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Search Results: 1 - 10 of 494 matches for " Eve Pickering "
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Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease
Xiaolan Hu,Eve Pickering,Yingxue Cathy Liu,Stephanie Hall,Helene Fournier,Elyse Katz,Bryan Dechairo,Sally John,Paul Van Eerdewegh,Holly Soares
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016616
Abstract: Recent GWAS studies focused on uncovering novel genetic loci related to AD have revealed associations with variants near CLU, CR1, PICALM and BIN1. In this study, we conducted a genome-wide association study in an independent set of 1034 cases and 1186 controls using the Illumina genotyping platforms. By coupling our data with available GWAS datasets from the ADNI and GenADA, we replicated the original associations in both PICALM (rs3851179) and CR1 (rs3818361). The PICALM variant seems to be non-significant after we adjusted for APOE e4 status. We further tested our top markers in 751 independent cases and 751 matched controls. Besides the markers close to the APOE locus, a marker (rs12989701) upstream of BIN1 locus was replicated and the combined analysis reached genome-wide significance level (p = 5E-08). We combined our data with the published Harold et al. study and meta-analysis with all available 6521 cases and 10360 controls at the BIN1 locus revealed two significant variants (rs12989701, p = 1.32E-10 and rs744373, p = 3.16E-10) in limited linkage disequilibrium (r2 = 0.05) with each other. The independent contribution of both SNPs was supported by haplotype conditional analysis. We also conducted multivariate analysis in canonical pathways and identified a consistent signal in the downstream pathways targeted by Gleevec (P = 0.004 in Pfizer; P = 0.028 in ADNI and P = 0.04 in GenADA). We further tested variants in CLU, PICALM, BIN1 and CR1 for association with disease progression in 597 AD patients where longitudinal cognitive measures are sufficient. Both the PICALM and CLU variants showed nominal significant association with cognitive decline as measured by change in Clinical Dementia Rating-sum of boxes (CDR-SB) score from the baseline but did not pass multiple-test correction. Future experiments will help us better understand potential roles of these genetic loci in AD pathology.
Global Law Firms in Real-World Contexts: Practical Limitations and Ethical Implications  [PDF]
Eve Darian-Smith
Beijing Law Review (BLR) , 2015, DOI: 10.4236/blr.2015.61010
Abstract: This article argues that despite the rise in the numbers of global law firms in recent years, the future of these firms should not be assumed given escalating levels of economic (and legal) uncertainty. These uncertainties are the result, in part, of growing global and regional conflicts, terrorism, environmental degradation, pandemics, forced migrations, trade embargoes and so on which are in turn linked to global inequalities and disparities of wealth between and within the global south and global north. It is argued that global law firms, as the “lubricators of global capitalism”, should pay attention to the localized real-world impacts of finance, development and trade that their legal work enables. This is important not only to ensure the future security and revenues of global law firms, but more importantly to ensure democratic aspirations and the stability of democratic institutions around the world.
Moderated PEF from Transitioning between the Micro and Macroscopic Usage of Coulomb’s Law  [PDF]
Eve G. Zoebisch
Computational Chemistry (CC) , 2015, DOI: 10.4236/cc.2015.31002
Abstract: The dielectric constant in Coulomb’s Law, D, can quantify an empirical reduction of force. It can also quantify a reduction of electrostatic field as seen in classical electrostatic theory where the induced charge layer is assumed to be infinitely thin. The two approaches exemplify two traditions that have been used in parallel for decades. They produce Potential Energy Functions (PEFs) that differ by a factor of the permittivity, εr. The classical electrostatic theory result can be incorporated into force field models with an effective dielectric function, Deff, which spans the induced charge layer and accommodates both traditions. The Deff function increases the magnitude of local terms as compared with cumulative long distance terms. It is shown that the Deff function reduces distance dependence of the radial PEF within the induced charge layer and improves computational stability for some systems including substrate in dilute salt solution. End use applications include pharmaceutical development (e.g. protein calculations with docking), materials development, solvation energy calculations and QM/MM calculations.
Rhododendron Uses and Distribution of this Knowledge within Ethnic Groups in Northwest Yunnan Province, China  [PDF]
Elizabeth Georgian, Eve Emshwiller
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.41018
Abstract: This research investigated the interplay between nature and culture by focusing on knowledge about the genus Rhododendron in seven ethnic minorities (Bai, Dulong, Lisu, Naxi, Nu, Tibetan, and Yi) and the majority (Han) in Yunnan Province, China. Ethnobotanical uses of rhododendron were determined by interviewing 252 individuals. Using these data, we investigated patterns of knowledge distribution within each ethnic group and the majority to gain an understanding of who holds specific types of ethnobotanical knowledge. We conducted additional interviews with a subset of the interviewees to discuss their perception of knowledge loss and possible solutions. We find that every ethnic minority and the Han had uses for Rhododendron and that this knowledge is distributed unevenly within each ethnic group. Rhododendron knowledge is distributed by age, gender, or distance from tourist areas for use categories such as knowledge of songs, handicrafts, religious uses, and tourism. Additionally, 67.5% of 84 interviewees believe that ethnobotanical knowledge is being lost.
Ivory tower or welcoming neighbor? Engaging our local communities
Jane Pickering
University Museums and Collections Journal , 2009,
Abstract: The Yale Peabody Museum is situated in the economically and ethnically diverse urban environment of New Haven. For over ten years the museum has run extremely popular cultural festivals that attract a diverse audience of thousands, but we discovered that attendees rarely came from the city itself. Clearly, having high-quality programming was not enough to attract our local community. To investigate this issue the museum launched a year-long research study to address the following questions: What is the perception that residents have of the museum and what are the barriers to their engagement with the museum? How can we serve visitors from our neighborhood? How does being part of Yale University affect people’s relationship with the museum? Our results were comparable to other studies by urban institutions but there were some differences that are of particular interest to university museums. For example, we discovered that negative opinions about the university were a significant barrier. There was also confusion as to our target audience, and a perception that our programs would not be of interest to “regular” people. University museums need to make considerable efforts if they hope to attract and serve non traditional museum goers – particularly changes in how they communicate and partner with the community. New initiatives at the Peabody include programming for local teenagers, diversity training for frontline staff, new outreach programs, and targeted marketing plans.
Counterexamples to Rational Dilation on Symmetric Multiply Connected Domains
James Pickering
Mathematics , 2007, DOI: 10.1007/s11785-008-0079-5
Abstract: We show that if R is a compact domain in the complex plane with two or more holes and an anticonformal involution onto itself (or equivalently a hyperelliptic Schottky double), then there is an operator T which has R as a spectral set, but does not dilate to a normal operator with spectrum on the boundary of R.
Test Functions in Constrained Interpolation
James Pickering
Mathematics , 2008,
Abstract: We give a set of test functions for the interpolation problem on $H_1^\infty$ , the constrained interpolation problem studied by Davidson, Paulsen, Raghupathi and Singh. We show that this set of test functions is minimal.
Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis
Rebecca Craig-Schapiro,Max Kuhn,Chengjie Xiong,Eve H. Pickering,Jingxia Liu,Thomas P. Misko,Richard J. Perrin,Kelly R. Bales,Holly Soares,Anne M. Fagan,David M. Holtzman
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018850
Abstract: Clinicopathological studies suggest that Alzheimer's disease (AD) pathology begins ~10–15 years before the resulting cognitive impairment draws medical attention. Biomarkers that can detect AD pathology in its early stages and predict dementia onset would, therefore, be invaluable for patient care and efficient clinical trial design. We utilized a targeted proteomics approach to discover novel cerebrospinal fluid (CSF) biomarkers that can augment the diagnostic and prognostic accuracy of current leading CSF biomarkers (Aβ42, tau, p-tau181).
Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway
Hongjie Zhu, Mikhail B. Bogdanov, Stephen H. Boyle, Wayne Matson, Swati Sharma, Samantha Matson, Erik Churchill, Oliver Fiehn, John A. Rush, Ranga R. Krishnan, Eve Pickering, Marielle Delnomdedieu, Rima Kaddurah-Daouk, Pharmacometabolomics Research Network
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068283
Abstract: Therapeutic response to selective serotonin (5-HT) reuptake inhibitors in Major Depressive Disorder (MDD) varies considerably among patients, and the onset of antidepressant therapeutic action is delayed until after 2 to 4 weeks of treatment. The objective of this study was to analyze changes within methoxyindole and kynurenine (KYN) branches of tryptophan pathway to determine whether differential regulation within these branches may contribute to mechanism of variation in response to treatment. Metabolomics approach was used to characterize early biochemical changes in tryptophan pathway and correlated biochemical changes with treatment outcome. Outpatients with MDD were randomly assigned to sertraline (n = 35) or placebo (n = 40) in a double-blind 4-week trial; response to treatment was measured using the 17-item Hamilton Rating Scale for Depression (HAMD17). Targeted electrochemistry based metabolomic platform (LCECA) was used to profile serum samples from MDD patients. The response rate was slightly higher for sertraline than for placebo (21/35 [60%] vs. 20/40 [50%], respectively, χ2(1) = 0.75, p = 0.39). Patients showing a good response to sertraline had higher pretreatment levels of 5-methoxytryptamine (5-MTPM), greater reduction in 5-MTPM levels after treatment, an increase in 5-Methoxytryptophol (5-MTPOL) and Melatonin (MEL) levels, and decreases in the (KYN)/MEL and 3-Hydroxykynurenine (3-OHKY)/MEL ratios post-treatment compared to pretreatment. These changes were not seen in the patients showing poor response to sertraline. In the placebo group, more favorable treatment outcome was associated with increases in 5-MTPOL and MEL levels and significant decreases in the KYN/MEL and 3-OHKY/MEL; changes in 5-MTPM levels were not associated with the 4-week response. These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL.
The effect of time of onset on community preferences for health states: an exploratory study
Eve Wittenberg
Health and Quality of Life Outcomes , 2011, DOI: 10.1186/1477-7525-9-6
Abstract: A survey of community-perspective preferences for hypothetical health states was conducted among a convenience sample of healthy adults recruited from a hospital consortium's research volunteer pool. Standard gambles for three hypothetical health states of varying severity were compared across three frames describing time of onset: six months prior onset, current onset, and no onset specified in the description. Results were compared within health state across times of onset, controlling for respondent characteristics known to affect utility scores. Sub-analyses were conducted to confirm results on values meeting inclusion criteria indicating a minimum level of understanding and compliance with the valuation task.Standard gamble scores from 368 completed surveys were not significantly different across times of onset described in the health state descriptions regardless of health condition severity and controlling for respondent characteristics. Similar results were found in the subset of 292 responses that excluded illogical and invariant responses.The inclusion of information on the time of onset of a health condition in community-perspective utility survey health state descriptions may not be salient to or may not induce expression of preferences related to disease onset among respondents. Further research is required to understand community preferences regarding condition onset, and how such information might be integrated into health state descriptions to optimize the validity of utility data. Improved understanding of how the design and presentation of health state descriptions affect responses will be useful to eliciting valid preferences for incorporation into decision making.As demands to improve efficiency of health care expenditures increase, valid and accurate measures of the effectiveness of health interventions are becoming increasingly important[1]. Primary among such measures are health utilities, the basis for quality adjusted life years (QALYs)[2].
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