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Search Results: 1 - 10 of 133200 matches for " Fang Wang2 "
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Cross-immunizing potential of tumor MAGE-A epitopes recognized by HLA-A*02:01-restricted cytotoxic T lymphocytes
Ze-Min Huang1,#, Zheng-Cai Jia2,#, Jun Tang3, Yi Zhang1, Yi Tian1, Dong-Jing Ni1, Fang Wang2, Yu-Zhang Wu1,* & Bing Ni1,*
BMB Reports , 2012,
Abstract: Almost all melanoma cells express at least one member of theMAGE-A antigen family, making the cytotoxic T cells (CTLs)epitopes with cross-immunizing potential in this family attractivecandidates for the broad spectrum of anti-melanomaimmunotherapy. In this study, four highly homologous peptides(P264: FLWGPRALA, P264I9: FLWGPRALI, P264V9:FLWGPRALV, and P264H8: FLWGPRAHA) from the MAGE-Aantigens were selected by homologous alignment. All fourpeptides showed high binding affinity and stability toHLA-A*02:01 molecules, and could prime CTL immune responsesin human PBMCs and in HLA-A*02:01/Kb transgenicmice. CTLs elicited by the four epitope peptides couldcross-lyse tumor cells expressing the mutual target antigens,except MAGE-A11 which was not tested. However, CTLs inducedby P264V9 and P264I9 showed the strongest target celllysis capabilities, suggesting both peptides may represent thecommon CTL epitopes shared by the eight MAGE-A antigens,which could induce more potent and broad-spectrum antitumorresponses in immunotherapy.
Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats
In Hee Kim1,2, Dae-Ghon Kim1,2*, Peipei Hao2, Yunpeng Wang2, Seong Hun Kim1,2, Sang Wook Kim1,2, Seung Ok Lee1,2 & Soo Teik Lee1,2
BMB Reports , 2012,
Abstract: L-2-Oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodrugthat maintains glutathione in tissues. The present studywas designed to investigate anti-fibrotic and anti-oxidative effectsof OTC via modulation of nuclear factor erythroid 2-relatedfactor 2 (Nrf2) in an in vivo thioacetamide (TAA)-inducedhepatic fibrosis model. Treatment with OTC (80 or 160 mg/kg)improved serum liver function parameters and significantlyameliorated liver fibrosis. The OTC treatment groups exhibitedsignificantly lower expression of α-smooth muscle actin, transforminggrowth factor-β1, and collagen α1 mRNA than that inthe TAA model group. Furthermore, the OTC treatment groupsshowed a significant decrease in hepatic malondialdehyde levelcompared to that in the TAA model group. Nrf2 and hemeoxygenase-1 expression increased significantly in the OTCtreatment groups compared with that in the TAA model group.Taken together, these results suggest that OTC restores the anti-oxidative system by upregulating Nrf2; thus, ameliorating liverinjury and a fibrotic reaction.
Identification of interacting proteins of retinoid-related orphan nuclear receptor gamma in HepG2 cells
Ze-Min Huang1,#, Jun Wu2,#, Zheng-Cai Jia1, Yi Tian1, Jun Tang3, Yan Tang1, Ying Wang2, Yu-Zhang Wu1,* & Bing Ni1,*
BMB Reports , 2012,
Abstract: The retinoid-related orphan nuclear receptor gamma (RORγ)plays critical roles in regulation of development, immunity andmetabolism. As transcription factor usually forms a proteincomplex to function, thus capturing and dissecting of theRORγ protein complex will be helpful for exploring themechanisms underlying those functions. After construction ofthe recombinant tandem affinity purification (TAP) plasmid,pMSCVpuro RORγ-CTAP(SG), the nuclear localization ofRORγ-CTAP(SG) fusion protein was verified. Followingisolation of RORγ protein complex by TAP strategy, sevencandidate interacting proteins were identified. Finally, the heatshock protein 90 (HSP90) and receptor-interacting protein 140(RIP140) were confirmed to interplay with RORγ byco-immunoprecipitation. Interference of HSP90 or/and RIP140genes resulted in dramatically decreased expression ofCYP2C8 gene, the RORγ target gene. Data from this studydemonstrate that HSP90 and RIP140 proteins interact withRORγ protein in a complex format and function asco-activators in the RORγ-mediated regulatory processes ofHepG2 cells.
Discussion of Function of Church and State in Public Education in the U.S.  [PDF]
Fang Wang
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.29047
Abstract: Religion in relation to public education has been a topic of keen interest in the U.S. It has two components: one deals with the theme of religious content in the curriculum and the other concerns fringe benefits to nonpublic schools. And, where the State stands, the decisions and measures made by the U.S. Supreme Court concern religious matters in public schools.
A Model of Translation of Politeness Based on Relevance Theory  [PDF]
Fang Wang
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.29045
Abstract: Sperber and Wilson developed the Relevance Theory of communication. It did not take long before it was applied to translation. This dissertation attempts to illustrate the model of the translation of politeness. Translation is a cross-linguistic sociocultural practice, in which a text in one language is replaced by a text with equivalent relevance degree in another. The original contains three variables, which, once summed, give the weightiness of the face-threatening act and the choice of stimulus is decided.
An Eco-Translatology Approach to the English Translation of Chinese Internet Catchwords  [PDF]
Fang Wang
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.210007
Abstract: In this article, qualitative analysis is adopted. Data of internet catchwords are chosen from those popular in recent five years. The thesis aims at throwing lights on further studies of the English translation of Chinese internet catchwords and promoting the worldwide transmission of Chinese internet catchwords and internet culture. It is hoped that the dissertation could provide a new perspective for the study of internet catchwords.
A Discussion of Administration of Local Public Schools in U.S.  [PDF]
Fang Wang
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.211028
Abstract: The enriched lifestyle enjoyed by U.S. citizens is a result of free public education. Education has gradually evolved into a very complex process because of the expectations of the American people and because of technological advances. Thus, effective education can occur only within an organization that is capable of analyzing the needs of future generations and that is capable of creating delivery systems that will meet the needs. In this article, the author explored the nature of public school districts and public school management in primary schools and secondary schools in U.S. to shed light on the pros and cons of the educational system.
The Biological and Social Determination of Man’s Psychic Development  [PDF]
Fang Wang
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.212011
Abstract: Throughout the history of education research, certain views were expressed which considered that the main determining force in an individual’s personality development was the biological factor. On the other hand, there were other experts who underestimated the biological factor and concentrated on the social factor. The struggle between these contradictory views was of long duration. In this article, the author tries to discuss about both the biological determination of personality development and the training of man, and the influence of the social environment on personality development and the training of man.
Study on Formation Mechanism of Defects in Monoclinic KLu(WO4)2 Crystals  [PDF]
Kunpeng Wang, Jinzhi Fang
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.26086
Abstract: The laser host crystals of KLu(WO4)2(KLuW) with large sizes up to 43 × 35 × 16 mm3 have been grown along, [110], b, and c crystallographic directions, respectively, by the top-seeded solution growth (TSSG) slow-cooling method. The macro defects are observed using optical microscopy. The main defects found were cracks, inclusions, growth striations, sector boundaries and twin boundaries. The formation mechanism and approaches to reduce or eliminate the defects have been analyzed.
Some Steiner Symmetry Results in Overdetermined Boundary Value Problem  [PDF]
Zhongbo Fang, Anna Wang
Advances in Pure Mathematics (APM) , 2011, DOI: 10.4236/apm.2011.16061
Abstract: In this paper, we use the moving planes method to prove that the domain Ω and the solution u are Steiner symmetric if u is a positive solution of the overdetermined boundary value problem in Ω.
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