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Search Results: 1 - 10 of 23494 matches for " Fernando Kemta Lekpa "
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Prevalence and Risk Factors of Peripheral Artery Disease in a Group of Apparently Healthy Young Cameroonians: A Cross-Sectional Study  [PDF]
Félicité Kamdem, Yacouba Njankouo Mapoure, Ba Hamadou, Fanny Souksouna, Ahmadou Musa Jingi, Caroline Kenmegne, Fernando Kemta Lekpa, Jaff Fenkeu Kweban, Gisèlei Mandy, Jean Pierre Nda Mefo’o, Henry Luma, Marie Solange Doualla
World Journal of Cardiovascular Diseases (WJCD) , 2018, DOI: 10.4236/wjcd.2018.82011
Background: The?burden of peripheral artery disease (PAD) is not well known among apparently healthy people in Africa. Aim: To determine the prevalence and associated risk factors of PAD in a group of blood donors seen at the Douala General HospitalCameroon. Methods: Between 1st November 2015 and 30th April 2016, we carried out a cross-sectional study. Participants were consenting adults of both sexes, aged ≥ 21 years who presented for blood donation, and were tested HIV negative. We collected socio-demographic data and their past history. We carried out a physical examination and measured their Ankle-Brachial Index (ABI). We defined PAD as an ABI < 0.9. We also measured their fasting blood glucose and lipid profile. Results: We recruited 103 participants, 55.4% males. The mean age was 33 ± 10 years. The mean ABI on left and right leg was 1.04 ± 0.1 and 1.02 ± 0.1respectively. ABI was higher in males than females both legs (p < 0.05). PAD was seen in 11 (10.7%) participants. This was higher in females than males (3.6% versus 19.2%, p = 0.026). Among those with PAD, 8 (72.7%) were asymptomatic (Males: 100% versus Females: 66%, p
Epidemiology, Clinical and Paraclinical Presentations of Pulmonary Embolism: A Cross-Sectional Study in a Sub-Saharan Africa Setting  [PDF]
Bertrand Hugo Mbatchou Ngahane, Félicité Kamdem, Silvain Raoul Simeni Njonnou, Nina Chebou, Anastase Dzudie, Serge Arnold Ebongue, Bruno Tengang, Fernando Kemta Lekpa, Yacouba Mapoure Njankouo, Sidick Mouliom, Henri Roger Ngote, Henry Luma Namme
Open Journal of Respiratory Diseases (OJRD) , 2019, DOI: 10.4236/ojrd.2019.93008
Abstract: Background: Venous thromboembolic (VTE) disease burden is increasing worldwide, representing a major cause of cardiovascular death and public health problem. Pulmonary embolism (PE) is the most serious clinical presentation of VTE. Epidemiological and clinical data on PE are still lacking in Africa, particularly in Cameroon. This study aimed at determining the clinical features as well as imaging presentation and outcome of pulmonary embolism. Methods: A cross-sectional study was carried out in three hospitals in Douala. We retrospectively reviewed patient records admitted for PE from January 2009 to May 2017. We collected data on epidemiology, clinical presentation, venous Doppler/pulmonary computed tomographic angiography (CTA), and outcome. Results: We included 103 patients (56 males) with PE. Their median age was 52 years. The main risk factors were obesity (49.5%), hypertension (35.0%), long trip (24.3%) and cancer (18.4%). The most frequent clinical presentations were dyspnoea (83.4%), chest pain (78.6%), and cough (40.8%). Additionally, pleural effusion (32.8%), atelectasis (25.7%) and pulmonary hyperlucency (20.0%) were the most frequent findings on chest X-ray. The main abnormalities found in electrocardiogram were sinus tachycardia (63.4%), S1Q3T3 aspect (37.6%) and right axial deviation (28.7%). Moreover, right cavities dilatation (26.0%), pulmonary artery hypertension (35.0%) and pulmonary artery dilatation (21.0%) were the main echocardiographic findings. Low-molecular-weight heparin (LMWH) was the initial anticoagulant in all cases. There were 19 (18.4%) in-hospital deaths, and the mean hospital stay was 8.5 ± 5 days. Conclusion: PE is not rare in our setting. Obesity, long trip and cancer are the main risk factors, while dyspnoea, chest pain and respiratory distress are the main clinical presentation for PE. LMWH remains the therapeutic agent of choice. Lastly, in-hospital mortality is very high.
Is IL-6 an appropriate target to treat spondyloarthritis patients refractory to anti-TNF therapy? a multicentre retrospective observational study
Fernando Lekpa, Cécile Poulain, Daniel Wendling, Martin Soubrier, Michel De Bandt, Jean Berthelot, Philippe Gaudin, Eric Toussirot, Philippe Goupille, Thao Pham, Jérémie Sellam, Rémy Bruckert, Muriel Paul, Valérie Farrenq, Pascal Claudepierre, the Club Rhumatismes et Inflammation
Arthritis Research & Therapy , 2012, DOI: 10.1186/ar3766
Abstract: French rheumatologists and internal-medicine practitioners registered on the Club Rhumatismes et Inflammations website were asked to report on patients given tocilizumab (4 or 8 mg/kg) to treat active disease meeting Assessment of SpondyloArthritis International Society (ASAS) criteria for axial or peripheral spondyloarthritis, after anti-TNFα treatment failure. Safety and efficacy after 3 and 6 months were assessed retrospectively using standardised questionnaires.Data were obtained for 21 patients, 13 with axial spondyloarthritis (46% men; median age, 42 years; disease duration, 11 years; HLA-B27-positive, 92.3%) and eight with peripheral spondyloarthritis (25% men; median age, 40 years; disease duration, 10 years; HLA-B27-positive, 62.5%). No patients with axial disease had at least a 20 mm decrease in the BASDAI, nor a BASDAI50 response or major ASAS-endorsed disease activity score improvements after 3 or 6 months; an ASAS-endorsed disease activity score clinically important improvement was noted at month 3 in five of 13 patients and at month 6 in one of four patients. A good DAS28 response was achieved in four patients with peripheral disease, including one in EULAR remission at month 3. Four patients were still taking tocilizumab at month 6, including one in EULAR remission and one with a good DAS28 response. Tocilizumab was well tolerated, with no serious adverse events. Initially elevated acute-phase reactants declined during tocilizumab therapy.In patients having failed anti-TNFα therapy, tocilizumab decreased acute-phase reactants but failed to substantially improve axial spondyloarthritis and was inconsistently effective in peripheral spondyloarthritis.The introduction of TNFα antagonists (anti-TNFα) has revolutionised the management of patients with spondyloarthritis (SpA). Randomised controlled trials demonstrated substantial efficacy of anti-TNFα therapy in ankylosing spondylitis (AS) [1-3] and psoriatic arthritis (PsA) [4-6], with high drug continuati
International Trade and Unemployment in Less Developed Countries  [PDF]
Fernando Mesa
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.25101

The main interest focus of this paper is the relation between international trade and the labour market, with an emphasis on the unemployment rate, and the allocation of workers among sectors. A general trade equilibrium model with three sectors is constructed for a less developed country. An informal and un-tradable sector is characterised by flexible wages, while the other two sectors are tradable, export and import sectors. The model imposes a binding minimum wage on unskilled labour and wage distortions on skilled labour. Comparative statics are used to analyse the effects on the labour market of an open economy, a rise in the minimum wage and a positive productivity shock in the export sector.

Intergenerational Real Wages, Technological Change, and Economic Growth in Colombia  [PDF]
Fernando Mesa
Modern Economy (ME) , 2016, DOI: 10.4236/me.2016.72015
Abstract: This paper focuses on the decomposition of real wages in Colombia both by workers’ ages and by cohorts, which overlap over time. The paper analyses how the Colombia’s labour structure has undergone important changes in the period 1982-2007. This period has been characterized by a demographic transition that has tilted the balance from a relatively young population to an older one. The effects of capital accumulation have been estimated and modelled considering the presence of ever more sophisticated machinery, usually replacing less-skilled, younger workers, in relation to older and more qualified ones. In general real wages present a curved shape for each generation, as is acknowledged in the life-cycle hypothesis, according to which people generally start their working life with low incomes and rising debts and then obtain higher income and accumulate assets.
On the Walker’ Model for the Carbon Dioxide in the Earth’s Atmosphere  [PDF]
Fernando Vadillo
Journal of Environmental Protection (JEP) , 2019, DOI: 10.4236/jep.2019.101004
Abstract: Climate change is a wicked problem because it is hard to say what the problem is, and to define it clearly. However, we know that global temperature rise correlates with increasing levels of atmospheric carbon dioxide [1] and [2]. In this paper, we analyze a model for the carbon dioxide developed by Walker in [3] with several source terms. Our numerical results show that the burning fossil fuels have an effect on the carbon dioxide in the earth’s atmosphere and the climate change problem, one of the major global challenger of our time.
On the Communication Requirements for the Smart Grid  [PDF]
Mohamed Daoud, Xavier Fernando
Energy and Power Engineering (EPE) , 2011, DOI: 10.4236/epe.2011.31008
Abstract: The current power grid is facing many challenges that it was not designed or engineered to handle which range from congestions and major blackouts to the overwhelming increase in demand and security concerns. The current electric grid was established before the 1960’s. It is believed that the electric grid is the most complex and gigantic machine ever made in human history; it consists of wires, cables, towers, transformers and circuit breakers installed together in outdated manner. During the 60’s, computers and sensors were used to monitor and slightly control the grid; however, fifty years later these sensors are considered less than ideal. Presented here is a review of the smart grid communication network in terms of configuration, bandwidth and latency requirements as well as the technology used. We simulate the access layer of the smart grid net-work and show that no single available communication technology can be used for all layers of the smart grid; thus, different technologies for different layers are needed. A new protocol for optimizing the smart grid is recommended.
A New Approach to the Optimization of the CVRP through Genetic Algorithms  [PDF]
Mariano Frutos, Fernando Tohmé
American Journal of Operations Research (AJOR) , 2012, DOI: 10.4236/ajor.2012.24058
Abstract: This paper presents a new approach to the analysis of complex distribution problems under capacity constraints. These problems are known in the literature as CVRPs (Capacitated Vehicle Routing Problems). The procedure introduced in this paper optimizes a transformed variant of a CVRP. It starts generating feasible clusters and codifies their ordering. In the next stage the procedure feeds this information into a genetic algorithm for its optimization. This makes the algorithm independent of the constraints and improves its performance. Van Breedam problems have been used to test this technique. While the results obtained are similar to those in other works, the processing times are longer.
Quality Requirements for Multimedia Interactive Informative Systems  [PDF]
Sylviane Levy, Fernando Gamboa
Journal of Software Engineering and Applications (JSEA) , 2013, DOI: 10.4236/jsea.2013.68051

Multimedia Interactive Informative Systems (MIIS) are software applications resulting from the convergence of multiples technologies such as audiovisual, computing and communication. They aim to transmit information to a large, diverse and dispersed public. As with other mass media, the fulfillment of MIIS goals depends largely on the quality of communication between the system and end users. Therefore, those systems should be developed in order to ensure that this quality requirement is satisfied. If MIIS are constructed according to usual software engineering practices, the analysis discipline of the development process includes requirements identification and specification; however, these techniques are focused on functional requirements, and they do not give much importance to non-functional requirements. In this paper, we propose a development process based on the production of videogames which has two different phases: preproduction and production. The first phase, corresponding to requirements identification, derives into the concept of system. In order to translate this concept into a specification, we propose the use of new communicational attributes and a MIIS metamodel. The establishment of MIIS non-functional specification is the result of analyzing class diagrams through quality attributes. In order to evaluate if the specifications are responding to communicational attributes, a functional prototype is built and evaluated with end users. The proposed methodology is applied to a real case study.

Large-Scale Structure Formation via Quantum Fluctuations and Gravitational Instability  [PDF]
Fernando Porcelli, Giancarlo Scibona
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.56058

This is a review of the status of the universe as described by the standard cosmological model combined with the inflationary paradigm. Their key features and predictions, consistent with the WMAP (Wilkinson Microwave Anisotropies Probe) and Planck Probe 2013 results, provide a significant mechanism to generate the primordial gravitational waves and the density perturbations which grow over time, and later become the large-scale structure of the universe—from the quantum fluctuations in the early era to the structure observed 13.7 billion later, our epoch. In the single field slow-roll paradigm, the primordial quantum fluctuations in the inflaton field itself translate into the curvature and density perturbations which grow over time via gravitational instability. High density regions continuously attract more matter from the surrounding space, the high density regions become more and more dense in time while depleting the low density regions. At late times the highest density regions peaks collapse into the large structure of the universe, whose gravitational instability effects are observed in the clustering features of galaxies in the sky. Thus, the origin of all structure in the universe probably comes from an early era where the universe was filled with a scalar field and nothing else.

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