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Background: Several epidemiological studies have been carried to identify
the risk factors for developing breast cancer. The aim of this study was to
evaluate the risk factors associated with breast cancer in different age groups
in the Moroccan women and to determine susceptible and protective factors.
Methods: This was？a case control study？including 400 women with
breast cancer and 400 controls of the National Institute of Oncology Sidi
Mohamed Ben Abdallah, Rabat, Morocco from 2008 to 2010. These women were
interviewed for epidemiological information and risk factor for breast cancer.
Results: Early age at menarche, late menopause, oral contraceptive and family
history with first degree were positively associated with breast cancer in all
the series and in the age group between 22 and 34 years. In the age group
between 44 and 34 years, a risk of breast cancer was associated only with a
family history of breast cancer. In the age group of 45 years or older, the
factors which seem to influence a breast cancer are: late menopause, oral
contraceptive and family history in the first degree. In contrast, early
childbearing, multiparity and lactation were negatively associated with breast
cancer. Conclusion: This study is rather in favour of positive association between
hormonal factors and breast cancer, and confirms the protective role of
multiparity and lactation.
Multiple myeloma, a
disease of elderly, is extremely rare in those about 30 years of age. A patient
with MM diagnosed at age 27 is described. He was a male with a four-month
history of back pain and later, hemurus and tibia pain persisting despite
NSAIDS. X-rays had shown lytic lesions on lateral radiograph of the skull and
the humerus. His ESR was 120 mm. Serum calcium was 125 mg/l and glomerular filtration
rate at 25 ml/min. There was a beta2 peak in the serum protein electrophoresis.
The Immunohistochemical examination demonstrated a strong reaction for the
Lambda light chain in all tumor cells. Bence Jones protein was present in
urine. Bone marrow biopsy confirmed the diagnosis of multiple myeloma. Our
patient was treated with dexamethasone, zoledronic acid, cyclophosphamide and
thalidomide with good evolution. Actually, he was proposed for stem cell
transplantation. This report illustrated that multiple myeloma should be even
evoked in young patients.