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Search Results: 1 - 10 of 827 matches for " Fanny Reichert "
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Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin
Smadar Hadas, Maya Spira, Uwe-Karsten Hanisch, Fanny Reichert, Shlomo Rotshenker
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-166
Abstract: Syk was continuously activated during prolonged phagocytosis. Phagocytosis increased when Syk activity and expression were reduced, suggesting that normally Syk down regulates CR3-mediated myelin phagocytosis. Levels of inactive p-cofilin (phosphorylated cofilin) decreased transiently during prolonged phagocytosis. In contrast, p-cofilin levels decreased continuously when Syk activity and expression were continuously reduced, suggesting that normally Syk advances the inactive state of cofilin. Observations also revealed inverse relationships between levels of phagocytosis and levels of inactive p-cofilin, suggesting that active unphosphorylated cofilin advances phagocytosis. Active cofilin could advance phagocytosis by promoting F-actin remodeling, which supports the production of membrane protrusions (e.g., filopodia), which, as we also revealed, are instrumental in myelin phagocytosis.CR3 both activates and downregulates myelin phagocytosis at the same time. Activation was previously documented. We presently demonstrate that downregulation is mediated through Syk, which advances the inactive phosphorylated state of cofilin. Self-negative control of phagocytosis by the phagocytic receptor can be useful in protecting phagocytes from excessive phagocytosis (i.e., “overeating”) during extended exposure to particles that are destined for ingestion.
Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
Miri Gitik, Sigal Liraz-Zaltsman, Per-Arne Oldenborg, Fanny Reichert, Shlomo Rotshenker
Journal of Neuroinflammation , 2011, DOI: 10.1186/1742-2094-8-24
Abstract: CD47 and SIRPα expression was studied by confocal immunofluorescence microscopy, and myelin phagocytosis by ELISA.We first document that myelin, oligodendrocytes and Schwann cells express CD47 without SIRPα and further confirm that microglia and macrophages express both CD47 and SIRPα. Thus, CD47 on myelin can bind to and subsequently activate SIRPα on phagocytes, a prerequisite for CD47/SIRPα-dependent down-regulation of CD47+/+ myelin phagocytosis by itself. We then demonstrate that phagocytosis of CD47+/+ myelin is augmented when binding between myelin CD47 and SIRPα on phagocytes is blocked by mAbs against CD47 and SIRPα, indicating that down-regulation of phagocytosis indeed depends on CD47-SIRPα binding. Further, phagocytosis in serum-free medium of CD47+/+ myelin is augmented after knocking down SIRPα levels (SIRPα-KD) in phagocytes by lentiviral infection with SIRPα-shRNA, whereas phagocytosis of myelin that lacks CD47 (CD47-/-) is not. Thus, myelin CD47 produces SIRPα-dependent down-regulation of CD47+/+ myelin phagocytosis in phagocytes. Unexpectedly, phagocytosis of CD47-/- myelin by SIRPα-KD phagocytes, which is not altered from normal when tested in serum-free medium, is augmented when serum is present. Therefore, both myelin CD47 and serum may each promote SIRPα-dependent down-regulation of myelin phagocytosis irrespective of the other.Myelin down-regulates its own phagocytosis through CD47-SIRPα interactions. It may further be argued that CD47 functions normally as a marker of "self" that helps protect intact myelin and myelin-forming oligodendrocytes and Schwann cells from activated microglia and macrophages. However, the very same mechanism that impedes phagocytosis may turn disadvantageous when rapid clearance of degenerated myelin is helpful.Oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) form specialized myelin extensions of their plasma membranes that surround axons normally enabling
Reducing Stigma Barriers to Help-Seeking Behaviors among College Students  [PDF]
Emily Reichert
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.310134
Abstract: College students suffer disproportionately from depression, an illness with significant consequences that, untreated, escalates in severity. A review of literature reveals that seeking help for this health issue is often stigmatized, reducing the likelihood of treatment. While the literature identifies the types of stigma, less is known about the communicative processes involved in stigma coping. This paper applies Meisenbach’s (2010) Theory of Stigma Management Communication (SMC) to this issue, suggested strategies researching depression stigma coping as well as new and promising intervention strategies to increase help seeking rates among college students.
Experience with the SE in Germany
Jochem Reichert
Utrecht Law Review , 2008,
Abstract: A rather significant proportion of the Societas Europaeas (the European Company, or SE) formed to date have had German roots. German corporate law has been enriched by an interesting alternative which meanwhile seems to have gained momentum. This contribution focuses on SEs incorporated by German entrepreneurs and provides an interesting account concerning the use of SEs in Germany in practice, such as Allianz, Fresenius, BASF and Porsche. Has the SE been used to circumvent rigid company law provisions or is it a more flexible and effective tool, perhaps, for company mobility? The practical motives behind setting up this company form are also reflected upon. These include: the facilitation of cross-border mergers; transfer of the registered office; the ‘European’ image; a more flexible form of co-determination in large companies (reduction of the number of supervisory board members); avoidance and freezing of co-determination for medium-sized enterprises; the appeal of the one-tier system and its endangerment by German co-determination; and flat and uniform structures for company groups. The author also briefly discusses some of the problems arising from the formation of SEs in Germany. He ultimately concludes that practice has shown that it is possible to work with the legal regime of the SE in Germany, which adds a new company form to those available in that Member State.
Political Competences and Political Participation: On The Role of “Objective” Political Knowledge, Political Reasoning, and Subjective Political Competence in Early Adulthood
Frank Reichert
Journal of Social Science Education , 2010,
Abstract: This article deals with the relation of objective political competences and the subjective assessment of one’s own political competence. The theoretical frame states that at least in early adulthood, only the subjective competence but not political knowledge is an autonomous and important determinant for (socio-)political participation, mediating the influence of objective political competences (or political knowledge, respectively). To test the role of subjective political competence and the (remaining) effect of political knowledge in early adulthood, empirical evidence using a sample of university students is presented. Cross-sectional analyses show that political knowledge has at least, if anything, an impact on voting, while fully mediated by subjective political competence relating non-electoral legal political activities. In contrast, the more profound competence of political reasoning has clear and stable positive effects on the intention to engage in non-electoral legal political actions – here subjective competence seems to be less important. Eventually, after a short excursus on school participation the findings are summarised and discussed by relating them back to framework and hypothesis. A concluding section proposes two opposing developmental-psychological considerations about the findings, raising further questions and giving an outlook into future research.
Time-dependent amplitude analysis of semileptonically-tagged D0 -> KS0 pi+ pi- decays at LHCb
Stefanie Reichert
Physics , 2013,
Abstract: The hadronic decay D0 -> KS0 pi+ pi- provides access to the measurement of the mixing parameters of the neutral D-meson system and allows to test for CP violation. A measurement of the mixing parameters x_D and y_D as well as of the parameters |q/p| and phi=arg(q,p), which govern indirect CP violation, will be performed based on a time-dependent amplitude-model analysis of the full LHCb dataset of 2011 and 2012 corresponding to an integrated luminosity of 3/fb.
Measurements of mixing and indirect CP violation
Stefanie Reichert
Physics , 2015,
Abstract: LHCb has collected the world's largest sample of charmed hadrons. This sample is used to measure the mixing parameters in the $D^0$-$\bar{D}^0$ system and to search for indirect $CP$ violation. This contribution focuses on measurements of $A_{\Gamma}$ with $D^*$ and semileptonic $B$ decays and on mixing measurements and a search for $CP$ violation in $D\to K\pi$ decays.
On The Complexity of Counter Reachability Games
Julien Reichert
Computer Science , 2013,
Abstract: Counter reachability games are played by two players on a graph with labelled edges. Each move consists in picking an edge from the current location and adding its label to a counter vector. The objective is to reach a given counter value in a given location. We distinguish three semantics for counter reachability games, according to what happens when a counter value would become negative: the edge is either disabled, or enabled but the counter value becomes zero, or enabled. We consider the problem of deciding the winner in counter reachability games and show that, in most cases, it has the same complexity under all semantics. Surprisingly, under one semantics, the complexity in dimension one depends on whether the objective value is zero or any other integer.
Traiter des suicides sans Durkheim : analyses et méthodes d’action de la psychodynamique du travail.
Fanny Darbus,Fanny Jedlicki
EspacesTemps.net , 2010,
Abstract: Paru fin 2009, l’ouvrage du psychanalyste Christophe Dejours et de la psychologue Florence Bègue s’inscrit au c ur d’une actualité sociale tragique : l’augmentation des suicides liés au travail. De ce point de vue, la médiatisation sans précédent du nombre croissant de suicides parmi les salariés de France Télécom constitue la partie émergée de l’iceberg. C’est dans un contexte politique et social particulier, où les enjeux sont également économiques et ...
Algunas anécdotas sobre las peripecias de los archivos de Jujuy: Reflexiones sobre la legislación y valoraciones sobre su importancia como patrimonio cultural
Cuadernos de la Facultad de Humanidades y Ciencias Sociales. Universidad Nacional de Jujuy , 2002,
Abstract: this paper takes into consideration jujuy′s public and private document files from its foundation to the present. firstly we will refer to the historical comings an goings leading to the dispersion or disappearance of documents belonging to the present-day province of jujuy from early times to these days. secondly, we wil analyse the legislation pertaining provincial public documents files (1) and the political tendencies revealed in such legislation about the whereabouts and importance of the document sources. thereafter, we will proceed to consider private document files existing in the province and the necessity of their cataloguing in order to appraise such documentation so that researchers and public in general could access them as valuable elements of co-operation in their approach to jujuy′s history. finally we will formulate some considerations about the importance granted to document files and his public records offices by the province and society as a whole, not only as heritage to be safeguarded but fundamentally as a "future memory", which should be regarded as an invaluable resort for the reconstruction of our history - not the history woven by suspicious readings - but also as an approach to reality which will contribute to a new formulation of our identity as a result of our past.
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