In this study, we
focus on the class of BL-GARCH models, which is initially introduced by Storti
& Vitale  in order to handle leverage effects and
volatility clustering. First we illustrate some properties of BL-GARCH (1, 2)
model, like the positivity, stationarity and marginal distribution; then we
study the statistical inference, apply the composite likelihood on panel of
BL-GARCH (1, 2) model, and study the asymptotic behavior of the estimators,
like the consistency property and the asymptotic normality.
Multiple myeloma, a
disease of elderly, is extremely rare in those about 30 years of age. A patient
with MM diagnosed at age 27 is described. He was a male with a four-month
history of back pain and later, hemurus and tibia pain persisting despite
NSAIDS. X-rays had shown lytic lesions on lateral radiograph of the skull and
the humerus. His ESR was 120 mm. Serum calcium was 125 mg/l and glomerular filtration
rate at 25 ml/min. There was a beta2 peak in the serum protein electrophoresis.
The Immunohistochemical examination demonstrated a strong reaction for the
Lambda light chain in all tumor cells. Bence Jones protein was present in
urine. Bone marrow biopsy confirmed the diagnosis of multiple myeloma. Our
patient was treated with dexamethasone, zoledronic acid, cyclophosphamide and
thalidomide with good evolution. Actually, he was proposed for stem cell
transplantation. This report illustrated that multiple myeloma should be even
evoked in young patients.