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Search Results: 1 - 10 of 4969 matches for " Eva Haastrup "
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Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort
Margit H?rup Larsen, Anders Albrechtsen, Lise Wegner Th?rner, Thomas Werge, Thomas Hansen, Ulrik Gether, Eva Haastrup, Henrik Ullum
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066262
Abstract: Background Cytokine response plays a vital role in various human lipopolysaccharide (LPS) infectious and inflammatory diseases. This study aimed to find genetic variants that might affect the levels of LPS-induced interleukin (IL)-6, IL-8, IL-10, IL-1ra and tumor necrosis factor (TNF)-α cytokine production. Methods We performed an initial genome-wide association study using Affymetrix Human Mapping 500 K GeneChip? to screen 130 healthy individuals of Danish descent. The levels of IL-6, IL-8, IL-10, IL-1ra and TNF-α in 24-hour LPS-stimulated whole blood samples were compared within different genotypes. The 152 most significant SNPs were replicated using Illumina Golden Gate? GeneChip in an independent cohort of 186 Danish individuals. Next, 9 of the most statistical significant SNPs were replicated using PCR-based genotyping in an independent cohort of 400 Danish individuals. All results were analyzed in a combined study among the 716 Danish individuals. Results Only one marker of the 500 K Gene Chip in the discovery study showed a significant association with LPS-induced IL-1ra cytokine levels after Bonferroni correction (P<10?7). However, this SNP was not associated with the IL-1ra cytokine levels in the replication dataset. No SNPs reached genome-wide significance for the five cytokine levels in the combined analysis of all three stages. Conclusions The associations between the genetic variants and the LPS-induced IL-6, IL-8, IL-10, IL-1ra and TNF-α cytokine levels were not significant in the meta-analysis. This present study does not support a strong genetic effect of LPS-stimulated cytokine production; however, the potential for type II errors should be considered.
E. Deidre Pribram: Emotion, Genre, Justice in Film and Television. Detecting Feeling. New York & London: Routledge. 2011.
Helle Kannik Haastrup
MedieKultur : Journal of Media and Communication Research , 2012,
Abstract:
Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression
Ulla Knorr, Maj Vinberg, Marianne Klose, Ulla Feldt-Rasmussen, Linda Hilsted, Anders Gade, Eva Haastrup, Olaf Paulson, J?rn Wetterslev, Christian Gluud, Ulrik Gether, Lars Kessing
Trials , 2009, DOI: 10.1186/1745-6215-10-66
Abstract: The AGENDA trial is designed as a participant, investigator, observer, and data-analyst-blinded randomized trial. Participants are 80 healthy first-degree relatives of patients with depression. Participants are randomized to escitalopram 10 mg per day versus placebo for four weeks. Randomization is stratified by gender and age. The primary outcome measure is the change in plasma cortisol in the dexamethasone-corticotrophin releasing hormone test at entry before intervention to after four weeks of intervention. With the inclusion of 80 participants, a 60% power is obtained to detect a clinically relevant difference in the primary outcome between the intervention and the placebo group. Secondary outcome measures are changes from baseline to four weeks in scores of: 1) cognition and 2) neuroticism. Tertiary outcomes measures are changes from baseline to four weeks in scores of: 1) depression and anxiety symptoms; 2) subjective evaluations of depressive symptoms, perceived stress, quality of life, aggression, sleep, and pain; and 3) salivary cortisol at eight different timepoints during an ordinary day. Assessments are undertaken by assessors blinded to the randomization group.Local Ethics Committee: H-KF 307413Danish Medicines Agency: 2612-3162.EudraCT: 2006-001750-28.Danish Data Agency: 2006-41-6737.ClinicalTrials.gov: NCT 00386841Robins and Guze described five phases in the development of a valid classification of psychiatric illness: clinical description, laboratory studies, delimitation from other disorders, follow-up studies and family studies [1]. Later, response to treatment was added as a sixth phase [2]. Recently, the endophenotype concept has emerged as a strategic tool in neuropsychiatric research [3].Endophenotypes are quantifiable components in the "genes-to-behaviours" pathways distinct from psychiatric symptoms [3]. In parallel with the classification of psychiatric diseases, endophenotypes are validated by specificity, state independence, heritability,
Strengthening the Roles of Parent Teacher Association in Secondary Schools for Better Community Participation in Educational Development in Nigeria
Haastrup Timilehin Ekundayo,Hezekiah Ogbomida Alonge
Journal of Educational and Developmental Psychology , 2012, DOI: 10.5539/jedp.v2n2p16
Abstract: The paper examined the traditional roles of the Parent Teacher Association (PTA) in secondary schools in Nigeria. The state of secondary schools in Nigeria suggests that there are still some problems facing the school in which the PTA had been found wanting. These include inadequate financial support of the PTA to the schools; lack of cooperation between the schools and the parents; inadequate supervision of schools among others. The paper therefore made some recommendations on how the roles of the PTA can be strengthened for better community participation in the provision of qualitative education at the secondary school level. These include giving the PTA more involvement in educational financing; giving them more responsibilities in school administration; giving them direct labour for execution of school projects instead of giving to outside contractors.
“The Deregulation of University Education in Nigeria: Implications for Quality Assurance.”
I. A. Ajayi and Haastrup T. Ekundayo
Nebula , 2008,
Abstract:
Modeling of Wind Turbine Gearbox Mounting
Morten Haastrup,Michael R. Hansen,Morten K. Ebbesen
Modeling, Identification and Control , 2011, DOI: 10.4173/mic.2011.4.2
Abstract: In this paper three bushing models are evaluated to find a best practice in modeling the mounting of wind turbine gearboxes. Parameter identification on measurements has been used to determine the bushing parameters for dynamic simulation of a gearbox including main shaft. The stiffness of the main components of the gearbox has been calculated. The torsional stiffness of the main shaft, gearbox and the mounting of the gearbox are of same order of magnitude, and eigenfrequency analysis clearly reveals that the stiffness of the gearbox mounting is of importance when modeling full wind turbine drivetrains.
Modeling and Parameter Identification of Deflections in Planetary Stage of Wind Turbine Gearbox
Morten Haastrup,Michael R. Hansen,Morten K. Ebbesen,Ole ?. Mouritsen
Modeling, Identification and Control , 2012, DOI: 10.4173/mic.2012.1.1
Abstract: The main focus of this paper is the experimental and numerical investigation of a 750kW wind turbine gearbox. A detailed model of the gearbox with main shaft has been created using MSC.Adams. Special focus has been put on modeling the planet carrier (PLC) in the gearbox. For this purpose experimental data from a drive train test set up has been analyzed using parameter identification to quantify misalignments. Based on the measurements a combination of main shaft misalignment and planet carrier deflection has been identified. A purely numerical model has been developed and it shows good accordance with the experimental data.
Exploring Coping Effectiveness and Optimism among Municipal Employees  [PDF]
Tuija Muhonen, Eva Torkelson
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.26090
Abstract: The aim of the study was to examine the relationship between coping, optimism, psychological and physical well-being. The effectiveness of the different coping strategies and the role of optimism were investigated by analyzing how they predicted psychological and physical well-being. Altogether 136 municipal employees participated in a questionnaire study. The results showed that the most adaptive or effective coping strategy concerning psychological and physical well-being was acceptance, which can be classified as engagement coping. Ineffective strategies regarding psychological well-being included disengagement coping strategies such as sub- stance use, behavioral disengagement and self-blame. An ineffective strategy regarding physiological well-being was denial, which can be classified as a disengagement strategy. Optimism correlated significantly with both psychological and physical well-being. However, when all the variables in the model were included in the regression analysis, optimism explained additional variance in physical well-being but not in psychological well-being.
The role of histamine H4 receptors as a potential targets in allergic rhinitis and asthma  [PDF]
Eva Hanuskova, Jana Plevkova
Open Journal of Molecular and Integrative Physiology (OJMIP) , 2013, DOI: 10.4236/ojmip.2013.31002
Abstract:

Histamine—the main product of mast cells plays critical role in the pathogenetic pathways of both allergic rhinitis and asthma. The novel concept of the unique airway diseases its only supported by the similarities within pathogenetic process. Antagonists of H1 and H2 receptors are quite effective in allergic rhinitis, but not effective enough in asthma. In an era of corticosteroids, leucotriene antagonists and Anti-IgE treatment, there is still a challenge to search for more effective, more acurate and more safe treatment option. Antagonists (inversive agonists) of histamine receptors H4 seems to be one of the promising targets in the allergic rhinitis and asthma treatment. The first H4 antagonist entered to clinics and the results from a proof-of-concept Phase II clinical study is expected to be disclosed soon. This review article summarizes current knowledge on H4R that have been collected in various studies sharing evidences about efficacy of H4R as a reasonable target for diseases with histamine involved pathogenetic pathways.

What Reasons Might the Other One Have?—Perspective Taking to Reduce Psychological Reactance in Individualists and Collectivists  [PDF]
Christina Steindl, Eva Jonas
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.312A170
Abstract:

Previous research has demonstrated a considerable amount of negative consequences resulting from psychological reactance. The purpose of this study was to explore opportunities to reduce the amount of reactance. Using the method of perspective taking as an intervention, the current study of 196 Austrians and 198 Filipinos examined whether reactance could be reduced and whether individualists and collectivists differ concerning reactance and their perspective taking abilities. Our results indicated that participants who took the perspective of the person who threatened them experienced less reactance than participants who did not take this approach. This was the case for people from both cultural backgrounds. Nevertheless, comparisons among the two cultural groups yielded different reactions to restrictions. This indicates that individualists are more sensitive to a self-experienced restriction than collectivists, but less sensitive to a restriction of another person. Consequently, we consider culture to be a crucial determinant in predicting the amount of reactance.

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