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Search Results: 1 - 10 of 1074 matches for " Fausto; "
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Coronary flow reserve in stress-echo lab. From pathophysiologic toy to diagnostic tool
Fausto Rigo
Cardiovascular Ultrasound , 2005, DOI: 10.1186/1476-7120-3-8
Abstract: Normally coronary blood flow can increase approximately four-to-six fold to meet increasing myocardial oxygen demands. This effect is mediated by vasodilation at the arteriolar bed, which reduces vascular resistance, thereby augmenting flow. The coronary reserve (CFR) represents the capacity of the coronary circulation to dilate following an increase in myocardial metabolic demands and can be expressed by the difference between the hyperemic flow and the resting flow curve (figure 1). In 1974, Lance K Gould [1] proposed the relationship between the anatomic condition and behaviour of coronary hyperaemic flow (figure2), whereby an inverse curvilinear relationship exists between the narrowing of lumen of coronary artery and hyperaemic capability, up to a completely abolished coronary reserve for stenosis >90%. This experimental paradigm can be accurately reproduced clinically in highly selected series of patients with single vessel disease, no myocardial infarction, no coronary collateral circulation, normal baseline function, no left ventricular hypertrophy, without evidence of coronary vasospasm, and off therapy at the time of testing. The perfect, predictable relationship found in the experimental animal or in a very selected patient population [2] is not so perfect in clinical practice [3,4], where many variables can modulate the imperfect match between epicardial coronary artery stenosis and coronary flow reserve (figure 2), such as the geometric characteristics of the stenosis, the presence of coronary collateral circulation, the microvascular component of coronary resistance, the presence of left ventricular hypertrophy modulating the myocardial extravascular component of coronary resistance, the viable or necrotic state of the myocardium distal to the stenosis, the presence of coronary macrovascular or microvascular spasm, and, last but not least, the presence of concomitant anti-ischemic therapy.Up to now, coronary flow reserve has been evaluated invasively i
Genetics of SCID
Fausto Cossu
Italian Journal of Pediatrics , 2010, DOI: 10.1186/1824-7288-36-76
Abstract: Over the last years novel genetic defects causing SCID have been discovered, and the molecular and immunological mechanisms of SCID have been better characterized. Distinct forms of SCID show both common and peculiar (e.g., absence or presence of nonimmunological features) aspects, and they are currently classified into six groups according to prevalent pathophysiological mechanisms: impaired cytokine-mediated signaling; pre-T cell receptor defects; increased lymphocyte apoptosis; defects in thymus embryogenesis; impaired calcium flux; other mechanisms.This review is the updated, extended and largely modified translation of the article "Cossu F: Le basi genetiche delle SCID", originally published in Italian language in the journal "Prospettive in Pediatria" 2009, 156:228-238.The initial clinical manifestations of SCID (Severe Combined Immunodeficiency), a heterogeneous group of genetic defects with an overall incidence of about 1 in 40,000 to 75,000 newborns [1-3], are most frequently observed in the first few months of life and the median age at diagnosis is 4-7 months. However, human SCID is a prenatal disorder of T lymphocyte development, already present at birth even if clinically silent in most affected newborns.On January 1, 2008, Wisconsin (USA) became the first state in the world to screen all newborns for SCID through a method based on measurement of T cell receptor excision circles (TRECs) by polymerase chain reaction (PCR), using DNA extracted from newborn dried blood spots (Guthrie cards); TRECs are by-products generated during normal T cell maturation (Figure 1) and are consistently absent or present in very low numbers in newborns with SCID [4]. Recently an infant with SCID has been identified by newborn screening in Massachusetts [5], and the U.S. Department of Health and Human Services recommended the addition of SCID to the uniform screening panel for all newborns [6].Wisconsin SCID screening poster (Figure 2) describes the fundamental features of S
O deslocamento da popula??o brasileira para as metrópoles
Brito, Fausto;
Estudos Avan?ados , 2006, DOI: 10.1590/S0103-40142006000200017
Abstract: the aim of this article is the analysis of the brazilian urbanization process during the second half of the 20th century. for this purpose it is important to take note that the 1970 demographic census indicated that the urban population had surpassed the rural population for the first time. the rapid contemporary urbanization due to intense internal migration concentrated the urban population in the larger brazilian cities and metropolitan areas. during the last two decades, however, the growth rates of the larger cities has declined due to lower fertility rates and, more importantly, decreasing number of immigrants. indeed, the metropolitan area of s?o paulo, for example, presented negative net migration for the 1995-2000 period. although internal migration trends do not point to a process of "hipermetropolitanization", it must be taken into account that as of 2000 40% of the country?s urban population still inhabited the larger metropolitan areas.
Octavio Gouvêa de Bulh?es
Saretta, Fausto;
Estudos Avan?ados , 2001, DOI: 10.1590/S0103-40142001000100010
Abstract: this article is an attempt to synthesize the important role played by octavio gouvêa bulh?es in brazil's economy. considered a model brazilian liberal, bulh?es was a remarkably active civil servant. founder of banco central [brazil's national bank] and sumoc [a superintendency for the local currency and credit] and finance minister from 1964 to 1967, he was outstanding for his constant preoccupation about financial and monetary issues, mainly concerning inflation. in tune with the line of thought which had eugênio gudin as a leader, bulh?es published academic works dealing with economy policy issues focussing mainly on stability, in his view a fundamental factor for economic growth. a university professor and member of the instituto brasileiro de economia, octavio gouvêa bulh?es, both for his life and work, is one of the most important referential names to understand brazilian economy.
Em torno da pré-história intelectual do totalitarismo igualitarista
Fausto, Ruy;
Lua Nova: Revista de Cultura e Política , 2008, DOI: 10.1590/S0102-64452008000300008
Abstract: the article aims at some logical-historical conditions of "left-wing" totalitarianism, or "equalitarist totalitarianism". the first part intends to show that there is a blind spot in marxism - the twentieth-century hegemonic theory on the left - about democracy, and how that same blind spot gave favorable conditions to the rise of totalitarianism and its ideology. the second part traces a genesis of equalitarist totalitarianism. the outstanding reference is bolshevism as pretotalitarian ideology and practice. from that point, the article makes a double logical move: a regressive one, showing how, below marxism, bolshevism rescues the jacobinist politics and how it is going to fuse the jacobinist legacy with the previous traditions blended in marxism itself; and a progressive one, analysing the passage from bolshevik neojacobinism to the ideology and practice of stalinist neodespotism.
Trotski, a democracia e o totalitarismo (a partir do Trotsky de Pierre Broué)
Fausto, Ruy;
Lua Nova: Revista de Cultura e Política , 2004, DOI: 10.1590/S0102-64452004000200007
Abstract: the starting point of the present article is trotsky's biography by pierre broué, but it intends to be more than a mere review of the book. following trotsky's life story, it insists specially on the most democratic moments of his political life (our political tasks, 1904) and on the most authoritarian ones (the rejection of all political alliances in october 1917, the militarisation of labor etc). after that, the text analyses closely two problems related to trotsky's fate: the problem of the tension between the internal democracy within the party and the external dictatorship, and, on a more general level, the problem of the nature of the political system under lenin, and afterwards, under stalin. finally, it discusses the question of the relation between marxism, leninism and stalinism.
Entre Adorno e Lukács: dois livros de Paulo Arantes
Fausto, Ruy;
Lua Nova: Revista de Cultura e Política , 1997, DOI: 10.1590/S0102-64451997000300008
Abstract: where is the emphasis to be put, on the internal analysis in the strong sense of the word or on the historical conditions of the production of texts? since what is in question are works by an author which is at home in the universe of marxism (ressentimento da dialética and o fio da meada, by the philosopher paulo arantes), it is argued in this article devoted to a critical examinations of these books that the opposition may be stated to be between two thinkers that play central roles in arantes' works: lukács and adorno.
A polêmica sobre o poder Bolchevista: Kautsky, Lenin, Trotsky
Fausto, Ruy;
Lua Nova: Revista de Cultura e Política , 2001, DOI: 10.1590/S0102-64452001000200003
Abstract: the character of the bolclievist power is examined on the basis of texts of one of its main critics, karl kautsky, and of two of its leading figures, lenin and trotsky (including trotsky's pre-bolchevist phase). such issues as dictatorship, revolutionary terror and bureaucratic power are dealt with in this polemic.
Donos demais: maestria e domínio na Amaz?nia
Fausto, Carlos;
Mana , 2008, DOI: 10.1590/S0104-93132008000200003
Abstract: this text is concerned with a specific indigenous category - usually translated as "owner" or "master" - which, in amazonia, transcends the simple expression of a relationship of property or domain. the category and its reciprocal terms designate a generalized mode of relating that characterizes interactions between humans, between non-humans, between humans and non-humans and between persons and things. it is a key category for understanding indigenous sociologies and cosmologies, which, notwithstanding its importance, has received relatively little attention. through the analysis of ethnographical evidence, this text seeks to explore the consequences of imagining the amerindian universe as a world of owners and the owner as a model for the magnified person, in order to discuss notions of ownership, domain and power in lowland south america.
A interpreta??o do nazismo, na vis?o de Norbert Elias
Fausto, Boris;
Mana , 1998, DOI: 10.1590/S0104-93131998000100006
Abstract: this paper analyzes the significance of nazism, one of the central themes in the latest book by norbert elias. it refers to the reasons behind the perplexity of the liberal and marxist currents in dealing with the phenomenon, at least initially. beginning with this observation, the author presents elias' point of view, which strays from a kind of progress-history towards an increasingly perfected civilizatory process. it seeks to demonstrate how elias' interpretation is founded on a long-range analysis of german history, highlighting the constitution of habitus as an original explicatory concept, not to be confused with that of national character. the essay also discusses the secondary (albeit relevant) weight elias ascribes to the context of the 1920s and early 1930s in implanting nazism. finally, the author asks whether in elias' view nazism was a dated, specific phenomenon and - depending on the answer - what the possibilities might be for its reemergence in the current context.
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