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Search Results: 1 - 10 of 5399 matches for " Eu Ddeum Chung "
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Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs
Qianwei Wang, Jacqueline Chow, Jenny Hong, Anne Smith, Carol Moreno, Peter Seaby, Paul Vrana, Kamelia Miri, Joon Tak, Eu Ddeum Chung, Gabriela Mastromonaco, Isabella Caniggia, Susannah Varmuza
BMC Genomics , 2011, DOI: 10.1186/1471-2164-12-204
Abstract: We analyzed allelic expression of approximately 20 genes within a 3.9 Mb domain and found that Sfmbt2 and an overlapping non-coding antisense transcript are the only imprinted genes in this region. These transcripts represent a very narrow imprinted gene locus. We also demonstrate that rat Sfmbt2 is imprinted in extraembryonic tissues. An interesting feature of both mouse and rat Sfmbt2 genes is the presence of a large block of miRNAs in intron 10. Other mammals, including the bovine, lack this block of miRNAs. Consistent with this association, we show that human and bovine Sfmbt2 are biallelic. Other evidence indicates that pig Sfmbt2 is also not imprinted. Further strengthening the argument for recent evolution of Sfmbt2 is our demonstration that a more distant muroid rodent, Peromyscus also lacks imprinting and the block of miRNAs.These observations are consistent with the hypothesis that the block of miRNAs are driving imprinting at this locus. Our results are discussed in the context of ncRNAs at other imprinted loci.Accession numbers for Peromyscus cDNA and intron 10 genomic DNA are [Genbank:HQ416417 and Genbank:HQ416418], respectively.Genomic imprinting is an epigenetic process that affects a small subset of genes resulting in their expression/repression in a parent of origin dependent fashion. One set of imprinted genes is expressed only from the paternally inherited allele, while another set is expressed only from the maternally inherited chromosome. The imprint is reset at each generation when the two haploid genomes are separate, either during gametogenesis or immediately after fertilization, when the two genomes are physically separated in their own pronuclei.Imprinted genes generally reside in clusters around a cis acting element called an Imprinting Control Region (ICR) that exerts its effects over a large chromosomal domain (up to 4 Mb) (reviewed in [1]). Imprinted domains can contain genes that are biallelic, paternally expressed or maternally expres
Gender identity: A force in Igbo traditional musical practices
EU Ibekwe
Creative Artist: A Journal of Theatre and Media Studies , 2009,
Abstract: Right from the genesis of creation, God made them male and female. In the same vein, specific roles are assigned in relation to or in response to such gender distinction, either humanly ascribed or Divine. The type of role to a large extent determines the nature of musical involvement at any given situation. This essay views some of such gender ascribed roles as they concern Igbo traditional society and the type of musical performances associated with each of the roles. It also examines the implications of gender upon music performance in Igbo traditional society.
Pain as a reason for primary care visits: Cross-sectional survey in a rural and periurban health clinic in the Eastern Cape, South Africa
EU Igumbor
South African Family Practice , 2012,
Abstract: Background: The burden of pain in primary care has not been described for South Africa. This study aimed to determine the prevalence of pain in primary care and to characterise pain among adult patients attending a rural and a periurban clinic in the Eastern Cape (EC) Province. Method: A cross-sectional descriptive survey was conducted among adult patients attending a rural and periurban clinic over four days. Consecutive patients were asked whether they were in the clinic because of pain and whether the pain was the major reason for their visit. Pain was characterised using an adaptation of the Brief Pain Inventory and the Pain Disability Index. The prevalence percentage and the 95% confidence interval (CI) of pain were estimated, and the relationship with demographic variables was determined at a significance level of P < 0.05. Results: Seven hundred and ninety-six adult patients were interviewed, representing a response rate of 97.4%. Almost three-quarters (74.6%; 95% CI: 63.2-81.4%) reported visiting the clinic because of pain. Pain was the primary reason for 393 (49.4%; 95% CI: 32.1-61.0%) visits and was secondary in 201 (25.3%; 95% CI: 12.8-33.7%) visits. The common sites of pain were the head, back and chest. The median pain score was eight on a scale of 0-10 (interquartile range: 6-8). Respondents experienced limitations in a number of activities of daily living as a result of pain. Conclusion: Pain is a central problem in public primary care settings in the EC Province and must therefore be a priority area for primary care research. Strategies are needed to develop to improve pain management at primary care level in the province.
Iterative Approximation of a Common Zero of a Countably Infinite Family of -Accretive Operators in Banach Spaces
Ofoedu EU
Fixed Point Theory and Applications , 2008,
Abstract: Let be a real reflexive and strictly convex Banach space which has a uniformly Gateaux differentiable norm and be a closed convex nonempty subset of . Strong convergence theorems for approximation of a common zero of a countably infinite family of -accretive mappings from to are proved. Consequently, we obtained strong convergence theorems for a countably infinite family of pseudocontractive mappings.
A Case of Pancreatic Cancer in the Setting of Autoimmune Pancreatitis with Nondiagnostic Serum Markers
Manju D. Chandrasegaram,Su C. Chiam,Nam Q. Nguyen,Andrew Ruszkiewicz,Adrian Chung,Eu L. Neo,John W. Chen,Christopher S. Worthley,Mark E. Brooke-Smith
Case Reports in Surgery , 2013, DOI: 10.1155/2013/809023
Abstract: Background. Autoimmune pancreatitis (AIP) often mimics pancreatic cancer. The diagnosis of both conditions is difficult preoperatively let alone when they coexist. Several reports have been published describing pancreatic cancer in the setting of AIP. Case Report. The case of a 53-year-old man who presented with abdominal pain, jaundice, and radiological features of autoimmune pancreatitis, with a “sausage-shaped” pancreas and bulky pancreatic head with portal vein impingement, is presented. He had a normal serum IgG4 and only mildly elevated Ca-19.9. Initial endoscopic ultrasound-(EUS-) guided fine-needle aspiration (FNA) of the pancreas revealed an inflammatory sclerosing process only. A repeat EUS guided biopsy following biliary decompression demonstrated both malignancy and features of autoimmune pancreatitis. At laparotomy, a uniformly hard, bulky pancreas was found with no sonographically definable mass. A total pancreatectomy with portal vein resection and reconstruction was performed. Histology revealed adenosquamous carcinoma of the pancreatic head and autoimmune pancreatitis and squamous metaplasia in the remaining pancreas. Conclusion. This case highlights the diagnostic and management difficulties in a patient with pancreatic cancer in the setting of serum IgG4-negative, Type 2 AIP. 1. Introduction Sarles et al. described the first reported case of idiopathic chronic pancreatitis with hypergammaglobulinemia secondary to an autoimmune process in 1961 [1]. It was, however, not until 1995 when Yoshida et al. proposed autoimmune pancreatitis (AIP) as a diagnostic entity [2]. AIP is characterised by unique clinical, radiological, and histological features. AIP commonly presents with obstructive jaundice and enlargement of the pancreas and mimics pancreatic cancer [3]. Several diagnostic criteria for AIP have been proposed. There are very few cases reported in the literature of both pancreatic cancer and autoimmune pancreatitis diagnosed together. Here, an unusual case of pancreatic cancer in the setting of autoimmune pancreatitis is reported, and the diagnostic and management dilemmas explored. 2. Case Report A 53-year-old man presented initially to his general practitioner with epigastric pain, jaundice, and significant weight loss over the preceding 3 months. He had no significant past medical or surgical history. He smoked 20 cigarettes a day and denied regular alcohol consumption. On examination, he was clinically jaundiced and had a soft abdomen with a nontender palpable gall bladder. His initial blood tests demonstrated deranged liver
Intra-Group Conflict and Teamwork Quality: The Moderating Role of Leadership Styles
Petru L. Cur?eu
Administrative Sciences , 2011, DOI: 10.3390/admsci1010003
Abstract: The study examines the extent to which task and relations oriented leadership moderate the impact of task and relationship conflict on teamwork quality. In a sample of 37 teams, the study shows that relationship oriented leadership is beneficial for dealing with relationship conflict, but it does not have the expected positive interaction effect with task conflict. The main practical implication of the results is that in order to mitigate the negative effects of intra-group conflict on teamwork quality the leadership style should fit the type of disagreement (task versus relational) predominantly experienced by the teams.
Effect of modification with nitrocellulose and phenol formaldehyde resins on some performance characteristics of rubber seed oil alkyds
EU Ikhuoria, AI Aigbodion
African Journal of Biotechnology , 2006,
Abstract: Three alkyd samples each of 50% oil length were prepared with phthalic anhydride, glycerol and crude rubber seed oil (I), refined rubber seed oil (II) and methyl esters of rubber seed oil (III) employing the alcoholysis method. All the alkyds were processed to acid value below 10 mg KOH/g. The alkyd samples were blended with nitrocellulose and phenol formaldehyde resins in different proportions. The performance of the blends in terms of drying schedule, chemical resistance and pencil hardness was determined. The blends were observed to show improved properties to a substitution level of 40% rubber seed oil alkyd in the blend. The resistance of the blends to different service media was found to be better than the rubber seed oil based alkyd resins
Characterization of avocado pear (Persea americana) and African pear (Dacryodes edulis) extracts
EU Ikhuoria, M Maliki
African Journal of Biotechnology , 2007,
Abstract: The oil from edible avocado pear (Persea americana) and African pear (Dacryodes edulis) were extracted with chloroform. The oil were characterized for melting point, refractive index, relative viscosity, free fatty acids, saponification value, iodine value, acid value and percentage unsaponifable matter. The percent oil content in the fruit pulp was determined. The oil content of avocado pear was 9.1% while that of African pear was 23.2%.The physico-chemical characteristics and fatty acid composition of these oils, suggest some industrial potentials.
Assessment of toxic heavy metal loading in topsoil samples within the vicinity of a limestone quarry in South Western Nigeria
EU Etim, GU Adie
African Journal of Environmental Science and Technology , 2012,
Abstract: Loading of Pb, Cd, Cr, Cu, Co, Mn, Ni, Zn, and Fe in topsoil samples (TS) collected from the vicinity of limestone quarry in South Western Nigeria was investigated. Thirty TS were sampled within km radius from exploration area and 5 background samples from undeveloped area 10 km away from the study area. Limestone rock samples (RK) were also analyzed for metals’ content. All samples were pretreated and leached with appropriate acid solutions for some properties. All leachates were analyzed with atomic absorption spectrophotomer (AAS) technique. Soil pH ranged from 6.65 to 8.23, sand from 55.8 to 75.0%, silt from 16.6 to 34.6%, clay from 8.43 to 13.6%, and organic matter from 0.97 to 4.84%, respectively. These properties compared with those of background samples. Rock samples (RK) showed high Fe and Mn enrichment. Metals levels (mg/kg) in TS with background levels in parenthesis ranged as follows: 11.5 to 27.7 (10.5) Pb, 0.28 to 3.18 (0.55) Cd, 12.1 to 17.4 (5.50) Cr, 80.6 to 55.8 (3.81) Cu, 8.93 to 23.5 (11.1) Co, 262 to 710 (637) Mn, 6.34 to 17.4 (6.10) Ni, 36.0 to 620 (24.4) Zn, and 6585 to 13440 (4563) Fe. The elevated enrichment suggests influence from exploration activities. Residual phase showed highest enrichment for all metals possibly, because of high sand content. Positive correlations were shown between all metals, except Mn and Cd that were negative. Geoaccumulation index rating showed <0 for Mn denoting uncontamination, while others ranged from 1 to 2 indicating moderate contamination.
Urinary schistosomiasis epidemiological survey of urinary schistosomiasis among children in selected schools: A preliminary study in Minna, Nigeria
EU Chidozie, SY Daniyan
African Journal of Biotechnology , 2008,
Abstract: The study was carried out in Minna Metropolis, between August and December, 2005, with a total of 387 school children interviewed and 217 urine samples analysed. This research employs the use of questionnaires, validation of questionnaires by urinalysis and the microscopic examination of the urine samples. The research is aimed at appreciating prevalent level of urinary schistosomiasis in Minna metropolis. The overall prevalence of urinary schistosomiasis, as confirmed by the presence of egg of Schistosoma haematobium was 12.9%, reported blood in the urine 34.4%, microhaematuria 52.5%, protenuria 32.7% and red blood cells 24.6%. The frequency of gross haematuria, and the degree of microhaematuria and proteinuria detectable by chemical reagent strips was observed to correlate with intensity of infection. The urinary schistosomiasis prevalence, confirmed by urine microscopy, of 12.9% in the selected school children within Minna, in spite its urban status, suggests that Minna is an endemic area, and the state requires an effective urinary schistosomiasis control programme. A major concern which represents a serious issue in the study includes the very poor level of awareness about the possible cause of urinary schistosomiasis or reported blood in the urine, as only 0.78% of the children have knowledge about the infection and 12% of the children that reported having blood in their urine have visited a health center.
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