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Search Results: 1 - 10 of 554644 matches for " Fernanda M. P. Souza "
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Atypical Calcified Ganglioglioma: A Rare Case Report  [PDF]
Seizo Yamashita, Luiz Antonio Resende, Fernanda M. P. Souza, Marco Zanini, Carlos Clayton, André P. Trindade
Advances in Computed Tomography (ACT) , 2014, DOI: 10.4236/act.2014.31002

Considered rare tumors, gangliogliomas account for 0.4% - 0.9% of intracranial neoplasms. The peak of its incidence occurs between 10 and 20 years of age. These tumors are composed of glial and ganglion cells and they are relatively low-grade neoplasms associated with good prognoses. We report a case of an atypical calcified ganglioglioma in an 18-year-old woman with history of four months of stabbing right-sided parietal headache, paroxysmal. On image studies were noted the presence of thick wall calcification in gangliogliomas. Although rare, this atypical ganglioglioma should be included in the differential diagnosis of lesions occurring in this area of the brain.

Importancia dos testes sorológicos de triagem e confirmatórios na detec??o de doadores de sangue infectados pelo vírus da hepatite C
Garcia, Fernanda B.;Gomide, Geisa P. M.;Pereira, Gilberto A.;Moraes-Souza, Helio;
Revista Brasileira de Hematologia e Hemoterapia , 2008, DOI: 10.1590/S1516-84842008000300011
Abstract: serological screening of blood donors with low indexes of infection, including hepatitis c virus (hcv), accounts for a substantial percentage of false-positive results with consequent loss of non-infected blood components. the aim of this study was to evaluate the occurrence of hepatitis c using confirmatory tests for blood donors with positive or inconclusive results at hemocentro regional de uberaba (hru). confirmatory tests were performed by the detection of hcv rna in plasma using qualitative rt-pcr. the study was carried out from 1992 to 2005 for 171,027 blood donors, 24.3% first-time and 75.7% repeat donors. the ineligibility rate to hcv was 0.3% (561 donors) with 52.9% of them being first-time donors and 47.0% repeat donors with prevalences of 0.5% and 0.2% respectively (p<0.0001). the rate of inconclusive results was significantly higher among repeat donors (p=0.0214). ninety-eight samples were subjected to qualitative pcr and only 34.7% (34) had positive results, with a significantly lower rate of positiveness for repeat donors (p = 0.0184) and almost a threefold lower rate of inconclusive results for the same donors. these results showed that, for a large number of donors with positive and inconclusive tests for anti-hcv, the infection was not confirmed. we concluded that serological ineligibility for hepatitis c of donors at hru was not always associated with the presence of viral infection.
Amblyomma tigrinum no Município de Lages, SC e observa??es da biologia em condi??es de laboratório
Cardoso, Cristina P.;Stalliviere, Fernanda M.;Schelbauer, Crisciane A.;Souza, Antonio P. de;Bellato, Valdomiro;Sartor, Amélia A.;
Revista Brasileira de Parasitologia Veterinária , 2008, DOI: 10.1590/S1984-29612008000100013
Abstract: to study the biological features of amblyomma tigrinum, samples of engorged females collected from dogs in the city of lages, sc, brazil, were maintained in petri dishes into an incubator at 27±1oc and 80±10% rh, for egg laying. for the development of the subsequent experimental phases, artificial infestations were performed in rabbits using the technique of the cotton bag glued to the ear's base. the mean period of hatch, feeding and larval molt were 11.67, 5.93 and 10.96 days, respectively, whereas the mean period of feeding and nymph's molt were 12.40 and 16.27 days, respectively. only one engorged female was obtained, with detachment observed on the 22nd day. the longevity periods for larvae, nymphs and adults were 75, 96 and 150 days respectively.
New triterpene and antibacterial labdenoic acid derivatives from Moldenhawera nutans
David, Juceni P.;Ferrari, Jailton;David, Jorge M.;Guimar?es, Alaíse G.;Lima, Fernanda W. de M.;Souza, Geórgia L. S. de;
Journal of the Brazilian Chemical Society , 2007, DOI: 10.1590/S0103-50532007000800022
Abstract: a new triterpene derivative (22b-hydroxylupeol) was isolated from the meoh extract of stems of moldenhawera nutans (leguminosae) together with labdenoic acid derivatives of common occurrence in this species. from the labd-8(17)-en-15-oic acid were prepared simple derivatives, which exhibited in vitro weak activity against staphylococcus aureus, pseudomonas aeruginosa, escherichia coli, salmonella cholerasuis, and vibrio parahaemolyticus.
Efeito do Soil-borne wheat mosaic virus sobre o metabolismo de cinco genótipos de trigo com diferentes níveis de resistência à doen?a
Souza, Rocheli de;Schons, Jurema;Brammer, Sandra P.;Prestes, Ariano M.;Scheeren, Pedro L.;Nicolini-Teixeira, Fernanda;Cecchetti, Dileta;Lanzarini, Ariane C.;
Fitopatologia Brasileira , 2005, DOI: 10.1590/S0100-41582005000400010
Abstract: the objective of this study was to verify the metabolic alterations induced by soil-borne wheat mosaic virus (sbwmv), one of the most economically harmful viruses infecting wheat (triticum aestivum) farming. the study analyzed the levels of soluble proteins and determined the activities of peroxidase and protease in four wheat cultivars (brs guabiju, br 23, brs 179, brs 194) and one line (pf 980524) with different levels of resistance to the virus. the data obtained were submitted to analysis of variance, and averages were compared by duncan's test at 5%. soluble protein levels were higher in plants without symptoms, while peroxidase and protease activities were higher in plants with mosaic symptoms than in assymptomatic plants. moreover, it appeared that genotypes with high susceptibility to sbwmv have high protease activity. these results could help in the design of future studies aimed at controlling the virus through inhibition of protease.
The second step in the construction of a stigma scale of epilepsy
Salgado, Priscila C.B.;Fernandes, Paula T.;Noronha, Ana Lúcia A.;Barbosa, Fernanda D.;Souza, Elisabete A.P.;Li, Li M.;
Arquivos de Neuro-Psiquiatria , 2005, DOI: 10.1590/S0004-282X2005000300005
Abstract: rationale: the issue of stigmatization is one of the most common psychosocial problems faced by people with epilepsy. purpose: a second step towards the development of a scale to measure epilepsy stigma. method: we applied a closed questionnaire to 12 patients and 32 relatives from the epilepsy outpatient clinic at the university hospital of campinas. results: the results are grouped in three main domains: medical, social and personal areas. medical: the subjects did not know exactly what epilepsy is or how it is caused; nonetheless they know how to treat it. social: the most important areas that people with epilepsy are discriminated are at work and social relationships. patients also complained about their lack of freedom and limits on recreation activities. personal area: subjects apparently have the same feelings and thoughts about epilepsy and seizures. conclusion: this study analyzed the most common aspects presented in the questionnaire to assess epilepsy stigma for the brazilian culture which are the base to the elaboration of a stigma scale of epilepsy.
In Vitro effect of low-level laser therapy on typical oral microbial biofilms
Basso, Fernanda G.;Oliveira, Camila F.;Fontana, Amanda;Kurachi, Cristina;Bagnato, Vanderlei S.;Spolidório, Denise M. P.;Hebling, Josimeri;Costa, Carlos A. de Souza;
Brazilian Dental Journal , 2011, DOI: 10.1590/S0103-64402011000600011
Abstract: the aim of this study was to evaluate the effect of specific parameters of low-level laser therapy (lllt) on biofilms formed by streptococcus mutans, candida albicans or an association of both species. single and dual-species biofilms - ssb and dsb - were exposed to laser doses of 5, 10 or 20 j/cm2 from a near infrared ingaasp diode laser prototype (lasertable; 780 ± 3 nm, 0.04 w). after irradiation, the analysis of biobilm viability (mtt assay), biofilm growth (cfu/ml) and cell morphology (sem) showed that lllt reduced cell viability as well as the growth of biofilms. the response of s. mutans (ssb) to irradiation was similar for all laser doses and the biofilm growth was dose dependent. however, when associated with c. albicans (dsb), s. mutans was resistant to lllt. for c. albicans, the association with s. mutans (dsb) caused a significant decrease in biofilm growth in a dose-dependent fashion. the morphology of the microorganisms in the ssb was not altered by lllt, while the association of microbial species (dsb) promoted a reduction in the formation of c. albicans hyphae. lllt had an inhibitory effect on the microorganisms, and this capacity can be altered according to the interactions between different microbial species.
The A Allele of the rs1990760 Polymorphism in the IFIH1 Gene Is Associated with Protection for Arterial Hypertension in Type 1 Diabetic Patients and with Expression of This Gene in Human Mononuclear Cells
Ana P. Bou?as, Letícia A. Brondani, Bianca M. Souza, Natália E. Lemos, Fernanda S. de Oliveira, Luis H. Canani, Daisy Crispim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083451
Abstract: Background The rs1990760 polymorphism of interferon induced with helicase C domain 1 (IFIH1) has been associated with type 1 diabetes mellitus (T1DM). Here, we investigated whether this polymorphism is associated with T1DM or its clinical characteristics in a Brazilian population, and if IFIH1 gene expression in mononuclear cells from T1DM patients differs according to the genotypes of this polymorphism. A meta-analysis was also conducted to evaluate if the rs1990760 polymorphism is associated with T1DM. Methods Frequencies of the rs1990760 polymorphism were analyzed in 527 T1DM patients and in 517 healthy subjects. IFIH1 gene expressions according to genotypes were measured in a sub-sample of 26 T1DM patients by quantitative real-time PCR. Results Our data show the association of the A allele with risk to T1DM under a dominant model of inheritance [odds ratio (OR) = 1.421, P = 0.037], adjusting for ethnicity. The meta-analysis revealed significant association between the rs199760A allele and risk for T1DM for all analyzed inheritance models. Surprisingly, T1DM patients carrying the A allele showed lower levels of systolic (P = 0.001) and diastolic (P = 1×10?10) blood pressures as compared to G/G carriers. Furthermore, the A/A genotype seems to be associated with protection to arterial hypertension (AH) after adjustment for covariates (OR = 0.339, P = 0.019). IFIH1 gene expression in mononuclear cells from 26 T1DM patients did not differ among genotypes (P = 0.274). Nevertheless, IFIH1 gene expression was increased in mononuclear cells from T1DM patients with AH as compared with T1DM patients without AH [6.7 (1.7–2.0) vs. 1.8 (1.3–7.1) arbitrary units; P = 0.036]. The association with blood pressures and AH was not observed in patients with type 2 diabetes mellitus. Conclusions Our results indicate that the rs1990760 polymorphism is associated with T1DM. Interestingly, the rs1990760 A allele seems to be associated with protection for AH in T1DM patients. Further studies are needed to confirm the association with AH.
A murine model of xenotransplantation of human glioblastoma with imunosupression by orogastric cyclosporin
Cunha, Alexandre M.;Nascimento, Fernanda S.;Amaral, Jane C.O.F.;Konig, Sandra;Takiya, Crhistina M.;M. Neto, Vivaldo;Rocha, Eduardo;Souza, Jorge P.B.M.;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000100021
Abstract: several animal experimental models have been used in the study of malignant gliomas. the objective of the study was to test the efficacy of a simple, reproducible and low cost animal model, using human cells of glioblastoma multiforme (gbm) xenotransplantated in subcutaneous tissue of wistar rats, immunosuppressed with cyclosporin given by orogastric administration, controlled by nonimunosuppressed rats. the animals were sacrificed at weekly intervals and we have observed gradual growth of tumor in the immunosuppressed group. the average tumor volume throughout the experiment was 4.38 cm3 in the immunosuppressed group, and 0.27 cm3 in the control one (p<0.001). tumors showed histopathological hallmarks of gbm and retained its glial identity verified by gfap and vimentin immunoreaction. immunosuppression of rats with cyclosporin was efficient in allowing the development of human glioblastoma cells in subcutaneous tissues. the model has demonstrated the maintenance of most of the histopathological characteristics of human glioblastoma in an heterotopic site and might by considered in research of molecular and proliferative pathways of malignant gliomas.
Rinoplastia endonasal: um estudo do grau de satisfa??o dos pacientes em cinco anos
Pinto, Ewaldo Bolivar de Souza;Maloof, Rachid Gorron;Dutra, Rodrigo Thiago;Carvalho, Alexandre Sanfurgo de;Morelli, Luis Humberto Uribe;Zanetta, Fernanda Provazi;Rocha, Rogério Porto da;Moía, Sandra Márcia da Silva;Abdalla, Priscila C. S. P.;
Revista Brasileira de Cirurgia Plástica , 2010, DOI: 10.1590/S1983-51752010000400013
Abstract: background: much has been discussed about the various techniques and access routes in rhinoplasty. all seek a predictable and reproducible associated with improved aesthetic and functional nose. this study evaluated the level of satisfaction of patients undergoing rhinoplasty in the past five years: by endonasal reductional rhinoplasty associated or not to rhino dynamic. methods: through a retrospective study identified 201 patients who underwent endonasal rhinoplasty the period between 2005 and 2010. all procedures were performed with the same routine as surgical indication. were evaluated in an objective manner about the surgery and subjectively about their lung function before and after surgery and the degree of satisfaction with the nasal aesthetics through a questionnaire. results: the age ranged between 14 and 68 years of age; predominant among caucasians (96.75%). 83.87% of the patients changed their minds after surgery, indicating improvement in breathing pattern. regarding the nasal aesthetic, 30 (32.26%) patients had exceeded their expectations, 42 (45.16%) felt very good, 18 (19.36%) looked as good and three (3.22%) evaluated with lower than expected. conclusion: the high degree of satisfaction with the aesthetics espoused by patients as well as lead to an improvement of respiratory function in 90% notes that the procedure performed has great result so far.
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