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Search Results: 1 - 10 of 189896 matches for " Ferhan G Sagin "
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A panel of oxidative stress assays does not provide supplementary diagnostic information in Behcet's disease patients
Yasemin D Akcay, Ferhan G Sagin, Kenan Aksu, Gokhan Keser, Emma Taylor, Iona Knight, Paul G Winyard, Eser Y Sozmen
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-13
Abstract: We aimed to measure oxidative and inflammatory markers, along with the markers of reactive nitrogen species, S-nitrosothiols and 3-nitrotyrosine, in BD patients (n = 100) and healthy volunteers (n = 50). These markers were evaluated in regard to their role in the pathogenesis of BD as well as their relation to clinical presentation, disease activity and duration.Median values for erythrocyte sedimentation rate (ESR), C-reactive protein, leukocyte count, and IL-18 levels, as well as myeloperoxidase (MPO) activity, were statistically higher in the patient group compared to controls. Some inflammation markers (ESR, neutrophil and leukocyte counts) were statistically higher (p < 0.05) in the active period. In contrast, oxidative stress-associated measures (erythrocyte lipid peroxidation, antioxidant enzymes and measures of serum antioxidant capacity), revealed no statistically significant differences between the median values in BD patients versus healthy control subjects (p > 0.05 in all statistical comparisons), nor was there any difference in median levels of these oxidative stress markers in active disease versus disease remission. S-nitrosothiols and 3-nitrotyrosine were undetectable in BD plasma.The application of oxidative stress-associated measures to BD blood samples offered no supplemental diagnostic or disease activity information to that provided by standard laboratory measures of inflammation. S-nitrosothiols and 3-nitrotyrosine appeared not to be markers for active BD; thus the search for biochemical markers that will indicate the active period should be continued with larger studies.Behcet's disease (BD) is a multisystem, chronic inflammatory, relapsing disorder that is characterized by oral and genital ulcerations and ocular, arthritic, vascular and neurological involvement. Its diagnosis is generally clinical with a higher endemic rate in Turkey, Iraq, Iran, Korea and Japan. There is no biochemical parameter showing the active phase of the disease, othe
nchopulmonary dysplasia, ophtalmological and auditory problems in prematurely born infants
Ferhan Karademir
Turk Pediatri Ar?ivi , 2010,
Abstract: Post discharge follow-up of prematurely born infants has some special concerns. Bronchopulmonary dysplasia, ophtalmological and auditory problems of these infants are discussed. (Turk Arch Ped 2010; 45: 80th Year: 23-4)
Biodegradation of Trichloroethylene (TCE) in the Presence of Phenolic Compound
Muhammad Ferhan
Journal of Biological Sciences , 2003,
Abstract: Experimental bioreactors operated as closed recirculation systems were inoculated with aerobic bacterial cultures that utilized tryptone–yeast extract as carbon and energy sources. These were inoculated with the bacterial culture, which degraded trichloroethylene (TCE) and was observed after 5 days of incubation. Each bioreactor consisted of an expanded bed column through which the liquid phase was recirculated. TCE degradation was also observed with the metabolism of aromatic hydrocarbons established for indigenous microbial population in soil and ground water, in which TCE removal has been shown to be stimulated by the addition of phenol. So co-metabolism occurred when a non-specific enzyme or co-factor was used to transform the growth supporting carbon source, also capable of degrading non-growth supporting compounds. Gas chromatography was use to monitor TCE and their metabolites which compare to run their standards and to check their retention time (tr) values. The retention time (tr) values of phenol, catechol, TCA, TCE were 7.22, 8.82, 8.55 and 2.25.
Türkiye’de 1988-2010 D neminde E itim ve Büyümenin Gen sizli ine Etkisinin Analizi (Analysis of the Impact of the Education and the Growth in Turkey from 1988 to 2010 on Youth Unemployment)
Ferhan SAYIN
Dokuz Eylül üniversitesi Sosyal Bilimler Enstitüsü Dergisi , 2011,
Abstract: Youth has an important role in the development of countries and Turkey has a large share of young people in its overall population. In that regard, Turkey should be in a position to take important steps on the way to development. However, Turkey cannot provide employment opportunities to its young population as understood by the increasing unemployment figures during the recent years. As educated young people have a higher share among the unemployed, analyzing youth unemployment is of special importance. To this end, by using a Vector Auto-regressive Model (VAR), we econometrically analyzed the impacts of education and growth on unemployment of the young people during 1988-2010. Through the variables analyzed, our findings guided us to causality from youth unemployment to secondary school enrolment, from secondary school enrolment rate to growth rate, from youth unemployment and secondary school enrolment to higher education enrolment. In the long run, apart from itself, the most important variable influencing youth unemployment was the growth rate and the higher education enrolment rate. If these variables were to be used as policy tools to combat youth unemployment, we identified that there would be a trend towards decreasing youth unemployment.
Quality of life of elderly nursing home residents and its correlates in Kayseri. A descriptive-analytical design: A cross-sectional study  [PDF]
Vesile ?enol, Ferhan Soyuer, Mahmut Argün
Health (Health) , 2013, DOI: 10.4236/health.2013.52029

Purpose: To define the level of quality of life in an elderly population and to investigate the effects of selected variables, such as anemia, fatigue, depression and sleep disorders, on the quality of life. Design and Methods: The study was conducted in Gazio?lu Nursing Home, located in the city center of Kayseri, on 136 subjects ≥65 in the year 2008-2009. Data were collected using the Geriatric Depression Scale (GDS), Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI) and the World Health Organization Quality of Life-OLD (WHOQOL- OLD) Module. In the statistical analysis mean ± standard deviation, student’s t-test, ANOVA and Spearman correlation analysis were used. Re- sults: The mean total score of quality of life was 43.45 ± 10.30. Of the residents 47.0% had a poor quality of life. Autonomy had the lowest (35.70 ± 19.96) and intimacy had the highest (48.75 ± 17.96) subdomain scores. Fatigue significantly decreased the total and autonomy, social par- ticipation and death and dying subdomain scores. Anemia had a significant adverse effect on intimacy, depression on autonomy and intimacy and sleep disorder on death and dying. There were negative correlations between fatigue with past-present-future activities and social participation, depression with social participation, intimacy, death and dying and glucose levels with social participation and intimacy. Implications: About half of the subjects had a poor quality of life. Fatigue was the sole factor to negatively affect the total score in WHOQOL-OLD. Depression, anemia and sleep disorder adversely affected the autonomy, social participation, intimacy, death and dying subdomain scores but not in all.

A rapid and robust assay for detection of S-phase cell cycle progression in plant cells and tissues by using ethynyl deoxyuridine
Edit Kotogány, Dénes Dudits, Gábor V Horváth, Ferhan Ayaydin
Plant Methods , 2010, DOI: 10.1186/1746-4811-6-5
Abstract: Applications of EdU-based S-phase assay in microscopy and flow cytometry are presented by using cultured cells of alfalfa, Arabidopsis, grape, maize, rice and tobacco. We present the advantages of EdU assay as compared to BrdU-based replication assay and demonstrate that EdU assay -which does not require plant cell wall digestion or DNA denaturation steps, offers reduced assay duration and better preservation of cellular, nuclear and chromosomal morphologies. We have also shown that fast and efficient EdU assay can also be an efficient tool for dual parameter flow cytometry analysis and for quantitative assessment of replication in thick root samples of rice.In plant cell cycle studies, EdU-based S-phase detection offers a superior alternative to the existing S-phase assays. EdU method is reliable, versatile, fast, simple and non-radioactive and it can be readily applied to many different plant systems.Detection of cell proliferation is a fundamental method for assessing cell health, determining genotoxicity, and evaluating stress responses. The most accurate method utilizes direct measurement of new DNA synthesis. Traditionally, this has been performed by incorporating tritium-labeled thymidine and detection by autoradiography [1]. Because of the involvement of radioactivity, this method has been replaced by incorporation of a thymidine analog such as bromodeoxyuridine (BrdU) into DNA, followed by immunodetection with a specific antibody raised against the thymidine analog [2]. Although being effective, this method requires DNA denaturation or digestion (using hydrochloric acid, heat or DNase) to expose BrdU to the antibody. This step is lengthy, difficult to perform consistently, and can adversely affect the morphology of the sample. Antibody-based detection method of BrdU assay also necessitates cell wall digestion in experiments carried out on plant cells. Therefore protoplasts, partially cell-wall-digested cells and organs or tissue sections are often used for
Sclerosing encapsulating peritonitis; silent danger in continuous ambulatory peritoneal dialysis patients: case report and review of the literature
Gürsel Y?ld?z,Abdulkerim Y?lmaz,?brahim ?ztoprak,Ferhan Candan
Cumhuriyet Medical Journal , 2013,
Abstract: Sclerosing encapsulating peritonitis is a rare complication of continuous ambulatory peritoneal dialysis. Sclerosing encapsulating peritonitis causes weight loss, intermittent bowel obstruction and decrease in peritoneal water and solute transport. Mortality may reach up to 50% due to severe malnutrition and ileus. Although the etiology is not fully known, many reasons such as frequent peritonitis attacks, bio-incompatibility of dialysate and catheter, intra-peritoneal contamination with clorhexidine, and use of beta-blockers are held responsible. Diagnosis is difficult in early stage. In this stage, abdominal computed tomography findings are important. It is often diagnosed during operation of the patients who developed complications such as bowel obstruction. Termination of peritoneal dialysis and providing nutritional support, use of immunosuppressive drugs, and surgical approach can be used for treatment. In this article, a 46-year-old male who had been using continuous ambulatory peritoneal dialysis as a renal replacement therapy for 9 years, presenting with peritonitis attacks, severe abdominal pain together with weight loss and was diagnosed as sclerosing encapsulating peritonitis is presented.
Physical activity in normal weight and obese university students
Ferhan Soyuer,Demet ünalan,Ferhan Elmal?3
International Journal of Human Sciences , 2010,
Abstract: The specific objective of this study was to examine the physical activity patterns among normal weight and obese university students. This cross-sectional research study was carried out on the 176 university students. As a data-collecting device, the Physical activity assessment questionnaire (FADA) was used. An additional questionnaire was administered to obtain Body Mass Index (BK ) and demographic data. 8.5% (15) of students were obese (Body Mass Index ≥ 25). The mean age, gender, where the student lived , family type, social guarantee and income were not statistically different between subjects who were normal weight and subjects who were obese (p>0.05). There was difference between normal weight and obese groups from the perspective of FADA stair, FADA sport, FADA travel and FADA total variables, in physical activity measurement (p<0.05). When the obese groups were categorized according to their total physical activity score which was obtained from FADA, 83.5 % (15) of them found as sedentary. A negatively significant correlation was found between BK and FADA stair, sport, travel, total scores (r= -0.223- 0.285, p<0.05). According to Binary logistic regression analysis, it was found that the FADA sport and total decreased, as the value of BK increased (p<0.02). Proper weight and higher physical activity levels should be promoted among university students. Additionally, schools should provide opportunities for young people to participate in a wider range of physical activities that address their individual needs while promoting the health benefits of engaging in regular exercise.
Effect of PAC addition in combined treatment of landfill leachate and domestic wastewater in semi-continuously fed batch and continuous-flow reactors
Ferhan Cecen, Ozgur Aktas
Water SA , 2001,
Abstract: The combined biological treatability of landfill leachate and domestic wastewater was investigated in both semi-continuously fed batch (SCFB) and continuous-flow (CF) activated sludges with recycle. Powdered activated carbon (PAC) was added in order to investigate the improvement in organic carbon removal and nitrification. The results obtained in SCFB and CF operations were compared to each other. In both types of operations, COD and ammonia removal efficiencies decreased with an increase in the leachate ratio of the total wastewater. As the leachate ratio increased, the positive effect of PAC on COD removal and nitrification became more apparent. In SCFB-type operations, nitrification was more inhibited than in CF operations. Additionally, the enhancement of nitrification was more apparent in CF operations than in SCFB operations where there was PAC addition. In CF operations, sufficient PAC addition could completely prevent nitrification inhibition and nitrite accumulation was avoided. With regard to nitrification, the positive impact of PAC was observed after some time since inhibition of nitrifiers was more severe than heterotrophs. WaterSA Vol.27(2) 2001: 177-188
Comparison of the effect of thermal stresses on tooth-colored posts, cores and tooth structures by finite element analysis
Ferhan Egilmez,Levent Nalbant
Cumhuriyet Dental Journal , 2012, DOI: 10.7126/cdj.2012.1092
Abstract: Objectives: The aims of this study were to analyze the influence of cold heat flow in all ceramic crown material, composite core, zirconium and glass fiber reinforced composite post materials, resin based luting cement and root dentin; and to compare these two tooth-colored post systems about their temperature and thermal stress distributions. Materials and Methods: A 3-dimesional finite element model of maxillary left canine tooth was constructed. All ceramic crown, composite core, tooth dentin, post and bone were modeled. In the first part of this study, initial body temperature was assumed to be 36.5°C and the outer temperature was reduced to 0°C for 5 secs. In the second part, the thermal stress was calculated as a result of temperature change. For the analysis, 7 nodes of the finite element model were selected and heat flow, temperature and thermal stres on these nodes were evaluated. Results: Mean temperature value was 15.75 °C for GFRC post model and 15.47 °C for Zr post model. The maximum von Mises stress was obtained at the node C in both post systems. In general, thermal stress was observed on the cervical part of all-ceramic crown and there was an interface between root dentin-composite core and post material. The temperature gradient of the GFRC post was smaller than that of the zirconia post. Conclusions: Within the limitation of this study, zirconia posts produced greater stress than GFRC posts. Temperature changes had more effect on the post-cement interface and cervical areas than on the other areas.
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