecida de,Reis Marlene Ant?nia dos,Castro Eumênia Costa da Cunha,Cunha Selma Freire de Carvalho da
Revista da Sociedade Brasileira de Medicina Tropical , 2004,
Abstract: O envelhecimento populacional no Brasil está associado às altera es na morbimortalidade da popula o. Nesse estudo, foi verificado as causas de morte e outros processos patológicos em idosos autopsiados. Os idosos com idade maior ou igual a 60 anos, no período de 1976 a 1998 representaram 394 casos (24,4%). A mediana da idade foi 69 (60 a 120) anos, sendo maior nas mulheres (70,5 versus 68 anos; p<0,05). O sexo masculino (67,5%), a cor branca (69,8%) e as causas de morte cardiovascular (43,7%) e infecciosa (31%) prevaleceram. A subnutri o (76,2%) estava associada à pneumonite e cistite, (p<0,05). A arteriosclerose (61,9%) e as cardiopatias chagásica (42,1%) e hipertensiva (39,1%) foram os processos mais freqüentes. Portanto, foi observado sobreposi o das causas de morte cr nico-degenerativas e infecciosas. Isso demonstra a necessidade de valorizar medidas como o acompanhamento do índice de massa corporal e dos fatores de risco para o desenvolvimento de doen as no envelhecimento, como a pneumonite.
Anatomopathological aspects of neurocysticercosis in autopsied patients
Lino-Junior, Ruy de Souza;Faleiros, Ana Carolina Guimar?es;Vinaud, Marina Clare;Oliveira, Flávia Aparecida de;Guimar?es, Janaína Valadares;Reis, Marlene Ant?nia dos;Teixeira, Vicente de Paula Antunes;
Arquivos de Neuro-Psiquiatria , 2007, DOI: 10.1590/S0004-282X2007000100019
Abstract: the aim of this paper was to describe the occurrence and morphology of neurocysticercosis (ncc) in autopsies. we revised 2218 autopsies performed at the school hospital from federal unversity of triangulo mineiro, 1970-2003. data referring to age, gender and color of patients were reported and ncc was microscopically and macroscopically analyzed. we found 53 (2.4%) ncc cases. the mean age was 50 years old, 34 (64.1%) individuals were male and 36 (67.9%) white. macroscopically, 17 cysticerci were analyzed. the most frequent location was meningocortical in 12 (70.6%) cases. microscopically, the cysticerci presented an ovoid shape, containing the larvae preserved in 4 (23.5%) cases or in destruction degrees in 13 (76.5%) cases. therefore, in ncc was found several general pathologic processes (necrosis, interstitial deposits, fibrosis, gliosis, inflammation) amongst which are highlighted beta-fibrillose in 13 (76.5%) cases associated to inflammatory process in 16 (94.1%) cases caused by the parasite, not yet related to ncc, and calcification present in viable and destruction parasites.
Brazilian Green Propolis: Anti-Inflammatory Property by an Immunomodulatory Activity
Joleen Lopes Machado,Anne Karine Martins Assun??o,Mayara Cristina Pinto da Silva,Aramys Silva dos Reis,Graciomar Concei??o Costa,Diêgo de Sousa Arruda,Bruno Alves Rocha,Mirela Mara de Oliveira Lima Leite Vaz,Antonio Marcus de Andrade Paes,Rosane Nassar Meireles Guerra,Andresa Aparecida Berretta,Flávia Raquel Fernandes do Nascimento
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/157652
Abstract: The immunomodulatory and anti-inflammatory activities of green propolis extracts from Apis mellifera were investigated using acute and chronic inflammation models. Swiss mice were anesthetized and a cotton pellet granuloma was implanted in subcutaneous tissue. Then the mice were divided into six groups and received apyrogenic water or different propolis extracts by oral route (5?mg/kg). According to the treatment the groups were designated as E1A, E1B, E10, E11, and E12. The control group received apyrogenic water. The treatment was performed by six days when the mice were killed. The blood and the bronchoalveolar lavage (BAL) were collected to measure the leukocyte recruitment. In acute pulmonary inflammation, Balb/c mice received lipopolysaccharide (LPS) of Escherichia coli by intranasal route for three days. Concomitantly the mice received by oral route apyrogenic water (control) or E10 and E11 propolis extracts. BAL was performed to assess the inflammatory infiltrate and cytokine quantification. The results showed that the E11 extract has anti-inflammatory property in both models by the inhibition of proinflammatory cytokines and increase of anti-inflammatory cytokines suggesting an immunomodulatory activity. 1. Introduction Green propolis is well known due to the color [1, 2] and is produced by Apis mellifera honeybees that utilize Baccharis dracunculifolia DC (Asteraceae), a common species found in the Brazilian cerrado, as the main plant source [3]. Several studies have reported green propolis to have antiulcerogenic [3], anti-inflammatory [4], antimutagenic [5], antifungal [6–8], immunomodulatory [9], angiogenesis [10], and antioxidant [11] properties. The biological activities of propolis are due to its high levels of phenolic acids [12], while flavonoids are considered responsible for the activities of the European propolis extracts [13]. The typical constituents of Brazilian green propolis are caffeoylquinic acid and prenylated derivatives of cinnamic acid, such as artepillin C and baccarin [14, 15]. The immunomodulatory effects of natural substances have been considered as alternative adjuvant therapies in the treatment of various diseases [16]. In the case of propolis, this effect has been associated with a combination of different constituents [17]. The administration of green propolis in animals subjected to chronic stress increased the generation of hydrogen peroxide, suggesting that this product modulated the activation of macrophages [18]. In an in vivo model of chronic inflammation, it has been also demonstrated that green propolis
MicroRNA expression profile in epilepsy: breaking molecular barriers
Dogini, Danyella B.;Avansini, Simoni Helena;Torres, Fábio Rossi;Rogério, Fabio;Rocha, Cristiane S.;Secolin, Rodrigo;Yasuda, Clarissa L.;Coan, Ana Carolina;Costa, Ana Flávia;Piaza, Ana Claúdia Sparapani;Reis, zia Aparecida Magalh?es Ribeiro;Queiroz, Luciano de S.;Tedeschi, Helder;Oliveira, Evandro;Cendes, Fernando;Lopes-Cendes, Iscia;
Journal of Epilepsy and Clinical Neurophysiology , 2012, DOI: 10.1590/S1676-26492012000200008
Abstract: background: micrornas (mirnas) are small rna molecules (21-24 nt) that negatively regulate gene expression, either by repression of translation or by degradation of messenger rna. these molecules are involved in many important processes including cell differentiation, neurogenesis, formation of nervous system and others. mesial temporal lobe epilepsy and epilepsy caused by cortical dysgenesis are among the leading causes of drug resistant epilepsy. objectives: the objectives of this study were to characterize the expression profile of mirnas and to investigate their regulation in mesial temporal lobe epilepsy (mtl) and in focal cortical dysplasias (fcds). methods: total rna was extracted from hippocampal and neocortical tissue, maintained in paraffin or fresh-frozen, from patients who underwent surgery for seizure control. for comparison we used tissue obtained from autopsy. rna was extracted and used in real time pcr reactions (157 mirnas analyzed) or microarray chips (847 mirnas analyzed). results: bioinformatics analyzes identified three mirnas with expression significantly different in patients with mtle: let-7d, mir-29b and mir-30d; while in patients with fcds we found 23 micrornas differentially expressed. in addition, we found that different pathological forms of had different molecular signatures. conclusions: the possible genes regulated by mirnas with differential expression in tissue with mesial temporal sclerosis (mts) are mainly related to neurogenesis and apoptosis. while in dcfs they were predominantly related to cell proliferation and migration. our results demonstrate the importance of mirna regulation the in molecular processes that lead to the lesions present in the mts and the fcds.
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