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Search Results: 1 - 10 of 31338 matches for " Fabricio Rios Santos "
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N-acetyltransferase 2: Slow, intermediate or fast? A booming question of the molecular epidemiology in cancer research  [PDF]
Giuliano Di Pietro, Sandra Rocha Gadelha, Sandra Mara Bispo Sousa, Paulo Roberto Santana de Melo, Fabricio Rios Santos
Open Journal of Genetics (OJGen) , 2012, DOI: 10.4236/ojgen.2012.24028
Abstract: Throughout history, humanity has referred to reactions occurring with food, plants and, recently, medicines or drugs. The increase in pulmonary tuberculosis cases and the availability of treatment showed that genetic human differences can interfere in the capacity to metabolize drugs. There are remarkable genetic polymorphisms of N-acetyltransferase 2 (NAT2) activity that have been associated with different levels of susceptibility to developing many kinds of cancers. This review considers the field as an open window for the application of molecular epidemiology tools that led to the development of pharmacogenomics. We cover historical data and the most recent knowledge about NAT2 genetic polymorphisms and its distribution in different populations, which is an important concept being incorporated in epidemiological studies of cancer risk. We present up to date information about these studies, including meta-analysis based on the NAT2 distribution in different types of cancer. A critical broad at advances in NAT2 research, high-lighting recent studies related to NAT2 alleles in cancer susceptibility. Although there are multifactorial aspects involved in cancer risk, the variability in NAT2 allelic frequency can be related to carcinogenesis through alterations in the metabolic rate after exposure to carcinogens.
A expuls?o dos jesuítas da Bahia: aspectos econ?micos
Santos, Fabricio Lyrio;
Revista Brasileira de História , 2008, DOI: 10.1590/S0102-01882008000100009
Abstract: this article analyzes the expulsion of jesuits from bahia, focusing mainly upon the confiscation of their patrimony and the sale of their main properties between 1758 and 1763. because of the crisis faced by the society of jesus in portugal during the 1750's, the question of its expressive patrimony and supposed richness proved to be a key issue. however, the matter was not dissociated from the ample spectrum of measures that configured a true political reform of the portuguese state in the second half of the 18th century. from that time on, the religious orders and the church assumed a new role in the public sphere and in the political body of the reign.
A habilidade de comunica??o com o paciente no processo de aten??o farmacêutica
Possamai, Fabricio Pagani;Dacoreggio, Marlete dos Santos;
Trabalho, Educa??o e Saúde , 2007, DOI: 10.1590/S1981-77462007000300008
Abstract: the article discusses the importance communications have in the pharmacist/patient relationship in the pharmaceutical care process, in the ambit of this professional's performance in commercial and private pharmacies in both public and private systems. the article identifies factors that interfere with the communication process and discusses the importance of the health professionals' attitudes as allies in valuing communications with the patient, which, in turn, favors the therapeutics to be used. the goal is to discuss the importance of communications in the pharmacist/patient relationship as a professional pedagogic resource to develop a pharmaceutical care process. the relationship is formed by a learning process in which the pharmacist is a learning facilitator for his or her patient. his or her function is to provide proper information on medication use; to teach by not only conveying the information, rather by creating conditions for the patient to receive such information in a useful, effective manner, organizing strategies to learn the prescribed therapy.
Molecular Data for the Sea Turtle Population in Brazil
Sibelle Torres Vila?a,Fabricio Rodrigues dos Santos
Dataset Papers in Science , 2013, DOI: 10.1155/2013/196492
Abstract: We report here a dataset comprising nine nuclear markers for the Brazilian population of Cheloniidae turtles: hawksbills (Eretmochelys imbricata), loggerheads (Caretta caretta), olive ridleys (Lepidochelys olivacea), and green turtles (Chelonia mydas). Because hybridization is a common phenomenon between the four Cheloniidae species nesting on the Brazilian coast, we also report molecular markers for the hybrids E. imbricata × C. caretta, C. caretta × L. olivacea, and E. imbricata × L. olivacea and for one hybrid E. imbricata × C. mydas and one between three species C. mydas × E. imbricata × C. caretta. The data was used in previous studies concerning (1) the description of frequent hybrids C. caretta × E. imbricata in Brazil, (2) the report of introgression in some of these hybrids, and (3) population genetics. As a next step for the study of these hybrids and their evolution, genome-wide studies will be performed in the Brazilian population of E. imbricata, C. caretta, and their hybrids. 1. Introduction From the seven known sea turtle species, five species nest on the Brazilian coast: leatherback (Dermochelys coriacea), green (Chelonia mydas), olive ridley (Lepidochelys olivacea), loggerhead (Caretta caretta), and hawksbill (Eretmochelys imbricata). The Brazilian sea turtle population differs from other worldwide populations because of its high hybrid frequency. Almost 43% of nesting E. imbricata individuals were reported as hybrids in a short stretch of the Brazilian coast (Bahia state), while other sites where E. imbricata nests did not show presence of hybrids [1, 2]. The sea turtles that nest in the Brazilian coast have been shown to form a separate genetic pool from other populations [3–5]. Studies with species nesting in Brazil show that their populations are differentiated from other worldwide populations. Recent telemetry studies corroborate the results from genetic data: C. caretta, E. imbricata, C. mydas, and L. olivacea individuals that nest in Brazilian beaches tend to stay in feeding aggregations within the Brazilian continental shelf [6–9]. On the other hand, Brazilian feeding aggregations are characterized by a mixture of turtles coming from different regions worldwide. Mixed-stock results based on mitochondrial DNA showed that E. imbricata feeding areas receive migrants from Africa, Caribbean, and Pacific Ocean [10]; C. caretta foraging aggregations are characterized by a mixture of Brazilian, Australian, Mediterranean, and northwestern Atlantic turtles [3]; and C. mydas feeding grounds are characterized by the contribution of other
Multicystic dysplastic kidney: a review of eleven years (2000 - 2010)
Rios,Helena; Santos,Raquel; Gomes,Clara; Correia,António Jorge;
Portuguese Journal of Nephrology & Hypertension , 2012,
Abstract: introduction. multicysticdysplastic kidney is the most common form of renal dysplasia. the natural history of multicystic dysplastic kidney is involution of the affected kidney, which justifies conservative management. the aim of this study was to evaluate the clinical course of a group of children with multicystic dysplastic kidney and compare these results with a previous study conducted 1989 -2000 in the same clinic. patients and methods. retrospective analysis of the medical records of all children with multicystic dysplastic kidney referred to the paediatric nephrology unit of a tertiary paediatric hospital 2000-2010. results. fifty-two children (54% female) with multicystic dysplastic kidney were studied. the mean age at the time of the first visit was nineteen months with a mean follow-up time of sixty-five months. prenatal ultrasound showed renal abnormalities in 96% of the children, 80% of which were suggestive of multicystic dysplastic kidney. all children underwent renal ultrasound and renal scintigraphy, 48 (92%) had a voiding cystourethrography and two (4%) intravenous urography. ten (19%) children had contralateral kidney anomalies without obstruction of urinary tract, with the most frequent being pelvicalyceal dilatation (5) and vesicoureteral reflux (5). nephrectomy was performed in five children (10%). indications for nephrectomy were increased multicystic dysplastic kidney size in two children, ureterocele in two and bladder diverticulum in one. of the 47 children (90%) with conservative treatment, 21 (45%) had total kidney involution (over a mean follow-up of three years). ten (19%) children had complications, eight (15%) of them had urinary tract infection, and two proteinuria. conclusions. as in the 1989-2000 study, prenatal ultrasound was the main form of multicystic dysplastic kidney diagnosis and contralateral kidney anomalies remain frequent (19% vs.=29%). there has been a significant reduction in the number of intravenous urographies (4% vs
Mariangela Rios de Oliveira,Leonardo Pereira dos Santos
Signótica , 2011, DOI: 10.5216/sig.v23i2.17529
Abstract: Com base na perspectiva da gramaticaliza o de constru es (traugott, 2008; no l, 2007), este artigo trata dos padr es de uso da express o sei lá verificados em textos falados por estudantes brasileiros: como modalizador e como marcador discursivo. A partir da aplica o de seis fatores aos dados de pesquisa, é possível constatar que a fun o modalizadora situa-se em cline menos avan ado de gramaticaliza o face à fun o marcadora, bem como detectar que fatores de ordem metonímica, no nível interno da express o e dos contextos maiores de sua ocorrência (gênero textual e sequência tipológica), motivam os padr es funcionais em que se articula sei lá.
Enterite necrótica aviária
Gil de los Santos, Jo?o Rodrigo;Concei??o, Fabricio Rochedo;Gil-Turnes, Carlos;
Ciência Rural , 2008, DOI: 10.1590/S0103-84782008000700047
Abstract: avian necrotic enteritis is an acute enterotoxaemia that appears suddenly producing rapid deaths, affecting mainly young animals. although its negative impact in poultry production is already known, factors related to etiology, pathogenesis and control of this important disease need better clarifications. for a long time its control was based on the use of antibiotics in poultry feed, whose the use was banned by several consumer markets, requiring the development of new control strategies. informations on the etiology, epizootiology, pathogenesis, diagnosis and control are reviewed, emphasizing the role of probiotics and vaccines as control alternatives.
Substancias húmicas aquáticas: fracionamento molecular e caracteriza??o de rearranjos internos após complexa??o com íons metálicos
Sargentini Junior, ézio;Rocha, Julio Cesar;Rosa, André Henrique;Zara, Luiz Fabricio;Santos, Ademir dos;
Química Nova , 2001, DOI: 10.1590/S0100-40422001000300010
Abstract: the aquatic humic substances (ahs) investigated in this study were conventionally isolated from rio negro waters - amazonas state/brazil by means of the collector xad 8. a special five-stage tangential-flow ultrafiltration device was used for analytical fractionation of ahs. the fractionation patterns (6 fractions each) showed that metal traces remaining in ahs after their xad 8 isolation have different size distributions. for instance, the major percentage of traces of ni, cu, zn, cd and pb (determined using icp-aes) was preferably complexed by molecules with relatively high molecular size (30-100 kda) and the following complexation order was characterized: f2 >> f1 = f4 = f5 > f3 > f6. moreover, the species formed between ahs and metals prepared by spiking, showed distribution patterns changing as a function of the complexation time (ageing process), indicating a slow transformation process and an inner rearrangements in the binding sites within the ahs molecules.
Microscopia de varredura por sonda (SPM) aplicada a a?os inoxidáveis dúplex
Santos, Fabricio Sim?o dos;Gheno, Simoni Maria;Kuri, Sebasti?o Elias;
Rem: Revista Escola de Minas , 2007, DOI: 10.1590/S0370-44672007000100028
Abstract: in this work, scanning probe microscopy (spm), in the contact (atomic force microscopy - afm) and magnetic force (magnetic force microscopy - mfm) modes, has been used to analyze the microstructure of a solution-treated and aged 2205 duplex stainless steel. a surface analysis of the solution-treated steel has been performed by afm after passive film growth. by afm it was obtained a indication of film growth on the microstructure of the solution-treated steel, while by mfm the phase distribution could be observed without the need of surface etching.
Reproduction of Trichospilus diatraeae (Hymenoptera: Eulophidae) in pupae of two lepidopterans defoliators of eucalypt Reproducción de Trichospilus diatraeae (Hymenoptera: Eulophidae) en pupas de dos lepidópteros defoliadores de eucalipto
Revista Colombiana de Entomología , 2012,
Abstract: Biological control of lepidopteran defoliators using parasitoids is a promising alternative. The objective of this work was to evaluate the reproduction of Trichospilus diatraeae (Hymenoptera: Eulophidae) in pupae of the eucalypt defoliators Thyrinteina arnobia (Lepidoptera: Geometridae) and Hylesia paulex (Lepidoptera: Saturniidae). Host pupae were individualized in glass tubes (14 x 2.2 cm) with six parasitoid females for 24 h under controlled conditions [25 ± 2°C; 70 ± 10% (RH) and; 14 h photo phase]. T. diatraeae parasitized 95.8 ± 2.85% pupae of T. arnobia and 79.2 ± 6.72% of H. paulex, with an emergence rate of 89.6 ± 5.03% and 69.8 ± 6.13%, respectively. However, H. paulex pupae yielded large parasitoid progenies. No difference in the parasitoid sex ratio, adult size and longevity were observed between both hosts. The successful parasitism and development of T. diatraeae in pupae of T. arnobia and H. paulex suggest that this parasitoid can be an alternative for the biological control of these defoliators in eucalyptus plantations. El control biológico con parasitoides de los lepidópteros defoliadores con parasitoides es una alternativa prometedora. El objetivo de este trabajo fue evaluar la reproducción de Trichospilus diatraeae (Hymenoptera: Eulophidae) en pupas de los defoliadores del eucalipto Thyrinteina arnobia (Lepidoptera: Geometridae) e Hylesia paulex (Lepidoptera: Saturniidae). Pupas del anfitrión fueron individualizadas en tubos de vidrio (14 x 2,2 cm) con seis hembras del parasitoide durante 24 h en condiciones controladas [25 ± 2°C, 70 ± 10% (HR) y foto-período de 14 horas]. T. diatraeae parasita 95,8 ± 2,85% de las pupas de T. arnobia y 79,2 ± 6,72% de H. paulex, con un índice de emergencia de 89,6 ± 5,03% y 69,8% ± 6,13, respectivamente. Sin embargo, las pupas de H. paulex produjeron grandes progenies del parasitoide. No se observaron diferencias en la proporción de sexos, tama o de adulto y longevidad de los parasitoides en las progenies. El éxito del parasitismo y desarrollo de T. diatraeae en las pupas de T. arnobia y H. paulex sugieren que este parasitoide puede ser una alternativa para el control biológico de estos defoliadores en plantaciones de eucalipto.
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