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Search Results: 1 - 10 of 42586 matches for " Fengyan Xu "
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Interior Space Design of Community Activity Center Based on Service Function  [PDF]
Fengyan Shao
Open Journal of Social Sciences (JSS) , 2019, DOI: 10.4236/jss.2019.75017
Abstract: Community activity center is a public space to serve the community masses, which is also the purpose of its existence. The function of community activity center will be adjusted according to the different service population, so the determination of service population and demand is the key to the division and layout of spatial function. This article takes the community service crowd as the breakthrough point, analyzes the different behavior pattern and the use demand of the service crowd, carries on the interior space design to the community activity center based on the service function, promotes the design of public space and the construction of spiritual civilization in the community, and serves the people of the community to live and work in peace and contentment.
Association of CD40 Gene Polymorphisms with Sporadic Breast Cancer in Chinese Han Women of Northeast China
Chen Shuang, Li Dalin, Yuan Weiguang, Fu Zhenkun, Xu Fengyan, Pang Da, Dianjun Li
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023762
Abstract: Background Breast cancer is a polygenetic disorder with a complex inheritance pattern. Single nucleotide polymorphisms (SNPs), the most common genetic variations, influence not only phenotypic traits, but also interindividual predisposition to disease, treatment outcomes with drugs and disease prognosis. The co-stimulatory molecule CD40 plays a prominent role in immune regulation and homeostasis. Accumulating evidence suggests that CD40 contributes to the pathogenesis of cancer. Here, we set out to test the association between polymorphisms in the CD40 gene and breast carcinogenesis and tumor pathology. Methodology and Principal Findings Four SNPs (rs1800686, rs1883832, rs4810485 and rs3765459) were genotyped by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method in a case-control study including 591 breast cancer patients and 600 age-matched healthy controls. Differences in the genotypic distribution between breast cancer patients and healthy controls were analyzed by the Chi-square test for trends. Our preliminary data showed a statistically significant association between the four CD40 gene SNPs and sporadic breast cancer risk (additive P = 0.0223, 0.0012, 0.0013 and 0.0279, respectively). A strong association was also found using the dominant, recessive and homozygote comparison genetic models. In the clinical features analysis, significant associations were observed between CD40 SNPs and lymph node metastasis, human epidermal growth factor receptor 2 (C-erbB2), estrogen receptor (ER), progesterone receptor (PR) and tumor protein 53 (P53) statuses. In addition, our haplotype analysis indicated that the haplotype Crs1883832Grs4810485, which was located within the only linkage disequilibrium (LD) block identified, was a protective haplotype for breast cancer, whereas Trs1883832Trs4810485 increased the risk in the studied population, even after correcting the P value for multiple testing (P = 0.0337 and 0.0430, respectively). Conclusions and Significance Our findings primarily show that CD40 gene polymorphisms contribute to sporadic breast cancer risk and have a significant association with clinicopathological features among Chinese Han women from the Heilongjiang Province.
Association of OX40L Polymorphisms with Sporadic Breast Cancer in Northeast Chinese Han Population
Yuan Weiguang, Li Dalin, Xu Lidan, Cai Yonggang, Chen Shuang, Liu Yanhong, Xu Fengyan, Fu Zhenkun, Pang Da, Li Dianjun
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041277
Abstract: OX40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of OX40-OX40L is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. The genetic variants of OX40L can increase the risk of SLE, atherosclerosis, systemic sclerosis and show gender-specific effects in some studies. Accordingly, we performed a case-control study including 557 breast cancer patients and 580 age- and sex-matched healthy controls to investigate whether single nucleotide polymorphisms (SNPs) in the OX40L gene are associated with sporadic breast cancer susceptibility and progression in Chinese Han women. Seven SNPs of OX40L (rs6661173, rs1234313, rs3850641, rs1234315, rs12039904, rs844648 and rs10912580) were genotyped with the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results indicated that rs3850641G allele could increase the susceptibility to breast cancer (P = 0.009662), even in the validation study (P = 0.0001515). A significant association between rs3850641 and breast cancer risk was observed under the additive model and dominant model (P = 0.01042 and 0.01942, respectively). The haplotype analysis showed that haplotype Ars844648Ars10912580 was significantly associated with breast cancer, even after 10,000 permutations for haplotypes in block only (P = 0.0003). In clinicopathologic features analysis, the association between rs1234315 and C-erbB2 status was significant (P = 0.02541). Our data primarily indicates that rs3850641 of OX40L gene contributes to sporadic breast carcinogenesis in a northeast Chinese Han population.
Investigation of CD28 Gene Polymorphisms in Patients with Sporadic Breast Cancer in a Chinese Han Population in Northeast China
Shuang Chen, Qing Zhang, Liming Shen, Yanhong Liu, Fengyan Xu, Dalin Li, Zhenkun Fu, Weiguang Yuan, Da Pang, Dianjun Li
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048031
Abstract: Background CD28 is one of a number of costimulatory molecules that play crucial roles in immune regulation and homeostasis. Accumulating evidence indicates that immune factors influence breast carcinogenesis. To clarify the relationships between polymorphisms in the CD28 gene and breast carcinogenesis, a case-control study was conducted in women from Heilongjiang Province in northeast of China. Methodology/Principal Findings Our research subjects consisted of 565 female patients with sporadic breast cancer and 605 age- and sex-matched healthy controls. In total, 12 single nucleotide polymorphisms (SNPs) in the CD28 gene were successfully determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The relationship between the CD28 variants and clinical features, including histological grade, tumor size, lymph node metastasis, human epidermal growth factor receptor 2 (C-erbB2), estrogen receptor (ER), progesterone receptor (PR), and tumor protein 53 (P53) status were analyzed. A statistically significant association was observed between rs3116496 and breast cancer risk under different genetic models (additive P = 0.0164, dominant P = 0.0042). Different distributions of the rs3116496 ‘T’ allele were found in patients and controls, which remained significant after correcting the P value for multiple testing using Haploview with 10,000 permutations (corrected P = 0.0384). In addition, significant associations were observed between rs3116487/rs3116494 (D’ = 1, r2 = 0.99) and clinicopathological features such as C-erbB2 and ER status, in breast cancer patients. Conclusions/Significance Our findings indicate that CD28 gene polymorphisms contribute to sporadic breast cancer risk and have a significant association with clinicopathological features in a northeast Chinese Han population.
ICOS gene polymorphisms are associated with sporadic breast cancer: a case-control study
Fengyan Xu, Dalin Li, Qiujin Zhang, Zhenkun Fu, Jie Zhang, Weiguang Yuan, Shuang Chen, Da Pang, Dianjun Li
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-392
Abstract: In the study cohort, we genotyped five SNPs (rs11889031, rs10932029, rs4675374, rs10183087 and rs10932037) in ICOS gene among 609 breast cancer patients and 665 age-matched healthy controls. Furthermore, the positive results were replicated in an independent validation cohort of 619 patients and 682 age-matched healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the genotypes.In rs10932029, compared with TT genotype and T allele, the CT genotype and C allele showed a significantly increased risk of breast cancer (P = 0.030, OR = 1.467, 95% CI 1.037-2.077; P = 0.017, OR = 1.481, 95% CI 1.070-2.049, respectively), and the associations were also significant in the validation cohort (P = 0.002, OR = 1.693, 95% CI 1.211-2.357; P = 0.003, OR = 1.607, 95% CI 1.171-2.204, respectively). Haplotype analysis showed that CTCAC haplotype containing rs10932029 T allele had a lower frequency in cases than in controls (P = 0.015), whereas haplotype CCCAC containing rs10932029 C allele was more common in cases than in controls (P = 0.013). In the analysis of clinicopathologic features, rs11889031 CT genotype and T allele were associated with progesterone receptor (PR) status and lymph node metastasis, which were further supported by our validation cohort. Moreover, some haplotypes were associated with estrogen receptor (ER) and PR statuses.These results indicate that ICOS gene polymorphisms may affect the risk of breast cancer and show that some SNPs are associated with breast cancer characteristics in a northern Chinese population.Breast cancer is one of the most common malignant tumors contributing to the high mortality of females worldwide. The etiology of breast cancer is a complex combination of both environmental and genetic factors, so the determination of genetic polymorphism provided a new way to investigate the etiology of such complex genetic disease. Accordingly, significant associations have been demonstr
Association of TNF-α, TNFRSF1A and TNFRSF1B Gene Polymorphisms with the Risk of Sporadic Breast Cancer in Northeast Chinese Han Women
Fengyan Xu, Guiqin Zhou, Shaoli Han, Weiguang Yuan, Shuang Chen, Zhenkun Fu, Dalin Li, Hua Zhang, Dianjun Li, Da Pang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101138
Abstract: Background The interaction of tumor necrosis factor-α (TNF-α) with its receptors: TNFRSF1A and TNFRSF1B is critical for the promotion of tumor growth, invasion and metastasis. To better understand the roles of single nucleotide polymorphisms (SNPs) in the TNF-α, TNFRSF1A and TNFRSF1B genes in the development of breast cancer, we explored the associations between SNPs in these three genes and breast cancer susceptibility in northeast Chinese Han women. Methodology/Principal Findings This case-control study was conducted among 1016 breast cancer patients and 806 age-matched healthy controls. Seven SNPs in the TNF-α (rs1800629, rs361525), TNFRSF1A (rs767455, rs4149577 and rs1800693) and TNFRSF1B (rs1061622 and rs1061624) genes were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. In TNFRSF1B, the rs1061622 GT genotype and the G allele conferred a reduced susceptibility to breast cancer (P = 0.000662, OR = 0.706, 95% CI: 0.578–0.863; P = 0.002, OR = 0.769, 95% CI; 0.654–0.905, respectively). Moreover, the AG genotype, the AA genotype and the A allele in rs1061624 conferred an increased risk of breast cancer (P = 0.007, OR = 1.470, 95% CI:1.112–1.943; P = 0.00109, OR = 1.405 95% CI:1.145–1.724; P = 0.001, OR = 1.248 95% CI:1.092–1.426, respectively). These two SNPs also had associations with breast cancer risk under the dominant model. In haplotype analysis, the CTA (rs767455 C-rs4149577 T-rs1800693 A) haplotype in TNFRSF1A and the TA (rs1061622 T-rs1061624 A) haplotype in TNFRSF1B had higher frequencies in breast cancer patients (P = 0.00324; P = 0.000370, respectively), but the frequency of GG (rs1061622 G-rs1061624 G) haplotype in TNFRSF1B was lower in breast cancer patients (P = 0.000251). The associations of the three haplotypes remained significant after correcting for multiple testing. In addition, significant associations were also observed between TNFRSF1A polymorphisms and lymph node metastasis, P53, estrogen receptor (ER) and progesterone receptor (PR) statuses. Conclusions Our results suggest that rs1061622 and rs1061624 in TNFRSF1B may affect breast cancer risk, and SNPs in TNFRSF1A are associated with the clinical features of breast cancer.
A marriage of chemistry and biology
FENG Yan,
FENGYan

科学通报(英文版) , 2003,
Abstract: 1 Feature: Harvard Institute of Chemistry and Cell Biology (ICCB) One of the major challenges of post-genomic world is how to identify functions of all the proteins encoded by our genome and speed up the process of drug discovery. Harvard Institute of Chemistry and Cell Biology (ICCB) was set up in 1998 to meet this challenge by pursuing a novel field called "Chemical Biology". ICCB is headed by world-renowned chemist Dr. Stuart Schreiber and biologist Dr. Tim Mitchison. Currently ICCB consists of 14 laboratories from the Department of Cell Biology, Harvard Medical School, at Boston and the Department of Chemistry, Harvard University, at Cambridge. Three core facilities, High-throughput Screening, Analytical Chemistry and Biological/Chemical Informatics, are open to the whole Harvard research community for identification of novel chemical ligands for interested biology. ICCB currently employs about 50 researchers and occupies around 10000 sq. ft. of lab space at Harvard Medical School campus. ICCB is supported by grants from NCI and NIGMS as well as by private funding from Merck, Merck KGaA, and the Keck foundation.
Error Estimates of Runge-Kutta Discontinuous Galerkin Methods for the Vlasov-Maxwell System
He Yang,Fengyan Li
Mathematics , 2013,
Abstract: In this paper, error analysis is established for Runge-Kutta discontinuous Galerkin (RKDG) methods to solve the Vlasov-Maxwell system. This nonlinear hyperbolic system describes the time evolution of collisionless plasma particles of a single species under the self-consistent electromagnetic field, and it models many phenomena in both laboratory and astrophysical plasmas. The methods involve a third order TVD Runge-Kutta discretization in time and upwind discontinuous Galerkin discretizations of arbitrary order in phase domain. With the assumption that the exact solution has sufficient regularity, the $L^2$ errors of the particle number density function as well as electric and magnetic fields at any given time $T$ are bounded by $C h^{k+\frac{1}{2}}+C\tau^3$ under a CFL condition $\tau /h \leq \gamma$. Here $k$ is the polynomial degree used in phase space discretization, satisfying $k \geq \left \lceil \frac{d_x + 1}{2} \right \rceil$ (the smallest integer greater than or equal to $\frac{d_x+1}{2}$, with $d_x$ being the dimension of spatial domain), $\tau$ is the time step, and $h$ is the maximum mesh size in phase space. Both $C$ and $\gamma$ are positive constants independent of $h$ and $\tau$, and they may depend on the polynomial degree $k$, time $T$, the size of the phase domain, certain mesh parameters, and some Sobolev norms of the exact solution. The analysis can be extended to RKDG methods with other numerical fluxes and to RKDG methods solving relativistic Vlasov-Maxwell equations.
Identification of Genome-Wide Variations among Three Elite Restorer Lines for Hybrid-Rice
Shuangcheng Li, Shiquan Wang, Qiming Deng, Aiping Zheng, Jun Zhu, Huainian Liu, Lingxia Wang, Fengyan Gao, Ting Zou, Bin Huang, Xuemei Cao, Lizhi Xu, Chuang Yu, Peng Ai, Ping Li
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030952
Abstract: Rice restorer lines play an important role in three-line hybrid rice production. Previous research based on molecular tagging has suggested that the restorer lines used widely today have narrow genetic backgrounds. However, patterns of genetic variation at a genome-wide scale in these restorer lines remain largely unknown. The present study performed re-sequencing and genome-wide variation analysis of three important representative restorer lines, namely, IR24, MH63, and SH527, using the Solexa sequencing technology. With the genomic sequence of the Indica cultivar 9311 as the reference, the following genetic features were identified: 267,383 single-nucleotide polymorphisms (SNPs), 52,847 insertion/deletion polymorphisms (InDels), and 3,286 structural variations (SVs) in the genome of IR24; 288,764 SNPs, 59,658 InDels, and 3,226 SVs in MH63; and 259,862 SNPs, 55,500 InDels, and 3,127 SVs in SH527. Variations between samples were also determined by comparative analysis of authentic collections of SNPs, InDels, and SVs, and were functionally annotated. Furthermore, variations in several important genes were also surveyed by alignment analysis in these lines. Our results suggest that genetic variations among these lines, although far lower than those reported in the landrace population, are greater than expected, indicating a complicated genetic basis for the phenotypic diversity of the restorer lines. Identification of genome-wide variation and pattern analysis among the restorer lines will facilitate future genetic studies and the molecular improvement of hybrid rice.
A three-dimensional diffusion equation of suspended sediment by waves and currents
Pingxing Ding,Fengyan Shi,Yazhen Kong
Chinese Science Bulletin , 1999, DOI: 10.1007/BF02886167
Abstract: Based on the law of mass conservation, a general three-dimensional diffusion equation of suspended sediment due to waves and currents, adaptable to estuarial and coastal areas, is derived by decomposing the instantaneous velocities and concentrations into three-different-time-scale components respectively. A three-dimensional suspended sediment diffusion equation adaptable to actual calculations is available as the result of the parameterizations of turbulent diffusion term and wave diffusion term. Different from the former diffusion equations, the influence of waves and currents on suspended sediment diffusion can be simultaneously reflected in the newly derived equation.
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