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Search Results: 1 - 10 of 16830 matches for " Eun Ji Jeun "
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Ulmus davidiana var. japonica Nakai Upregulates Eosinophils and Suppresses Th1 and Th17 Cells in the Small Intestine
Han-Sung Lee, Min Seong Jang, Jung-Hwan Kim, Chun-Pyo Hong, Eun-Jung Lee, Eun Ji Jeun, Chan Kim, Eun-Kyung Kim, Kwang-Seong Ahn, Bo-Gie Yang, Kwang Seok Ahn, Young Pyo Jang, Kyoo-Seok Ahn, You-Me Kim, Myoung Ho Jang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076716
Abstract: The bark of Ulmus davidiana var. japonica Nakai (Ulmaceae) has been used in traditional Korean medicine for chronic inflammation in the gastrointestinal tract. Here we investigated the frequency and cytokine profile of the major immune cells in the small intestinal lamina propria (SI LP), spleen, and mesenteric lymph nodes (MLNs) of mice treated orally with Ulmus davidiana var. japonica Nakai bark water extract (UDE) to address the immunomodulatory role of this herb in intestinal homeostasis. B6 mice were given 5g/kg UDE once daily for 14 days. They were then sacrificed, and cells were isolated from the spleen, MLNs, and SI LP. The proportion of B versus T lymphocytes, CD4+ versus CD8+ T lymphocytes, Th1 and Th17 cells, and Foxp3+ regulatory T cells in the spleen, MLNs, and SI LP were analyzed. The frequency of antigen-presenting cells (APCs), including dendritic cells, macrophages, and eosinophils in the SI LP and the expression of costimulatory molecules on APCs were also evaluated. The numbers and frequencies of Th1 and Th17 cells in the SI LP were significantly reduced in the UDE-treated mice compared with PBS controls. In addition, the proportion of IL-4-producing eosinophils in the SI LP was significantly elevated in the UDE-treated mice compared with controls. Taken together, these data indicate that UDE up-regulates the number and frequency of SI LP eosinophils, which can down-regulate the Th1 and Th17 responses via IL-4 secretion and contribute to intestinal homeostasis.
The Application of the Korean Dietary Pattern Score; KNHANES (Korean National Health and Nutrition Examination Survey) 2007  [PDF]
Kyung Won Lee, Ji Eun Oh, Mi Sook Cho
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.312221
Abstract: The aim of this study was to apply the Korean Dietary Pattern Score (KDPS) to Korean subjects based on traditional Korean-style meals. The KDPS is based on the 3-Chup Bansang (the traditional Korean daily table setting) and considers the intake of 6 major food groups according to the Korean Dietary Reference Intakes (KDRIs). The KDPS consists of 2 parts: the Korean-Style Meal Score (KSMS) and the Food Group Score (FGS). The KDPS was applied dietary data collected during the Korean National Health and Nutrition Examination Survey (KNHANES) in 2007. Socio-demographic status, gender, age, and body mass index are all factors that have been shown to be meaningful predictors for the KDPS. When the effect of the KDPS on risk of disease was evaluated, a higher total KDPS was associated with a decreased risk of elevated systolic blood pressure (p < 0.05) and hypercholesterolemia (p < 0.05). In addition, as the KSMS increased, the risk of central obesity (p < 0.05) and hypertension (p < 0.01) significantly decreased. A higher total KDPS suggests a greater diversity of food intake, and therefore greater dietary diversity appears to lower the risk of disease. The KDPS is relevant because it integrates scores for Korean-style meal patterns and meal evaluation from a nutritional perspective. In conclusion, the KDPS is appropriate for evaluating the quality of diet, adherence to Korean-style meal patterns, and risk of related diseases. These results will be useful for evaluating the nation’s dietary patterns, nutrition, and health status when planning nutrition policies and programs.
Cornual patency and integrity following laparoscopic cornuotomy for interstitial pregnancy  [PDF]
Young-Sam Choi, Dae-Sook Eun, Yun-Sang Oh, Ji-No Park
Open Journal of Obstetrics and Gynecology (OJOG) , 2012, DOI: 10.4236/ojog.2012.22024
Abstract: Objective: To evaluate cornual patency and integrity following laparoscopic cornuotomy. Study Design: This is a prospective cohort study on seven women who underwent laparoscopic cornuotomy for interstitial pregnancy. The cornual patency and integrity were evaluated using hysterosalpingography (HSG) and magnetic resonance imaging (MRI). On MRI, the entire cornual wall thickness were measured bilaterally at 5-mm intervals. The thickness of the affected and unaffected cornua matched at the corresponding contralateral point in each of the women. Statistically, all possible pairwise 28 comparisons were compared using paired t-tests. Results: Among six eligible women, four women had excellent cornual patency on the affected side. Among seven women (i.e., 28 pairs), no significant difference was observed in cornual thickness compared to the unaffected cornu and no remarkable defects were seen in the endometrial and cornual contour. But there is no statistical significance. Conclusion: Laparoscopic cornuotomy seems to have advantage to preserve the cornu in interstitial pregnancy.
A systems-biology approach to understanding the ciliopathy disorders
Ji Eun Lee, Joseph G Gleeson
Genome Medicine , 2011, DOI: 10.1186/gm275
Abstract: Motile cilia (flagella) arose in the eukaryotic lineage in single-celled protists, where they took on signaling capacities, and it was only with the emergence of the multicellular animal kingdom that their non-motile cousins (primary cilia) appeared. Motile cilia in multi-ciliated organisms beat in coordinated waves and are found in various tissues, where they perform a variety of functions. For example, motile cilia in the trachea function in sweeping mucus and particulates out of the lungs and in the fallopian tubes they assist in moving the ovum from the fallopian tube to the uterus. Primary cilia, on the other hand, have a role in sensory detection. In worms, for example, they are present exclusively in a handful of neurons used to detect food. Although there are some cells with motile and primary cilia in vertebrates, most cells have primary cilia whereas only a handful of cells have motile cilia. Both types of cilia have a protruding microtubule structure called the axoneme emerging from a basal body that contains the pair of centrioles (Figure 1). Structurally, the axonemes in both motile and primary cilia comprise nine doublet microtubules, but primary cilia differ in that they lack the two central microtubules (9 + 0) that motile cilia have (9 + 2).Cilia maintain separate cytoplasmic and membrane compartments, but are completely lacking vesicles. Instead cilia rely on specialized modes of transportation called intraflagellar transport (IFT) to deliver cargo proteins and lipids along the axoneme. IFT can operate in the anterograde direction (towards the ciliary tip) using complex B factors, or in the retrograde direction (towards the ciliary base) using complex A factors; together these factors regulate the transport speed and net cargo flux. An important, recently emerged aspect of cilia is the gatekeeper role of the septin family of proteins, regulating initial entry and exit of ciliary factors at the base of the cilium [1]. The transition zone, where the
On certain classes of meromorphically starlike functions
Nak Eun Cho,Ji A. Kim
International Journal of Mathematics and Mathematical Sciences , 1995, DOI: 10.1155/s0161171295000585
Abstract: The object of the present paper is to introduce a new class ¢ ‘n( ±) of meromorphic functions defined by a multiplier transformation and to investigate some properties for the class ¢ ‘n( ±) Further we study integrals of functions in ¢ ‘n( ±).
Power Law Exponents for Vertical Velocity Distributions in Natural Rivers  [PDF]
Hae-Eun Lee, Chanjoo Lee, Youg-Jeon Kim, Ji-Sung Kim, Won Kim
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.512114

While log law is an equation theoretically derived for near-bed region, in most cases, power law has been researched by experimental methods. Thus, many consider it as an empirical equation and fixed power law exponents such as 1/6 and 1/7 are generally applied. However, exponent of power law is an index representing bed resistance related with relative roughness and furthermore influences the shapes of vertical velocity distribution. The purpose of this study is to investigate characteristics of vertical velocity distribution of the natural rivers by testing and optimizing previous methods used for determination of power law exponent with vertical velocity distribution data collected with ADCPs during the years of 2005 to 2009 from rivers in South Korea. Roughness coefficient has been calculated from the equation of Limerinos. And using theoretical and empirical formulae, and representing relationships between bed resistance and power law exponent, it has been evaluated whether the exponents suggested by these equations appropriately reproduce vertical velocity distribution of actual rivers. As a result, it has been confirmed that there is an increasing trend of power law exponent as bed resistance increases. Therefore, in order to correctly predict vertical velocity distribution in the natural rivers, it is necessary to use an exponent that reflects flow conditions at the field.

International Comparative Case Study of High School Students about Empathy  [PDF]
Heesun Yang, Jung-Eun Park, Ji Hye Kim, Seong-Joo Kang
Psychology (PSYCH) , 2019, DOI: 10.4236/psych.2019.102013
Abstract: In this study, we attempted to investigate the empathy ability of Korean adolescents. Davis’ Interpersonal Reactivity Index was applied to 1155 high school students in Korea, and the results were compared with those obtained from the survey of the American and Dutch students with similar ages. As a result, high school students in Korea had higher cognitive empathy than other countries. But, in cognitive empathy, Fantasy (FN) was lower than Perspective Taking (PT), unlike other countries. The mean score of women in all empathy subscales was higher than that of men. And there is significant difference between humanities and natural science high school students in PT, Empathic Concern (EC) and Personal Distress (PD). However, in the comparison of mean score’s effect size and correlation in the subscales of the empathetic scale, it was confirmed as an unstable structure in PD. Therefore, there is a need to educationally discuss how to improve this limitation of measuring empathy in the further research.
Valproic Acid Downregulates the Expression of MGMT and Sensitizes Temozolomide-Resistant Glioma Cells
Chung Heon Ryu,Wan Soo Yoon,Kwang Ywel Park,Seong Muk Kim,Jung Yeon Lim,Ji Sun Woo,Chang Hyun Jeong,Yun Hou,Sin-Soo Jeun
Journal of Biomedicine and Biotechnology , 2012, DOI: 10.1155/2012/987495
Abstract: Temozolomide (TMZ) has become a key therapeutic agent in patients with malignant gliomas; however, its survival benefit remains unsatisfactory. Valproic acid (VPA) has emerged as an anticancer drug via inhibition of histone deacetylases (HDACs), but the therapeutic advantages of a combination with VPA and TMZ remain poorly understood. The main aim of the present study was to determine whether an antitumor effect could be potentiated by a combination of VPA and TMZ, especially in TMZ-resistant cell lines. A combination of VPA and TMZ had a significantly enhanced antitumor effect in TMZ-resistant malignant glioma cells (T98 and U138). This enhanced antitumor effect correlated with VPA-mediated reduced O6-methylguanine-DNA methyltransferase (MGMT) expression, which plays an important role in cellular resistance to alkylating agents. In vitro, the combination of these drugs enhanced the apoptotic and autophagic cell death, as well as suppressed the migratory activities in TMZ-resistant cell lines. Furthermore, in vivo efficacy experiment showed that treatment of combination of VPA and TMZ significantly inhibited tumor growth compared with the monotherapy groups of mice. These results suggest that the clinical efficacy of TMZ chemotherapy in TMZ-resistant malignant glioma may be improved by combination with VPA.
Microporation is a valuable transfection method for efficient gene delivery into human umbilical cord blood-derived mesenchymal stem cells
Jung Lim, Sun Park, Chang Jeong, Ji Oh, Seong Kim, Chung Ryu, Soon A Park, Jae Ahn, Wonil Oh, Sin-Soo Jeun, Jong Chang
BMC Biotechnology , 2010, DOI: 10.1186/1472-6750-10-38
Abstract: Using microporation with EGFP as a reporter gene, hUCB-MSCs were transfected with higher efficiency (83%) and only minimal cell damage than when conventional liposome-based reagent (<20%) or established electroporation methods were used (30-40%). More importantly, microporation did not affect the immunophenotype of hUCB-MSCs, their proliferation activity, ability to differentiate into mesodermal and ectodermal lineages, or migration ability towards cancer cells. In addition, the BDNF gene could be successfully transfected into hUCB-MSCs, and BDNF expression remained fairly constant for the first 2 weeks in vitro and in vivo. Moreover, microporation of BDNF gene into hUCB-MSCs promoted their in vitro differentiation into neural cells.Taken together, the present data demonstrates the value of microporation as an efficient means of transfection of MSCs without changing their multiple properties. Gene delivery by microporation may enhance the feasibility of transgenic stem cell therapy.Stem cells are highly attractive and valuable candidates for biomedical applications including the development of cell and gene therapy. Of the various stem cells, mesenchymal stem cells (MSCs) show a particular potential for clinical use because of their high proliferative capacity, ability to differentiate into multiple lineages [1-3], and ability to migrate into injured organs [4,5] and cancers [6,7]. Moreover, MSCs are not immunogenic, and so do not elicit a proliferative response of allogeneic lymphocytes in vitro [8]. Therefore, MSCs have become a major focus of research for potential therapeutic applications for various diseases.In recent years, efforts have been made to improve the therapeutic efficacy of MSCs through combination approaches using MSCs and genes. Additionally, a new therapeutic strategy has been developed that uses MSCs for the targeted delivery and local production of biologic agents in tumors [6,9]. Viruses are commonly used as vehicles to deliver transgenes into
Investigating Sub-Spine Actin Dynamics in Rat Hippocampal Neurons with Super-Resolution Optical Imaging
Vedakumar Tatavarty,Eun-Ji Kim,Vladimir Rodionov,Ji Yu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007724
Abstract: Morphological changes in dendritic spines represent an important mechanism for synaptic plasticity which is postulated to underlie the vital cognitive phenomena of learning and memory. These morphological changes are driven by the dynamic actin cytoskeleton that is present in dendritic spines. The study of actin dynamics in these spines traditionally has been hindered by the small size of the spine. In this study, we utilize a photo-activation localization microscopy (PALM)–based single-molecule tracking technique to analyze F-actin movements with ~30-nm resolution in cultured hippocampal neurons. We were able to observe the kinematic (physical motion of actin filaments, i.e., retrograde flow) and kinetic (F-actin turn-over) dynamics of F-actin at the single-filament level in dendritic spines. We found that F-actin in dendritic spines exhibits highly heterogeneous kinematic dynamics at the individual filament level, with simultaneous actin flows in both retrograde and anterograde directions. At the ensemble level, movements of filaments integrate into a net retrograde flow of ~138 nm/min. These results suggest a weakly polarized F-actin network that consists of mostly short filaments in dendritic spines.
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