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Search Results: 1 - 10 of 31097 matches for " Eun Lee1 "
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Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats
Sang Hyun Lee1, Eun Lee1,* & Young Tag Ko2,*
BMB Reports , 2012,
Abstract: To investigate the therapeutic effect of a Korean herbal medicinePulsatilla koreana as an anti-septic agent, anti-inflammatoryeffects of the herbal medicine were determined in lipopolysaccharide(LPS)-exposed rats. Treatment with a methanol extractfrom Pulsatilla koreana significantly inhibited LPS-inducedinflammatory responses. Results from ELISA analysis showed thatPulsatilla koreana decreased the plasma and hepatic levels ofpro-inflammatory cytokines such as IL-1β, IL-6, TNF-α whileincreased the level of anti-inflammatory cytokine IL-10 inLPS-exposed rats. Pulsatilla koreana also decreased the plasmalevels of other inflammatory mediators such as NO3-/NO2-,ICAM-1, PGE2, and CINC-1 in LPS-exposed rats. Although nosignificant effects were observed in the phagocytic activities, thedistribution of lymphocyte population was significantly shiftedby the treatment with Pulsatilla koreana. All together, Pulsatillakoreana exerts anti-inflammatory activities in the immunechallengedanimals implicating that this Korean herbal medicineis therapeutically useful for the treatment of inflammatorydiseases like sepsis.
Identification and extensive analysis of inverted-duplicated HBV integration in a human hepatocellular carcinoma cell line
Jeong Bok1,#, Kwang Joong Kim1,#, Mi-Hyun Park1, Seung-Hak Cho2, Hye-Ja Lee1, Eun-Ju Lee1, Chan Park1 & Jong-Young Lee1,*
BMB Reports , 2012,
Abstract: Hepatitis B virus (HBV) DNA is often integrated intohepatocellular carcinoma (HCC). Although the relationshipbetween HBV integration and HCC development has beenwidely studied, the role of HBV integration in HCCdevelopment is still not completely understood. In the presentstudy, we constructed a pooled BAC library of 9 establishedcell lines derived from HCC patients with HBV infections. Byamplifying viral genes and superpooling of BAC clones, weidentified 2 clones harboring integrated HBV DNA. Screeningof host-virus junctions by repeated sequencing revealed anHBV DNA integration site on chromosome 11q13 in theSNU-886 cell line. The structure and rearrangement ofintegrated HBV DNA were extensively analyzed. An invertedduplicated structure, with fusion of at least 2 HBV DNAmolecules in opposite orientations, was identified in theregion. The gene expression of cancer-related genes increasednear the viral integration site in HCC cell line SNU-886.
The roles of FADD in extrinsic apoptosis and necroptosis
Eun-Woo Lee1,*, Jinho Seo1, Manhyung Jeong1, Sangsik Lee2 & Jaewhan Song1,*
BMB Reports , 2012,
Abstract: Fas-associated protein with death domain (FADD), an adaptorthat bridges death receptor signaling to the caspase cascade, isindispensible for the induction of extrinsic apoptotic cell death.Interest in the non-apoptotic function of FADD has greatlyincreased due to evidence that FADD-deficient mice ordominant-negative FADD transgenic mice result in embryoniclethality and an immune defect without showing apoptoticfeatures. Numerous studies have suggested that FADD regulatescell cycle progression, proliferation, and autophagy, affectingthese phenomena. Recently, programmed necrosis, also callednecroptosis, was shown to be a key mechanism that inducesembryonic lethality and an immune defect. Supporting thesefindings, FADD was shown to be involved in various necroptosismodels. In this review, we summarize the mechanism ofextrinsic apoptosis and necroptosis, and discuss the in vivo andin vitro roles of FADD in necroptosis induced by various stimuli.
Application of Mini-abdominoplasty after Conservative Excision of Extensive Cesarean Scar Endometriosis
Eui Tai Lee1,Hyun Min Park1,Dong Geun Lee1,Kyung Jin Shin1
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.5.551
Abstract: Endometriosis is defined as the presence of functioning endometrial tissue outside the uterinecavity, and the standard treatment is extensive surgical excision. Cesarean scar endometriosisis a type of cutaneous endometriosis arising on or near a Cesarean section scar. A 44-year-oldwoman presented with a 9×6 cm sized dark-brown, stony-hard, irregular, lower abdominalmass of four years duration. The patient had a history of two Cesarean deliveries, 14 and16 years ago. Suspecting endometriosis, we excised the tumor conservatively rather thanextensively to prevent incisional hernia considering the benign nature of the tumor andthe low possibility of recurrence because the patient’s age was near menopause, alongwith simultaneous bilateral salpingo-oophorectomy that was performed in this case. Onreconstruction, mini-abdominoplasty was adopted to avoid possible wound complicationsand cosmetic deformities. The patient was satisfied with the cosmetic results, and neitherrecurrence nor functional problems occurred during the 1-year follow-up period. Plasticsurgeons should keep in mind the possibility of cutaneous endometriosis in an abdominalmass of a female of reproductive age with a previous history of pelvic or intra-abdominalsurgery. An optimal result from oncological, functional, and cosmetic standpoints can beachieved with conservative excision followed by mini-abdominoplasty of extensive Cesareanscar endometriosis.
PEP-1-p18 prevents neuronal cell death by inhibiting oxidative stress and Bax expression
Duk-Soo Kim2,#, Eun Jeong Sohn1,#, Dae Won Kim1, Young Nam Kim1, Seon Ae Eom1, Ga Hyeon Yoon1, Sung-Woo Cho3, Sang-Hyun Lee1, Hyun Sook Hwang1, Yoon Shin Cho1, Jinseu Park1, Won Sik Eum1,* & Soo Young Choi1,*
BMB Reports , 2012,
Abstract: P18, a member of the INK4 family of cyclin-dependent kinaseinhibitors, is a tumor suppressor protein and plays a key cellsurvival role in a variety of human cancers. Under pathophysiologicalconditions, the INK4 group proteins participate in novelbiological functions associated with neuronal diseases andoxidative stress. Parkinson’s disease (PD) is characterized by loss ofdopaminergic neurons, and oxidative stress is important in itspathogenesis. Therefore, we examined the effects of PEP-1-p18 onoxidative stress-induced SH-SY5Y cells and in a PD mouse model.The transduced PEP-1-p18 markedly inhibited 1-methyl-4-phenylpyridinium-induced SH-SY5Y cell death by inhibiting Baxexpression levels and DNA fragmentation. Additionally, PEP-1-p18prevented dopaminergic neuronal cell death in the substantia nigraof a 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine-induced PDmouse model. These results indicate that PEP-1-p18 may be auseful therapeutic agent against various diseases and is a potentialtool for treating PD.
A New Record of Cymatium encausticum (Ranellidae: Tonnoidea: Gastropoda) from Korea
Junhee Lee1,Sang-Hwa Lee,Jongrak Lee,Joong-Ki Park
Animal Systematics, Evolution and Diversity , 2012, DOI: http://dx.doi.org/10.5635/ased.2012.28.3.212
Abstract: The Cymatium Roding, 1798 is a small- to large-sized marine gastropod genus. Three species has been reported thus far for Cymatium in the Korean waters. In general, Cymatium encausticum (Reeve, 1844) is known to occur in tropical seawaters including the Philippine Islands along with its congeners C. gutturnium, C. springsteeni, and C. exile. A single individual of the species was collected from Jejudo Island by SCUBA diving and morphological features were observed using a stereomicroscope. This is the first study to report the occurrence of Cymatium encausticum (Reeve, 1844) from the Korean waters, providing a detailed description of the species with the illustration for the shell morphology.
Usefulness of Intravenous Anesthesia Using a Target-controlled Infusion System with Local Anesthesia in Submuscular Breast Augmentation Surgery
Kyu-Jin Chung,Kyu-Ho Cha,Jun-Ho Lee1,Yong-Ha Kim
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.5.540
Abstract: Background Patients have anxiety and fear of complications due to general anesthesia.Through new instruments and local anesthetic drugs, a variety of anesthetic methods havebeen introduced. These methods keep hospital costs down and save time for patients. Inparticular, the target-controlled infusion (TCI) system maintains a relatively accurate level ofplasma concentration, so the depth of anesthesia can be adjusted more easily. We conductedthis study to examine whether intravenous anesthesia using the TCI system with propofol andremifentanil would be an effective method of anesthesia in breast augmentation.Methods This study recruited 100 patients who underwent breast augmentation surgeryfrom February to August 2011. Intravenous anesthesia was performed with 10 mg/mLpropofol and 50 μg/mL remifentanil simultaneously administered using two separate modulesof a continuous computer-assisted TCI system. The average target concentration was set at2 μg/mL and 2 ng/mL for propofol and remifentanil, respectively, and titrated against clinicaleffect and vital signs. Oxygen saturation, electrocardiography, and respiratory status werecontinuously measured during surgery. Blood pressure was measured at 5-minute intervals.Information collected includes total duration of surgery, dose of drugs administered duringsurgery, memory about surgery, and side effects.Results Intraoperatively, there was transient hypotension in two cases and hypoxia in threecases. However, there were no serious complications due to anesthesia such as respiratorydifficulty, deep vein thrombosis, or malignant hypertension, for which an endotrachealintubation or reversal agent would have been needed. All the patients were discharged on theday of surgery and able to ambulate normally.Conclusions Our results indicate that anesthetic methods, where the TCI of propofol andremifentanil is used, might replace general anesthesia with endotracheal intubation in breastaugmentation surgery.
An Entropy Decision Model for Selection of Enterprise Resource Planning System
Ming-Chang Lee1 , Jui-Fang Chang2 , Jung-Fang Chen3
International Journal of Computer Trends and Technology , 2011,
Abstract: There exist some several method offer similar functions and current technologies are poor to discriminate the important weights of attributes of enterprise resource planning system, due to the complexity of metrics and involvement of consumer’s vague perception. Entropy method is used to determine the weight of evaluation indexes and establish multi-level fuzzy synthetic evaluation model. Its application is illustrated with example, which can provide the intuitive and effective method for decision-makers in enterprise resource planning system selection. In this paper, we introduce a linguistic entropy method and fuzzy synthetic evaluation method. Moreover, a satisfaction-based index of software quality model is established to perform the discrimination of fuzzy ranking of alternatives. Finally, a numerical example is given to demonstrate the process of enterprise resource planning system selection. The experimental results demonstrated that it is a feasible and trustworthy manner to select of the system selection using the proposed scheme.
Angioleiomyoma of the Auricle
Hyo-In Kim1,Si-Gyun Roh1,Nae-Ho Lee1,Kyung-Moo Yang1
Archives of Plastic Surgery , 2013, DOI: http://dx.doi.org/10.5999/aps.2013.40.1.68
Nuclear Akt promotes neurite outgrowth in the early stage of neuritogenesis
Ji Hye Park1,2,3#, Sang Bae Lee1,#, Kyung-Hoon Lee2,3,* & Jee-Yin Ahn1,3,*
BMB Reports , 2012,
Abstract: In addition to its pivotal role in neuronal survival, PI3K/Aktsignaling is integral to neuronal differentiation and neuriteoutgrowth. However, the exact role of Akt in neuronaldifferentiation is still controversial. Here, we found thatnuclear expression of CA-Akt resulted in unusual rapid neuriteoutgrowth and overexpression of KD-Akt caused multipledendrite growth without specific axon elongation. Moreover,microarray data revealed that the expression of FOXQ1expression was about 10-fold higher in cells with nuclear,active Akt than in control cells. Quantitative real-time PCRanalysis showed that mRNA levels were upregulated inNLS-CA-Akt cells as compared to KD or EV cells. Furthermore,our FACS analysis demonstrated that overexpression ofNLS-CA-Akt accumulate cells in the G1 phase within 24 h,fitting with the rapid sprouting of neuritis. Thus, our dataimplied that at least in this early time frame, the overexpressionof nuclear, active Akt forced cells into neurite developmentthrough probably FOXQ1regulation.
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