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Associa??o entre a presen?a da proteína p53 e o grau de diferencia??o em carcinomas ductais invasivos de mama
Siroma, Márcia Sanae;Baracat, Fausto Farah;
Revista Brasileira de Ginecologia e Obstetrícia , 2006, DOI: 10.1590/S0100-72032006000500006
Abstract: purpose: to assess p53 protein expression in infiltrating ductal breast carcinoma and to analyze its association with histological and nuclear grade. methods: sixty-five consecutive females who were diagnosed with primary infiltrating ductal breast tumor from july 1999 to july 2001 were included in the present study. mean patient age at diagnosis was 69.2 years (range 41 - 90). all patients were first treated with surgical therapy, conservative surgery or mastectomy. none of the patients received any preoperative adjuvant therapy. resected breast tumor specimens were fixed in 10% formalin, paraffin embedded, and conserved for immunohistochemical analysis. p53 protein expression was evaluated. primary monoclonal anti-human p53 antibody do-7 (dako) was used. frequency distributions were tested by the c2 test. a level of p<0,05 was considered significant. results: p53 expression was detected in 24 (36,9%) of 65 carcinomas. of the cases with protein expression, 13 (54,2%) were high or histological grade iii, 8 (33,3%), were grade ii, 3 (12,5%) were grade i. on nuclear grade analysis, of the cases with protein expression, 13 (4,2%) were nuclear grade iii, 9 (37,5%) were grade ii and 2 (8,3%) were grade i. p53 expression was frequent in carcinomas with high histological and nuclear grades. conclusions: p53 expression was significantly associated with the histological grade. on the other hand, nuclear grade was not significantly related to p53 expression.
Resultados perinatais em grávidas com mais de 35 anos: estudo controlado
Andrade, Priscilla Chamelete;Linhares, José Juvenal;Martinelli, Silvio;Antonini, Marcelo;Lippi, Umberto Gazi;Baracat, Fausto Farah;
Revista Brasileira de Ginecologia e Obstetrícia , 2004, DOI: 10.1590/S0100-72032004000900004
Abstract: purpose: to evaluate perinatal results in pregnant women over 35 years old and to check differences between two groups: 35 to 39-year-old women and women older than 40. methods: a retrospective survey was made during the period between january/2000 and july/2003, through the analysis of obstetric charts of 3,093 pregnant women who delivered in the "hospital do servidor público estadual - francisco morato de oliveira", excluding 933 patients. the patients were divided into 3 groups: 18 to 29 years old (control group), 35 to 39 years old, and over 40 years old. data collection was done with standardized forms, and the data were transferred to an electronic spreadsheet (excel - microsoft office 2000). statistical analysis was performed using the c2 test and the fisher test. the alpha risk was less or equal to 5% and the confidence interval 95%. results: cesarean section was the most used method not only in the 35 to 39-year-old group (438/792; 55.3%) but also in the group of women over 40 (153/236; 64.8%). the rates of prematurity (39/236; 16.5%), low weight (37/236; 15.7%), and restriction of fetal growth (38/236; 16.1%) were significantly higher in the group of women over 40, when compared to the other groups. concerning fetal death, a five times higher incidence was observed in the group over 40 years old, as compared to the other groups, a statistically significant difference. conclusion: the only difference between the 35 to 39-year-old group and the control group was the cesarean section rate. this allows us to suggest a differentiated prenatal attendance for pregnant women over 40.
índice de risco de malignidade para tumores do ovário incorporando idade, ultra-sonografia e o CA-125
Fernandes, Luís Roberto Araujo;Lippi, Umberto Gazi;Baracat, Fausto Farah;
Revista Brasileira de Ginecologia e Obstetrícia , 2003, DOI: 10.1590/S0100-72032003000500007
Abstract: purpose: to estimate the sensitivity, specificity and accuracy of patient age, ultrasound result and ca-125 marker variables for the differential diagnosis between malignant and benign ovarian tumors. in addition, to establish a risk of malignancy index (rmi) incorporating these three variables and to estimate its sensitivity, specificity and accuracy for the differential diagnosis. methods: one hundred patients with ovarian tumors with surgical indication were included. the age, ultrasonographic findings and ca-125 level variables were evaluated separately and later on together as the rmi. the study was performed based on the evaluation of the sensitivity, specificity and diagnostic accuracy and the use of the measurements: likelihood ratio, odds ratio, and the student's t test, c2, and logistic regression with univariate and multivariate analysis. results: for the age variable, sensitivity, specificity and diagnostic accuracy were 58.8, 68.2 and 65.0%, respectively. for ultrasound, 88.2, 77.3 and 81.0%. for ca-125 dosage, the values were 64.7, 74.2 and 71.0%. when the three variables were put together, as the rmi, a sensitivity of 76.5%, a specificity of 87.9% and a diagnostic accuracy of 84.0% were observed. conclusions: rmi, made up of the association of patient age, ultrasound results and ca-125 dosage variables is a valuable indicator to distinguish between malignant and benign ovarian tumor, especially in regard to its specificity.
O esporte na qualidade de vida de indivíduos com les?o da medula espinhal: série de casos
Medola, Fausto Orsi;Busto, Rosangela Marques;Mar?al, ?ngela Farah;Achour Junior, Abdalla;Dourado, Antonio Carlos;
Revista Brasileira de Medicina do Esporte , 2011, DOI: 10.1590/S1517-86922011000400008
Abstract: introduction and objective: the spinal cord injury is a trauma of physical and social impact to the individual, which causes profound changes in the lives of those affected by the resultant paraplegia or quadriplegia. the aim of this study was to evaluate the perception of quality of life of individuals with spinal cord injury before and after a period of sport training. methods: the study included 16 people with paraplegia by spinal cord injury, who underwent sports training of basketball in wheelchairs, with a frequency of 2 times per week for a period of 1 year. to assess the quality of life before and after the training period, we used the sf-36. results: there was overall improvement in quality of life (p = 0.006) when considering the average of all areas of the questionnaire combined scores pre (605.7) and post (651.9) training. additionally, the analysis of the results showed statistically significant improvement in functional capacity (p = 0.004), general health (p = 0.001) and emotional aspects (p = 0.02). conclusion: the sport can promote improvement in quality of life for people who need a wheelchair for mobility, and represents new goals and challenges in continuing the process of rehabilitation.
Endometrial biopsy with uretral plastic No. 12 sonde
Guerreiro, Ismael Dale Cotrim;Castanho, Paulo Roberto de Oliveira Lima;Baracat, Fausto Farah;
Sao Paulo Medical Journal , 1995, DOI: 10.1590/S1516-31801995000100006
Abstract: the authors demonstrate technique for obtaining endometrial fragments in 25 patients sent to gynecological cancer preventive service of the arnaldo vieira de carvalho cancer institute, during the period of september 1991 through january 1992, presenting abnormal uterine hemorrhage. technique consists in vacuum aspiration with the support of a no. 12 uretral sonde , provided with one lateral opening only. correlation with curettage was positive in 88% of the patients; biopsy with sonde did not result in confirmation in three patients only. no complications at all were observed (infection, hemorrhage or uterus perforation). authors understand that this method is in conformity with a correct diagnostic performance, being a low cost procedure, almost painless, easy to be done and furnishing sufficient material for the histopathologic diagnosis, in 88% of the cases studied.
índice de risco de malignidade para tumores do ovário incorporando idade, ultra-sonografia e o CA-125
Fernandes Luís Roberto Araujo,Lippi Umberto Gazi,Baracat Fausto Farah
Revista Brasileira de Ginecologia e Obstetrícia , 2003,
Abstract: OBJETIVOS: calcular a sensibilidade, a especificidade e a acurácia das variáveis: idade da paciente, aspecto ultra-sonográfico e dosagem do marcador CA-125 para o diagnóstico diferencial entre tumores malignos e benignos do ovário. Estabelecer, ainda, índice de risco de malignidade (IRM) com a incorpora o dessas três variáveis e calcular a sua sensibilidade, especificidade e acurácia para aquele diagnóstico diferencial. MéTODOS: foram incluídas prospectivamente 100 pacientes portadoras de tumor do ovário com indica o cirúrgica. As variáveis idade, resultado da ultra-sonografia e níveis do CA-125 foram avaliadas isoladamente e depois em conjunto, sob a forma de índice (IRM). O estudo compreendeu a avalia o da sensibilidade, da especificidade e da acurácia diagnóstica e a aplica o das medidas: raz o de probabilidade, raz o de chances e dos testes: t de Student, chi2 e regress o logística com análise uni e multivariada. RESULTADOS: para a variável idade, a sensibilidade, a especificidade e a acurácia diagnóstica foram respectivamente 58,8, 68,2 e 65,0%. Para a ultra-sonografia, 88,2, 77,3 e 81,0%. Para a dosagem do CA-125 esses valores foram 64,7, 74,2 e 71,0%. Quando as três variáveis foram agrupadas sob a forma do IRM observou-se sensibilidade de 76,5%, especificidade de 87,9% e acurácia diagnóstica de 84,0%. CONCLUS ES: o IRM constituído pela associa o das variáveis idade da paciente, resultado da ultra-sonografia e dosagem do CA-125 é indicador valioso para se distinguir entre tumores malignos e benignos de ovário, principalmente no que diz respeito à sua especificidade.
Modeling Breast Cancer Incidence Rates: A Comparison between the Components of Functional Time Series (FTS) Model Applied on Karachi (Pakistan) and US Data  [PDF]
Farah Yasmeen
Open Journal of Applied Sciences (OJAppS) , 2016, DOI: 10.4236/ojapps.2016.68052
Abstract: Several studies showed that the breast cancer incidence rates are higher in high-income (developed) countries, due to the link of breast cancer with several risk factors and the presence of systematic screening policies. Some of the authors suggest that lower breast cancer incidence rates in low-income (developing) countries probably reflect international variation in hormonal factors and accessibility to early detection facilities. Recent studies showed that the breast cancer increased rapidly among women in Pakistan (a developing country) and it became the first malignancy among females of Pakistan. Although, the incidence rates may contain important evidence for understanding and control of the disease; however in Pakistan, the breast cancer incidence data have never been available in the last five decades since independence; rather, only hospital-based data are available. In this study, we intend to apply Functional Time Series (FTS) models to the breast cancer incidence rates of United State (developed country), and to see the difference between various components (age and time) of Functional Time Series (FTS) models applied independently on the breast cancer incidence rates of Karachi (Pakistan) and US. Past studies have already suggested that the incidence of US breast cancer cases was expected to increase in the coming decades. A progressive increase in the number of new cases is already predetermined by the high birth rate that occurred during the middle part of the century, and it will lead to nearly a doubling in the number of cases in about 4 decades. We also obtain 15 years predictions of breast cancer incidence rates in United States and compare them with the forecasts of incidence curves for Karachi. Development of methods for cancer incidence trend forecasting can provide a sound and accurate foundation for planning a comprehensive national strategy for optimal partitioning of research resources between the need for development of new treatments and the need for new research directed toward primary preventive measures.
Measuring Global Warming: Global and Hemisphere Mean Temperature Anomalies Predictions Using Sliced Functional Time Series (SFTS) Model  [PDF]
Farah Yasmeen
Open Journal of Applied Sciences (OJAppS) , 2019, DOI: 10.4236/ojapps.2019.95026
Abstract: In this study, the sliced functional time series (SFTS) model is applied to the Global, Northern and Southern temperature anomalies. We obtained the combined land-surface air and sea-surface water temperature from Goddard Institute for Space Studies (GISS), NASA. The data are available for Global mean, Northern Hemisphere mean and Southern Hemisphere means (monthly, quarterly and annual) since 1880 to present (updated through March 2019). We analyze the global surface temperature change, compare alternative analyses, and address the questions about the reality of global warming. We detected the outliers during the last century not only in global temperature series but also in northern and southern hemisphere series. The forecasts for the next twenty years are obtained using SFTS models. These forecasts are compared with ARIMA, Random Walk with drift and Exponential Smoothing State Space (ETS) models. The comparison is made on the basis of root mean square error (RMSE), mean absolute percentage error (MAPE) and the length of prediction intervals.
Videoangiografia digital com a fluoresceína sódica e indocianina verde na doen?a hipertensiva específica da gesta??o
Pereira, Maurício B.;Salum, Juliana Ferraz;Calucci, Daniela;Ferraz, Paulo Eduardo;Uno, Fausto;Farah, Michel E.;
Arquivos Brasileiros de Oftalmologia , 2000, DOI: 10.1590/S0004-27492000000100004
Abstract: purpose: to describe the ophthalmoscopic and videoangio-graphic findings with sodium fluorescein and indocyanine green (icg-v) in pregnancy toxemia (pt). methods: four female patients with pt underwent ophthal-mologic evaluation and fluorescein angiography, comple-mented in two of them with digital indocyanine green videoangiography (icg-v). results: all patients presented with bilateral serous retinal detachment that spontaneously regressed after arterial pressure stabilization. the fluorescein angiography disclo-sed early multiple patchy nonperfusion choroidal areas and hyperfluorescent spots with leakage and late pooling in the areas of serous retinal detachment. in the late lesions window defect hyperfluorescence and pigmentary blockage were observed. the icg-v showed early choroidal nonper-fusion and multiple hyperfluorescent spots with late areas of dye pooling. conclusions: pt is generally associated with recovery of vision after resolution of the disease, although some vision loss may persist due to pigmentary changes in the macular region. the icg-v better shows the choroidal involvement in the pathogenesis of the serous retinal detachment in pt, previously suggested by fluorescein angiographic studies.
Influência da lubrifica??o do espéculo vaginal na interpreta??o da colpocitologia oncótica
Silva, Josie Bittencourt da;David, Simone Denise;Zalc, Julieta Massabni;Lippi, Umberto Gazzi;Baracat, Fausto Farah;Lopes, Reginaldo Guedes Coelho;
Revista Brasileira de Ginecologia e Obstetrícia , 2005, DOI: 10.1590/S0100-72032005000600009
Abstract: purpose: to assess the interference of two vaginal lubricants (vaseline and silicone) in the interpretation of cervical oncotic cytology. methods: a prospective research on one hundred women from august to october 2003. the women were divided into two groups of 50 patients each, according to the type of lubricant used. two smears were obtained from every patient: the first specimen soon after the introduction of non-lubricated speculum and the second after the use of lubricated speculum with vaseline (group v) or silicone (group s). the samples were analyzed by two cytotechnicians, who were unaware of the origin of the smears. results: among the 100 pairs of slides, 8 results were partially different. the reasons for the differences were not directly related to the use of lubricant and did not interfere with the cytologic findings. the number of discordant results was 6 in group s and 2 in group v, without a statistically significant difference (p=0.269). the number of satisfactory and satisfactory but limited results was statistically similar regarding the use or not of lubricant: group s: 46 satisfactory slides and 4 satisfactory but limited slides (p=0.001 and kappa=0.802) and group v: 48 satisfactory and 2 satisfactory but limited slides (p=0.001 and kappa=0.953). there were no unsatisfactory results. no artefacts were found in slides obtained with lubricated speculum. conclusion: the use of lubricated speculum with vaseline or silicone does not affect cervical oncotic cytology outcome.
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