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Search Results: 1 - 10 of 9883 matches for " Felix Fl?ricke "
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In Vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch
Alexander A Hanke, Stephanie Maschler, Herbert Sch?chl, Felix Flricke, Klaus G?rlinger, Klaus Zanger, Peter Kienbaum
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2011, DOI: 10.1186/1757-7241-19-12
Abstract: The study was designed as experimental non-randomized comparative in vitro study. Following institutional review board approval and informed consent blood samples were taken from 10 healthy volunteers and diluted in vitro with either HH (HyperHaes?, Fresenius Kabi, Germany), hypertonic saline (HT, 7.2% NaCl), hydroxyethylstarch (HS, HAES6%, Fresenius Kabi, Germany) or NaCl 0.9% (ISO) in a proportion of 5%, 10%, 20% and 40%. Coagulation was studied in whole blood by rotation thrombelastometry (ROTEM) after thromboplastin activation without (ExTEM) and with inhibition of thrombocyte function by cytochalasin D (FibTEM), the latter was performed to determine fibrin polymerisation alone. Values are expressed as maximal clot firmness (MCF, [mm]) and clotting time (CT, [s]). Platelet aggregation was determined by impedance aggregrometry (Multiplate) after activation with thrombin receptor-activating peptide 6 (TRAP) and quantified by the area under the aggregation curve (AUC [aggregation units (AU)/min]). Scanning electron microscopy was performed to evaluate HyperHaes induced cell shape changes of thrombocytes.Statistics: 2-way ANOVA for repeated measurements, Bonferroni post hoc test, p < 0.01.Dilution impaired whole blood coagulation and thrombocyte aggregation in all dilutions in a dose dependent fashion. In contrast to dilution with ISO and HS, respectively, dilution with HH as well as HT almost abolished coagulation (MCFExTEM from 57.3 ± 4.9 mm (native) to 1.7 ± 2.2 mm (HH 40% dilution; p < 0.0001) and to 6.6 ± 3.4 mm (HT 40% dilution; p < 0.0001) and thrombocyte aggregation (AUC from 1067 ± 234 AU/mm (native) to 14.5 ± 12.5 AU/mm (HH 40% dilution; p < 0.0001) and to 20.4 ± 10.4 AU/min (HT 40% dilution; p < 0.0001) without differences between HH and HT (MCF: p = 0.452; AUC: p = 0.449).HH impairs platelet function during in vitro dilution already at 5% dilution. Impairment of whole blood coagulation is significant after 10% dilution or more. This effect can be pinpoin
On Jacobian algebras associated with the once-punctured torus
Charlotte Ricke
Mathematics , 2014,
Abstract: We consider two non-degenerate potentials for the quiver arising from the once-punctured torus, which are a natural choice to study and compare: the first is the Labardini-potential, yielding a finite-dimensional Jacobian algebra, whereas the second potential gives rise to an infinite dimensional Jacobian algebra. In this paper we determine the graph of strongly reduced components for both Jacobian algebras. Our main result is that the graph is connected in both cases. Plamondon parametrized the strongly reduced components for finite-dimensional algebras using generic g-vectors. We prove that the generic g-vectors of indecomposable strongly reduced components of the finite-dimensional Jacobian algebra are precisely the universal geometric coefficients for the once-punctured torus, which were determined by Reading.
Interventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with colorectal liver metastases: A phase II-study and historical comparison with the surgical approach
Bert Hildebrandt, Maciej Pech, Annett Nicolaou, Jan M Langrehr, Jacek Kurcz, Birgit Bartels, Alexandra Miersch, Roland Felix, Peter Neuhaus, Hanno Riess, Bernd D?rken, Jens Ricke
BMC Cancer , 2007, DOI: 10.1186/1471-2407-7-69
Abstract: 41 patients with isolated liver metastases of colorectal cancer were enrolled into a phase II-study and provided with IIPCS between 2001 and 2004 (group A). The primary objective of the trial was defined as evaluation of device-related complications and port duration. Results were compared with those observed in a pre-defined historical collective of 40 patients treated with HAI via SIPCS at our institution between 1996 and 2000 (group B).Baseline characteristics were balanced between both groups, except for higher proportions of previous palliative pre-treatment and elevated serum alkaline phosphatase in patients of group A. Implantation of port catheters was successful in all patients of group A, whereas two primary failures were observed in group B. The frequency of device-related complications was similar between both groups, but the secondary failure rate was significantly higher with the use of surgical approach (17% vs. 50%, p < 0.01). Mean port duration was significantly longer in the interventional group (19 vs. 14 months, p = 0.01), with 77 vs. 50% of devices functioning at 12 months (p < 0.01). No unexpected complications were observed in both groups.HAI via interventionally implanted port catheters can be safely provided to a collective of patients with colorectal liver metastases, including a relevant proportion of preatreated individuals. It appears to offer technical advantages over the surgical approach.The role of hepatic arterial infusion in patients with colorectal liver metastases has been frequently studied throughout the past decades. More than a dozen of randomized trials have been completed in which HAI with one of the fluoropyrimidines floxuridine (FUDR) or 5-flourouracil (5-FU) was compared to intravenous drug application in patients with unresectable metastases or after resection (reviewed in [1,2]). In summary, HAI largely improved response rates in patients with unresectable disease and time to hepatic progression for both indications. H
Application of Molecular Approaches for Understanding Foodborne Salmonella Establishment in Poultry Production
Steven C. Ricke
Advances in Biology , 2014, DOI: 10.1155/2014/813275
Abstract: Salmonellosis in the United States is one of the most costly foodborne diseases. Given that Salmonella can originate from a wide variety of environments, reduction of this organism at all stages of poultry production is critical. Salmonella species can encounter various environmental stress conditions which can dramatically influence their survival and colonization. Current knowledge of Salmonella species metabolism and physiology in relation to colonization is traditionally based on studies conducted primarily with tissue culture and animal infection models. Consequently, while there is some information about environmental signals that control Salmonella growth and colonization, much still remains unknown. Genetic tools for comprehensive functional genomic analysis of Salmonella offer new opportunities for not only achieving a better understanding of Salmonella pathogens but also designing more effective intervention strategies. Now the function(s) of each single gene in the Salmonella genome can be directly assessed and previously unknown genetic factors that are required for Salmonella growth and survival in the poultry production cycle can be elucidated. In particular, delineating the host-pathogen relationships involving Salmonella is becoming very helpful for identifying optimal targeted gene mutagenesis strategies to generate improved vaccine strains. This represents an opportunity for development of novel vaccine approaches for limiting Salmonella establishment in early phases of poultry production. In this review, an overview of Salmonella issues in poultry, a general description of functional genomic technologies, and their specific application to poultry vaccine developments are discussed. 1. Introduction Salmonella induced gastroenteritis is the result of consumption of contaminated food and subsequent local infection in the gastrointestinal tract leading to symptoms of diarrhea, abdominal pain, and fever within 12 to 72 hours that can persist up to a week and in rare cases become fatal [1]. Salmonella infections are the leading cause of hospitalizations and deaths due to foodborne illness [2, 3]. Consequently, foodborne disease resulting from exposure to serovars of Salmonella continues to be a major human health concern resulting in billions of dollars in annual costs [3]. Salmonella comes in contact with food production and preparation from a wide range of sources including animal and pet feed, during food processing, at retail establishments and in the home during meal preparation [1, 4–12]. Salmonellosis occurs worldwide and can
A Cantor set in the unit sphere in $\mathbb{C}^2$ with large polynomial hull
Burglind J?ricke
Mathematics , 2004,
Abstract: It is an old question how massive polynomial hulls of Cantor sets in $\mathbb{C}^n$ can be. In contrast to expectation e.g. Rudin, Vitushkin and Henkin showed on examples that it can be rather massive. Motivated by problems of holomorphic convexity of subsets of strictly pseudoconvex boundaries and removable singularities the question was asked for Cantor sets in the unit sphere. It was known that tame Cantor sets in the unit sphere are polynomially convex. We give an example of a wild Cantor set in the sphere whose polynomial hull contains a large ball. In some sense this can be opposed to a still open conjecture of Vitushkin on the existence of a lower bound for the diameter of the largest boundary component of a relatively closed complex curve in the ball passing through the origin.
Braids, Conformal Module and Entropy
Burglind J?ricke
Mathematics , 2012,
Abstract: The conformal module of conjugacy classes of braids implicitly appeared in a paper of Lin and Gorin in connection with their interest in the 13. Hilbert Problem. This invariant is the supremum of conformal modules (in the sense of Ahlfors) of certain annuli related to the conjugacy class. This note states that the conformal module is inverse proportional to a popular dynamical braid invariant, the entropy. The entropy appeared in connection with Thurston's theory of surface homeomorphisms. An application of the concept of conformal module to algebraic geometry is given.
Braids, conformal module and entropy
Burglind J?ricke
Mathematics , 2014,
Abstract: In the paper we discuss two invariants of conjugacy classes of braids. The first invariant is the conformal module which occurred in connection with the interest in the 13th Hilbert problem. The second is a popular dynamical invariant, the entropy. It occurred in connection with Thurston's theory of surface homeomorphisms. We prove that these invariants are related: They are inverse proportional. This allows to use known results on entropy for applications to the concept of conformal module. In particular, we give a short conceptional proof of a theorem which appeared in connection with research on the Thirteen's Hilbert Problem. We also give applications of the concept of conformal module to the problem of isotopy of continuous objects involving braids to the respective holomorphic objects. The objects considered here are quasipolynomials of degree three as well as elliptic fiber bundles. A byproduct of the proof is a systematic treatment of reducible braids and of the entropy of mapping classes on Riemann surfaces of second kind, as well as expressions of entropy and conformal module of conjugacy classes of reducible braids in terms of the respective invariants of the irreducible components.
Analytic knots, satellites and the 4-ball genus
Burglind J?ricke
Mathematics , 2015,
Abstract: Call a smooth knot (or smooth link) in the unit sphere in $\mathbb{C}^2$ analytic (respectively, smoothly analytic) if it bounds a complex curve (respectively, a smooth complex curve) in the complex ball. Let $K$ be a smoothly analytic knot. For a small tubular neighbourhood of $K$ we give a sharp lower bound for the 4-ball genus of an arbitrary analytic link $L$ contained in it.
Apoptose e disfun o organica induzida pela ventila o pulmonar mecanica na SDRA
Carvalho Werther Brunow de,Le?o Flávia Vanesca Felix
Revista da Associa??o Médica Brasileira , 2003,
Abstract:
Rolle neuer Schnittbildtechniken bei Diagnose und Verlaufskontolle von chronisch entzündlichen Darmerkrankungen
Seidensticker M,Ricke J,Furth C
Journal für Gastroenterologische und Hepatologische Erkrankungen , 2010,
Abstract: Bei der Diagnostik und Verlaufskontrolle von chronisch entzündlichen Darmerkrankungen (CED) konnten sich neben den Basismethoden der Endoskopie, des Ultraschalls und der kontrastmittelgestützten Durchleuchtung neue Bildtechniken etablieren, die neben der Komplettierung der Basisdiagnostik insbesondere in der Verlaufskontrolle und der Komplikationsdiagnostik einen hohen Stellenwert erlangt haben. Neben der Computertomographie, die in der akuten Komplikationsdiagnostik (Abszess, Perforation) sicher nicht wegzudenken ist, ist hier die Magnetresonanztomographie (MRT) zu erw hnen. Mittels dieser strahlenfreien Technik ist durch neue Sequenztechniken eine komplement re Diagnostik des gesamten Abdomens zu erzielen, wobei durch orale Aufnahme von Kontrastmitteln eine Distension und Beurteilbarkeit des Dünn- und Dickdarms erzielt wird. Mit der MRT konnte eine Sensitivit t von 80 % in der Detektion von entzündlichen Darmabschnitten erreicht werden. Da Patienten mit einer CED in der Regel auf repetitive Untersuchungen im Krankheitsverlauf angewiesen sind und die Erkrankungen h ufig bereits im Kindesalter beginnen, ist der strahlungsfreie Charakter der MRT hervorzuheben. Der Beitrag wird durch Fallbeispiele aus der Praxis im Anhang abgerundet.
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