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Contribution of activated platelets to plasma IL-27 levels
Hind Hamzeh-Cognasse, Pauline Damien, Kim Nguyen, Fabrice Zeni, Bruno Pozzetto, Fabrice Cognasse, Olivier Garraud
Critical Care , 2013, DOI: 10.1186/cc11925
Abstract: IL: interleukin; TRAP: thrombin receptor activating peptide.The authors declare that they have no competing interests.The authors thank MA Eyraud and CA Arthaud for technical assistance. This work was supported by the EFS (grant APR2010-No10) the ANR (grant ANR-12- JSV1), the ART, and the 'Les Amis de Rémi' Association; France. In accordance with French regulations, platelets were obtained from regular blood donors who signed a form indicating that they do not preclude the use of their sample for medical research.
Meningitis in adult patients with a negative direct cerebrospinal fluid examination: value of cytochemical markers for differential diagnosis
Alain Viallon, Nicolas Desseigne, Olivier Marjollet, Albert Birynczyk, Mathieu Belin, Stephane Guyomarch, Jacques Borg, Bruno Pozetto, Jean Bertrand, Fabrice Zeni
Critical Care , 2011, DOI: 10.1186/cc10254
Abstract: This was a prospective study, started in 1997, including all patients admitted to the emergency unit with acute meningitis and a negative direct CSF examination. Serum and CSF samples were taken immediately on admission. The patients were divided into two groups according to the type of meningitis: bacterial (BM; group I) or viral (VM; group II). The CSF parameters investigated were cytology, protein, glucose, and lactate; the serum parameters evaluated were C-reactive protein and procalcitonin. CSF/serum glucose and lactate ratios were also assessed.Of the 254 patients with meningitis with a negative direct CSF examination, 35 had BM and 181, VM. The most highly discriminative parameters for the differential diagnosis of BM proved to be CSF lactate, with a sensitivity of 94%, a specificity of 92%, a negative predictive value of 99%, a positive predictive value of 82% at a diagnostic cut-off level of 3.8 mmol/L (area under the curve (AUC), 0.96; 95% confidence interval (CI), 0.95 to 1), and serum procalcitonin, with a sensitivity of 95%, a specificity of 100%, a negative predictive value of 100%, and a positive predictive value of 97% at a diagnostic cut-off level of 0.28 ng/ml (AUC, 0.99; 95% CI, 0.99 to 1).Serum procalcitonin and CSF lactate concentrations appear to be the most highly discriminative parameters for the differential diagnosis of BM and VM.The emergency therapeutic management of meningitis involves rapid identification of the bacterial or viral nature of this disease, so that antibiotic treatment can be started without delay [1], even though the relation between prognosis and delay in starting antibiotic therapy has not been clearly established [2-5].The immediate identification of bacterial meningitis (BM) is based on direct examination of the cerebrospinal fluid (CSF) or the detection of bacterial antigens in the CSF. These tests have a low sensitivity, and in 30% to 50% of cases, they do not contribute to differential diagnosis [6-9].A model for p
Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study
Michael Darmon, Francois Vincent, Jean Dellamonica, Frederique Schortgen, Frederic Gonzalez, Vincent Das, Fabrice Zeni, Laurent Brochard, Gilles Bernardin, Yves Cohen, Benoit Schlemmer
Critical Care , 2011, DOI: 10.1186/cc10327
Abstract: We conducted an observational, prospective, multicenter study at three ICUs in university hospitals. Unselected patients, except those with obstructive AKI, were admitted to the participating ICUs during a six-month period. Transient AKI was defined as AKI caused by renal hypoperfusion and reversal within three days. The results are reported as medians (interquartile ranges).A total of 203 patients were included. According to our definitions, 67 had no AKI, 54 had transient AKI and 82 had persistent AKI. FeUrea was 39% (28 to 40) in the no-AKI group, 41% (29 to 54) in the transient AKI group and 32% (22 to 51) in the persistent AKI group (P = 0.12). FeUrea was of little help in distinguishing transient AKI from persistent AKI, with the area under the receiver operating characteristic curve being 0.59 (95% confidence interval, 0.49 to 0.70; P = 0.06). Sensitivity was 63% and specificity was 54% with a cutoff of 35%. In the subgroup of patients receiving diuretics, the results were similar.FeUrea may be of little help in distinguishing transient AKI from persistent AKI in critically ill patients, including those receiving diuretic therapy. Additional studies are needed to evaluate alternative markers or strategies to differentiate transient from persistent AKI.Acute kidney injury (AKI) is common and associated with high mortality in critically ill patients [1-3]. The causes of AKI other than urinary tract obstruction are usually divided into two categories: prerenal causes, in which low renal perfusion leads to promptly reversible renal dysfunction, and intrinsic causes with renal tissue damage and persistent renal dysfunction. Although pathological studies are lacking, the leading cause of persistent AKI in critically ill patients is believed to be acute tubular necrosis (ATN) [4,5]. It is usually assumed that there is a continuum that leads from prerenal AKI to ATN [4-6]. Many publications in the fields of internal medicine, nephrology and critical care still advoca
O negro drama do rap: entre a lei do c?o e a lei da selva
Zeni, Bruno;
Estudos Avan?ados , 2004, DOI: 10.1590/S0103-40142004000100020
Abstract: in this text i set out some considerations that stem from keen personal interests and concerns regarding rap - e.g., the production of lyrics, the relationship between such manifestations and the universe of poverty and imprisonment, and the dialogue between this rhythm and the broader tradition of brazilian music and literature. i discuss some aesthetic and ethical issues related to the variety of rap that i am most intimately involved with, namely, the one made in s?o paulo.
Marco Zeni
Italiano LinguaDue , 2010, DOI: 10.6092/2037-3597/639
Abstract: L'Irlanda è recentemente divenuta un paese di immigrazione. Se la presenza di immigrati italiani non è significativa lo studio dell'italiano LS è invece discretamente diffuso, sebbene non ai livelli ben maggiori del francese, del tedesco e dello spagnolo. L'articolo presenta un'analisi quantitativa dell'offerta e dello studio dell'italiano LS nelle scuole e nelle università irlandesi. L'analisi è stata condotta raccogliendo dati da fonti istituzionali, da siti internet, da materiale cartaceo, ma si fonda anche su esperienze dirette di insegnamento dell'italiano in Irlanda da parte dell'autore. Il risultato è il computo numerico degli studenti che studiano l'italiano come LS nelle scuole superiori e dell'offerta didattica delle maggiori università irlandesi e in particolare della National University of Ireland di Galway di cui si presentano i diversi corsi di lingua e di cultura italiana. Ireland has recently attracted more and more immigration. Even if there are not many Italian immigrants living in Ireland, the study of Italian as a foreign language is quite wide-spread, although not quite as popular as French, German and Spanish. This paper is a quantitative analysis of the study of Italian as a foreign language in Irish schools and universities. The survey was carried out using data from institutional sources, internet sites, printed materials as well as the author's personal experience teaching Italian in Ireland. The results illustrate the number of students studying Italian as a foreign language in high schools and the courses offered in the main Irish universities, in particular at the National University of Ireland in Galway, which offers numerous courses on Italian language and culture.
Continuous infusion of ceftazidime in critically ill patients undergoing continuous venovenous haemodiafiltration: pharmacokinetic evaluation and dose recommendation
Christophe Mariat, Christophe Venet, Fran?ois Jehl, Sandrine Mwewa, Vesna Lazarevic, Eric Diconne, Nathalie Fonsale, Anne Carricajo, Stéphane Guyomarc'h, Régine Vermesch, Gérald Aubert, Roselyne Bidault, Jean-Claude Bertrand, Fabrice Zeni
Critical Care , 2005, DOI: 10.1186/cc3993
Abstract: Seven critically ill patients were prospectively enrolled in the study. CVVHDF was performed using a 0.6 m2 AN69 high-flux membrane and with blood, dialysate and ultrafiltration flow rates of 150 ml/min, 1 l/hour and 1.5 l/hour, respectively. Based on a predicted haemodiafiltration clearance of 32.5 ml/min, all patients received a 2 g loading dose of ceftazidime, followed by a 3 g/day continuous infusion for 72 hours. Serum samples were collected at 0, 3, 15 and 30 minutes and at 1, 2, 4, 6, 8, 12, 24, 36, 48 and 72 hours; dialysate/ultrafiltrate samples were taken at 2, 8, 12, 24, 36 and 48 hours. Ceftazidime concentrations in serum and dialysate/ultrafiltrate were measured using high-performance liquid chromatography.The mean (± standard deviation) elimination half-life, volume of distribution, area under the concentration-time curve from time 0 to 72 hours, and total clearance of ceftazidime were 4 ± 1 hours, 19 ± 6 l, 2514 ± 212 mg/h per l, and 62 ± 5 ml/min, respectively. The mean serum ceftazidime steady-state concentration was 33.5 mg/l (range 28.8–36.3 mg/l). CVVHDF effectively removed continuously infused ceftazidime, with a sieving coefficient and haemodiafiltration clearance of 0.81 ± 0.11 and 33.6 ± 4 mg/l, respectively.We conclude that a dosing regimen of 3 g/day ceftazidime, by continuous infusion, following a 2 g loading dose, results in serum concentrations more than four times the minimum inhibitory concentration for all susceptible pathogens, and we recommend this regimen in critically ill patients undergoing CVVHDF.The β-lactam antibiotics are known to exhibit little concentration-dependent activity. The maximal killing rate occurs when antibiotic concentrations have reached four to five times the minimum inhibitory concentration (MIC) for the causative pathogens [1], and higher concentrations do not significantly enhance the bactericidal activity. Conversely, an increase in the time for which free β-lactam serum levels are above the MIC is likely
A ciência e a gest?o da informa??o: compatibilidades no espa?o profissional
Marchiori, Patricia Zeni;
Ciência da Informa??o , 2002, DOI: 10.1590/S0100-19652002000200008
Abstract: presents the actual context regarding the information professionals' activities, bearing in mind the job market, which is getting more and more exigent and concern about information problems resolution. it defines information resource management, as well as the academic and operational approach, based on the information science theoretical assumptions. the main focus is the core content, related with the overall management of information resources, needed by individuals, groups and institutions. it stress the common processes regarding the information field shared by the information resources manager and others professionals, related the trinomy data, information and knowledge. describes the skills and abilities needed by the information resources manager as well as the inherent difficulties concerning any professional approach to the information activities field.
"Ciberteca" ou biblioteca virtual: uma perspectiva de gerenciamento de recursos de informa??o
Marchiori, Patricia Zeni;
Ciência da Informa??o , 1997, DOI: 10.1590/S0100-19651997000200002
Abstract: the technological modifications and the new concepts of information resource management are breaking the traditional library model paradigm. the concept of virtual library is an alternative to amplify the search and access to informational sources, in a wide world, in a qualitative, pertinent and racional manner, joinning local access to remot access by infoways. in spite of the concept of virtual library is still being constructed, a carefull planning is desirable for the change the traditional library to the virtual library perspective. some steps for this evaluation are discussed, mainly for specialized libraries, as well as some experiences in process in developed countries. the development of new profiles for librarians and library staff is urgent, in order to ensure changes in attitudes and activities.
Para os que desejam entender a gest o da informa o Para los que desean entender la gestión de la información
Patricia Zeni Marchiori
Informa??o & Informa??o , 1999, DOI: 10.5433/1981-8920.1999v4n1p
Abstract: PONJUáN DANTE, Glória. Gestión deInformación en las organizaciones: princípios,conceptos y aplicaciones. Santiago deChile : CECAPI, 1998. 222 p.
Retorno (valor) de investimento em informa o: decifra-me ou te devoro Retorno (valor) de inversión en información: deciframe o te devoro
Patricia Zeni Marchiori
Informa??o & Informa??o , 2008, DOI: 10.5433/1981-8920.2008v13n0p
Abstract: O artigo discute a aplica o de levantamentos de retorno/valor de investimento (ROI/VOI) para produtos/servi os de informa o em dife-rentes ambientes, abordando o comportamento de uso da informa o pelo usuário final, as possíveis métricas e suas inerentes complexidades. Identifica e analisa os parametros de custo e benefícios sociais advindos das a es informativas sob a ótica do fluxo dado-informa o-conhecimento e prop e quatro enfoques estratégicos para a elabora o do ROI/VOI em informa o. Adiciona um segundo nível de reflex o ao destacar o reconhecimento do “custo total da falha” como sendo um estímulo a práticas de gest o da informa o e documenta o conectadas direta e indiretamente ao ROI/VOI.
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