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Search Results: 1 - 10 of 2232 matches for " Fabiana Salm "
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Novel Agents Targeting the IGF-1R/PI3K Pathway Impair Cell Proliferation and Survival in Subsets of Medulloblastoma and Neuroblastoma
Anna Wojtalla, Fabiana Salm, Ditte G. Christiansen, Tiziana Cremona, Paulina Cwiek, Tarek Shalaby, Nicole Gross, Michael A. Grotzer, Alexandre Arcaro
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047109
Abstract: The receptor tyrosine kinase (RTK)/phosphoinositide 3-kinase (PI3K) pathway is fundamental for cancer cell proliferation and is known to be frequently altered and activated in neoplasia, including embryonal tumors. Based on the high frequency of alterations, targeting components of the PI3K signaling pathway is considered to be a promising therapeutic approach for cancer treatment. Here, we have investigated the potential of targeting the axis of the insulin-like growth factor-1 receptor (IGF-1R) and PI3K signaling in two common cancers of childhood: neuroblastoma, the most common extracranial tumor in children and medulloblastoma, the most frequent malignant childhood brain tumor. By treating neuroblastoma and medulloblastoma cells with R1507, a specific humanized monoclonal antibody against the IGF-1R, we could observe cell line-specific responses and in some cases a strong decrease in cell proliferation. In contrast, targeting the PI3K p110α with the specific inhibitor PIK75 resulted in broad anti-proliferative effects in a panel of neuro- and medulloblastoma cell lines. Additionally, sensitization to commonly used chemotherapeutic agents occurred in neuroblastoma cells upon treatment with R1507 or PIK75. Furthermore, by studying the expression and phosphorylation state of IGF-1R/PI3K downstream signaling targets we found down-regulated signaling pathway activation. In addition, apoptosis occurred in embryonal tumor cells after treatment with PIK75 or R1507. Together, our studies demonstrate the potential of targeting the IGF-1R/PI3K signaling axis in embryonal tumors. Hopefully, this knowledge will contribute to the development of urgently required new targeted therapies for embryonal tumors.
Tree species diversity in a seasonally-dry forest: the case of the Pinkaití site, in the Kayapó Indigenous Area, Southeastern limits of the Amazon
Salm, Rodolfo;
Acta Amazonica , 2004, DOI: 10.1590/S0044-59672004000300009
Abstract: this study investigates patterns of forest structure and tree species diversity in an anthropogenic palm grove and undisturbed areas at the seasonally-dry pinkaití research station, in the kayapó indigenous area. this site, managed by the conservation international do brasil, is the most southeastern site floristically surveyed in the amazon until now. the secondary and a nearby undisturbed forest were sampled in a group of 52 floristic plots of 0.0625-ha (25x25-m) where all trees with dbh > 10 cm were measured and identified. the analyses were complemented with other two floristic plots of 1-ha (10x1000-m). the present study has shown that the pinkaití, like other seasonally-dry forests, have great heterogeneity in forest structure and composition, associated with biotic characteristics of the most important tree species, natural disturbance and history of land-use. the palm grove, moderately dominated by the arborescent palm attalea maripa (aubl.) mart., presented high tree species diversity and was floristically similar to undisturbed forests at the study site. it is discussed the importance of large arborescent palms for the seasonally-dry amazon forests regeneration.
The importance of forest disturbance for the recruitment of the large arborescent palm Attalea maripa in a seasonally-dry Amazonian forest
Salm, Rodolfo;
Biota Neotropica , 2005, DOI: 10.1590/S1676-06032005000100004
Abstract: the hypothesis that forest disturbance is important for the recruitment of the large arborescent palms attalea maripa was tested with a natural experiment in the pinkaití site (7o 46's; 51o 57'w), a seasonally-dry amazonian forest. a 8,000 m long trail, that crosses, in its lower half, an open forest along the pinkaití stream bottomlands and, on its upper half, a dense forest on a hill, was divided in 160 0.15 ha (50x30 m) sampling units. at each unit, adult palms were counted and percentage of canopy openness was measured with a concave spherical densiometer. the palms were nearly five times more abundant at the bottomlands, whose forest had a canopy 14.8% more open than that of the hill; supporting the hypothesis that disturbance is important for their recruitment.
Arborescent palm seed morphology and seedling distribution
Salm, Rodolfo;
Brazilian Journal of Biology , 2005, DOI: 10.1590/S1519-69842005000400018
Abstract: this study examines how the seed morphology of two large arborescent palms, attalea maripa (aubl.) mart. and astrocaryum aculeatum g. mey, may affect their seed shadow in a seasonally dry amazonian forest. in addition to being smaller and produced in larger numbers than those of a. aculeatum, a. maripa seeds also presented a substantially lower amount of nutritional reserves available for the embryo. however, a. maripa seedlings were found in much higher numbers than those of a. aculeatum. the results suggest that, within the spatial scale considered, the seed rain of a. maripa is more restricted to the area surrounding around reproductive conspecifics than that of a. aculeatum. furthermore, in comparison with those of a. aculeatum, the smaller seeds of a. maripa might be less attractive to scatterhoarding rodents (e.g. dasyprocta aguti). the pattern observed emphasizes the importance of scatterhoarding rodents as dispersers of large-seeded plant species in neotropical forests.
Theoretical Descriptions of the Nucleon Electromagnetic Form Factors in the Space- and Time-like regions
Salmè, Giovanni
High Energy Physics - Phenomenology , 2008, DOI: 10.1016/j.nuclphysbps.2008.09.004
Abstract: Some recent advances in the theoretical description of the Nucleon electromagnetic form factors, both in the space- and time-like regions, will be briefly illustrated. In particular, both the present stage of the lattice calculations and updated phenomenological approaches, like the ones based on dispersion relations and on microscopical models, will be reported.
O longo caminho da luta contra a pobreza e seu alentador encontro com os direitos humanos
Salmón G., Elizabeth;
Sur. Revista Internacional de Direitos Humanos , 2007, DOI: 10.1590/S1806-64452007000200007
Abstract: this article proposes to find a possible legal basis for the fight against poverty, even in post-conflict contexts, taking into consideration the principle of human rights and the contemporary international order.
Los aspectos internacionales en la reforma de la Constitución
Elizabeth Salmón
Pensamiento Constitucional , 2003,
Abstract: No presenta resumen.
Una historia del pensamiento indianista Ukhamawa Jakawisaxa
Salmón, Josefa
Revista de Indias , 2008,
Abstract: The objective of this article is to show the contribution that the autobiography os the Aymara leader, Luciano Tapia has made to the official Bolivian history and at the same time to expose the foundations of his indianista thought. The characteristics of his thought deal with the recognition of his own culture, the transposition of Andean notions to an urban context, the imbalance of political praxis with the notion of complementarity of theory and praxis, thought as an event, and ethinicity as a process instead of identity. I have done research in the Archives of the Cámara de Diputados in La Paz and I have consulted academic articles on Andean culture and history. El objetivo de este trabajo es mostrar la aportación de la microhistoria, principalmente a través de la autobiografía del líder político aimara Luciano Tapia, a la historia oficial boliviana y exponer su pensamiento indianista. En éste destacan la revaloración cultural, el replanteamiento de nociones andinas en la urbe, los desajustes entre la práctica política y el principio de complementariedad, el pensar como evento, y la etnicidad en tanto proceso y no como identidad. He consultado los Archivos de la Cámara de Diputados en La Paz y textos académicos sobre la cultura e historia andina.
Bases da Educa o da For a de Trabalho
Cláudio Salm
Revista Paranaense de Desenvolvimento , 1994,
Abstract: O objetivo do artigo é, inicialmente conceituar "educa o tecnológica" e assinalar, a partir daí, as diferen as face aos conceitos que orientam, entre nós, as a es institucionais.
Las entregas extraordinarias y el acervo humanitario del Derecho internacional Abre la nueva administración americana alguna perspectiva de cambio?
Elizabeth Salmón
Derecho PUCP , 2009,
Abstract: No contine resumen
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