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Search Results: 1 - 10 of 327725 matches for " F. C. Oladele "
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In-Vitro Metabolite Colonic Production from Otili (Sphenostylis stenocarpa) as Influenced by Selected Gastrointestinal Microbes  [PDF]
O. A. Awoyinka, T. R. Omodara, F. C. Oladele, O. O. Aina, O. E. Ajayi
Advances in Bioscience and Biotechnology (ABB) , 2018, DOI: 10.4236/abb.2018.911041
Abstract: In human nutrition, dietary fibers are un-degradable by mammalian enzymes, and are therefore potentially available for fermentation by micro-organisms living in the gastrointestinal tract. It is thought that these fermentable carbohydrates affect fermentation by stimulating the growth or metabolism of specific bacterial species, which are potentially beneficial for health. Hence in this study three gut associated microbes—Escherichia coli, Bacillus subtilis, and Lactobacillus acidophilus were made to ferment the non-digestible fraction of OtiliSphenostylis stenocarpa, a well-established underutilized wild bean with high economic importance. After 18 hours’ fermentation period short chain fatty acids (SCFAs) and medium chain fatty acids (MCFAs) were detected and evaluated by GC-MS analysis. Metabolic products were relatively dependent on the fermenter. This present study affirmed butyric acid as the main SCFAs after 18 hours’ fermentation. The clinical significance of thirteen other MCFAs detected and quantified was also explored thus conferring a valuable prebiotic on Otili.
Profile of Turbidity and Glucose Formation from Underutilised Wild, Edible Bean during In-Vitro Gastro Intestinal Digestion and Fermentation  [PDF]
T. R. Omodara, O. A. Awoyinka, F. C. Oladele, O. O. Aina, M. E. Olaiya
Advances in Microbiology (AiM) , 2018, DOI: 10.4236/aim.2018.812067
Abstract: Fermentation takes place throughout the gastrointestinal tract of all animals, but the intensity and products of fermentation depend on number and types microbes, which are generally highest in the large bowel. Large intestinal epithelial cells do not produce digestive enzymes, but contain huge numbers of bacteria which have the enzymes to digest and utilize many substrates. The seeds of beans (Otili, Feregede, Pakala and Oloyin) analyzed in this present study contain indigestible fraction called dietary fiber which helps to maintain functioning of the digestive system. Fermentation of indigestible fraction (IF) of these beans was mimicked through in-vitro method which leads to biochemical changes in the samples. During this experiment, increase in acidity and turbidity was observed. The glucose concentration decreases with some exceptions, such as Pakala fermented by Lactobacillus acidophilus which had the value of 6.260 mmol/L at 6 hr and increased to 6.616 mmol/L after 18 hours fermentation, Otili fermented by various microorganisms which had its turbidity increased by 50%. Lactobacillus acidophilus fermenting Pakala had the highest glucose concentration during the fermentation period. The increase in turbidity could be as a result of increase in microbial flora or production of metabolites, such as glucose. The approach followed here may be used as a predictive model to assess the metabolic implications of food substrates present in the traditional Nigerian orphan beans.
Comparison of Phytochemicals and Anti-Nutritional Factors in Some Selected Wild and Edible Bean in Nigeria  [PDF]
Awoyinka O. A., Ileola A. O., Imeoria C. N., Tijani T. D., Oladele F. C., Asaolu M. F.
Food and Nutrition Sciences (FNS) , 2016, DOI: 10.4236/fns.2016.72012
Abstract: This work aims at analyzing the bioactive and anti-nutritional compounds of edible and wild beans when unprocessed and malted. Qualitative screening of phytochemicals in the various bean samples was determined in ethanol and petroleum ether solvents. Results of the anti-nutritional compositions of unprocessed wild bean extracted with petroleum ether showed there were no traces of saponin and polyphenol, in Feregede and also in edible bean-IT07K-243-1-10 which also had no traces of saponin and tannin. After malting, saponin was totally absent in Pakala, Mucuna, IT97k-499-35, IT07k-243-1-10, and IT04k-333-2 respectively. Polyphenol was also found to be absent in IT07k-243-1-10. Mucuna has the highest phytic acid level (7.8867 ± 0.011) while Feregede has the lowest phytic acid level (2.9810 ± 0.004). Otili has the highest anti-trypsin level (12.001 ± 0.0013). This study showed varying levels of anti-nutrients on the respective bean samples when unprocessed but decreased marginally after malting. It was keenly noted that values derived, either before and after malting were not significantly different (P ≤ 0.05) from each other. In all, this study had further shown that malting process enhanced removal of anti-nutrients which invariably would lead to availability of nutrient for animal and human consumption.
Interaction of Glucose/Sucrose Binding Lectin Isolated from Nigeria Wild Bean with E. coli and S. aureus  [PDF]
O. A. Awoyinka, J. O. Awe, O. A. Omosebi, O. Osukoya, F. C. Oladele, B. A. Olofinbiyi, M. F. Asaolu
Food and Nutrition Sciences (FNS) , 2017, DOI: 10.4236/fns.2017.812080
Lectin purified from wild underutilized local bean—Otili, Feregede, Pakalai was comparatively characterized and further evaluated for interaction with gastrointestinal bacteria—Esherichia coli and Staphylococcus aureus. The purified lectin in all the bean samples showed to be glucose and sucrose binding. The hemagglutinating activity, was non selective to type of blood group (A, B, AB and O). Anti-bacteria interaction with Escherichia coli showed clear zone of inhibition of about 1.5 ± 0.5 mm with lectin from Feregede and Otili while there was slight agglutination with lectin from Pakala. Staphylococcus aureus sensitivity to the lectin extracted from Otili with clear zone of inhibition of 2.0 ± 0.5 mm was also found in the control chloramphenicol. However there was pronounced agglutination with lectin from Feregede and Pakala with Staphylococcus auereus. This may be a clear indication that lectin from local underutilized wild bean understudy will agglutinate and interact with a gram positive bacteria more than gram negative bacteria.
Comparative Effects of Selected Underutilized Wild Beans on Plasma Lipid Profile and Liver Function of Rats Fed with High Fats Diet  [PDF]
O. A. Awoyinka, T. R. Omodara, F. C. Oladele, D. D. Ajayi, H. A. Babalola, B. A. Olofinbiyi, G. S. Adeleye, E. O. Odesanmi
Food and Nutrition Sciences (FNS) , 2019, DOI: 10.4236/fns.2019.104034
Abstract: Dietary fiber content of beans is known to be responsible in the management of metabolic syndrome by delaying the degree of glucose as fuels, changing fat utilization, and controlling appetite through increased satiety, thus lowering the risk of cardiovascular diseases. Hence some selected varieties of underutilized wild beans were evaluated to study their anti-lipidemic effects. Prior to this, attempts were made to ferment the non-digestible fractions of the beans with fermentable micro-organism and the respective gut metabolites were determined. Lipid profile result carried out in the blood showed high density lipoprotein to be significantly (p ≤ 0.05) high in Pakala group with a value of 2.2 ± 0.02 compared to other groups. While for low density lipoprotein (LDL); rats with Otili in their diet had the highest LDL with a value of 0.45 ± 0.01. However, the group of rats fed with Feregede had the least cholesterol level compared to other groups of rats fed with respective wild beans and the negative control group. Otili had the highest ALP with value of 89 ± 1.0. Otili group also had a significant lower value of both aspartate amino transferase and alanine amino transferase. The biochemical indices reported in this study vary from one type of wild bean to another.
Functional Properties and Nutritional Quality of Some Wild and Edible Bean in Nigeria  [PDF]
O. A. Awoyinka, A. O. Ileola, C. N. Imeoria, S. T. Olumakinde, F. C. Oladele, M. F. Asaolu
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102411
Abstract: In this study on bean, four wild types were compared with the edible for their functional and nutritional characteristics in unprocessed and malted form. Results obtained in functional properties showed that bulk density was higher in wild types compared to edibles types. Feregede has the least dispersibility compared to all the bean samples. The swelling power of all the wild and edible types was almost the same with the edible bean IT845-2246-4 having the highest value of 26.15 ± 0.02. Pakala had the broadest foaming stability even up to the region of alkaline pH. In proximate compositions, the entire edible bean had more carbohydrate and crude fibre content than the wild types but after malting, there was no significant difference (P < 0.05) in the crude fibre content between the edible and the wild type beans. After malting, it was observed that Pakala and edible bean IT99K-573-1-1 had more moisture content with the values 9.2 ± 0.14 and 9 ± 0.15 respectively. There was no significant difference in the protein content across both the wild and edible bean and ranged between 28.45 ± 0.012 and 30.70 ± 0.014 while these values were slightly reduced after malting. This study reveals that Mucuna and other types of underutilized wild beans— Otili, Feregede, and Pakala are important food sources that can be exploited to mitigate shortage in animal protein and under nutrition facing families in many developing countries particularly in Nigeria.
Comparative Study on Nigerian Wild and Edible Beans in Reversing Incidence of Colon Cancer in Albino Rats  [PDF]
O. A. Awoyinka, A. Ileola, C. N. Imeoria, A. E. Omonisi, F. C. Oladele, M. F. Asaolu
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102708
This work is an investigation of the curative effects of some edible and wild type beans on colonic inflammation induced by Dextran Sulphate Sodium (DSS) in wister albino rats. Macroscopic examination performed on the colon after seven-day exposure of the animals to both DSS and bean sample revealed a high incidence of colonic inflammation in rats fed with macuna compared to other groups. However, from the histological examination, the groups fed with Otili and Feregede had a low incidence of dysplasia showing Otili and Feregede to be good candidates that could mitigate effect of Dextran Sodium Sulphate.
A Trapezoidal-Like Integrator for the Numerical Solution of One-Dimensional Time Dependent Schrödinger Equation  [PDF]
Johnson Oladele Fatokun
American Journal of Computational Mathematics (AJCM) , 2014, DOI: 10.4236/ajcm.2014.44023

In this paper, the one-dimensional time dependent Schr?dinger equation is discretized by the method of lines using a second order finite difference approximation to replace the second order spatial derivative. The evolving system of stiff Ordinary Differential Equation (ODE) in time is solved numerically by an L-stable trapezoidal-like integrator. Results show accuracy of relative maximum error of order 10?4 in the interval of consideration. The performance of the method as compared to an existing scheme is considered favorable.

Chronic loin pain in a 65-year old adult polycystic kidney disease patient
Chukwuonye I.I,Oladele C,Abali C,Oviasu E
International Journal of Medicine and Biomedical Research , 2013, DOI: 10.14194/ijmbr.229
Abstract: Background: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is often characterized clinically by acute/chronic pain, hypertension and variable progression to end-stage renal disease. About 60% of all ADPKD patients are estimated to have chronic pain, and often this is the initially presenting symptom of an ADPKD patient that brings them to medical attention. Aim: This study reports a case of a 65-year old with polycystic kidney disease and chronic loin pain. Findings: Our patient presented with history of chronic loin pain which we believed was due to increased cysts sizes/increase in weight of the kidneys. A good history was taken from him on presentation, and also laboratory investigations were carried out. However, the cause of the pain was believed to be due to increase in cysts sizes/weight of the kidneys. The patient was educated on the possible cause of the pain and various treatment options for the condition. He was placed on intermittent use of paracetamol with good response. Conclusion: A concept that must be employed in patients suffering from chronic loin pain is to educate the patient that the pain may not be relieved permanently by any intervention method adopted, and also to offer them the treatment modalities available to enable them to cope with the pain.
Adolescent Girls Self Reported STI Symptoms and Mothers Perception of Their HIV Risk in an Urban Marketing Lagos, Nigeria
D. Oladele,A. Adeiga,F. Ricketts,H. Goodluck
Research Journal of Medical Sciences , 2012,
Abstract: Young women in Sub-Saharan Africa are vulnerable to HIV infection because of their immature reproductive system, difficulty of negotiating condom use and the presence of untreated Sexually Transmitted Infection (STI) as well as the culture of silence on open discussion of reproductive health issues with their parent. The study assesses women account of STI symptoms received from their adolescent girls and their perception of the risk of their daughter contacting HIV infection through heterosexual contact. Interviewer administered questionnaires were used to gather information from 230 women who have adolescent girls selected through stratified random sampling method. Average age of respondent is 42 years and 75.1% are in stable marital relationship while 63% have at least secondary school education. There was low report of STI symptoms from adolescent girls to their mothers (15% for Vaginal discharge, 23.5% for vaginal itching and 4.3% for genital ulcer) and elderly as well as widowed women were found to likely receive the complaint of STI symptoms. Also, 48% of respondents believe that heterosexual contact is the major route of HIV transmission, 90.7% also believe that healthy looking individual could transmit HIV and 53.6% agree that condom could protect their daughters from HIV infection. However, 89.3% believe that abstinence is the best method of protecting their girls from STI and HIV infection. It follows that parent-child communication about STI and condom use need to be reinforced while not undermining mother s traditional belief of abstinence till marriage.
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