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The study aimed to evaluate the in vitro properties of a new gel formulation (P-3086) as anti-aging treatment. Two in vitro methods aimed to assess and compare the efficacy of the gel formulation in reducing oxidative damages, artificially induced by UVA on skin-derived keratinocytes and in promoting the synthesis of collagen, compared with other four formulations. P-3086 reduced reactive oxygen species production after UVA stress with the highest effect observed at 0.016 mg/ml and 0.031 mg/ml concentration. P-3086 also promoted the collagen synthesis faster when compared with other formulations. The new gel product, based on hyaluronic acid, Vitamin E and Humulus lupulus, showed a good efficacy as anti-aging effect reducing the oxidative damages derived by the action of ROS, moreover stimulating the synthesis of one of the components of the connective tissue, the collagen.
Background/Purpose: In the frame of a development of a formulation to be used in perineal massage in pregnant women, a screening program was built up among compositions with elasticising properties. Methods: This was an open-label, controlled study in 21 volunteers. The participants applied once, on the volar surface of both forearms, five formulations with elasticising properties (test products 1 to 5) and a reference standard (test product 6). The formulations were applied on three sites on each forearm that were randomly assigned. Skin elasticising parameters were evaluated using the Dermal Torque Meter, at baseline and 30 minutes after application. Results: Among the test products, only test product 2 significantly increased skin elasticity compared with the baseline value, with a trend toward superiority versus the reference standard (+24% vs. +13%, respectively). There was a significant increase in elastic recovery of 23% with test product 2, compared with a significant increase of 13% with the reference standard. Conclusion: Test product 2, comprising a thiolated compound and a mixture of esters of fatty acids, had the greatest elasticising effect. Compared with the other tested formulations, product 2 led to a greater increase in extensibility and faster elastic recovery of the skin on the volar surface of the forearm.
aimed to evaluate the instrumental and clinical properties of an innovative gel
formulation for anti-aging treatment. This was an open, non-controlled study, where
the eligible subjects, divided into three subgroups according to age, had to
perform a single dose application of the gel on the face for a short-term
evaluation and a 4-week repeated use, twice a day, for a long-term evaluation.
Instrumental and clinical evaluations had to be performed mono-laterally at the
level of the face (right or left side according to a predisposed randomization
list) in basal conditions (T0), 20 minutes after the first dose
application (T20min) and after 2 and 4 weeks of treatment (T2wks - T4wks). Thirty-three subjects completed the study showing, after
only 20 minutes from the 1st product application, a clinically
important and statistically significant improvement of crow’s feet, skin
dullness clinical score and cutaneous microrelief clinical score (p < 0.05),
after 2 weeks of treatment an improvement of skin tonicity (p < 0.05) and after
4 weeks of treatment having a significant decrease of nasolabial folds clinical
score (p < 0.05). The study showed the great efficacy of an innovative
anti-aging gel in reducing the skin roughness and skin dryness, improving the
skin firmness and, in general, providing a global skin rejuvenation.
A data assimilation system combines all available information on the atmospheric state in a given time-window to produce an estimate of atmospheric conditions valid at a prescribed analysis time. Nowadays, increased computing power coupled with greater access to real-time asynoptic data is paving the way toward a new generation of high-resolution (i.e. on the order of 10 km) operational mesoscale analyses and forecasting systems. Moreover, better initial conditions are increasingly considered of the utmost importance for Numerical Weather Prediction (NWP) at the short range (0 - 12 h). This paper presents a general-purpose data assimilation system, which is coupled with the Regional Atmospheric Modelling System (RAMS) to give the analyses for: zonal and meridional wind components, temperature, relative humidity, and geopotential height. In order to show its potential, the data assimilation systems applied to produce analyses over Central Europe. For this application the background field is given by a short-range forecast (12 h) of the RAMS and analyses are produced by 2D-Var with 0.25? horizontal resolution. Results show the validity of the analyses because they are closer to the observations, consistently with the settings of the data assimilation system. To quantify the impact of improved initial conditions on the forecast, the analyses are then used as initial conditions of a short-range (6 h) forecast of the RAMS model. The results show that the RMSE is effectively reduced for the one- and two hours forecast, with some improvement for the three-hours forecast.
Mexico is the largest cactus exporter of the world and 40% of the production cost is provided from the harvest operation. Many workers are required to operate daily and suffer wrist pain after two weeks of collecting pears with mechanical pruners. A motor driven tool supplied from a photovoltaic system was employed for harvesting; different blades were tested at different cutting speeds. It was found that toothed blades sliced the pears with efficiencies over 90%. Abrasive blades were finally selected as the current required per cut was minimum, permitting a longer battery lifetime before requiring recharging.