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Search Results: 1 - 10 of 195030 matches for " Eugenio D’Angelo "
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The Virtuous Circle of Corporate Social Performance and Corporate Social Disclosure  [PDF]
Francesco Gangi, Eugenio DAngelo
Modern Economy (ME) , 2016, DOI: 10.4236/me.2016.712129
Abstract: Previous literature in the field of corporate social responsibility investigates whether corporate social performance can be seen as a determinant of corporate social disclosure or, conversely, if corporate social disclosure is a determinant of corporate social performance. The aim of this paper is to join these two streams of research in a unique theoretical model, which can demonstrate that there is a mutual interaction between performance and disclosure. This can result, in the long run, in a virtuous circle where higher social performance generates future higher social disclosure and this determines higher future social performance and so on. An analytical model has been adopted to demonstrate the research hypothesis. Gathering data from the portfolios of the European Socially responsible funds (SRFs) listed on the Morningstar platform in 2010, the study analyzed 160 social reports published by 80 companies during 2008 and 2009. Findings, by demonstrating the non-one-way relationship between social performance and social disclosure, confirm the existence of a mutual influence between the results gained in different CSR areas and the capability to control and communicate such performance. In this way, the paper provides not only theoretical insights, but also practical implications for managers that are required to put in place responsive and effective initiatives towards the increasing pressure exerted by the internal and external environments in which they operate.
Is the Lending Decision-Making Process Affected by Behavioral Biases?
—Evidence from Southern Italy
 [PDF]

Eugenio DAngelo, Mario Mustilli, Rossana Piccolo
Modern Economy (ME) , 2018, DOI: 10.4236/me.2018.91010
Abstract: The objective of this article was to verify whether, in the decision-making process concerning bank loans issuance, managers have been influenced or not by how they perceive some personal characteristics of the applicant, even if these characteristics have nothing to do with the financial aspects typically analyzed to determine creditworthiness. In particular, we analyzed the impact of gender, age, beauty, race and education of the borrower on the probability to be funded. The study was conducted submitting face-to-face questionnaires to 212 officers working in the credit chain of 25 banks and data have been analyzed using the logistic regression model. The chosen setting was the south of Italy and in particular of the Campania region. The results show that there has been some influence of bias regarding gender, age and beauty, while no significant relationship has been found with reference to the racial discrimination or to the cultural level of the applicant. These results, which confirm the evidence already found in other settings by previous empirical analyses, would lead to highlight that there is an adverse selection mechanism in the provision of banks' credit capital.
Cross-Country Differences in How Behavioral Biases Affect Decision-Making in the Bank Industry: Evidence from Italy and Serbia  [PDF]
Mario Mustilli, Rossana Piccolo, Eugenio DAngelo
American Journal of Industrial and Business Management (AJIBM) , 2018, DOI: 10.4236/ajibm.2018.82016
Abstract: Since non-performing loans, despite the implementation of the Basel accords, which should have improved creditworthiness estimation, are strongly affecting European banks’ liquidity and stability, there could be a behavioral bias behind banks misallocation of capital. The purpose of this study is to investigate whether behavioral biases affect credit allocation in different ways in different countries. Particularly, we investigated how certain characteristics of the applicants, such as race, age, gender and education, affect bank officers’ decision-making process. The study was conducted submitting face-to-face questionnaires to 299 officers, 212 in Italy and 87 in Serbia, working in the credit chain. Running a Mann-Whitney U test on the mentioned two independent samples, result show that Italian officers are more influenced by behavioral biases than their Serbian colleagues when they have to decide whether or not to approve a loan application.
Entrepreneurial Orientation and Financial Resources Availability as Determinants of Firms’ Growth  [PDF]
Mario Mustilli, Eugenio DAngelo, Francesco Campanella, Domenico Graziano
Modern Economy (ME) , 2017, DOI: 10.4236/me.2017.82021
Abstract: The purpose of this empirical paper is to investigate the determinants of firms’ growth during different financial cycles. In particular, we analyze the relationship between firms’ growth and their entrepreneurial orientation. In addition, we investigate how firms’ financial constraints moderate the relation between entrepreneurial orientation and growth before and during financial crisis. We test our hypotheses with an OLS regression model run on a sample of 382 European listed firms between 2003 and 2012. We found that entrepreneurial orientation is a determinant of firms’ growth and that during the period of crisis this relation is slightly exacerbated. Furthermore, we found that financial constraints only slightly attenuate the entrepreneurial orientation prediction of growth, which may mean that when firm is more financial constraint could be forced to increase its entrepreneurial orientation in order to maintain a higher growth rate.
A Systems Biology Approach to Characterize the Regulatory Networks Leading to Trabectedin Resistance in an In Vitro Model of Myxoid Liposarcoma
Sarah Uboldi, Enrica Calura, Luca Beltrame, Ilaria Fuso Nerini, Sergio Marchini, Duccio Cavalieri, Eugenio Erba, Giovanna Chiorino, Paola Ostano, Daniela D'Angelo, Maurizio D'Incalci, Chiara Romualdi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035423
Abstract: Trabectedin, a new antitumor compound originally derived from a marine tunicate, is clinically effective in soft tissue sarcoma. The drug has shown a high selectivity for myxoid liposarcoma, characterized by the translocation t(12;16)(q13; p11) leading to the expression of FUS-CHOP fusion gene. Trabectedin appears to act interfering with mechanisms of transcription regulation. In particular, the transactivating activity of FUS-CHOP was found to be impaired by trabectedin treatment. Even after prolonged response resistance occurs and thus it is important to elucidate the mechanisms of resistance to trabectedin. To this end we developed and characterized a myxoid liposarcoma cell line resistant to trabectedin (402-91/ET), obtained by exposing the parental 402-91 cell line to stepwise increases in drug concentration. The aim of this study was to compare mRNAs, miRNAs and proteins profiles of 402-91 and 402-91/ET cells through a systems biology approach. We identified 3,083 genes, 47 miRNAs and 336 proteins differentially expressed between 402-91 and 402-91/ET cell lines. Interestingly three miRNAs among those differentially expressed, miR-130a, miR-21 and miR-7, harbored CHOP binding sites in their promoter region. We used computational approaches to integrate the three regulatory layers and to generate a molecular map describing the altered circuits in sensitive and resistant cell lines. By combining transcriptomic and proteomic data, we reconstructed two different networks, i.e. apoptosis and cell cycle regulation, that could play a key role in modulating trabectedin resistance. This approach highlights the central role of genes such as CCDN1, RB1, E2F4, TNF, CDKN1C and ABL1 in both pre- and post-transcriptional regulatory network. The validation of these results in in vivo models might be clinically relevant to stratify myxoid liposarcoma patients with different sensitivity to trabectedin treatment.
Livestock Antibiotic Effects on Nitrification, Denitrification, and Microbial Community Composition in Soils  [PDF]
Sagarika Banerjee, Elisa DAngelo
Open Journal of Soil Science (OJSS) , 2013, DOI: 10.4236/ojss.2013.35024
Abstract:

The broiler (Gallus gallus domesticus) industry in the United States and several other countries routinely includes subtherapeutic levels of antibiotics such as roxarsone, virginiamycin, and bacitracin in the feed to improve bird growth yields. Large fractions of the antibiotics fed to the birds are excreted in manure (litter), which is often applied to soils to improve fertility. Some concerns with this practice are antibiotic-induced alterations in microbially-mediated nutrient cycling, which could influence plant productivity and environmental quality. To investigate this possibility, a series of lab experiments were conducted to determine the effects of increasing levels of the three livestock antibiotics on nitrification, denitrification, and microbial community composition (fatty acid methyl ester profiles) of soils collected along a catena. Roxarsone and virginiamycin significantly influenced microbial community composition and inhibited nitrification in the soils, but only at levels that were several-fold higher than expected in poultry litter-applied soils. Bacitracin did not affect microbial growth, microbial community composition, or nitrification at any concentration tested (up to 500 mg·kg-1). None of the antibiotics influenced denitrification at environmentally-relevant concentrations. Amounts of antibiotics in soil solution were greatly reduced by sorption, which followed Freundlich models in the concentration range of 1 - 500 mg·L-1. Results from this study indicated that addition of roxarsone, virginiamycin, or bacitracin to these soils at environmentally-relevant concentrations would not likely impact microbial community composition, nitrification or denitrification due to intrinsic resistance/insensitivity of microorganisms to these antibiotics and reductions in the bioavailable amounts due to sorption by soil surfaces.

Protective Factors for the Well-Being in Caregivers of Patients with Alzheimer’s: The Role of Relational Quality  [PDF]
Caterina Gozzoli, Antonino Giorgi, Chiara DAngelo
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.46A1009
Abstract:

The work highlights one of the direct stakeholders of RSA organization, the caregivers of patients with Alzheimer. It studies if and in which measure the caregivers’ level of health are strongly influenced by their perceived Relational Quality of the retirement homes in which their loved ones are hospitalized. Participants were 111 caregivers of patients with a diagnosis of dementia and recovered in RSA since at least 6 months. The study measures if the relational quality perceived by caregivers has a positive and direct influence on two mood states of caregivers: depression-dejection, anger-hostility. It also investigates if the protective function of relational quality remains significant also in presence of moderator variable such as social support and burden. The analysis confirms that increasing perceived relational quality corresponds to a decreased perception of caregivers’ discomfort humoral. The social support factor does not act as moderator, but it is confirmed the moderator role of burden. The research work provided some important empirical about the important role of caregivers retirement homes. They represent an emotional and relational link that connects the guest on one hand with the familiar net and on the other hand with the service operators. Therefore caregiver is a central resource, who needs protection and valorisation.

Fernández de Buján, Federico (con la colaboración de Luis Eugenio Oliver), Sistema contractual romano (2a ed., Madrid, Dykinson, 2004, incluye CD-Rom), 525 págs
Francisco Eugenio Díaz
Revista de estudios histórico-jurídicos , 2005,
Abstract:
Immunomodulatory Agents with Antivascular Activity in the Treatment of Non-Small Cell Lung Cancer: Focus on TLR9 Agonists, IMiDs and NGR-TNF
Angelo Corti,Monica Giovannini,Carmen Belli,Eugenio Villa
Journal of Oncology , 2010, DOI: 10.1155/2010/732680
Abstract: Standard treatments for nonsmall cell lung cancer (NSCLC), such as surgery, chemotherapy, and radiotherapy, often lead to disappointing results. Unfortunately, also the various immunotherapeutic approaches so far tested have not produced satisfactory results to be widely applied in the clinical practice. However, the recent development of new immunomodulatory agents may open promising therapeutic options. This paper focuses on PF3512676, lenalidomide, and NGR-TNF, that is, drugs belonging to three different classes of immunomodulatory agents, that are also capable to affect tumor blood vessels with different mechanisms, and discusses the potential role of such agents in NSCLC treatment strategy. 1. Introduction Lung cancer is the leading cause of cancer death in both men and women and one of the leading causes of death worldwide [1]. Non small cell lung cancer (NSCLC) represents of all types of lung cancer. Most patients present with locally advanced (stage III) or metastatic (stage IV) cancer [2, 3]. Despite chemotherapy treatment, sometimes in combination with radiotherapy, most patients die of disease progression, due to acquired or intrinsic resistance to chemotherapeutic drugs. Various immunotherapeutic approaches have been also attempted, ranging from the use of nonspecific immunostimulants like Bacillus Calmette-Guerin (BCG) to more specific strategies, unfortunately often with disappointing results [4, 5]. However, the recent improvement of our understanding of how the immune system works, the identification of new target antigens, and the development of new immunomodulators capable to affect the immune system and the tumor neovasculature could open new therapeutic options that deserve further investigation. This review discusses the potential role of three immunomodulatory agents that, besides regulating immune cells, can also affect the tumor neovasculature with different mechanisms and to different extent. In particular we discuss: (a) PF3512676, a Toll-like receptor 9 agonist primarily endowed of immunomodulatory activity, (b) lenalidomide, an immunomodulator with antiangiogenic properties and (c) NGR-TNF, an immunomodulatory agent with strong vascular damaging activity. 2. PF3512676 (TLR9 Agonist) Toll like receptors (TLRs) are a family of highly conserved receptors that regulate innate antigen-specific immunity via the recognition of pathogen-associated molecular pattern [6–9]. TLR9 is expressed in endosomes of B and T lymphocytes, plasmocytoid cells, and dendritic cells [10]. Immunostimulatory oligonucleotides containing certain CpG
A modernidade pelo olhar de Walter Benjamin
D'Angelo, Martha;
Estudos Avan?ados , 2006, DOI: 10.1590/S0103-40142006000100016
Abstract: this article's aim is to sketch a profile of modernity using as reference the essays "paris, capital of the 19th century" and "paris of the second empire in baudelaire", by walter benjamin. it attempts to fathom the relationships between the french revolutionary process, the commercialization of society and art, and the poetic work of baudelaire.
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