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Search Results: 1 - 10 of 24385 matches for " Fernando Dominguez;Rogido "
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Uma vis?o evidente da prática baseada em evidências na medicina perinatal: ausência de evidência n?o é evidência de ausência
Sola, Augusto;Dieppa, Fernando Dominguez;Rogido, Marta R.;
Jornal de Pediatria , 2007, DOI: 10.2223/JPED.1702
Abstract: objective: to provide valuable elements and some humor in this so-called era of "evidence-based practice" with the aim of helping clinicians make better choices in the care they deliver based on evidence, not simply or exclusively based on a randomized clinical trial (rct) or meta-analysis (which may not be evidence). sources: books and peer-reviewed articles are quoted and listed in the bibliography. evidence of life, learning from our own mistakes and many other evident facts that support this review are not quoted. summary of the findings: 1) "absence of evidence is not evidence of absence" and "lack of evidence of effect does not mean evidence of no effect". 2) rcts with "negative" results and those with "positive" results, but without outcomes that matter, often cannot conclude what they conclude. 3) non-randomized clinical trials and practical trials may be important. 4) research to prove is different than research to improve. 5) clinical choice must assess effects on outcomes that matter to patients and their parents. 6) quantifying adverse outcomes, number needed to damage and to treat is not that simple. conclusions: significant challenges inherent to health service research must be correlated to possible clinical applications using tools to have a more "evident view of evidence-based practice" in perinatal medicine, recalling that absence of evidence is not evidence of absence.
Melhoria contínua e aprendizagem organizacional: múltiplos casos em empresas do setor automobilístico
Gonzalez, Rodrigo Valio Dominguez;Martins, Manoel Fernando;
Gest?o & Produ??o , 2011, DOI: 10.1590/S0104-530X2011000300003
Abstract: fierce competition, highlighted by global competition has increasingly required organizations to adopt frequent and quick innovations to meet the current technological, economic, and political changes in society. accordingly , the continuous improvement of products and production processes is necessary to keep the company competitive. however, many of these initiatives fail in organizations. in order to analyze how the mechanisms of learning support improvement activities, a field research based on case study of three companies in the automotive sector was carried out. the article concludes that in addition to programs and tools for solving problems, organizations need to develop environments that encourage learning and cooperation among its individuals working in human resources development to achieve continuous improvement.
Melhoria contínua no ambiente ISO 9001:2000: estudo de caso em duas empresas do setor automobilístico
Gonzalez, Rodrigo Valio Dominguez;Martins, Manoel Fernando;
Produ??o , 2007, DOI: 10.1590/S0103-65132007000300014
Abstract: this article evaluate how two companies certified by the norm iso 9001:2000, supplier of the automotive sector, accomplish continuous improvement activities in its productive processes. it is obvious that the different industrials environments, presented by the companies in particular, shows differences in relation to the conduction of the continuous improvement programs, and also, the stimulus to get the certification in this quality system which also inspires in the amplitude and constancy of the processes improvement. at this way, the article analyses how the researched organizations develop and organize internally the continuous improvement, emphasizing the production organization, improvement management model and programs and techniques used to these activities.
A pesquisa histórica sobre o Brasil nos arquivos dos Estados Unidos: identifica o preliminar e projeto de compila o
Paulo Roberto de Almeida,Francisco Rogido Fins
Revista Brasileira de Política Internacional , 2001, DOI: 10.1590/s0034-73292001000100011
Gest?o do conhecimento em uma estrutura organizacional em rede
Gonzalez, Rodrigo Valio Dominguez;Martins, Manoel Fernando;Toledo, José Carlos de;
Ciência da Informa??o , 2009, DOI: 10.1590/S0100-19652009000100004
Abstract: the relations of partnership are more and more common among organizations, establishing structures of relations in network. an important task arising from providing service enterprises is knowledge management for improving their processes. the objective of this article is to analyze how the organizational aspects, both technical and social, of an organizational structure in network may enhance the knowledge management for promoting activities of continuous improvement. the enterprise where this research took place, a provider of industrial services, implemented a structure of sites full service, responsible for full time customers' activities of routine and improvement, in addition to excellence centers that promote the process of knowledge management. in order to reach this objective, a qualitative research, based on a study of exploratory case, was carried out. the result of this research points out that the flow of knowledge among individuals and different sites has been intensified owing to interactions in network, increasing the potential of the organization in promoting improvements.
Effects of a Centered Virtual Teaching Environment on Learning Styles in the Academic Performance of College Students
Fernando Segundo Iriarte Díaz-Granados,E. Dominguez,C. Ricardo,H. Fontalvo
International Journal of Emerging Technologies in Learning (iJET) , 2009, DOI: 10.3991/ijet.v4i0.809
Abstract: Based on the concept of adaptive hypermedia, the webCT platform was used to design a learning virtual environment that would allow students’ interaction of different support materials with their usual styles of learning. GA Latin Square design was used to determine the role that environment and learning styles, along with intrinsic motivation, played on academic performance, navigation patterns, and number of visits to the support materials. The study showed an important difference in academic performance in favor of the Balanced group. Intrinsic motivation was the main explicative factor for the differences found beyond learning styles. The conclusion was that there are differences in the way of using the objects of learning, and that there are differentiated patterns to access the support material, depending on the students’ learning styles.
Retinoblastoma Loss Modulates DNA Damage Response Favoring Tumor Progression
Marcos Seoane, Pablo Iglesias, Teresa Gonzalez, Fernando Dominguez, Maximo Fraga, Carlos Aliste, Jeronimo Forteza, Jose A. Costoya
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003632
Abstract: Senescence is one of the main barriers against tumor progression. Oncogenic signals in primary cells result in oncogene-induced senescence (OIS), crucial for protection against cancer development. It has been described in premalignant lesions that OIS requires DNA damage response (DDR) activation, safeguard of the integrity of the genome. Here we demonstrate how the cellular mechanisms involved in oncogenic transformation in a model of glioma uncouple OIS and DDR. We use this tumor type as a paradigm of oncogenic transformation. In human gliomas most of the genetic alterations that have been previously identified result in abnormal activation of cell growth signaling pathways and deregulation of cell cycle, features recapitulated in our model by oncogenic Ras expression and retinoblastoma (Rb) inactivation respectively. In this scenario, the absence of pRb confers a proliferative advantage and activates DDR to a greater extent in a DNA lesion-independent fashion than cells that express only HRasV12. Moreover, Rb loss inactivates the stress kinase DDR-associated p38MAPK by specific Wip1-dependent dephosphorylation. Thus, Rb loss acts as a switch mediating the transition between premalignant lesions and cancer through DDR modulation. These findings may have important implications for the understanding the biology of gliomas and anticipate a new target, Wip1 phosphatase, for novel therapeutic strategies.
Los prostanoides, una revolución autacoide
Anales Venezolanos de Nutrición , 2006,
Abstract: from 1960 to the end of the xx century, efforts from different laboratories were done to understand the regulation of eicosanoids biosynthesis and metabolism. these autacoids are synthesized from 20 c polyunsaturated fatty acids, from where they got the prefix eico, twenty. the physiologic and in certain conditions pathphysiologic actions, requires ≤ mmolar concentrations remaining active for periods of time ranging from seconds to minutes. during this productive period of the xx century it was possible to identify: 1- araquidonic acid as the main eicosanoid?s precursor, 2- the membrane phospholipids compartment as the cellular storage of the precursor fatty acid and 3- the phospholipases as the enzymes required to liberate the precursor fatty acid rending possible its access to the eicosanoids biosynthetic machinery. two main groups of eicosanoids arrive on the scene, classified in function to its molecular structure, one that includes the cyclic or prostanoids, where the prostaglandin h (pgh) is the universal precursor, pgh is a cyclic endoperoxide synthesized by the enzyme prostaglandin endoperóxido synthase, better known by its acronym cox for cycloxygenase, and the other, linear eicosanoids:: leukotrienes, lypoxines, and epoxides which are products synthesized from different enzymatic pathways including the lypoxygenase and cytochrome oxidases. the most relevant findings in the history of the prostanoids are considered in this review.
O Complexo Avícola em Entre Ríos e suas Rela es Internas The Entre Ríos Chicken-raising Complex and its Inward Relations El Complejo Avícola Entrerriano y las Relaciones en su interior
Revista Brasileira de Gest?o de Negócios , 2007,
Abstract: RESUMO O trabalho faz parte dos avan os obtidos no projeto de pesquisa publicado pela Universidad Nacional de Entre Ríos (UNER). “As granjas avícolas integradas de Entre Ríos, mudan a tecnológica e reconvers o”, Faculdade de Ciências Econ micas, UNER, Expte. 4028-2 UNER, período 2004/2007. O trabalho pretende informar sobre as modalidades organizacionais da cadeia avícola de Entre Ríos nos últimos anos, particularmente no período 2001-2006, onde a característica predominante teve como destaque a expans o e o crescimento do setor e seu impacto nas características socio-tecnológicas das granjas, conforme as diferentes regi es produtoras de frangos existentes. Pelo trabalho é possível concluir que, apesar de ter-se incrementado a capacidade de produ o acompanhado de certo avan o tecnológico, sob a ótica das regi es produtoras e os agentes envolvidos ocorrem importantes heterogeneidades, onde a rentabilidade e as condi es nas quais se desenvolve a atividade, continuam sendo pouco favoráveis para alguns produtores, em conseqüência da disparidade dos agentes sociais e de seu poder de negocia o. ABSTRACT The work is part of the advances arrived in the project of investigation credited by the National University of Entre Ríos (UNER). “The integrated chiken-raising farms of Entre Ríos, technology change and re-conversion “ School of Economics Sciences, UNER, file 4028-2 UNER, 2004/2007. The work tries to give account of the organizational modalities of the chiken-raising chain of Entre Ríos, in the lasts years, particularly in period 2001 - 2005, in which the predominant characteristic was marked by the expansion and the growth of the sector, and its impact in the social and technological characteristics of the farms, according to the different existing productive zones of chickens. From the work it can conclude that, although an increase in the capacity of production accompanied by certain technological advance has taken place, from the plane of the producing zones and the involved agents there are many heterogeneities, in where the yield and the conditions in which the activity is carried out, follow not being the most favorable for some farmers because of the disparities of the social agents and it power of negotiation. RESUMEN El trabajo es parte de los avances arribados en el proyecto de investigación acreditado por la Universidad Nacional de Entre Ríos (UNER). “Las granjas avícolas integradas de Entre Ríos, cambio tecnológico y reconversión”, Facultad de Ciencias Económicas, UNER, Expte. 4028-2 UNER, período 2004/2007. El trabajo pretende analizar y exp
National Background is Associated with Disparities in Initiation and Persistence to Statin Treatment in Subjects with Diabetes in Denmark
Helena Dominguez
Frontiers in Pharmacology , 2010, DOI: 10.3389/fphar.2010.00142
Abstract: Background: To investigate the effects of statin use over the last 10 years among diabetic patients who initiated glucose-lowering medications (GLMs) in Denmark. Methods: we identified all Danish citizens 30 years and older who claimed their first GLM between 1997 and 2006, with follow-up until 2007. Use of medications, national background, income, and hospitalizations were obtained by cross-linkage of national registries in Denmark. We analyzed factors related to initiation and interruption of statin treatment. The analyses included country of birth, citizenship and, as proxy for ethnic origin, we constructed variables based on both the subjects and on their parent’s country of birth. Countries were grouped as Denmark, Western countries, Eastern countries, and Africa. Results: the cohort included 143,625 subjects. Compared with persons of Danish origin, the initiation of a statin medication during follow-up was significantly lower among patients of non-Danish origin: Odds ratio for subjects of Eastern origin 0.61 [CI 0.49–0.76] and 0.37 for subjects of African origin, [CI 0.24–0.59], both p < 0.001. The risk of interrupting statin treatment once it had been initiated was also higher in these groups (hazard ratio 2.03, [CI 1.91–2.17] for Eastern subjects and 1.94, [CI 1.63–2.32] for African subjects, both p < 0.0001). Combination of ethnic parameters to refine identification of the cohort led to the same conclusions as the analysis based only on country of birth or citizenship respectively. Conclusion: diabetes patients of African and Eastern origin in Denmark have less chance of being treated with a statin than those of western and Danish origin despite similar access to the Danish health care system.
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