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Search Results: 1 - 10 of 102708 matches for " Felipe José Fernández Coimbra "
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Molecular Analyses of Early-Onset Gastric Cancer in Brazilian Patients: TP53 Mutations, Cadherin-Catenin and Mucins Proteins Expression  [PDF]
Edaise Maria da Silva, José Humberto Tavares Guerreiro Fregnani, Ghyslaine Martel, Wilson Luiz Costa Jr., Felipe José Fernández Coimbra, Maria Isabel Waddington Achatz, Pierre Hainaut, Fernando Augusto Soares
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41A005

Early gastric carcinomas may develop with a molecular profile differing from sporadic carcinomas occurring at a later age. In this study, we analyzed a retrospective series of 88 patients with gastric adenocarcinoma diagnosed before the age of 45 years for the presence of TP53 mutations, clinicopathological features and immunohistochemistry to evaluate the expression of markers considered to be important in gastric carcinogenesis (E-cadherin, β-catenin, MUC1, MUC2, MUC5AC, MUC6 and p53). The majority of proportion of tumors were diffuse-type (70%) and advanced stage (56%). Familial history of cancer was positive in 21% of the cases. There was a significant association between altered expression of E-cadherin and β-catenin, and between p53 expression and perineural invasion. TP53 mutations were detected in 14.5% of evaluated cases, including a germline mutation (p.R337H) in a 12-year old patient. Overall survival analysis showed significant differences in relation with tumor stage and histopathology. The evaluated biomarkers did not present prognostic value in non-exploratory multivariate analyses. The low frequency of TP53 mutations in this series suggests these alterations are not a major molecular event in gastric cancer occurring at early age, although the identification of a case with germline p.R337H mutation is consistent with the hypothesis that a small proportion of early, apparently sporadic gastric cancer, may be associated with widespread Brazilian founder mutations. Further studies are needed to evaluate the prognostic significance of markers for specific groups of patients according to tumor histology and familial history.

Avan?os no tratamento cirúrgico das metástases hepáticas colorretais
Coimbra, Felipe José Fernández;Pires, Thiago Costa;Costa Junior, Wilson Luiz da;Diniz, Alessandro Landskron;Ribeiro, Héber Salvador de Castro;
Revista da Associa??o Médica Brasileira , 2011, DOI: 10.1590/S0104-42302011000200022
Abstract: colorectal cancer is the 3rd most common malignant neoplasm in the west. about 50% of patients develop liver metastases throughout the course of the disease. those are responsible for at least two-thirds of deaths. advances in surgical techniques and improvement in chemotherapy regimens have allowed offering treatment with curative intent to an increasing number of patients. this article reviews recent advances in the treatment of liver metastases, including strategies to increase resection (e.g., portal vein embolization, radiofrequency ablation, two-stage hepatectomy, conversion therapy and reverse treatment strategy) and hepatectomy in the presence of extrahepatic disease. finally, the results of surgical treatment of liver metastases at the hospital a.c. camargo are briefly shown.
Experiencia en cirugía oncoplástica en cáncer de mama
Fernández,Anyelin; Aguilar,Daysi; Gutiérrez,Néstor; Saldivia,Felipe; Prince,José; Ramos,Silvia;
Revista Venezolana de Oncología , 2010,
Abstract: objective: oncoplastic surgery is defined as the use of plastic surgery techniques in oncological procedures for breast cancer. evaluate the experience in oncological institute ?dr. miguel perez carre?o?, from 2000 - 2008. methods: a descriptive, retrospective study was performed. the clinical charts of 49 patients with diagnosis of breast cancer managed with reconstructive surgery after undergoing radical cancer treatment were reviewed. we evaluated age of the patients, histological diagnosis, location of primary tumor, stage, neoadjuvant and adjuvant therapy received type of oncoplastic surgery performed, reconstruction timing, appearance, location of relapse as well as postoperative complications encountered. results: of the 49 patients evaluated 27 % had ages between 41-50 years. the most frequent histological type was infiltrating ductal adenocarcinoma (90 %). the stage of the disease most commonly observed was iib (29 %). 56.% of patients received adjuvant therapy 72 % neoadjuvant therapy. the type of reconstructive surgery most commonly performed was prosthesis placement with preservation of the nipple areola complex (41 %) and reconstruction with transverse rectus abdominus myocutaneous flap (20 %). the 63 % of patients developed distant disease. 67 % of patients underwent immediate reconstruction. flap necrosis was seen in 12 % of cases. conclusion: surgical treatment of breast cancer has become oncologically radical with immediate reconstruction, depending on the conditions of each patient and the technique employed. the main goal is to provide effective treatment and aesthetically acceptable in order to improve the quality of life.
Fibroscopia o traqueostomía en cirugía maxilofacial
Díaz Fernández,José Manuel; Gómez Pacheco,Felipe; Pérez Arredondo,Ricardo;
Revista Cubana de Cirug?-a , 1998,
Abstract: certain maxillofacial conditions may lead to a compulsory tracheostomy and even, after some years, to fiberscope-assisted intubation before proceeding to a general anesthesia surgery. the fiber optic endoscopy is an effective but delicate method requiring a staff specially trained in difficult intubation since this technique avoids the disturbances of tracheostomy. indications and results of the fiberscope-aided intubation in non anesthetized patients are set forth
Fibroscopia o traqueostomía en cirugía maxilofacial
José Manuel Díaz Fernández,Felipe Gómez Pacheco,Ricardo Pérez Arredondo
Revista Cubana de Cirugía , 1998,
Abstract: Determinadas condiciones maxilofaciales pueden obligar a la realización de una traqueostomía e incluso, después de algunos a os, a una intubación con ayuda de un fibroscopio flexible con luz fría, antes de proceder a la operación con anestesia general. La fibroscopia es un método eficaz, pero delicado, que requiere la presencia de un personal especialmente entrenado para intubaciones difíciles, puesto que permite evitar las molestias de la traqueostomía. Se exponen las indicaciones y los resultados de la técnica de intubación, con auxilio del fibroscopio, en pacientes no anestesiados Certain maxillofacial conditions may lead to a compulsory tracheostomy and even, after some years, to fiberscope-assisted intubation before proceeding to a general anesthesia surgery. The fiber optic endoscopy is an effective but delicate method requiring a staff specially trained in difficult intubation since this technique avoids the disturbances of tracheostomy. Indications and results of the fiberscope-aided intubation in non anesthetized patients are set forth
Metástasis óseas en adenocarcinoma de mama
Fernández,Anyelin; Hernández,Aura; Martínez,Lisbet; Urbistazu,Jon; Saldivia,Felipe; Prince,José; Mora,Eddy V;
Revista Venezolana de Oncología , 2008,
Abstract: objective: bone metastasis still represents one of the main complications of breast cancer during the follow up of these patients. the objective of the current series was to determine the prevalence of bone metastasis in patients diagnosed of breast adenocarcinoma at our center, the location and number of lesions, treatment selected and the overall patient survival. methods: a retrospective study of a group of female patients with a diagnosis of breast adenocarcinoma and bone metastasis was carried out during a ten year period, between the years 1996 and 2005. medical charts of 1 610 women were analyzed. results: we found 200 cases with bone metastases, 90 % were diagnosed by bone scans. the ages of these patients ranged between 41 and 50 years. metastatic bone disease was multiple in 55 % of cases. all the patients received radiotherapy treatment. the main location of the bone lesions was the spine, accounting for 33 % of all cases. overall survival was one year in this group. conclusions: bone metastasis is a frequent clinical finding in the setting of breast adenocarcinoma. prognosis is dismal and it is corroborated when we compare our results to those reported in the literature.
Alternative Sensor System and MLP Neural Network for Vehicle Pedal Activity Estimation
Ahmed M. Wefky,Felipe Espinosa,José A. Jiménez,Enrique Santiso,José M. Rodríguez,Alfredo J. Fernández
Sensors , 2010, DOI: 10.3390/s100403798
Abstract: It is accepted that the activity of the vehicle pedals (i.e., throttle, brake, clutch) reflects the driver’s behavior, which is at least partially related to the fuel consumption and vehicle pollutant emissions. This paper presents a solution to estimate the driver activity regardless of the type, model, and year of fabrication of the vehicle. The solution is based on an alternative sensor system (regime engine, vehicle speed, frontal inclination and linear acceleration) that reflects the activity of the pedals in an indirect way, to estimate that activity by means of a multilayer perceptron neural network with a single hidden layer.
Adenocarcinoma gástrico: Variedad de células en anillo de sello. A propósito de un caso
González González,José Manuel; Corrales Alonso,Sahilí; Hernández Llanes,Jorge Luis; Espinosa Fernández,Osmany; Hernández Hernández,Ricardo; Felipe Fereira,Oristel I;
Revista M??dica Electr?3nica , 2009,
Abstract: the following case report gives us a follow up of a white, female 58 years-old patient, coming to a consultation for presenting dyspeptic disturbances of six-months evolution together with general syndrome and light anemia. we made panendoscopy of the high digestive tract, finding an ulcerated lesion in angular incision with malignant characteristics, endoscopically concluded as probably ulcerated gastric neoplasia, with subsequent anatomopathologic diagnostic of gastric adenocarcinoma of signet-ring cells.the patient was operated in our hospital, confirming the diagnosis with the study of the surgical piece.
Adaptación de nave-almacén existente en el lETcc, como edificio destinado a la realización de cursos y seminarios
Gómez Fernández, Felipe,Díaz-Romeral Brincas, Pablo,Díaz-Romeral Bringas, Juan,Fernández Sánchez, José
Informes de la Construccion , 1981,
Abstract: Ante la proximidad de la celebración del CEMCO 82 (Curso de Estudios Mayores de la Construcción) destinado fundamentalmente a postgraduados iberoamericanos, así como la simultánea realización de una serie de seminarios sobre temas monográficos de edificación, la Dirección del lETcc contempló la posibilidad de adaptar una nave-almacén, de una superficie aproximada de 500 m2, para albergar estos nuevos usos que permitiera, al mismo tiempo, eliminar las Interferencias que se producían en la normal actividad del Instituto cuando se celebraban este tipo de Cursos y otros similares, así como reuniones de comisiones técnicas y de elaboración de normas, que por otra parte se desarrollaban en espacios poco adecuados funcionalmente. Sí bien la adecuación de una nave exenta con referencia al edificio fundamentad del lETcc plantea algunos problemas funcionales, también permite obtener ventajas de suficiente peso sobre todo en lo que se refiere a actividades, que aunque se incluyen entre las normales del Instituto, tienen una cierta autonomía que permite puedan ser realizadas en una construcción independiente a la que por otro lado se le ha dotado de una serie de servicios que permitan su funcionamiento como unidad orgánica autosuficiente.
Differential Binary Encoding Method for Calibrating Image Sensors Based on IOFBs
Pedro R. Fernández,José Luis Lázaro-Galilea,Alfredo Gardel,Felipe Espinosa,Ignacio Bravo,ángel Cano
Sensors , 2012, DOI: 10.3390/s120404133
Abstract: Image transmission using incoherent optical fiber bundles (IOFBs) requires prior calibration to obtain the spatial in-out fiber correspondence necessary to reconstruct the image captured by the pseudo-sensor. This information is recorded in a Look-Up Table called the Reconstruction Table (RT), used later for reordering the fiber positions and reconstructing the original image. This paper presents a very fast method based on image-scanning using spaces encoded by a weighted binary code to obtain the in-out correspondence. The results demonstrate that this technique yields a remarkable reduction in processing time and the image reconstruction quality is very good compared to previous techniques based on spot or line scanning, for example.
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