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Search Results: 1 - 10 of 351584 matches for " Fernando de Castro e;Bacaltchuk "
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Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly
Laks, Jerson;Engelhardt, Eliasz;Marinho, Valeska;Rozenthal, Marcia;Souza, Fernando de Castro e;Bacaltchuk, Josué;Stoppe Jr., Alberto;Ferreira, R.C.R.;Bottino, Cassio;Scalco, M?nica;
Arquivos de Neuro-Psiquiatria , 2001, DOI: 10.1590/S0004-282X2001000600005
Abstract: background: behavioral and psychological symptoms in dementia (bpsd) contribute to caregiver burden and institutionalization of elderly. neuroleptics are prescribed to control agitation. side effects of typical neuroleptics are harmful, making atypical neuroleptics an indication. objectives: to evaluate efficacy and tolerability of risperidone oral solution (ros) given once daily to demented elderly outpatients with bpsd (agitation). method: patients (n=26), 76.35±8.63 years, diagnostic and statistical manual of mental disorders 4th ed. (dsm-iv) criteria for dementia. rso was given, starting dose of 0.25 mg and increments of 0.25 mg every week. mini-mental state examination (mmse) assessed cognitive status, behavioral and emotional activities manifested in dementia (beam-d) and clinical global impression (cgi) measured bpsd, extrapiramidal symptom rating scale (esrs) evaluated extrapyramidal symptoms. cardiovascular side effects were evaluated clinically. results: there was a 26% reduction in agitation and no cardiovascular side effects in the range from 1.0 to 1.25 mg. side effects were more prevalent above 2.5 mg. conclusion: risperidone oral solution improved agitation with good tolerability from 0.5 to 1.25 mg. a single dose with increments of 0.25 mg may be more acceptable to patients and caregivers.
Middle and inner ear malformations in two cases of velocardiofacial syndrome
Tabith Junior, Alfredo,Haetinger, Rainer Guilherme,Silva, Fernando Leite de Carvalho e,Gudmon, Monica de Castro
International Archives of Otorhinolaryngology , 2009,
Abstract: Objective: To describe audiometric characteristics and middle and inner ear malformations in two patients with velocardiofacial syndrome. Method: Audiometric evaluation, computerized tomography of the temporal bones and analysis of DNA for multiple markers of 22q11 region were performed in two patients with clinical signs of velocardiofacial syndrome. Results: Conductive hearing loss related to chronic otites media and middle and inner ear malformations were found, the latter with the use of reformations based on multislice acquisitions on of the computerized tomography of the temporal bones. Conclusion: We consider it to be highly important to carry out a thorough evaluation and monitoring of the hearing evolution, as well as the occurrence of symptoms related to the vestibular function in patients with velocardiofacial syndrome. From the radiological point of view, attention should be given to the use of high quality techniques for the tomographic study of temporal bones.
Malforma es das orelhas média e interna em dois casos de síndrome velocardiofacial
Tabith Junior, Alfredo,Haetinger, Rainer Guilherme,Silva, Fernando Leite de Carvalho e,Gudmon, Monica de Castro
Arquivos Internacionais de Otorrinolaringologia , 2009,
Abstract: Objetivo: Descrever as características audiométricas e malforma es das orelhas média e interna em dois pacientes portadores de síndrome velocardiofacial. Método: Avalia o audiométrica, tomografia computadorizada dos ossos temporais e análise de DNA, para marcadores múltiplos da regi o 22q11, foram realizadas em dois pacientes com sinais clínicos da síndrome velocardiofacial. Resultados: Perdas auditivas condutivas relacionadas com otite média cr nica e malforma es das orelhas média e interna foram encontradas, estas últimas com a utiliza o de reformata es baseadas em aquisi es multislice da tomografia computadorizada dos ossos temporais. Conclus o: Consideramos de grande importancia realizar uma completa avalia o e monitoramento da evolu o da fun o auditiva, bem como do surgimento de sintomas relacionados à fun o vestibular em pacientes com a síndrome velocardiofacial. Do ponto de vista radiológico chamamos a aten o para o uso de técnicas de alta qualidade para o estudo tomográfico dos ossos temporais. Palavras chave: orelha, perda auditiva, velocardiofacial.
Hepatectomia total com preserva??o da veia cava inferior: "piggy-back" experimental em c?es
Castro-e-Silva Jr, Orlando de;Ramalho, Fernando S;Pacheco, Eduardo G;
Acta Cirurgica Brasileira , 2002, DOI: 10.1590/S0102-86502002000900017
Abstract: during the recipient hepatectomy in liver transplantation, preservation of the retrohepatic segment of the inferior vena cava has several advantages: it decreases warm ischemia time by eliminating the infrahepatic caval anastomosis, eliminates the need for venovenous bypass and eases retransplantation. removal of the liver of the dog without sacrificing the inferior vena cava has been considered impossible because of the intrahepatic course of the vena cava at the sites of entry of the hepatic veins. the following report reviews the history of the piggyback method, and discuss about the feasibility of the total removal of the liver without injury to the vena cava in the dog.
Hepatectomia total com preserva o da veia cava inferior: "piggy-back" experimental em c es
Castro-e-Silva Jr Orlando de,Ramalho Fernando S,Pacheco Eduardo G
Acta Cirurgica Brasileira , 2002,
Abstract: No transplante de fígado, a preserva o do segmento retro-hepático da veia cava durante a hepatectomia do receptor apresenta uma série de vantagens: diminui o do tempo de isquemia quente por eliminar a anastomose da veia cava infra-hepática, redu o da necessidade da utiliza o de deriva es veno-venosas e simplifica o da cirurgia do re-transplante hepático. Em c es, os lobos hepáticos lateral direito e caudado s o caprichosamente atravessados pela veia cava inferior, dificultando a completa "esqueletiza o" do vaso. No presente trabalho, os autores revisam a singular história do método do "piggy-back" experimental e clínico, e discutem a técnica da cirurgia em c es.
Led enhancement in mitochondrial oxidative phosphorylation for hepatectomized rats
Castro-e-Silva Jr Orlando de,Castro-e-Silva Tiago,Ramalho Fernando Silva,Ramalho Leandra Naira Zambelli
Acta Cirurgica Brasileira , 2002,
Abstract: Recently, the LED (light emitting diode) developed by the Optics Group of IFSC-USP has been used instead of laser for the treatment of skin tumors by the PDT (Photodinamic Therapy) because of its low operational cost compared to the use of a laser. In this paper we investigate the effect of LED light on oxidative phosphorylation during liver regeneration after partial hepatectomy. Twenty-four male Wistar rats (250 g) were kept in identical housing units on a 12-hour light/12 hour dark cycle. The LED 10 group was exposed to LED at 638 nm (10 J/cm2 for 3 minutes). Seventy percent partial hepatectomy was performed in the LED 10 and HPC (Partial Hepatectomy-Control). A sham-operated group (C) was used for control. Twenty four hours after the procedure, LED 10, HPC and control animals were sacrificed. Samples of liver tissue were used for the mitochondrial respiration assay. Statistical comparisons of the groups were performed by analysis of variance (ANOVA), followed by the Bonferroni post-test. Probability values less than 0.05 were considered to be statistically significant. the phosphorylation index (FI) for the LED 10 group was higher than that for the HPC group and for the sham group (p<005). The FI for the HPC group was higher than that for the sham group (p<005). The values of the ADP:O ratio for the three groups, which did not differ significantly from one another (p > 0.05). In the present study we noted an effective interaction between LED light and hepatic mitochondria, with an increased phosphorylation rate for the latter.
Effect of antihypertensive agents on stellate cells during liver regeneration in rats
Ramalho Leandra N. Z.,Zucoloto Sérgio,Ramalho Fernando S.,Castro-e-Silva Jr. Orlando de
Arquivos de Gastroenterologia , 2003,
Abstract: BACKGROUND: Although most studies have focused on the hepatocytes, all the hepatic cells participate in the regenerative process, among them the stellate cells. The stellate cells are mesenchymal cells involved in local neurotransmission and paracrine regulation of several liver functions. Acute hepatic tissue loss promotes the proliferation and activation of stellate cells from a quiescent state to myofibroblast-like cells. AIM: Investigate the effects of antihypertensive agents on the stellate cell population during the liver regenerative phenomenon in rats. METHODS: Adult male Wistar rats received lisinopril, losartan, bradykinin, or saline solution in a proportional volume, intraperitoneally, before and after 70% partial hepatectomy. Animals from the experimental and saline groups were sacrificed at 36 hours after partial hepatectomy. The alpha-smooth muscle actin labelled stellate cells population was counted in the periportal and pericentral zones of the liver specimen. RESULTS: The labelled stellate cells were more numerous in the control group both in the periportal and pericentral zones at 36 hours after partial hepatectomy than at the other times. The population of stellate cells was significantly lower in the losartan group and higher in the bradykinin and lisinopril groups than in the control group. CONCLUSIONS: These results suggest that losartan can inhibit and bradykinin and lisinopril can stimulate the stellate cell population during liver regeneration in rats. These cells synthesize several substances to stimulate liver regeneration.
Nephrology Referral and Outcomes in Critically Ill Acute Kidney Injury Patients
Ver?nica Torres Costa e Silva, Fernando Lia?o, Alfonso Muriel, Rafael Díez, Isac de Castro, Luis Yu
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070482
Abstract: Background Delayed nephrology consultation (NC) seems to be associated with worse prognosis in critically ill acute kidney injury (AKI) patients. Design, Setting, Participants, & Measurements The aims of this study were to analyze factors related with timing of NC and its relation with AKI patients' outcome in intensive care units of a tertiary hospital. AKI was defined as an increase ≥50% in baseline serum creatinine (SCr). Early NC and delayed NC were defined as NC performed before and two days after AKI diagnosis day. Multivariable logistic regression and propensity scores (PS) were used to adjust for confounding and selection biases. Hospital mortality and dialysis dependence on hospital discharge were the primary outcomes. Results A total of 366 AKI patients were analyzed and NCs were carried out in 53.6% of the patients. Hospital mortality was 67.8% and dialysis required in 31.4% patients (115/366). Delayed NCs (34%) occurred two days after AKI diagnosis day. This group presented higher mortality (OR: 4.04/CI: 1.60–10.17) and increased dialysis dependence (OR: 3.00/CI: 1.43–6.29) on hospital discharge. Four variables were retained in the PS model for delayed NC: diuresis (1000 ml/24 h - OR: 1.92/CI: 1.27–2.90), SCr (OR: 0.49/CI: 0.32–0.75), surgical AKI (OR: 3.67/CI: 1.65–8.15), and mechanical ventilation (OR: 2.82/CI: 1.06–7.44). After correction by PS, delayed NC was still associated with higher mortality (OR: 3.39/CI: 1.24–9.29) and increased dialysis dependence (OR: 3.25/CI: 1.41–7.51). Delayed NC was associated with increased mortality either in dialyzed patients (OR: 1.54/CI: 1.35–1.78) or non-dialyzed patients (OR: 2.89/CI: 1.00–8.35). Conclusion Delayed NC was associated with higher mortality and increased dialysis dependence rates in critically ill AKI patients at hospital discharge. Further studies are necessary to ascertain whether this effect is due to delayed nephrology intervention or residual confounding factors.
Effect of antihypertensive agents on stellate cells during liver regeneration in rats
Ramalho, Leandra N. Z.;Zucoloto, Sérgio;Ramalho, Fernando S.;Castro-e-Silva Jr., Orlando de;Corrêa, Fernando M. A.;
Arquivos de Gastroenterologia , 2003, DOI: 10.1590/S0004-28032003000100009
Abstract: background: although most studies have focused on the hepatocytes, all the hepatic cells participate in the regenerative process, among them the stellate cells. the stellate cells are mesenchymal cells involved in local neurotransmission and paracrine regulation of several liver functions. acute hepatic tissue loss promotes the proliferation and activation of stellate cells from a quiescent state to myofibroblast-like cells. aim: investigate the effects of antihypertensive agents on the stellate cell population during the liver regenerative phenomenon in rats. methods: adult male wistar rats received lisinopril, losartan, bradykinin, or saline solution in a proportional volume, intraperitoneally, before and after 70% partial hepatectomy. animals from the experimental and saline groups were sacrificed at 36 hours after partial hepatectomy. the alpha-smooth muscle actin labelled stellate cells population was counted in the periportal and pericentral zones of the liver specimen. results: the labelled stellate cells were more numerous in the control group both in the periportal and pericentral zones at 36 hours after partial hepatectomy than at the other times. the population of stellate cells was significantly lower in the losartan group and higher in the bradykinin and lisinopril groups than in the control group. conclusions: these results suggest that losartan can inhibit and bradykinin and lisinopril can stimulate the stellate cell population during liver regeneration in rats. these cells synthesize several substances to stimulate liver regeneration.
A INFORMATIZA O DO PROCESSO: DO ACESSO à ADMINISTRA O DA JUSTI A
Fernando de Castro Fontainha
Revista da SJRJ , 2010,
Abstract: Este artigo enfrenta o tema do tratamento computacional dado às pequenas causas no projeto dos juizados especiais federais previdenciários do TRF3. Em um primeiro momento, faremos um breve histórico a respeito da recente evolu o do tratamento das pequenas causas no Brasil. Em seguida enfocaremos o problema do contencioso de massas na Justi a Federal. O artigo segue com uma descri o detalhada do processo virtual, conforme o projeto do TRF3. Por fim, analisaremos os limites e possibilidades da informatiza o do processo no Brasil, a partir de outras iniciativas documentadas ao redor do país. A pesquisa realizada concentrou-se em documentos oficiais do TRF3 – notadamente a Cartilha, o Projeto e o Caderno de Relatórios dos Juizados Especiais Federais Previdenciários –, bem como em bibliografia sobre o tema.
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