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Search Results: 1 - 10 of 229 matches for " FC Osuagwu "
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Sources of cadaver used for dissection at the Ibadan medical school, Nigeria - Analysis of a three-year data
FC Osuagwu, IO Imosemi, OW Oladejo
African Journal of Biomedical Research , 2004,
Abstract: Our experience with cadaver collection at the Department of Anatomy, University of Ibadan, Nigeria between 9th of February 1998 and 11th of October 2001 is presented. A total of twenty-eight bodies were collected from the State Hospital, Ring Road during this period viz: twenty-six were males (92.9%) and two females (7.1%). Twenty-two (78.6%) were suspected bandits who died during gun duel with law enforcement agents while six (21.4%) were bodies that were accident victims and unclaimed bodies. Four of the unclaimed bodies were males (66.7%) while females were two (33.3%). The majority of bodies that were those of suspected bandits were males and they were twenty-two (100%) while no female (0%) was recorded. No record of voluntary donation of cadavers for anatomy dissection was documented. Adequate documentation is advocated for the giving hospital and the receiving medical school. It is suggested that anatomists embark on a more aggressive enlightenment campaign to the society to encourage those that might be willing to voluntarily will their body after dying to further the quest of knowledge to do so.
Enhanced wound contraction in fresh wounds dressed with honey in wistar rats (Rattus novergicus)
FC Osuagwu, OW Oladejo, IO Imosemi, A Aiku, OE Ekpo, AA Salami, OO Oyedele, EU Akang
West African Journal of Medicine , 2004,
Abstract: Background: Due to reports that honey accelerates wound healing, an investigation on its role in wound contraction in fresh wounds inflicted on wistar rats was carried out. Method: Twenty adult male wistar rats had 2cm by 2cm square wound inflicted on their right dorsolateral trunk. They were divided into two groups. The experimental group had their wounds dressed with honey while the control group had normal saline dressing. Wound dressing was done every five days and measurements taken at each dressing. Wound morphology was also assessed. Results: Dressing with honey significantly enhanced percentage wound contraction on day 10 with value of 79.20 ± 2.94 compared to control value of 53.50 ±4.32. p=0.0. The mean wound measurement on day 10 reduced significantly in honey group, 1.15±0.18 compared to control group 2.38 ± 0.28. p=0.002. However, there was no significant difference in fibroblast count per high power field in honey group 68.0 ±2.59 compared to control 90.2 ± 17.40, p=0.242. Honey dressing increased mean blood vessel count per high power field, 18.8±3.77 albeit non significantly when compared to control value of 13.4±2.44, p=0.264. Also honey dressing caused increased granulation tissue formation in wounds dressed with honey compared to control group. Conclusion: Our study suggests that honey dressing enhances wound contraction in fresh wounds which is one of the key features of wound healing. Key Words: Wound contraction, Honey, Healing. Résumé Introduction: D\'après des rapports que la consommation du miel accélere la cicatrisation de blessure, une enquête sur son effet en matiére du reserrement en ce qui concerne une plaie récente fait aux wister rats a été effectuée. Méthode: On a fait une plaie de 2cm par 2cm carré dans le c té droit du trompe des vingt wistar rats du sexe masculin adultes. On a divisé ces rats en groupe de deux, et on a soigné le groupe d\'experimentation avec le miel tandis que le groupe du contr le était traité normalement avec le goutte-à-goutte de solution saline . On fait un pansement tous les cinq jours et on prend les mesures pendant chaque pansement. On a également évalué la morphologie de la blessure. Resultats: Le pansement avec le miel a remarquablement amélioré le pourcentage du resserrement de la plaie pendant le dixième jour avec la valeur 79,20 ±2.94 par rapport à la valeur du groupe du contr le de 53,50 ± 4.32 P =0,0 Le moyen de la mesure de la plaie dans le dixième jour était remarquablement en basse dans le groupe du miel, 1,15±0.18 par rapport au groupe du contr le 2,38 ± 0.28, P=0,002. Toutefois, il y a aucune difference importante en matière du compte fibroblast par high power field dans le groupe du miel 68,0 ± 2,59 par rapport au groupe du contr le 90,2 ± 17,40, P= 0.242. Le pansement avec du miel a augmenté le moyen du compte du vaisseau sanguin par power field élevé dans le groupe du miel 18,8±3,77 albeit non important par rapport à la valeur du contr le de 13,4 ± 2.44 P = 0,264. En plus
Histomorphometric studies on the effect of cyanide consumption of the developing cerebellum of wistar rat (Rattus novergicus)
AO Malomo, IO Imosemi, FC Osuagwu, OW Oladejo, EEU Akang, MT Shokunbi
West African Journal of Medicine , 2004,
Abstract: Objective: To investigate the microscopic effect of maternal cyanide consumption on the developing cerebellum of Wistar rats. Materials and methods: Twenty pregnant female rats weighing between 160 g and 180 g were used in this study. The rats were separated into two groups comprising ten control and ten experimental animals. The control animals were fed a standard diet of mice cubes, while the experimental animals were fed 500 ppm potassium cyanide, mixed with the standard diet. The diets were fed to the animals and their litters in separate cages and water provided ad libitum during pre and postnatal life. After birth, the offspring (five per group) of days 1,9, 14, 21, 28 and 50 were weighed and killed by cervical dislocation. The cerebellar tissues were processed and microscopic parameters studied. Results: A thicker external granular layer (EGL) was seen in the control group on day 1(39±9.2mm) compared with the experimental group (29±5.8mm) and on day 9(83± 7.1mm) compared with the experimental group (78± 13mm). However, these were not significantly different statistically. A thicker and persistent EGL was observed in the experimental group on days 14 and 21. A significant (P<0.05) reduction in the thickness of molecular layer (ML) was observed on days 28 and 50 in the experimental group. The density and size of the Purkinje cells were the same in both the control and experimental groups (P>0.05). Conclusion: Maternal consumption of 500 ppm cyanide in rats does not significantly affect light microscopic prenatal cerebellar development, but causes mild changes in the post-natal life. Maternal cyanide consumption causes delayed maturation of the cerebellum, as evidenced by the thicker EGL, and reduction in the ML in the experimental group which become noticeable only at about 28th day of postnatal life. Key Words: Cyanide, Diet, Development and Cerebellum Résumé Objectif: Etudier les effet microscopiques de la consommation cyanure maternelle sur le developpement du cervelet des rats Wistar Matériels et Méthodes: Vingt rats sexe féminin pleine pesant entre 160g et 180g ont été utilisés dans cette étude. Les rats ont été séparés en deux groupes comprend dix controle et dix animaux experimentaux. Les animaux du controle ont été nourri avec des alimentations complètes composées de morceau de viande des souris, tandis que les animaux expérimentaux ont été nourri de 500 ppm de cyanure de potassium, melangé avec une alimentation complète. Les alimentations ont été données aux animaux et leur litières dans des cages séparées, de l\'eau a été fourni ad libitum pendant la vie pré et postnatale. Après naissance; des descendants (cinq par groupe) des jours 1,9,14,21,28,et 50 ont été pésés et tués à travers la dislocation cervicale. On avait examiné les tissu nerveux et on avait également étudié les paramétres microscopiques. Resultats: La couche extérieure granulaire épaisse (CEG) était vue chez le groupe de controle pendant le premier jour (39± 9,2 Um) p
Enhancement of cutaneous wound healing by methanolic extracts of ageratum conyxoides in the wistar rat
OW Oladejo, IO Imosemi, FC Osuagwu, OO Oluwadara, A Aiku, O Adewoyin, OE Ekpo, OO Oyedele, EEU Akang
African Journal of Biomedical Research , 2003,
Abstract: In a bid to test the wound healing effect of a crude methanolic extract of Ageratum conyzoides (Linn.), 20 animals were divided into two groups of ten animals each representing control and experimental groups. Each animal had a 2cm x 2cm area of skin on the right dorsolateral flank area marked and excised. The resulting area of skin wound in the experimental group was dressed with crude methanolic extract of Ageratum conyzoides at a five daily interval while the animals in the control group were dressed with normal saline at the same interval. The wound area was measured at the tenth post-operative day for animals in both groups and the percentage wound contraction calculated. Sample of granulation tissues and end scar obtained from these animals and prepared by routine paraffin wax method. Fibroblast and blood vessel counts were determined in both groups. The result showed a significant increase in the percentage wound contraction at day 10 in the experimental group compared with the control (82.3 ± 1.6 % vs 55.0 ± 4.2 %), P < 0.05. The wound of animals in both groups showed excellent granulation tissue formation and minimal signs of wound infection. There was a significant reduction in the mean fibroblast count in the experimental group compared with the control (44.2 ± 5.8/ high power field vs 90.2 ± 17. 4 / high power field),P < 0.05. The exact significance of this cannot however be determined. There was no significance difference in the vessel count. It was concluded that extract of Ageratum conyzoides has a better wound healing enhancing action compared with normal saline treated controls. This effect may be due to the antimicrobial properties of Ageratum conyzoides
The energy cost of kidney proton dialysis in sickle cell anaemia
CG Osuagwu
African Journal of Biotechnology , 2007,
Abstract: The acidosis known to be associated with sickle cell anaemia is exploited in this work to estimate its energy cost to the kidney that has to dialyse the excess protons from the blood into urine against a concentration gradient, thereby doing significant extra work. The mean blood and urine pHs measured for the four discrete sickle cell states (42 subjects with approximately equal numbers of males and females per group, to minimise sex bias) are: HbAA = 7.39 ± 0.07 and 6.54 ± 0.15, HbAS = 7.35 ± 0.09 and 6.44 ± 0. 15, HbSS = 7.32 ± 0.08 and 5.89 ± 0. 39, HbSS-crisis = 7.15 ± 0.12 and 4.75 ± 0.46, respectively. From these data, the estimated enthalpies of dialysis, DHd, for each of the four states are: HbAA = 1.96RT 4.94 kJ, HbAS = 2.10RT 5.29 kJ, HbSS =3.29RT 8.29 kJ, and HbSS-crisis = 5.53RT 13.93 kJ. The estimated entropies of dialysis, TDSd, compared to the normal HbAA state are: HbAA = 0.00RT 0.00 kJ; HbAS = 0.14RT 0.35 kJ, HbSS = 1.34RT 3.38 kJ and HbSS-crisis = 3.57RT 8.99 kJ (R = 8.31J-mol-1 K-1 and T = 303K). The conclusion from this work is that sickle cell disease is very energy costly to the kidney as most of the energy for proton dialysis is wasted as a result of high entropy.
Polyhedral charge-packing model for blood pH changes in disease states
CG Osuagwu
African Journal of Biotechnology , 2007,
Abstract: This work is the extension to an earlier report of a model, which explained the normal blood pH of 7.4 in terms of the octahedral packing of the six hydroxyl, OH-, ions to one hydrogen, H+, ion that exist at that pH, as this would be the most, naturally, stable arrangement. The logical, possible shifts from the octahedral ideal are suggested to be to the next most stable and efficient natural structures, the other regular polyhedra (tetrahedron, cube, dodecahedron and the icosahedron), depending on the hydroxyl to proton ratio available. Polyhedral charge-structuring is suggested to help define a ‘polyhedral charge-packing pH zone’ (From pH = 7.30, for tetrahedral, to pH = 7.65 for dodecahedral packing), which lies in the neighborhood of the well known physiological pH range. Literature is cited in support of pH 7.65 as the extreme upper limit of tolerable alkalosis. Experimental results from studies on two acidotic diseases (Sickle cell disease, pH = 7.32 ± 0.08 and Asthma, pH = 7.29 ± 0.03) are presented as evidence of the tetrahedron-based tolerable, stable, low limit pH in acidosis. Some medical implications of these ideas are discussed. For instance, the model suggests that the generalized definition of metabolic acidosis as pH less than 7.3 (pH < 7.3) is informed by the underlying tetrahedral charge-packing structure at this pH, which would collapse immediately the blood pH falls below this critical threshold.
The influence of aqueous leaf and stem extracts of Adenia lobata (Jacq) on the flowering and fruiting of okra (Abelmischus esculenta) and groundnut (Arachis hypogea)
GGE Osuagwu, IC Ibeabuchi
African Journal of Biotechnology , 2010,
Abstract: The influence of the aqueous leaf and stem extracts of Adenia lobata (Jacq) on the flowering and fruiting of okra (Abelmischus esculenta) and groundnut (Arachis hypogea) was investigated. A. lobata extract prepared in the following dilutions: 1:1, 1:2.5 and 1:5 (v/v) from the original extracts and distilled water, which served as control were used for treatments. All treatments at (P < 0.05) significantly inhibited the flowering and fruiting of the plant species. This observation was consistent in all the plant species used in the research, as there was a significant reduction in the flowering and fruiting of the plants. The concentration of the extracts affected the rate of effects of the extracts on the flowering and fruiting of the plant species. The higher the concentration, the more the inhibitory effects of the extracts. This study reveals the presence of compounds capable of inhibiting the flowering and fruiting of plants in A. lobata.
Patient Blood Pressure and Pulse Rate Monitoring With an Alert System Using the Omron 790it Blood Pressure Monitor
I Oji, OE Osuagwu
West African Journal of Industrial and Academic Research , 2012,
Abstract: Blood pressure and pulse rate are two of the vital signs of humans and it is imperative that the chronically ill and the elderly patients need to have their blood pressure and pulse rate checked from time to time. This paper describes the use of the Omron 790it blood pressure monitor to check the blood pressure and the pulse rate of patients. This is achieved by transferring the readings taken by the Omron blood pressure monitor into the computer and using an Applications program developed with Visual Basic compiler called the Blood Pressure Loader (BPL) to automatically upload the blood pressure and pulse rate readings taken by the Omron blood pressure monitor directly into the hospital database. An alert can also be sent to the doctor’s phone wherever he is so that he can proffer a solution. The result of this research work is that patients can monitor their own blood pressure and pulse rate even from their homes and transfer the readings into the computer after which it can be uploaded into the hospital’s database. This has the capacity of giving the doctor a timely and detailed medical information on the vital signs of patients and will save many lives that may be lost.
Repeatability and interobserver reproducibility of Artemis-2 high-frequency ultrasound in determination of human corneal thickness
Ogbuehi KC, Osuagwu UL
Clinical Ophthalmology , 2012, DOI: http://dx.doi.org/10.2147/OPTH.S31690
Abstract: tability and interobserver reproducibility of Artemis-2 high-frequency ultrasound in determination of human corneal thickness Original Research (1633) Total Article Views Authors: Ogbuehi KC, Osuagwu UL Published Date May 2012 Volume 2012:6 Pages 761 - 769 DOI: http://dx.doi.org/10.2147/OPTH.S31690 Received: 11 March 2012 Accepted: 04 April 2012 Published: 21 May 2012 Kelechi C Ogbuehi, Uchechukwu L Osuagwu Outpatient Clinic, Department of Optometry, King Saud University, Riyadh, Kingdom of Saudi Arabia Background: The purpose of this study was to assess the repeatability and limits of agreement of corneal thickness values measured by a high-frequency ultrasound (Artemis-2), hand-held ultrasound pachymeter (DGH-500) and a specular microscope (SP-3000P). Methods: Central corneal thickness (CCT) was analyzed in this prospective randomized study that included 32 patients (18 men and 14 women) aged 21–24 years. Measurements were obtained in two sessions, one week apart, by two examiners with three devices in a randomized order. Nine measurements were taken (three with each device) on one randomly selected eye of each patient in each measurement session. The coefficient of repeatability and interobserver reproducibility for the values of each method were calculated. The limits of agreement between techniques were also evaluated. Results: There were no significant differences in CCT values between sessions for each of the three devices (P > 0.05). The repeatability coefficients for the Artemis-2 (±8 μm/±9 μm) were superior to those of the SP-3000P (±9 μm/±11 μm) and DGH 500 (±12 μm/±12 μm) in session 1/session 2 respectively, while the interobserver reproducibility index (differences between session 1 and session 2) was superior for the SP-3000P (±17 μm) with respect to DHG-500 (±29 μm) and the Artemis-2 (±31 μm). In session 1 and session 2, the limits of agreement between the techniques were 35 μm to -31 μm and 34 to -20 μm, respectively, for DGH-500 versus Artemis-2, 73 μm to 3 μm and 60 μm to 9 μm for Artemis-2 versus SP-3000P, and 58 μm to 22 μm and 72 μm to 10 μm for DGH-500 versus SP-3000P comparisons. The DGH-500 and Artemis-2 gave similar values (P > 0.05) in both sessions, but both (Artemis-2 and DGH-500) values were significantly greater than that of the SP-3000P (P < 0.05) in both sessions. Conclusion: Repeatability was comparably good for the three techniques. However, interobserver reproducibility was approximately twice as good with the SP-3000P compared with the other two devices. The Artemis-2 CCT values consistently agreed with the DGH-500 and less so with the SP-3000P. The Artemis-2 provided CCT values that were, on average, 38 μm and 34 μm greater than that of the SP-3000P in session 1 and session 2, respectively.
Repeatability and interobserver reproducibility of Artemis-2 high-frequency ultrasound in determination of human corneal thickness
Ogbuehi KC,Osuagwu UL
Clinical Ophthalmology , 2012,
Abstract: Kelechi C Ogbuehi, Uchechukwu L OsuagwuOutpatient Clinic, Department of Optometry, King Saud University, Riyadh, Kingdom of Saudi ArabiaBackground: The purpose of this study was to assess the repeatability and limits of agreement of corneal thickness values measured by a high-frequency ultrasound (Artemis-2), hand-held ultrasound pachymeter (DGH-500) and a specular microscope (SP-3000P).Methods: Central corneal thickness (CCT) was analyzed in this prospective randomized study that included 32 patients (18 men and 14 women) aged 21–24 years. Measurements were obtained in two sessions, one week apart, by two examiners with three devices in a randomized order. Nine measurements were taken (three with each device) on one randomly selected eye of each patient in each measurement session. The coefficient of repeatability and interobserver reproducibility for the values of each method were calculated. The limits of agreement between techniques were also evaluated.Results: There were no significant differences in CCT values between sessions for each of the three devices (P > 0.05). The repeatability coefficients for the Artemis-2 (±8 μm/±9 μm) were superior to those of the SP-3000P (±9 μm/±11 μm) and DGH 500 (±12 μm/±12 μm) in session 1/session 2 respectively, while the interobserver reproducibility index (differences between session 1 and session 2) was superior for the SP-3000P (±17 μm) with respect to DHG-500 (±29 μm) and the Artemis-2 (±31 μm). In session 1 and session 2, the limits of agreement between the techniques were 35 μm to -31 μm and 34 to -20 μm, respectively, for DGH-500 versus Artemis-2, 73 μm to 3 μm and 60 μm to 9 μm for Artemis-2 versus SP-3000P, and 58 μm to 22 μm and 72 μm to 10 μm for DGH-500 versus SP-3000P comparisons. The DGH-500 and Artemis-2 gave similar values (P > 0.05) in both sessions, but both (Artemis-2 and DGH-500) values were significantly greater than that of the SP-3000P (P < 0.05) in both sessions.Conclusion: Repeatability was comparably good for the three techniques. However, interobserver reproducibility was approximately twice as good with the SP-3000P compared with the other two devices. The Artemis-2 CCT values consistently agreed with the DGH-500 and less so with the SP-3000P. The Artemis-2 provided CCT values that were, on average, 38 μm and 34 μm greater than that of the SP-3000P in session 1 and session 2, respectively.Keywords: cornea thickness, Artemis-2 ultrasound, hand-held ultrasound, SP-3000P noncontact specular microscopy, reproducibility
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