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Search Results: 1 - 10 of 66608 matches for " Eun-Ju Yang3 "
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Anticoagulant activities of oleanolic acid via inhibition of tissue factor expressions
Wonhwa Lee1,2,#, Eun-Ju Yang3,#, Sae-Kwang Ku4,#, Kyung-Sik Song1 & Jong-Sup Bae1,*
BMB Reports , 2012,
Abstract: Oleanolic acid (OA), a triterpenoid known for its anti-inflammatoryand anti-cancer properties, is commonly present in severalmedicinal plants but its anticoagulant activities have not beenstudied. Here, the anticoagulant properties of OA were determinedby monitoring activated partial thromboplastin time (aPTT),prothrombin time (PT), fibrin polymerization as well as cell-basedthrombin and activated factor X (FXa) generation activities. Datashowed OA prolonged aPTT and PT significantly and inhibitedthrombin catalyzed fibrin polymerization. In addition, OA inhibitedthe activities of thrombin and FXa and inhibited the generationof thrombin or FXa in human endothelial cells. OA also inhibitedTNF-α-induced tissue factor expression on human endothelialcells. In accordance with these anticoagulant activities, OAshowed an anticoagulant effect in vivo. These results indicate thatOA possesses antithrombotic activities and suggest that daily consumptionof a herb containing OA may be preventing thrombosisin pathological states.
Increased expression of interleukin-1β in triglyceride-induced macrophage cell death is mediated by p38 MAP kinase
Ho Joong Sung1,#, Sin Jee Son2,#, Seung-ju Yang3, Ki-Jong Rhee2 & Yoon Suk Kim2,*
BMB Reports , 2012,
Abstract: Triglycerides (TG) are implicated in the development ofatherosclerosis through formation of foam cells and induction ofmacrophage cell death. In this study, we report that addition ofexogenous TG induced cell death in phorbol 12-myristate13-acetate-differentiated THP-1 human macrophages. TGtreatment induced a dramatic decrease in interleukin-1β (IL-1β)mRNA expression in a dose- and time-dependent manner. Theexpression of granulocyte macrophage colony-stimulating factorand platelet endothelial cell adhesion molecule remainedunchanged. To identify signaling pathways involved inTG-induced downregulation of IL-1β, we added p38 MAPK,protein kinase C (PKC) or c-Raf1 specific inhibitors. We foundthat inhibition of p38 MAPK alleviated the TG-induceddownregulation of IL-1β, whereas inhibition of PKC and c-Raf1had no effect. This is the first report showing decreased IL-1βexpression during TG-induced cell death in a human macrophageline. Our results suggest that downregulation of IL-1β expressionby TG-treated macrophages may play a role during atherogenesis.
Enhancement of Tumor Regression by Coulomb Nanoradiator Effect in Proton Treatment of Iron-Oxide Nanoparticle-Loaded Orthotopic Rat Glioma Model: Implication of Novel Particle Induced Radiation Therapy  [PDF]
Seung-Jun Seo, Jae-Kun Jeon, Eun-Ju Jeong, Won-Seok Chang, Gi-Hwan Choi, Jong-Ki Kim
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.411A004

Background: Proton-impact metallic nanoparticles, inducing low-energy electrons emission and characteristic X-rays termed as Coulomb nanoradiator effect (CNR), are known to produce therapeutic enhancement in proton treatment on experimental tumors. The purpose of this pilot study was to investigate the effect of CNR-based dose enhancement on tumor growth inhibition in an iron-oxide nanoparticle (FeONP)-loaded orthotopic rat glioma model. Methods: Proton-induced CNR was exploited to treat glioma-bearing SD rat loaded with FeONP by either fully-absorbed single pristine Bragg peak (APBP) or spread-out Bragg peak (SOBP) 45-MeV proton beam. A selected number of rats were examined by MRI before and after treatment to obtain the size and position information for adjusting irradiation field. Tumor regression assay was performed by histological analysis of residual tumor in the sacrificed rats 7 days after treatment. The results of CNR-treated groups were compared with the proton alone control. Results: Intravenous injection of FeONP (300 mg/kg) elevated the tumor concentration of iron up to 37 μg of Fe/g tissue, with a tumor-to-normal ratio of 5, 24 hours after injection. The group receiving FeONP and proton beam showed 65% - 79% smaller tumor volume dose-dependently compared with the proton alone group. The rats receiving FeONP and controlled irradiation field by MR imaging demonstrated more than 95% -

NF-κB-Targeted Anti-Inflammatory Activity of Prunella vulgaris var. lilacina in Macrophages RAW 264.7
Yu-Jin Hwang,Eun-Ju Lee,Haeng-Ran Kim,Kyung-A Hwang
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms141121489
Abstract: Prunella vulgaris var. lilacina, a herbal medicine, has long been used in Korea for the treatment of sore throat, and to alleviate fever and accelerate wound healing. Although the therapeutic effect of P. vulgaris var. lilacina is likely associated with anti-inflammatory activity, the precise underlying mechanisms are largely unknown. Here, we sought to elucidate the possible mechanisms of the anti-inflammatory activity. We have investigated the anti-inflammatory activity of the various solvent fractions (hexane, butanol, chloroform and water) from the ethanol extract of P. vulgaris var. lilacina in activated macrophages. The hexane fraction exhibited higher anti-inflammatory activities, inducing inhibition of nitric oxide and prostaglandin E2 production as well as inducible nitric oxide synthase, cyclooxygenase-2, and tumor necrosis factor-α mRNA expression in response to lipopolysaccharide stimulation. Moreover, the hexane fraction from P. vulgaris var. lilacina significantly inhibited the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and the nuclear translocation of the NF-κB p50 and p65 subunits. These results indicate that P. vulgaris var. lilacina has an anti-inflammatory capacity in vitro, suggesting that it could be a potential source of natural anti-inflammatory agents.
Quercetin Inhibits IL-1β-Induced Inflammation, Hyaluronan Production and Adipogenesis in Orbital Fibroblasts from Graves' Orbitopathy
Jin Sook Yoon, Hyun Jung Lee, Soo Hyun Choi, Eun-Ju Chang, Sang Yeul Lee, Eun Jig Lee
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026261
Abstract: Management of Graves' orbitopathy (GO) is challenging, as no reliable, specific, and safe medical therapeutic agents have yet been developed. We investigated the effect of quercetin in primary cultured orbital fibroblasts from GO, targeting pathways of inflammation, aberrant accumulation of extracellular matrix macromolecules, and adipose tissue expansion. Quercetin significantly attenuated intercellular adhesion molecule-1 (ICAM-1), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1β-induced increases in ICAM-1, IL-6, and IL-8 mRNA. Increased hyaluronan production induced by IL-1β or tumor necrosis factor-α was suppressed by quercetin in a dose- and time-dependent manner. Treatment with noncytotoxic doses of quercetin inhibited accumulation of intracytoplasmic lipid droplets and resulted in a dose-dependent decrease in expression of peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein (C/EBP) α, and C/EBPβ proteins. In conclusion, inhibition of inflammation, hyaluronan production, and adipogenesis by the natural plant product quercetin in vitro provides the basis for further study of its potential use in the treatment of GO.
Characteristics of HIV seroprevalence of visitors to public health centers under the national HIV surveillance system in Korea: cross sectional study
Mee-Kyung Kee, Jin-Hee Lee, Chaeshin Chu, Eun-Ju Lee, Sung-Soon Kim
BMC Public Health , 2009, DOI: 10.1186/1471-2458-9-123
Abstract: We used HIV-testing data from 246 PHCs in 2005 through the Health Care Information System. The number of test taker was calculated using the code distinguished by the residential identification number. The subjects were classified into four groups by reason for testing; General group, HIV infection suspected group (HIV ISG), HIV test recommended group (HIV TRG), and sexually transmitted infection (STI) risk group.People living with HIV/AIDS were 149 (124 male and 25 female) among 280,456 individuals tested at PHCs. HIV seroprevalence was 5.3 per 10,000 individuals. Overall, the male revealed significantly higher seroprevalence than the female (adjusted Odds Ratio (adj. OR): 6.2; CI 3.8–10.2). Individuals aged 30–39 years (adj. OR: 2.6; CI 1.7–4.0), and 40–49 years (adj. OR: 3.8; CI 2.4–6.0) had higher seroprevalence than 20–29 years. Seroprevalence of HIV ISG (voluntary test takers and cases referred by doctors) was significantly higher than those of others. Foreigners showed higher seroprevalence than native Koreans (adj. OR: 3.8; CI 2.2–6.4). HIV ISG (adj. OR: 4.9; CI 3.2–7.5), and HIV TRG (adj. OR: 2.6; CI 1.3–5.4) had higher seroprevalence than General group.A question on the efficiency of current mandatory test is raised because the seroprevalence of mandatory test takers was low. However, HIV ISG included voluntary test takers was high in our result. Therefore, we suggest that Korea needs to develop a method encouraging more people to take voluntary tests at PHCs, also to expand the anonymous testing centers and Voluntary Counselling and Testing Program (VCT) for general population to easily access to HIV testing.The first case of acquired immunodeficiency syndrome (AIDS) in Korea was a foreign resident, and the first human immunodeficiency virus (HIV)-infected Korean contracted the virus during overseas travel in 1985 [1]. This stimulated a national preventative system for this emerging infection in Korea, which became prevalent in the United States and Europ
Antibody against Porcine Parvovirus VP2 Protein Differentiated This Virus from Other Viruses
Weijuan Zhu§, Yudong Ren§1, Guangxing Li, Dingding Su2, Qing Yang3 and Xiaofeng Ren*
Pakistan Veterinary Journal , 2012,
Abstract: Viral protein 2 (VP2) of porcine parvovirus (PPV) is the major viral structural protein and responsible for eliciting neutralizing antibodies in immunized animals. In this study, the gene encoding VP2 of PPV was amplified by PCR. The VP2 gene was then cloned into the prokaryotic expression vector, pET-32a followed by expression in Escherichia coli Rosetta. The VP2 protein expression was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Rabbit polyclonal antiserum was generated using the recombinant VP2 protein. The optimal titer of the anti-VP2 antibody was determined by ELISA. The anti-VP2 antibody was able to distinguish PPV from other viruses in ELISA.
Satellite Data-Based Phenological Evaluation of the Nationwide Reforestation of South Korea
Su-Jong Jeong, Chang-Hoi Ho, Sung-Deuk Choi, Jinwon Kim, Eun-Ju Lee, Hyeon-Ju Gim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058900
Abstract: Through the past 60 years, forests, now of various age classes, have been established in the southern part of the Korean Peninsula through nationwide efforts to reestablish forests since the Korean War (1950–53), during which more than 65% of the nation's forest was destroyed. Careful evaluation of long-term changes in vegetation growth after reforestation is one of the essential steps to ensuring sustainable forest management. This study investigated nationwide variations in vegetation phenology using satellite-based growing season estimates for 1982–2008. The start of the growing season calculated from the normalized difference vegetation index (NDVI) agrees reasonably with the ground-observed first flowering date both temporally (correlation coefficient, r = 0.54) and spatially (r = 0.64) at the 95% confidence level. Over the entire 27-year period, South Korea, on average, experienced a lengthening of the growing season of 4.5 days decade?1, perhaps due to recent global warming. The lengthening of the growing season is attributed mostly to delays in the end of the growing season. The retrieved nationwide growing season data were used to compare the spatial variations in forest biomass carbon density with the time-averaged growing season length for 61 forests. Relatively higher forest biomass carbon density was observed over the regions having a longer growing season, especially for the regions dominated by young (<30 year) forests. These results imply that a lengthening of the growing season related to the ongoing global warming may have positive impacts on carbon sequestration, an important aspect of large-scale forest management for sustainable development.
Effect of Laparoscopic Adjustable Gastric Banding on Metabolic Syndrome and Its Risk Factors in Morbidly Obese Adolescents
Rushika Conroy,Eun-Ju Lee,Amy Jean,Sharon E. Oberfield,Aviva Sopher,Krystina Kiefer,Courtney Raker,Donald J. McMahon,Jeffrey L. Zitsman,Ilene Fennoy
Journal of Obesity , 2011, DOI: 10.1155/2011/906384
Abstract: We examined the effect of laparoscopic adjustable gastric banding (LAGB) on weight loss, inflammatory markers, and components of the Metabolic Syndrome (MeS) in morbidly obese adolescents and determined if those with MeS lose less weight post-LAGB than those without. Data from 14–18 yr adolescents were obtained at baseline, 6 and 12 months following LAGB. Significant weight loss and improvements in MeS components were observed 6 months and one year following LAGB. The incidence of MeS declined 56.8% after 6 months and 69.6% after 12 months. There was no significant difference in amount of weight lost post-LAGB between those with and without MeS at either timepoint. Correlations between change in weight parameters and components of MeS in those with and without MeS at baseline were examined and found to vary by diagnostic category. LAGB is effective for short-term improvement in weight, inflammatory markers, and components of MeS in morbidly obese adolescents.
Effects of a Tumor Necrosis Factor-α Antagonist on Experimentally Induced Rhinosinusitis
Dong-Hyun Kim,Eun-ju Jeon,Shi-Nae Park,Kyung-Ho Park,Yong-Soo Park,Sang Won Yeo
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/360457
Abstract: This prospective, randomized, and controlled study examined the effects of tumor necrosis factor soluble receptor type I (sTNFRI, a TNF-α antagonist) on experimentally induced rhinosinusitis in rats. The experimental groups received an instillation of lipopolysaccharide (LPS) plus an intramuscular injection of amoxicillin/clavulanate (antibiotic group), an instillation of sTNFRI (sTNFRI group), an instillation of sTNFRI and an injection of amoxicillin/clavulanate (sTNFRI/antibiotic group), or no additional treatment (LPS group). Histopathological changes were determined using hematoxylin-eosin and periodic acid-Schiff (PAS) staining. Leakage of exudate was determined using fluorescence microscopy. Vascular permeability was measured using the Evans blue dye technique. Expression of MUC5AC was measured using reverse transcriptase PCR. The sTNFRI, antibiotic, and sTNFRI/antibiotic groups had significantly less capillary permeability, mucosal edema, PAS staining, and expression of MUC5AC than the LPS group. There were no differences in capillary permeability, mucosal edema, PAS staining, and MUC5AC expression between the sTNFRI and sTNFRI/antibiotic groups. The antibiotic group had PAS staining similar to that of the sTNFRI and sTNFRI/antibiotic groups but had a greater increase in capillary permeability, mucosal edema, and MUC5AC expression. This study shows that sTNFRI reduces inflammatory activity and mucus hypersecretion in LPS-induced rhinosinusitis in rats.
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