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Search Results: 1 - 10 of 1315 matches for " Fatemeh Eghbalian "
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Antibiotic sensitivity pattern of common bacterial pathogens in NICU and neonatal ward in Hamedan province of Iran  [PDF]
Alireza Monsef, Fatemeh Eghbalian
Health (Health) , 2010, DOI: 10.4236/health.2010.26094
Abstract: Bacterial pathogens and drug resistance are different in hospitals of each country. In this study we determined bacterial path- ogens and drug sensitivity in the neonatal ward and neonatal intensive care unit (NICU) in Ekbatan hospital in Hamedan. This cross-sectional descriptive study was done on 1150 hospitalized neonates in neonatal and NICU wards of Ekbatan hospital of the Hamadan university of medical sciences from September 2004 to September 2006. Blood, cerebrospinal fluid (CSF), urine, stool, eye excretion, synovial fluid, umbilical secretion and ascitic fluid were evaluated. Positive cultures were evaluated for antibiotic resistance with disk diffusion test methed. All of the data in questionnaires was analyzed with SPSS 13. Cultures including blood, urine, CSF , stool, eye excretion, synovial fluid, umbilical secretion and ascitic fluid was done in 417 neonates (833 cultures). These cultures were including: urine, 323 cases (38.8%) blood 293 cases (35.2%), CSF 180 cases (21.6%) , stool 17 cases (2%), eye secretion 16 cases (1.9%) and other secretions (synovial, umbilical, etc) 4 cases (0.5%). The cultures were positive in 105 cases (25.2%). 60 male neonates (57.1%) and 45 female neonates (42.9%) were culture positive. The most common microorganisms were E coli 66.7% (70 cases), Klebsiella 10.5% (11 cases). Drug resistance was high in these microorganisms. The most common microorganisms were Ecoli and klebsiella. Drug resistance was high in the isolated microorganisms.
Does conventional phototherapy have any effect on platelet count in full term neonates with indirect hyperbilirubinemia?  [PDF]
Alireza Monsef, Fatemeh Eghbalian
Health (Health) , 2011, DOI: 10.4236/health.2011.312119
Abstract: This study evaluates the platelet count changes in neonates with hyperbillirubinemia who received phototherapy. In this Prospective Descriptive-cross sectional study 144 full term newborns with indirect hyperbillirubinemia who received phototherapy in neonatal ward of Bessat hospital in Hamedan province of Iran were studied from September 2007 to February 2008 for evaluation the effect of phototherapy on platelet count. The platelet had counted by cell counter and it had controlled by slide platelet counting. The data were analyzed using spss version. 13 and compared with paired-samples T test. 58 neonates (40.3%) were boys and 86 (59.7%) were girls. The mean age of neonates was 7.04 +/– 5.49 days (2 - 29 days). The mean (± SD) platelet counts were 287833.3 + 92332.4 before and 299444.4 + 98565.2 after phototherapy. Analysis of data with paired T test showed significant difference in platelet count before and after phototherapy. Mean platelet count after phototherapy was higher than that before treatment. The study had propounded that mean platelet count increased with extended mean phototherapy time. This study had propounded this hypothesis that phototherapy in full term icteric newborns leads to increased platelet count. It may be due to accelerated platelet turnover in peripheral microvasculature with adequate platelet reserve.
Frequency of Hypoxic-Ischemic Encephalopathy Among Hospitalized Neonates in West Iran
Fatemeh Eghbalian
Iranian Journal of Pediatrics , 2010,
Abstract: Hypoxic-ischemic encephalopathy (HIE) is brain damage from a shortage of oxygen or blood flow to the tissues[1,2] and is characterized by clinical and laboratory evidence of acute or subacute brain injury due to asphyxia[1-6]. It is a major contributor to neonatal death and morbidity[4-6]. 15%-20% of HIE cases die during the neonatal period and 30% of those who survive suffer from neurodevelopmental disorders[1,3,6].An estimated 23% of the 4 million neonatal deaths and 8% of all deaths at <5 years of age throughout the world each year are associated with signs of asphyxia at birth[1,4]. Even at referral centers in developed countries, death or moderate to severe disability occurs for 53% to 61% of infants diagnosed as having moderate to severe HIE[1,4,6]. Children with moderate/severe neonatal encephalopathy are at risk for reduced school performance, whereas those with mild encephalopathy have school performance scores similar to those of their peers[1,6]. HIE is one of the most common causes of cerebral palsy and other severe neurologic deficits in children occurring in two to nine of every 1000 live births [1-6]. The incidence of HIE reported in different studies varies widely[2-6], which may be explained by the selection criteria for studies of HIE during the neonatal period[3,4].The aim of the present study was to evaluate the frequency of hypoxic-ischemic encephalo-pathy in hospitalized neonates with seizure in Hamedan (west Iran) in a two year period.This is a retrospective cross sectional study on 34 neonates from 2004 to 2006.Inclusion criteria were: all neonates with seizures due to HIE asphyxia having pH below 7, 5th minute Apgar score between 0 and 3, decreased muscle tone and consciousness, cortical atrophy in brain CT scan and multiple organ involvement (eg, kidney, lungs, liver, heart, intestines). Neonates with jitteriness were excluded from the study.The study was based on the recorded files of the patients. CT scan findings, blood gas findings, Apgar score of 5th minute, decreased muscle tone and consciousness, seizure, age, sex and birth weight were recorded and analyzed using SPSS 13. Management plan for evaluation of hypoxic-ischemic encephalopathy included: Profound metabolic or mixed acidemia (pH<7), persistence of Apgar score of 0-3 for longer than 5 minutes, neonatal neurologic sequelae (eg, seizures, coma, hypotonia), multiple organ involvement (eg, kidney, lungs, liver, heart, intestines) and cortical atrophy in brain CT scan.from 34 neonates with seizure, 11 (32.4%) had HIE. The infants who developed HIE had significantly 5th
Evaluation of Diagnostic Value of Procalcitonin as a Marker of Neonatal Bacterial Infections
Alireza Monsef,Fatemeh Eghbalian
Iranian Journal of Pediatrics , 2012,
Abstract: Objective: This study tried to assess sensitivity, specificity, positive and negative predictive value of procalcitonin for diagnosis of neonatal bacterial infections.Methods: This prospective cross sectional study was carried out during an 18-month period in NICU and neonatal wards of Besat Hospital in Hamedan province, Iran. 39 symptomatic infants with clinical and laboratory findings in favor of bacterial infection with a positive blood, CSF, and/or supra pubic urine cultureentered the study; 32 newborns without any bacterial infection served as control group. Quantitative procalcitonin level ≥0.5 ng/ml was accepted as pathological. Finally sensitivity, specificity, positive (PPV) and negative predictive value (NPV) were calculated for procalcitonin test.Findings: 20 blood cultures, 17 urine cultures and 8 CSF cultures were positive. Sensitivity, specificity, PPV and NPV for procalcitonin test was 76.9%, 100%, 100% and 78% respectively. Diagnostic value of procalcitonin test in accordance with blood culture for mentioned items was 85%, 100%, 100% and 91.4%respectively. Its diagnostic value according to urine culture was: sensitivity 70.6%, specificity 100%, PPV 100% and NPV 86.4%, and according to CSF culture was: sensitivity 75%, specificity 100%, PPV 100% and NPV 94.1% respectively.Conclusion: The results show that the procalcitonin test has high sensitivity, specificity, PPV and NPV for diagnosis of neonatal infections.
Premature Loss of Permanent Teeth in Allgrove (4A) Syndrome in Two Related Families
Zahra Razavi,Mohammad-Mehdi Taghdiri,Fatemeh Eghbalian,Nooshin Bazzazi
Iranian Journal of Pediatrics , 2010,
Abstract: Background:Allgrove syndrome is a rare autosomal recessive condition characterized by adrenal insufficiency, achalasia, alacrima and occasionally autonomic disturbances. Mutations in the AAAS gene, on chromosome 12q13 have been implicated as a cause of this disorder. Case(s) Presentation:We present various manifestations of this syndrome in two related families each with two affected siblings in which several members had symptoms including reduced tear production, mild developmental delay, achalasia, neurological disturbances and also premature loss of permanent teeth in two of them, Conclusion: The importance of this report is dental involvement (loss of permanent teeth) in Allgrove syndrome that has not been reported in literature.
Auditory Ealuation of High Risk Newborns by Automated Auditory Brain Stem Response
Mohammad Mehdi Taghdiri,Fatemeh Eghbalian,Faranak Emami,Behnas Abbasi
Iranian Journal of Pediatrics , 2008,
Abstract: Objective: The objective of this study was to assess the prevalence of hearing impairment by automated auditory brain stem response (AABR) in newborns admitted to an intensive and intermediate care unit and to analyze the associated risk factors. Methods: An observational cross-sectional study was conducted between January 2005 and January 2006. 834 newborns (62% boys and 38% girls) were assessed. Newborns had a mean (SD) gestational age of 36 (2.1) weeks with a mean (SD) birth weight of 2950 (1250) grams. The presence of the following neonatal pathologies was investigated: craniofacial malformations, hyperbilirubinemia (total bilirubin 20 mg/dl for all newborns), neonatal asphyxia, congenital infections, septicemia, birth weight (<1500 g), meningitis, consanguinity, family history of congenital hearing loss and history of convulsion. Newborns who died before the age of 3 months and whose stay in the hospital lasted less than 48 hours were excluded. Chi-square test was used to identify the risk factors for hearing loss. Findings: Out of 834 neonates, 34 (4.07 %) had sensory-neural hearing loss. The most common risk factors of hearing loss included hyperbilirubinemia (11%), asphyxia (8%), birth weight less than 1500 g (6%), septicemia (6%), convulsion (2%), and meningitis (1%). There was a statistically significant association between hyperbilirubinemia (P=0.001), weight less than 1500 g (P=0.002), cesarean section (P=0.005) and impaired ABR results. There was no relation between family history of congenital hearing loss and craniofacial malformation as risk factors for hearing loss. Conclusion: This study showed statistically a relation between hyperbilirubinemia, weight less than 1500 g, cesarean section and impaired AABR results. The most common risk factors of hearing loss were hyperbilirubinemia, asphyxia, birth weight less than 1500 g, septicemia, convulsion, and meningitis.
Urinary Tract and Other Associated Anomalies in Newborns With Esophageal Atresia
Fatemeh Eghbalian,Alireza Monsef,Seyed Habibollah Mousavi-Bahar
Urology Journal , 2009,
Abstract: Esophageal atresia is often associated with other anomalies. Hereditary and environmental factors may influence the incidence of associated anomalies, particularly of the urogenital system. We had 63 neonates with esophageal atresia admitted to 2 centers in Hamadan, Iran, from 2002 to 2008. They were 38 girls (60.3%) and 25 boy (39.7%). Tracheoesophageal fistula was present in 54 neonates (85.7%), and other associated anomalies in 10 (15.9%). Cardiac anomalies were found in 7 neonates; anorectal anomalies, in 4; urinary tract anomalies, in 2; and limb anomaly, in 1. Urinary tract anomalies (3.2%) were bilateral polycystic kidney in 1 neonate and unilateral hydronephrosis due to ureteropelvic junction obstruction in another. Both neonates with urinary tract anomalies were female and both had tracheoesophageal fistula, as well. Many of the associated congenital abnormalities influence the management protocol of esophageal atresia, and therefore, should be detected as soon as possible after birth.
Aplasia Cutis Congenita After Methimazole Exposure in Utero; A case Report
F Eghbalian
Iranian Journal of Pediatrics , 2007,
Abstract: Objective: Aplasia Cutis Congenita (ACC) is a rare disorder with a complicated pattern of inheritance. Babies are born with the absence of certain layers of skin. It most commonly manifests as a solitary defect on the scalp, but sometimes it may occur as multiple lesions. The affected area is typically covered with a thin, transparent membrane. The skull and/or underlying areas may be visible and be abnormally developed. ACC may be the primary disorder or it may occur in association with other underlying disorders. Case presentation: This article presents a case of ACC in a newborn whose mother was treated with methimazole due to thyrotoxicosis during the first trimester of pregnancy. He was born term with midline scalp defects. This case report is presented to highlight the steps to successful management and review the relevant literatureConclusion: Management strategies are based on the size and presence of an underlying skull defect. A review of the literature seems to support the hypothesis that methimazole is a potential teratogen. Although the risk of birth defects is low with clinically applied doses of the drug, it cannot be regarded as safe and should therefore be avoided pregnant women. Propylthiouracil should be considered as the first choice drug for hyperthyroid pregnant women until further data on the safety of methimazole are available.
Low Birth Weight Causes Survey in Neonates
F Eghbalian
Iranian Journal of Pediatrics , 2007,
Abstract: Background: Neonatal mortality rate is one of the main health problems which is affected by prenatal status, maternal, fetal and perinatal conditions. Low birth weight (LBW) is one of the main causes of neonatal and infantile mortality. The aim of this study is an evaluation of the LBW causes in neonates. Methods: This descriptive cross sectional study was done on 1500 neonates, born in Fatemieh Hospital, Hamedan, 2004. Data such as birth weight, sex, maternal age, gestational age, birth interval, history of abortion, prenatal care, maternal occupation, level of education, systemic and underlying diseases, history of infections and smoking were extracted from medical records. Data were statistically analyzed by SPSS ver.13 using chi-square, t-test and fishers exact test. Findings: 19.1% of neonates were LBW newborns. Mean values for maternal age, gestational age, maternal weight and height, and the interval between births of LBW neonates were significantly lower compared with normal birth weight neonates. The number of siblings of LBW neonates was more than normal birth weight neonates. Maternal infections and systemic diseases, occupation, the presence and absence of prenatal care in LBW neonates, showed no significant differences with normal birth weight newborns. Smoking and history of abortion in the mothers of LBW neonates were more than those of normal birth weight neonates. Maternal educational level of LBW neonates was lower than mothers of normal birth weight neonates. The most common maternal infection was vaginitis and the most common maternal systemic disease was hypertension. Conclusions: The results revealed a correlation between LBW in neonates with maternal age, gestational age, maternal weight and height. There was also a correlation with the interval between pregnancies, number of siblings, maternal smoking, previous abortion and level of mothers education.
Surgical Interventions and Complications After Surgery in Newborns
F Eghbalian,M Ghorbanpour
Iranian Journal of Pediatrics , 2005,
Abstract: Background: Early diagnosis and treatment of neonatal disease, particulary the surgical disease has great importance. Methods: We had studied the neonatal diseases needed to surgical treatment, associated anomalies, medical treatment, short-term complications and mortality in a period of October 2002 to October 2004 in NICU of Ekbatan hospital. Findings: We studied 126 surgeried neonate in a prospective descriptive study, 63.5% were male. The diseases were: Hirshprung 19.0%, imperforated anus 16.7%, esophageal atresia 18.7%, inguinal hernia 9.5%, clef lip 6.3%, omphalocele 4.0%, meconium ileus 3.96%, jugenal atresia, necrotizing enterocolitis and meningomyelocele 1.58%, pneumothorax, chylothorax, sacrocoxygeal teratoma, hepatoblastoma, ovarian cyst, mechels diverticulum, gastrochesia, thyroglosal duct cyst, cystic hygroma, posterior urethral valve has 0.79% frequency in our study. We didn’t find any associated anomaly in 58.73% of our cases. Electrolyte abnormality was the most post-operative complication, majority of them needed to medical treatment. In this study, mortality rate was 10.3%. Conclusion: Our study revealed that NICU, appropriate surgical techniques, appropriate pre&post operative medical treatment has dramatic effect in improving their outcome and diminishing surgical complications.
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