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Search Results: 1 - 10 of 220404 matches for " Farid;Cólus "
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Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer
Magnani, Marciane;Castro-Gomez, Raul Jorge Hernan;Mori, Mateus Prates;Kuasne, Hellen;Gregório, Emerson Pereira;Libos Jr, Farid;Cólus, Ilce Mara de Syllos;
Genetics and Molecular Biology , 2011, DOI: 10.1590/S1415-47572010005000103
Abstract: carboxymethyl-glucan (cm-g) is a soluble derivative from saccharomyces cerevisiae (1 → 3)(1 → 6)-β-d-glucan. the protective efficiency of cm-g against dna damage in cells from patients with advanced prostate cancer (pca), and undergoing androgen deprivation therapy (adt), was evaluated. dna damage scores were obtained by the comet assay, both before and after treatment with cm-g. the reduction in dna damage, ranging from 18% to 87%, with an average of 59%, was not related to the increased number of leukocytes in peripheral blood. the results demonstrate for the first time the protective effect of cm-g against dna damage in patients with advanced pca. among smokers, three presented the highest reduction in dna damage after treatment with cm-g. there was no observable relationship between dna damage scores before and after treatment, and age, alcoholism and radiotherapy.
Mushroom Shiitake, is it mutagenic or antimutagenic agent? Shiitake, um cogumelo mutagênico ou antimutagênico?
Cíntia Kaori Miyaji,Ilce Mara de Syllos Cólus
Semina : Ciências Biológicas e da Saúde , 2001,
Abstract: Mushrooms have been consumed by eastern populations due to their edible and medicinal properties, for a long time. Over the years, there has also been a gradual increase in the consumption of mushrooms in the western countries, including Brazil. However, the benefits or harms that these mushrooms may cause to the human health are still uncertain. Shiitake (Lentinula edodes (Berk.) Pegler) is one of the most appreciated fungi in the Brazilian cuisine and its functional and nutritional properties have been extensively studied. Other characteristics of this basidiomycet have also been reported, including its antitumoral, antiviral, bactericidal properties, as well as being a homeostasis and biorhythm regulator. However, studies regarding its mutagenic and antimutagenic potential in prokaryotic and eukaryotic organisms are scarce. Knowledge of these biological properties is essential before a product can be recommended as food and/or drug. Therefore, its indication as a beneficial product to human health is premature since it is necessary to broaden studies on the mutagenic and antimutagenic activities of the mushroom Shiitake or of its active compounds. Desde a antigüidade, os cogumelos vêm sendo consumidos pelos povos orientais devido às suas propriedades medicinais e comestíveis e ao longo dos anos tem-se observado um aumento gradativo no consumo também nos países ocidentais, inclusive o Brasil. No entanto, ainda há dúvidas quanto aos benefícios ou prejuízos à saúde, decorrentes do uso destes cogumelos pelas popula es humanas. Entre os cogumelos muito apreciados na culinária brasileira, destaca-se o Shiitake (Lentinula edodes (Berk.) Pegler), um dos fungos comestíveis mais estudados quanto às suas propriedades funcionais e nutricionais. Já se tem conhecimento sobre várias atividades deste basidiomiceto superior, como antitumoral, antiviral, bactericida, regulador da homeostase e do biorritmo. No entanto, poucos trabalhos abordam suas propriedades mutagênicas e antimutagênicas em organismos procariontes e eucariontes e o conhecimento dessas propriedades biológicas s o importantes para que um produto seja recomendável como alimento e/ou medicamento. Dessa forma, é prematura sua recomenda o para a saúde humana, pois é necessário, para isso, a amplia o de estudos sobre as atividades mutagênicas e antimutagênicas do cogumelo Shiitake ou de seus compostos ativos.
Cytogenetic biomonitoring of Brazilian dentists occupationally exposed to low doses of X-radiation
Miyaji, Cintia Kaori;Cólus, Ilce Mara de Syllos;
Pesquisa Odontológica Brasileira , 2002, DOI: 10.1590/S1517-74912002000300003
Abstract: exposure to x-rays (ionizing radiation) may cause chromosomal aberrations (ca) in somatic or germinative cells in exposed individuals, and may lead to manifestations of diseases such as cancer. this study was carried out to assess the ca frequency in lymphocytes obtained by means of temporary culture of peripheral blood from dentists in londrina, paraná, brazil, who have worked for more than ten years with x-rays. the results obtained from the experimental group were compared with a matched negative control group, which had never been exposed to x-rays. all individuals, dentists and controls, answered a personal questionnaire, from which a profile of each group was obtained. slides, prepared after the cultures, were stained with giemsa, and 100 to 200 metaphase cells were analyzed per individual. ca frequencies and types were registered and statistical tests were not necessary to evaluate the obtained data. the analysis of mitotic index (mi) did not indicate significant differences (p < 0.05) between the group of individuals exposed to x-rays and the control group. the analyzed confounding factors did not influence the results of mi and ca frequencies.
Cytogenetic biomonitoring of Brazilian dentists occupationally exposed to low doses of X-radiation
Miyaji Cintia Kaori,Cólus Ilce Mara de Syllos
Pesquisa Odontológica Brasileira , 2002,
Abstract: Exposure to X-rays (ionizing radiation) may cause chromosomal aberrations (CA) in somatic or germinative cells in exposed individuals, and may lead to manifestations of diseases such as cancer. This study was carried out to assess the CA frequency in lymphocytes obtained by means of temporary culture of peripheral blood from dentists in Londrina, Paraná, Brazil, who have worked for more than ten years with X-rays. The results obtained from the experimental group were compared with a matched negative control group, which had never been exposed to X-rays. All individuals, dentists and controls, answered a personal questionnaire, from which a profile of each group was obtained. Slides, prepared after the cultures, were stained with Giemsa, and 100 to 200 metaphase cells were analyzed per individual. CA frequencies and types were registered and statistical tests were not necessary to evaluate the obtained data. The analysis of mitotic index (MI) did not indicate significant differences (p < 0.05) between the group of individuals exposed to X-rays and the control group. The analyzed confounding factors did not influence the results of MI and CA frequencies.
Glutathione S-transferase M1 (GSTM-1): ethnic distribution and relation with cancer Glutationa S-transferase M1 (GSTM-1): distribui o étnica e rela o com cancer
Roberta Losi Guembarovski,Ilce Mara de Syllos Cólus
Semina : Ciências Biológicas e da Saúde , 2001,
Abstract: Interindividual differences concerning the risk of cancer development are mostly due to a genetically determined capacity of the organism, from bacteria to man, in activating and detoxifying carcinogens. Therefore, the association among specific alleles of enzymes that are able to metabolize chemical compounds and the risk of developing several cancers, is attributed to the existence of various enzymatic steps in biometabolism, which can result in the activation or detoxification of xenobiotics. A great part of detoxification genes which have already described, is related to Glutathione S- transferase (GSTs) enzyme family. GSTM-1 gene, which belongs to this family, is polimorfic in the population and occurs in about 30-50% of the individuals, depending on the ethnical group which they belong to. In several works described in literature, GSTM-1 gene has been frequently associated to a high risk of developing several types of cancer, mostly lung cancer. Such informations are extremely important in order to determine the frequency of this gene in different populations, searching for an identification of markers that indicate cancer susceptibility. Os seres humanos apresentam diferen as individuais quanto ao risco de desenvolver cancer. Tais diferen as s o provenientes, entre outros fatores, da capacidade geneticamente determinada dos organismos, desde bactérias até o homem, em ativar e detoxificar os carcinógenos. Assim sendo, a associa o entre alelos específicos de genes responsáveis pela metaboliza o de compostos químicos e o risco aumentado ao desenvolvimento de tumores, se deve à existência de múltiplos passos enzimáticos no metabolismo, que podem resultar na ativa o ou detoxifica o de xenobióticos. O maior grupo de genes de detoxifica o já descritos até o momento envolve a grande família das enzimas Glutationa S-transferases (GSTs). O gene GSTM-1, que faz parte desta família, é polimórfico na popula o e ocorre em cerca de 30-50% dos indivíduos, dependendo do grupo étnico a que pertencem. Em diversos trabalhos descritos na literatura, o gene GSTM-1 vem sendo freqüentemente associado a um risco elevado de desenvolvimento de diversos tipos de tumores, principalmente o cancer de pulm o, o que torna de grande importancia a determina o da freqüência deste gene nas diferentes popula es, buscando a identifica o de marcadores de susceptibilidade ao cancer.
Tracing Water Flow and Colloidal Particles Transfer in an Unsaturated Soil  [PDF]
Dieuseul Prédélus, Laurent Lassabatere, Artur Paiva Coutinho, Cédric Louis, Thomas Brichart, Erij Ben Slimène, Thierry Winiarski, Rafael Angulo-Jaramillo
Journal of Water Resource and Protection (JWARP) , 2014, DOI: 10.4236/jwarp.2014.67067
Abstract:

In recent years, many studies have been carried out on colloidal particle transfer in the unsaturated zone because they can be a risk to the environment either directly or as a vector of pollutants. A study was conducted on the influence of porous media structure in unsaturated conditions on colloidal particle transport. Three granular materials were set up in columns to replicate a fluvio-glacial soil from the unsaturated zone in the Lyon area (France). It is a sand, a bimodal mixture in equal proportion by weight of sand and gravel, and a fraction of bimodal mixture. Nanoparticles of silica (SiO2-Au-FluoNPs), having a hydrodynamic diameter between 50 and 60 nm, labeled by organic fluorescent molecules were used to simulate the transport of colloidal particles. A nonreactive tracer, bromide ion (Br-) at a concentration of C0,s = 10-2 M was used to determine the hydrodispersive properties of porous media. The tests were carried out first, with a solution of nanoparticles (C0,p = 0.2 g/L) and secondly, with a solution of nanoparticles and bromine. The transfer model based on fractionation of water into two phases, mobile and immobile, MIM, correctly fits the elution curves. The retention of colloidal particles is greater in the two media of bimodal particle size than that in the sand, which clearly demonstrates the role of textural heterogeneity in the retention mechanism. The increase in ionic strength produced by alimenting the columns with colloidal particle suspension in the presence of bromide, increases retention up to 25% in the sand. The total concentration profile of nanoparticles collected at the end of the experiment shows that the colloidal particles are retained primarily at the entrance of the columns. Hydrodispersive calculated parameters indicate

On Classes of Matrices with Variants of the Diagonal Dominance Property  [PDF]
Farid O. Farid
Advances in Linear Algebra & Matrix Theory (ALAMT) , 2017, DOI: 10.4236/alamt.2017.72005
Abstract: We study the relations between several classes of matrices with variants of the diagonal dominance property, and identify those classes which form pairs of incomparable classes. For an incomparable pair (X1,X2) of classes of matrices with variants of the diagonal dominance property, we also study the problem of providing sufficient conditions for the matrices in Xi to be in Xj with {i,j}={1,2}. The article is a continuation of a series of articles on the topic and related topics by the author; see [1][2][3][4].
Generalized Krein Parameters of a Strongly Regular Graph  [PDF]
Lus Almeida Vieira, Vasco Mo?o Mano
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.61005
Abstract: We consider the real three-dimensional Euclidean Jordan algebra associated to a strongly regular graph. Then, the Krein parameters of a strongly regular graph are generalized and some generalized Krein admissibility conditions are deduced. Furthermore, we establish some relations between the classical Krein parameters and the generalized Krein parameters.
Glutathione S-transferase Mu (GSTM1) null genotype in relation to gender, age and smoking status in a healthy Brazilian population
Losi-Guembarovski, Roberta;D?Arce, Luciana Paula Grégio;Cólus, Ilce Mara de Syllos;
Genetics and Molecular Biology , 2002, DOI: 10.1590/S1415-47572002000400001
Abstract: the glutathione s-transferase mu (gstm1) gene which acts during phase ii of xenobiotic metabolism is polymorphic in the population, being absent in about 30-50% of individuals depending on the ethnic group from which they come. epidemiological studies suggest that individuals who are homozygous null at the gstm1 locus may have an increased risk of developing various types of neoplastic disease. we used the polymerase chain reaction (pcr) to estimate the frequency of gstm1 in 176 healthy individuals from the north of paraná (brazilian state), the null genotype being detected in 48.86% of these individuals. the student?s t-test was used to evaluate the frequency of the glutathione s-transferase null genotype in relation to age, gender and smoking habit and no significant differences were found. in our sample there were 142 individuals of caucasian origin, of which 47.88% had the null genotype. when applied to the caucasian group only (n = 142) the student?s t-test again showed no significant differences between the frequency of the gstm1 null genotype and age, gender and smoking habit.
Genotoxicity and antigenotoxicity assessment of shiitake (Lentinula edodes (Berkeley) Pegler) using the Comet assay
Miyaji, CK;Jord?o, BQ;Ribeiro, LR;Eira, AF;Cólus, IMS;
Genetics and Molecular Biology , 2004, DOI: 10.1590/S1415-47572004000100018
Abstract: the mushroom shiitake (lentinula edodes (berkeley) pegler) is been widely consumed in many countries, including brazil, because of its pleasant flavor and reports of its therapeutic properties, although there is little available information on the genotoxicity and/or antigenotoxicity of this mushroom. we used the comet assay and hep-2 cells to evaluate the in vitro genotoxic and antigenotoxic activity of aqueous extracts of shiitake prepared in three different concentrations (0.5, 1.0 and 1.5 mg/ml) and three different temperatures (4, 22 and 60 °c), using methyl methanesulfonate (mms) as a positive control and untreated cells as a negative control. two concentrations (1.0 and 1.5 mg/ml) of extract prepared at 4 °c and all of the concentrations prepared at 22 ± 2 and 60 °c showed moderate genotoxic activity. to test the protective effect of the three concentrations of the extracts against the genotoxicity induced by methyl methanesulfonate, three protocols were used: pre-treatment, simultaneous-treatment and post-treatment. treatments were repeated for all combinations of preparation temperature and concentration. two extracts (22 ± 2 °c 1.0 mg/ml (simultaneous-treatment) and 4 °c 0.5 mg/ml (post-treatment)) showed antigenotoxic activity.
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