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Immunomodulatory Effect of the Aqueous Extract of Erigeron floribundus (Kunth) Sch Beep (Asteraceae) Leaf in Rabbits
FA Yapo, FH Yapi, H Ahiboh, M-L Hauhouot-Attounbre, NZ Guédé, JA Djaman, D Monnet
Tropical Journal of Pharmaceutical Research , 2011,
Abstract: Purpose: The leaves of Erigeron floribundus (Kunth) Sch. Beep. or (syn: Conyza sumatrensis (Retz) E.K. Walker) (Asteraceae) are used by some traditional healers in West Africa in HIV/AIDS therapy. The purpose of this study was to assess the immune-boosting properties of the aqueous leaf extract of Erigeron floribundus (Ef) by monitoring blood markers of cellular immunity in rabbit. Methods: Two sets each of five groups (six rabbits per group) were used in this study. The groups in the first set each received intraperitoneally a single dose of Ef (25, 50, 75 or 100 mg/kg) or 0.9 % NaCl (control). The groups in the second set received methylprednisolone (15 mg/kg, MP15) and mixtures of MP15 with Ef (50, 75 or 100 mg/kg), MP15 or isoprinosine 50 mg/kg (Ip50, reference standard). Whole blood was collected in EDTA tubes from the marginal vein of the rabbit ear on Days 0, 3, 9, 15 and 21 after administration for the determination of CD4+ count by flow cytometry, and also of neutrophils and total lymphocytes in the blood. Results: Each plant extract dose tested (50, 75 and 100 mg/kg) induced a significant increase in neutrophils (p < 0.001), total lymphocytes and TCD4+ (p < 0.0001) from the 3rd to 15th day after administration, compared to control (0.9 % NaCl). Furthermore, the same test extract doses significantly reversed the immunosuppressive effect of methylprednisolone (p < 0.001) to the same extent as isoprinosine. Conclusion: The aqueous extract of the leaves of Erigeron floribundus stimulated the increase of neutrophils, total lymphocytes and TCD4+ in rabbit blood and thus provides some justification for its use in the traditional treatment of AIDS.
Uptake and kinetic properties of choline and ethanolamine in Plasmodium falciparum
H Ahiboh, AJ Djaman, FH Yapi, A Edjeme-Aké, ML Hauhouot-Attoungbré, ET Yayo, D Monnet
Tropical Journal of Pharmaceutical Research , 2008,
Abstract: Purpose: The asexual proliferation of Plasmodium, inside the erythrocyte, is accompanied by the synthesis of huge quantities of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn). These needful phospholipids for the cytoplasmic membrane of the merozoites are provided by the precursors choline and ethanolamine. PtdCho and PtdEtn are synthesized by the parasite because the erythrocyte is unable to do it. In order to assess the dynamism of the phospholipid pathways, we aimed to investigate the respective shape of the uptake of choline and ethanolamine by Plasmodium falciparum. Method: Time-course experiments and kinetic assays were performed respectively with fixed and ranged concentrations of radioactively-labelled choline and ethanolamine. The labelled-precursors were added in the culture of P. falciparum infected-erythrocytes and the incorporated molecules in phospholipids were measured with a scintigraph counter. Result: The results showed that the incorporation of precursors in the infected-erythrocyte occurred with a Michaelis-Menten\'s kinetic shape. According to the maximum rate (Vmax), the pathway of ethanolamine incorporation was faster than that of choline. Similarly, affinity for ethanolamine was greater than that of choline. Conclusion: Although PtdCho is the major phospholipid in the membrane, this study rules out that the influx of ethanolamine in the infected-erythrocyte, in vivo conditions, is more dynamic than choline.
Croissance et caractéristiques de carcasse de poulets issus de poules normales ou naines (dw)
FH Ricard
Genetics Selection Evolution , 1971, DOI: 10.1186/1297-9686-3-3-379
Liquid waste management: The case of Bahir Dar, Ethiopia
FH Mekonnen
Ethiopian Journal of Health Development , 2012,
Abstract: Background: Human beings pollute the environment with their industrial and domestic wastes. In Bahir Dar Town there is no conventional municipal waste water collection and treatment system. Objective: The aim of this study was to describe the liquid waste disposal practices of the residents of Bahir Dar Town and to assess the performance of waste water disposing institutions. Methods: Data were collected from 270 households and 16 experts working in liquid waste management institutions. Different closed and open ended structured questionnaires were prepared to collect the data from the samples. Results: Sixty-four percent of the respondents discharge their waste water in to the streets and open fields. The inadequacy of sanitation services resulted in defecating in open fields and discharging of raw waste water into inappropriate places and these, in turn, have created serious environmental problems. Conclusion: There is a weak implementation of the regional sanitation regulations in Bahir Dar. Controlling offenders through strict enforcement of the regulations should be encouraged. Skilled environmental health workers should be assigned at each kebele and sub-city to implement sanitation regulations and coordinate the sanitation efforts at the grassroots levels. [Ethiop. J. Health Dev. 2012;26(1):49-53]
The quest for a culture of learning: a South African schools perspective
FH Weeks
South African Journal of Education , 2012,
Abstract: Within the media and the literature the need is often expressed for the establishment of a culture of learning within South African schools. The contrasting view tends to be one of dysfunctional schools that have come into being, giving rise to significant learner behaviour problems and poor pass rates being encountered in practice. This paper is directed at gaining conceptual clarity as to what is meant by a “culture of learning” and exploring two fundamentally different views as to how such a culture can be nurtured within South African schools. The study is based on a multidisciplinary literature review to gain an understanding of the concept and the theories advocated for bringing about a culture change. A key finding emanating from the study is that the traditional culture management approach advocated in the literature may not be all that effective in practice and that an alternative approach that views “culture of learning” as an emergent phenomenon that has its origins in the social interaction taking place within classrooms, schools and learning communities may be more effective.
Biological genesis: the first step from dead matter to life. A contribution to the nature of DNA, RNA, and the genetic code
Schmidt FH
Research and Reports in Biology , 2013,
Abstract: Friedrich H Schmidt Retired, Schramberg, Germany Abstract: Information is understood semantically in the special case of the genetic code as the contents of news-bearing and genetically acting molecules. The connection of single molecules to groups and molecule chains can be referred to as syntactic. Well-defined information is not only exchanged between molecules in biology like nucleic and amino acids cooperating in the genetic code: the topic of this article is that an exchange of information could also occur between inorganic and organic substances, eg, mineral crystals interacting with organic molecules. This may have played a role in the origins of life on earth. As the origin of the genetic code and the mechanism of its translation is still an unresolved problem, so is the interaction of inorganic substances and organic substances still an open question. Stereochemical similarities existing between code and amino acids cannot explain the relationship completely and are not present between inorganic and organic molecules at all. Symmetry is a structural entity in organic chemistry and organisms, and Δ-values calculated by a mathematical algorithm and introduced in this article give an estimate of symmetry and transferred information. Symmetric Δ-values exist in minerals as well as in genetic molecules, and could thus bring dead material to life before DNA, RNA, and enzymes were developed. The fact that symmetry is important as a quality of organic matter with the function of the genetic code is pointed out in the works of other authors, who are cited in this paper. Keywords: genetic information, genetic code, symmetry in inorganic and organic molecules, calculation of Δ-values
Altered Erythrocyte Deformability and Antioxidant Status in Patients with Schizophrenia
Marmara Medical Journal , 2012,
Abstract: Objective: Schizophrenia is a major mental disorder whose etiology still remains unkown. There is evidence that free radicals are involved in membrane pathology in the central nervous system and may play a role in the pathophysiology of schizophrenia. Red blood cells are also considered to be a peripheral marker in psychiatric illnesses. We aimed to provide further insight into the effects of changed antioxidant status and lipid peroxidation on the rheological behavior of red blood cells in schizophrenia.Patients and Methods: Twenty patients with schizophrenia and 20 healthy subjects were included in the study. Antioxidant enzymes and lipid peroxidation were measured spectrophotometrically and red blood cell deformability was measured by shear stress diffractometer.Results: Deformability of red blood cells was found to be decreased, lipid peroxidation was increased and antioxidant status was altered in the patients (p<0.05).Conclusion: It is understood that erythrocyte deformability was impaired and antioxidant status was altered in patients with schizophrenia. (Marmara Medical Journal 2012;25:133-7)
Croissance et caractéristiques de carcasse de poulets sélectionnés en lignées divergentes soit sur la vitesse de croissance soit sur l'état d'engraissement
FH Ricard, B Leclercq
Genetics Selection Evolution , 1985, DOI: 10.1186/1297-9686-17-4-549
Le gène de nanisme dw et les performances des poules dans une souche de type femelle-chair
FH Ricard, LP Cochez
Genetics Selection Evolution , 1971, DOI: 10.1186/1297-9686-3-3-391
Heritability estimates of hatching time in the fayoumi chickens
FH Abdou, H Ayoub
Genetics Selection Evolution , 1975, DOI: 10.1186/1297-9686-7-4-421
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