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Search Results: 1 - 10 of 26725 matches for " FV3 "
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Immune Evasion Strategies of Ranaviruses and Innate Immune Responses to These Emerging Pathogens
Leon Grayfer,Francisco De Jesús Andino,Guangchun Chen,Gregory V. Chinchar,Jacques Robert
Viruses , 2012, DOI: 10.3390/v4071075
Abstract: Ranaviruses (RV, Iridoviridae) are large double-stranded DNA viruses that infect fish, amphibians and reptiles. For ecological and commercial reasons, considerable attention has been drawn to the increasing prevalence of ranaviral infections of wild populations and in aquacultural settings. Importantly, RVs appear to be capable of crossing species barriers of numerous poikilotherms, suggesting that these pathogens possess a broad host range and potent immune evasion mechanisms. Indeed, while some of the 95–100 predicted ranavirus genes encode putative evasion proteins (e.g., vIFα, vCARD), roughly two-thirds of them do not share significant sequence identity with known viral or eukaryotic genes. Accordingly, the investigation of ranaviral virulence and immune evasion strategies is promising for elucidating potential antiviral targets. In this regard, recombination-based technologies are being employed to knock out gene candidates in the best-characterized RV member, Frog Virus (FV3). Concurrently, by using animal infection models with extensively characterized immune systems, such as the African clawed frog, Xenopus laevis, it is becoming evident that components of innate immunity are at the forefront of virus-host interactions. For example, cells of the macrophage lineage represent important combatants of RV infections while themselves serving as targets for viral infection, maintenance and possibly dissemination. This review focuses on the recent advances in the understanding of the RV immune evasion strategies with emphasis on the roles of the innate immune system in ranaviral infections.
海洋科学 , 2014, DOI: 10.11759/hykx20130902001
Abstract: 2011年6月10日-6月27日调查了东海赤潮高发区PSⅡ最大光化学量子产量(Fv/Fm)的平面分布,发现在东海赤潮高发区Fv/Fm的平面分布与叶绿素的平面分布较为一致。利用现场营养盐加富培养的方法,通过检测添加不同的营养元素后Fv/Fm的变化,研究了2个调查站位浮游植物受何种营养盐的限制。结果表明,对于浮游植物来说,东海DH2-3站和DH6-2站浮游植物的生长受到N潜在限制。通过Fv/Fm的变化,可以反映出藻细胞实际的生理活性,从而更真实的反映营养盐对浮游植物的作用。
Relationship between Methylenetetrahydrofolate Reductase (C677T), Factor V Leiden (G1691A), Prothrombin Mutation (G20210A) and Severe Preeclampsia in a Brazilian Population  [PDF]
Thiago F. V. Freire, Gervina B. M. Holanda, Debora M. da Costa, Zuleika S. Sampaio, Francisco E. L. Feitosa, Silvia H. B. Rabenhorst
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.410087

Objectives: To better understand the etiologic factors that can influence preeclampsia, we inves- tigated hereditary factors for thrombosis, FV Leiden, F II 20210A mutation and the polymorphism C677T of the MTHFR, as singly and as in association, in a group of women from Ceará state-Northeast Brazil with severe preeclampsia. Material and Methods: We conducted a case-control study. 101 cases of severe preeclampsia were recruited from School Maternity Assis Chateaubriand, a reference Maternity of State of Ceará, Brazil, from December 2009 to December 2010. For clinical correlations, women were interrogated about fetal low weight (less than2500 grams) and fetal loss in previous pregnancies. Low weight, fetal loss and necessity of neonatal intensive care unit (neonatal ICU) related to current pregnancy were registered. 245 healthy voluntary women were recruited from the blood bank donors to verify the frequency of FV Leiden, FII and MTHFR as a control group. The study was approved by the Committee on Ethics in Human Research of Maternidade Escola Assis Chateubriand and all individuals gave their informed consent to participate in the study. Standard veinipuncture, with EDTA as anticoagulant, was used to collect blood samples. Genomic DNA was extracted, soon after, using a salting out method. Agarose gel electrophoresis with ethidium bromide staining was performed to ensure the quality of DNA extraction. Results: The frequencies of FV Leiden and FII mutation carrier were 0.99% (1/101) for both factors in the preeclampsia patients and 1.86% (4/214) and 0.93% (2/214), respectively, in control group. All mutates were heterozygous and concomitance of both mutations was not found. The genotype distribution of the MTHFR C677T in the patients and controls frequencies was in Hardy-Weinberg equilibrium (p ≤ 0.05). No statistical difference was observed between cases and controls in MTHFR genotypes or alleles. Conclusions: The FV Leiden, FII G20210A mutation and MTHFR C677T were not risks for preeclampsia development. FV Leiden and FII G20210A mutations had low frequency in the population studied, which may justify the absence of association.

Linear Relationships between Photosynthetic Rate and Photochemical Energy Expressed by PAR ×Fv/Fm  [PDF]
Dongbao Sun, Qingsuo Wang
American Journal of Plant Sciences (AJPS) , 2018, DOI: 10.4236/ajps.2018.92011
Abstract: Photosynthetic rate (Pn) of plants is simultaneously affected by photosynthetically active radiation (PAR) and maximum yield of primary photochemistry (Fv/Fm). In order to explore the quantitative relationship between Pn, PAR and Fv/Fm, those parameters were simultaneously measured for different plant species (maize, sunflower, daylily and alfalfa), growth stages and irrigation treatments. Results indicated that the diurnal variation of Pn had no significant correlation with that of Fv/Fm. Mean diurnal values of Pn were linearly correlated with those of Fv/Fm among the different irrigation treatments of
The relationship between FV Leiden and pulmonary embolism
W Craig Hooper, Christine De Staercke
Respiratory Research , 2001, DOI: 10.1186/rr180
Abstract: Pulmonary embolism (PE), a potential lethal complication of venous thromboembolism (VTE), is a leading cause of in-hospital death and the prevalence of symptomatic pulmonary embolism has been estimated to be approximately 630,000 cases per year in the United States [1]. It has also been estimated that PE may be directly responsible for up to 100,000 deaths and a contributing cause in another 100,000 [1]. Despite these estimates, it has been commonly agreed that the true magnitude of PE is unknown. The pathogenesis of VTE/PE is multifactorial and frequently reflects the interplay between environmental, clinical and genetic factors. Although it has been long recognized that deficiencies in the anticoagulation proteins protein C, protein S and antithrombin III were often the consequence of underlying genetic defects, there was little interest in defining the genetics of VTE/PE. This view changed, however, when FV Leiden was described and subsequently shown to be associated with 18–20% of all idiopathic VTE cases [2,3].FV Leiden is a consequence of a single G-to-A transition at nucleotide 1691 in the Factor V gene that results in the amino acid substitution of an arginine by glutamine [4,5]. This single nucleotide substitution is the only known mutation responsible for the FV Leiden genotype and a rapid molecular diagnosis can thus be easily made. A phenotypic diagnosis, which is commonly referred to as resistance to activated protein C, can also be made using findings from the clinical hematology laboratory [6]. The phenotypic diagnosis can be directly correlated with FV Leiden in approximately 90–95% of cases [7]. Since the initial description of FV Leiden, several studies have demonstrated that the prevalence of this mutation differs among the populations of the world, ranging from 5–12% of individuals of northern European descent to approximately 1% in those of African descent [7,8,9]. For example, in a case–control study of African-Americans with VTE, a FV Leiden p
The relationship between FV Leiden and pulmonary embolism
Hooper W Craig,De Staercke Christine
Respiratory Research , 2002,
Abstract: Pulmonary embolism (PE) is one of the leading causes of in-patient hospital deaths. As a consequence, the identification of hemostatic variables that could identify those at risk would be important in reducing mortality. It has previously been thought that deep vein thrombosis and PE are a single disease entity and would, therefore, have the same risk factors. This view is changing, however, with the realization that the prevalence of FV Leiden, a recognized genetic risk factor for deep vein thrombosis, may be a 'milder' genetic risk factor for PE. These observations suggest that PE is not only associated with a different set of risk factors, but may be reflective of a different clot structure.
Adverse Effect of Bermudagrass on Physiological and Growth Components of Cotton
P. Bouchagier,A. Efthimiadou,A. Katsileros,D. Bilalis
Journal of Agronomy , 2008,
Abstract: A two-year (2002/03 and 2003/04) experiment was conducted in the research site of the Agricultural University of Athens, Greece, to study the effects of Bermudagrass (Cynodon dactylon L.) in several agronomic and physiological characteristics of cotton (Gossypium hirsutum L.). Effects on cotton depended on timing of weed influence. Bermudagrass reduced stomatal aperture, chlorophyll content and chlorophyll fluorescence of cotton plants. Growth of cotton was also significantly reduced. Maximum reduction was 41.7% for stem height, 62.0% for root dry matter, 61.9% for stem dry matter and 34.7% for stem diameter. Stomatal resistance, chlorophyll content and chlorophyll fluorescence are proposed as suitable indicators that in addition to agronomic characteristics can reliably be used to measure adverse effects caused to cotton due to Bermudagrass interference.
Study on Disease Distribution and Test Results of Tuberculosis of Regional Control Project in Guangxi, China  [PDF]
Guosheng Su, Lida Mo, Xiaolu Luo, Wanhong Huang, Shanqiu Wei, Hanzhen Su
Advances in Infectious Diseases (AID) , 2015, DOI: 10.4236/aid.2015.54015
Abstract: The purpose of this study is to investigate the disease distribution of tuberculosis in national regional project. 960 patients were selected from national tuberculosis control program who took treatments in the Fourth People’s Hospital Clinical Laboratory in Nanning Guangxi from January to November in 2013. Then we observed all those patients’ disease distribution and analyzed all the lab test indexes. We analyzed the results according to gender and age distribution. From the age distribution, we found that the incidence was lower at the age of 40 or younger, while higher incidence occurred to patients over 40 years old. There is statistical significance comparing these two age groups. P is less than 0.001. Disease distribution: 731 patients were infected with TB; 21 patients were co-infected with tuberculosis (TB) and HIV. 196 patients were co-infected with TB and fungal. 12 patients were co-infected with TB, HIV and fungal. From the laboratory testing, we know there were 87 patients whose liver function indexes were abnormal. There were 192 patients whose blood RT indexes were abnormal. The liver function and blood RT indexes of patients with co-infection were higher than those infected purely. There is statistical significance in comparison P < 0.05. The study indicates that patients with older age are more likely infected with tuberculosis. In addition, there are a high proportion of patients with co-infection among these patients in this study. Meanwhile, the liver functions and blood RT indexes of patients combining with infection are higher than those infected TB purely. Prompt clinical prevention and treatment should be under reasonable inspections. General analysis can enable us to investigate more effective treatment plan. Then the best treatment result will be obtained.
热带农业科学 , 2012,
Abstract: 利用木薯光系统II(PSII)最大光化学效率(Fv/Fm)量化木薯受到干旱胁迫的程度,并测量木薯叶片与离层的内源乙烯在不同程度干旱胁迫下的量,以探讨内源乙烯的产生、Fv/Fm的下降速度与木薯抗旱性之间的关系。结果表明,抗旱性越强的品种,Fv/Fm下降速度越慢,内源乙烯上升的时间也越靠后。
Consensus structural models for the amino terminal domain of the retrovirus restriction gene Fv1 and the Murine Leukaemia Virus capsid proteins
William R Taylor, Jonathan P Stoye
BMC Structural Biology , 2004, DOI: 10.1186/1472-6807-4-1
Abstract: Molecular models were constructed for the amino terminal domains of the probable capsid-like structure for the mouse Fv1 gene product and the capsid protein of the MLV. The models were based on sequence alignments with a variety of other retrovirus capsid proteins. As the sequence similarity of these proteins with MLV and especially Fv1 is very distant, a threading method was employed that incorporates predicted secondary structure and multiple sequence information. The resulting models were compared with equivalent models constructed using the sequences of the capsid proteins of known structure.These comparisons suggested that the MLV model should be accurate in the core but with significant uncertainty in the loop regions. The Fv1 model may have some additional errors in the core packing of its helices but the resulting model gave some support to the hypothesis that it adopts a capsid-like structure.The Fv1 gene is one of a series of mouse genes that control the susceptibility of mice to murine leukaemia virus (MLV) [1-3]. The gene acts in the cell to restrict virus replication [4] through a mechanism that is still uncertain. Genetic studies suggest that the target for the Fv1 gene product is the capsid protein (CA) of MLV [5,6] and it is thought to interact with CA after entry of the virus into the cell but before integration and formation of the provirus.When cloned and sequenced [7], the Fv1 gene was found to have sequence similarity to endogenous retroviruses of the HERV-L and MuERV-L families [7,8]. Based on its position within the Gag gene of these endogenous elements, it appears that Fv1 encodes a capsid-like protein. This structural assignment of the Fv1 gene is consistent with its function as it can be postulated that the gene product might act as a dominant negative mutation and interfere with the MLV capsid function [9]. Sequence alignments have been made between Fv1 and other retroviral capsid proteins [8] but besides one region of clear similarity, ca
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